The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

DEFA6  -  defensin, alpha 6, Paneth cell-specific

Homo sapiens

Synonyms: DEF6, Defensin, alpha 6, Defensin-6, HD-6
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of DEFA6


High impact information on DEFA6


Biological context of DEFA6


Anatomical context of DEFA6

  • In this study, we determined the chromosomal localization of the human defensin (HD) genes expressed in Paneth cells, HD-5 and HD-6 [10].
  • Human alpha defensins (HD-5 and HD-6) are antibiotic effector molecules predominantly expressed in Paneth cells of the ileum [12].
  • We describe the isolation of naturally occurring human intestinal defensins HD-5 and HD-6 from ileal neobladder urine and ileal mucosa [13].
  • We compared the expression of human alpha- and beta-defensins by various human tissues. mRNA for alpha-defensins HNP1-3, abundant in bone marrow, was detected in peripheral blood leukocytes, spleen and thymus by RT-PCR, which revealed alpha-defensins HD5 and HD6 only in the small intestine [14].
  • HNP-1, HD-5, and HD-6 were present in significantly higher levels in colostrum than in mature milk [15].

Associations of DEFA6 with chemical compounds

  • SLED consisted of 8 h of HD 6 days a week, with blood flow of 200 ml/min, dialysate flows of 350 ml/min, and hemofiltration with 1 l of saline/h. CRRT patients were anticoagulated with either heparin or citrate, and SLED patients with either heparin or saline flushes [16].
  • Polarized HD6 cells exhibit low levels of CEA only at their apical luminal surface [11].

Other interactions of DEFA6

  • The natural antimicrobial defensin DEFA5 and DEFA6 genes were particularly over-expressed in CD [17].

Analytical, diagnostic and therapeutic context of DEFA6


  1. High level expression of human epithelial beta-defensins (hBD-1, 2 and 3) in papillomavirus induced lesions. Chong, K.T., Xiang, L., Wang, X., Jun, E.L., Xi, L.F., Schweinfurth, J.M. Virol. J. (2006) [Pubmed]
  2. Enteric defensin expression in necrotizing enterocolitis. Salzman, N.H., Polin, R.A., Harris, M.C., Ruchelli, E., Hebra, A., Zirin-Butler, S., Jawad, A., Martin Porter, E., Bevins, C.L. Pediatr. Res. (1998) [Pubmed]
  3. Defensin pattern in chronic gastritis: HBD-2 is differentially expressed with respect to Helicobacter pylori status. Wehkamp, J., Schmidt, K., Herrlinger, K.R., Baxmann, S., Behling, S., Wohlschläger, C., Feller, A.C., Stange, E.F., Fellermann, K. J. Clin. Pathol. (2003) [Pubmed]
  4. A single amino acid substitution in v-erbB confers a thermolabile phenotype to ts167 avian erythroblastosis virus-transformed erythroid cells. Choi, O.R., Trainor, C., Graf, T., Beug, H., Engel, J.D. Mol. Cell. Biol. (1986) [Pubmed]
  5. Induction of features characteristic of hairy cell leukemia in chronic lymphocytic leukemia and prolymphocytic leukemia cells. Ziegler-Heitbrock, H.W., Munker, R., Dörken, B., Gaedicke, G., Thiel, E. Cancer Res. (1986) [Pubmed]
  6. Reduced Paneth cell alpha-defensins in ileal Crohn's disease. Wehkamp, J., Salzman, N.H., Porter, E., Nuding, S., Weichenthal, M., Petras, R.E., Shen, B., Schaeffeler, E., Schwab, M., Linzmeier, R., Feathers, R.W., Chu, H., Lima, H., Fellermann, K., Ganz, T., Stange, E.F., Bevins, C.L. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  7. The DNA-binding properties of two heat shock factors, HSF1 and HSF3, are induced in the avian erythroblast cell line HD6. Nakai, A., Kawazoe, Y., Tanabe, M., Nagata, K., Morimoto, R.I. Mol. Cell. Biol. (1995) [Pubmed]
  8. Evaluation of ricin A chain-containing immunotoxins directed against CD19 and CD22 antigens on normal and malignant human B-cells as potential reagents for in vivo therapy. Ghetie, M.A., May, R.D., Till, M., Uhr, J.W., Ghetie, V., Knowles, P.P., Relf, M., Brown, A., Wallace, P.M., Janossy, G. Cancer Res. (1988) [Pubmed]
  9. Human enteric defensins. Gene structure and developmental expression. Mallow, E.B., Harris, A., Salzman, N., Russell, J.P., DeBerardinis, R.J., Ruchelli, E., Bevins, C.L. J. Biol. Chem. (1996) [Pubmed]
  10. Human enteric defensin genes: chromosomal map position and a model for possible evolutionary relationships. Bevins, C.L., Jones, D.E., Dutra, A., Schaffzin, J., Muenke, M. Genomics (1996) [Pubmed]
  11. Colon carcinoma cells blocked in polarization exhibit increased expression of carcinoembryonic antigen. Yan, Z., Robinson-Saddler, A., Winawer, S., Friedman, E. Cell Growth Differ. (1993) [Pubmed]
  12. NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expression. Wehkamp, J., Harder, J., Weichenthal, M., Schwab, M., Schäffeler, E., Schlee, M., Herrlinger, K.R., Stallmach, A., Noack, F., Fritz, P., Schröder, J.M., Bevins, C.L., Fellermann, K., Stange, E.F. Gut (2004) [Pubmed]
  13. Isolation of human intestinal defensins from ileal neobladder urine. Porter, E.M., Poles, M.A., Lee, J.S., Naitoh, J., Bevins, C.L., Ganz, T. FEBS Lett. (1998) [Pubmed]
  14. Widespread expression of beta-defensin hBD-1 in human secretory glands and epithelial cells. Zhao, C., Wang, I., Lehrer, R.I. FEBS Lett. (1996) [Pubmed]
  15. Identification and quantification of innate immune system mediators in human breast milk. Armogida, S.A., Yannaras, N.M., Melton, A.L., Srivastava, M.D. Allergy and asthma proceedings : the official journal of regional and state allergy societies. (2004) [Pubmed]
  16. Sustained low-efficiency dialysis in the ICU: cost, anticoagulation, and solute removal. Berbece, A.N., Richardson, R.M. Kidney Int. (2006) [Pubmed]
  17. Ulcerative colitis and Crohn's disease: distinctive gene expression profiles and novel susceptibility candidate genes. Lawrance, I.C., Fiocchi, C., Chakravarti, S. Hum. Mol. Genet. (2001) [Pubmed]
  18. Pharmacokinetics of recombinant hirudin in hemodialyzed end-stage renal failure patients. Vanholder, R., Camez, A., Veys, N., Van Loo, A., Dhondt, A.M., Ringoir, S. Thromb. Haemost. (1997) [Pubmed]
  19. Hodgkin's disease as a second malignant neoplasm in childhood: report of a case and review of the literature. Ragusa, R., Russo, S., Villari, L., Schilirò, G. Pediatric hematology and oncology. (2001) [Pubmed]
  20. Can factors influencing in-patient treatment in Hodgkin's disease be identified?--Retrospective analysis of HD6 patients of the GHSG. Pfistner, B., Paulus, U., Glossmann, J.P., Walshe, R., Tesch, H., Diehl, V. Studies in health technology and informatics. (2000) [Pubmed]
  21. In-vitro induction of some features of hairy cell leukemia in chronic lymphocytic leukemia and immunocytoma cells. Ziegler-Heitbrock, H.W., Dörken, B., Munker, R., Riethmüller, G., Thierfelder, S., Thiel, E. Blut (1985) [Pubmed]
WikiGenes - Universities