The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

DEFA5  -  defensin, alpha 5, Paneth cell-specific

Homo sapiens

Synonyms: DEF5, Defensin, alpha 5, Defensin-5, HD-5, HD5(20-94)
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of DEFA5


High impact information on DEFA5


Biological context of DEFA5


Anatomical context of DEFA5


Associations of DEFA5 with chemical compounds

  • The functional consequence of alpha-defensin expression levels was examined by using a transgenic mouse model, where we found changes in HD5 expression levels, comparable to those observed in CD, had a pronounced impact on the luminal microbiota [11].
  • Incubation of HD-5 in the presence of tumor necrosis factor alpha further increased IL-8 secretion synergistically, suggesting that HD-5 may act as a regulator of the intestinal inflammatory response [12].
  • Finally, the minor difference of lubricant capacity between Compritol HD5 ATO and Compritol 888 ATO has no consequence in compression practice [13].
  • The aim of this paper is to study the lubricant capacity of Compritol HD5 ATO, a glyceryl and polyethylene glycol dibehenate, obtained by atomization [13].
  • Comparative study of the lubricant performance of Compritol HD5 ATO and Compritol 888 ATO: effect of polyethylene glycol behenate on lubricant capacity [13].

Other interactions of DEFA5


Analytical, diagnostic and therapeutic context of DEFA5

  • The two isoforms detected by this PCR approach were human defensin family members, HD-5 and HD-6 [7].
  • Immunogold electron microscopy further localized HD-5 to the Paneth cell secretory granules [16].
  • We compared the expression of human alpha- and beta-defensins by various human tissues. mRNA for alpha-defensins HNP1-3, abundant in bone marrow, was detected in peripheral blood leukocytes, spleen and thymus by RT-PCR, which revealed alpha-defensins HD5 and HD6 only in the small intestine [17].
  • The hypothenar ECAP was liable to stimulus artefact interference because of the short onset latency at HD5 (2.2(SD 0.4)ms), whereas the adductor pollicis (3.0(SD 0.5)ms) position (TD2) yielded reliable results [18].


  1. High level expression of human epithelial beta-defensins (hBD-1, 2 and 3) in papillomavirus induced lesions. Chong, K.T., Xiang, L., Wang, X., Jun, E.L., Xi, L.F., Schweinfurth, J.M. Virol. J. (2006) [Pubmed]
  2. Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin. Salzman, N.H., Ghosh, D., Huttner, K.M., Paterson, Y., Bevins, C.L. Nature (2003) [Pubmed]
  3. Antibacterial activity and specificity of the six human {alpha}-defensins. Ericksen, B., Wu, Z., Lu, W., Lehrer, R.I. Antimicrob. Agents Chemother. (2005) [Pubmed]
  4. Enteric defensin expression in necrotizing enterocolitis. Salzman, N.H., Polin, R.A., Harris, M.C., Ruchelli, E., Hebra, A., Zirin-Butler, S., Jawad, A., Martin Porter, E., Bevins, C.L. Pediatr. Res. (1998) [Pubmed]
  5. Increased expression of antimicrobial peptides and lysozyme in colonic epithelial cells of patients with ulcerative colitis. Fahlgren, A., Hammarström, S., Danielsson, A., Hammarström, M.L. Clin. Exp. Immunol. (2003) [Pubmed]
  6. Paneth cell trypsin is the processing enzyme for human defensin-5. Ghosh, D., Porter, E., Shen, B., Lee, S.K., Wilk, D., Drazba, J., Yadav, S.P., Crabb, J.W., Ganz, T., Bevins, C.L. Nat. Immunol. (2002) [Pubmed]
  7. Human enteric defensins. Gene structure and developmental expression. Mallow, E.B., Harris, A., Salzman, N., Russell, J.P., DeBerardinis, R.J., Ruchelli, E., Bevins, C.L. J. Biol. Chem. (1996) [Pubmed]
  8. Human enteric defensin genes: chromosomal map position and a model for possible evolutionary relationships. Bevins, C.L., Jones, D.E., Dutra, A., Schaffzin, J., Muenke, M. Genomics (1996) [Pubmed]
  9. Gene expression, immunolocalization, and secretion of human defensin-5 in human female reproductive tract. Quayle, A.J., Porter, E.M., Nussbaum, A.A., Wang, Y.M., Brabec, C., Yip, K.P., Mok, S.C. Am. J. Pathol. (1998) [Pubmed]
  10. NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expression. Wehkamp, J., Harder, J., Weichenthal, M., Schwab, M., Schäffeler, E., Schlee, M., Herrlinger, K.R., Stallmach, A., Noack, F., Fritz, P., Schröder, J.M., Bevins, C.L., Fellermann, K., Stange, E.F. Gut (2004) [Pubmed]
  11. Reduced Paneth cell alpha-defensins in ileal Crohn's disease. Wehkamp, J., Salzman, N.H., Porter, E., Nuding, S., Weichenthal, M., Petras, R.E., Shen, B., Schaeffeler, E., Schwab, M., Linzmeier, R., Feathers, R.W., Chu, H., Lima, H., Fellermann, K., Ganz, T., Stange, E.F., Bevins, C.L. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  12. Structure-dependent functional properties of human defensin 5. de Leeuw, E., Burks, S.R., Li, X., Kao, J.P., Lu, W. FEBS Lett. (2007) [Pubmed]
  13. Comparative study of the lubricant performance of Compritol HD5 ATO and Compritol 888 ATO: effect of polyethylene glycol behenate on lubricant capacity. N'Diaye, A., Jannin, V., Bérard, V., Andrès, C., Pourcelot, Y. International journal of pharmaceutics. (2003) [Pubmed]
  14. Ulcerative colitis and Crohn's disease: distinctive gene expression profiles and novel susceptibility candidate genes. Lawrance, I.C., Fiocchi, C., Chakravarti, S. Hum. Mol. Genet. (2001) [Pubmed]
  15. Defensin pattern in chronic gastritis: HBD-2 is differentially expressed with respect to Helicobacter pylori status. Wehkamp, J., Schmidt, K., Herrlinger, K.R., Baxmann, S., Behling, S., Wohlschläger, C., Feller, A.C., Stange, E.F., Fellermann, K. J. Clin. Pathol. (2003) [Pubmed]
  16. Localization of human intestinal defensin 5 in Paneth cell granules. Porter, E.M., Liu, L., Oren, A., Anton, P.A., Ganz, T. Infect. Immun. (1997) [Pubmed]
  17. Widespread expression of beta-defensin hBD-1 in human secretory glands and epithelial cells. Zhao, C., Wang, I., Lehrer, R.I. FEBS Lett. (1996) [Pubmed]
  18. Effect of surface electrode positioning on the compound action potential evoked by ulnar nerve stimulation in anaesthetized infants and children. Kalli, I. British journal of anaesthesia. (1989) [Pubmed]
WikiGenes - Universities