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Gene Review

Lipe  -  lipase, hormone sensitive

Mus musculus

Synonyms: 4933403G17Rik, HSL, Hormone-sensitive lipase
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Disease relevance of Lipe


Psychiatry related information on Lipe


High impact information on Lipe


Chemical compound and disease context of Lipe


Biological context of Lipe


Anatomical context of Lipe


Associations of Lipe with chemical compounds

  • Studies addressing how Peri A PKA sites regulate adipocyte lipolysis have relied on non-adipocyte cell models, which express neither adipose triglyceride lipase (ATGL), the rate-limiting enzyme for triglyceride catabolism in mice, nor the "downstream" lipase, hormone-sensitive lipase (HSL) [13].
  • Except for the increased HDL cholesterol concentrations, these differences were not observed in fed animals, in which HSL activity is generally low [11].
  • Studies with ATGL-and HSL-directed small hairpin RNAs demonstrate that 1) ATGL activity is required for all PKA-stimulated FA and glycerol release in murine embryonic fibroblast adipocytes and 2) all PKA-stimulated FA release in the absence of HSL activity requires serine 517 phosphorylation [13].
  • Importantly, each FABP form stimulated HSL activity approximately 2-fold using cholesteryl oleate as substrate but exhibited no activation using p-nitrophenyl butyrate [15].
  • Maximum corticosterone production was identical in HSL(-/-) and double-LDLR/HSL(-/-) mice [16].

Physical interactions of Lipe


Regulatory relationships of Lipe

  • The overexpression of cholesterol acceptors in HSL-apoA-IV double-transgenic mice increases plasma HDL levels and decreases diet-induced atherosclerosis compared to HSL Tg mice, with aortic lesions reduced to sizes in nontransgenic littermates [18].

Other interactions of Lipe


Analytical, diagnostic and therapeutic context of Lipe


  1. Absence of hormone-sensitive lipase inhibits obesity and adipogenesis in Lep ob/ob mice. Sekiya, M., Osuga, J., Okazaki, H., Yahagi, N., Harada, K., Shen, W.J., Tamura, Y., Tomita, S., Iizuka, Y., Ohashi, K., Okazaki, M., Sata, M., Nagai, R., Fujita, T., Shimano, H., Kraemer, F.B., Yamada, N., Ishibashi, S. J. Biol. Chem. (2004) [Pubmed]
  2. Targeted disruption of hormone-sensitive lipase results in male sterility and adipocyte hypertrophy, but not in obesity. Osuga, J., Ishibashi, S., Oka, T., Yagyu, H., Tozawa, R., Fujimoto, A., Shionoiri, F., Yahagi, N., Kraemer, F.B., Tsutsumi, O., Yamada, N. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  3. The testicular form of hormone-sensitive lipase HSLtes confers rescue of male infertility in HSL-deficient mice. Vallet-Erdtmann, V., Tavernier, G., Contreras, J.A., Mairal, A., Rieu, C., Touzalin, A.M., Holm, C., Jégou, B., Langin, D. J. Biol. Chem. (2004) [Pubmed]
  4. Absence of perilipin results in leanness and reverses obesity in Lepr(db/db) mice. Martinez-Botas, J., Anderson, J.B., Tessier, D., Lapillonne, A., Chang, B.H., Quast, M.J., Gorenstein, D., Chen, K.H., Chan, L. Nat. Genet. (2000) [Pubmed]
  5. Overexpression of hormone-sensitive lipase prevents triglyceride accumulation in adipocytes. Sztalryd, C., Komaromy, M.C., Kraemer, F.B. J. Clin. Invest. (1995) [Pubmed]
  6. Hormone-sensitive lipase knockout mice have increased hepatic insulin sensitivity and are protected from short-term diet-induced insulin resistance in skeletal muscle and heart. Park, S.Y., Kim, H.J., Wang, S., Higashimori, T., Dong, J., Kim, Y.J., Cline, G., Li, H., Prentki, M., Shulman, G.I., Mitchell, G.A., Kim, J.K. Am. J. Physiol. Endocrinol. Metab. (2005) [Pubmed]
  7. The decrease of serum leptin levels in oestrogen-treated male mice. Nedvídková, J., Haluzík, M., Schreiber, V. Physiological research / Academia Scientiarum Bohemoslovaca. (1997) [Pubmed]
  8. The adipose tissue phenotype of hormone-sensitive lipase deficiency in mice. Wang, S.P., Laurin, N., Himms-Hagen, J., Rudnicki, M.A., Levy, E., Robert, M.F., Pan, L., Oligny, L., Mitchell, G.A. Obes. Res. (2001) [Pubmed]
  9. Perilipin promotes hormone-sensitive lipase-mediated adipocyte lipolysis via phosphorylation-dependent and -independent mechanisms. Miyoshi, H., Souza, S.C., Zhang, H.H., Strissel, K.J., Christoffolete, M.A., Kovsan, J., Rudich, A., Kraemer, F.B., Bianco, A.C., Obin, M.S., Greenberg, A.S. J. Biol. Chem. (2006) [Pubmed]
  10. Identification of Mouse Prp19p as a Lipid Droplet-associated Protein and Its Possible Involvement in the Biogenesis of Lipid Droplets. Cho, S.Y., Shin, E.S., Park, P.J., Shin, D.W., Chang, H.K., Kim, D., Lee, H.H., Lee, J.H., Kim, S.H., Song, M.J., Chang, I.S., Lee, O.S., Lee, T.R. J. Biol. Chem. (2007) [Pubmed]
  11. Hormone-sensitive lipase deficiency in mice changes the plasma lipid profile by affecting the tissue-specific expression pattern of lipoprotein lipase in adipose tissue and muscle. Haemmerle, G., Zimmermann, R., Strauss, J.G., Kratky, D., Riederer, M., Knipping, G., Zechner, R. J. Biol. Chem. (2002) [Pubmed]
  12. Perilipin A is essential for the translocation of hormone-sensitive lipase during lipolytic activation. Sztalryd, C., Xu, G., Dorward, H., Tansey, J.T., Contreras, J.A., Kimmel, A.R., Londos, C. J. Cell Biol. (2003) [Pubmed]
  13. Control of Adipose Triglyceride Lipase Action by Serine 517 of Perilipin A Globally Regulates Protein Kinase A-stimulated Lipolysis in Adipocytes. Miyoshi, H., Perfield, J.W., Souza, S.C., Shen, W.J., Zhang, H.H., Stancheva, Z.S., Kraemer, F.B., Obin, M.S., Greenberg, A.S. J. Biol. Chem. (2007) [Pubmed]
  14. Insulin and leptin acutely regulate cholesterol ester metabolism in macrophages by novel signaling pathways. O'Rourke, L., Yeaman, S.J., Shepherd, P.R. Diabetes (2001) [Pubmed]
  15. Fatty acid-binding protein-hormone-sensitive lipase interaction. Fatty acid dependence on binding. Jenkins-Kruchten, A.E., Bennaars-Eiden, A., Ross, J.R., Shen, W.J., Kraemer, F.B., Bernlohr, D.A. J. Biol. Chem. (2003) [Pubmed]
  16. The LDL receptor is not necessary for acute adrenal steroidogenesis in mouse adrenocortical cells. Kraemer, F.B., Shen, W.J., Patel, S., Osuga, J., Ishibashi, S., Azhar, S. Am. J. Physiol. Endocrinol. Metab. (2007) [Pubmed]
  17. Adipose tissue lipolysis as a metabolic pathway to define pharmacological strategies against obesity and the metabolic syndrome. Langin, D. Pharmacol. Res. (2006) [Pubmed]
  18. Reduced atherosclerosis in hormone-sensitive lipase transgenic mice overexpressing cholesterol acceptors. Choy, H.A., Wang, X.P., Schotz, M.C. Biochim. Biophys. Acta (2003) [Pubmed]
  19. Resistance to high-fat diet-induced obesity and altered expression of adipose-specific genes in HSL-deficient mice. Harada, K., Shen, W.J., Patel, S., Natu, V., Wang, J., Osuga, J., Ishibashi, S., Kraemer, F.B. Am. J. Physiol. Endocrinol. Metab. (2003) [Pubmed]
  20. Molecular mechanisms regulating hormone-sensitive lipase and lipolysis. Holm, C. Biochem. Soc. Trans. (2003) [Pubmed]
  21. Proteomic analysis of proteins associated with lipid droplets of basal and lipolytically stimulated 3T3-L1 adipocytes. Brasaemle, D.L., Dolios, G., Shapiro, L., Wang, R. J. Biol. Chem. (2004) [Pubmed]
  22. Long-term leptin treatment of ob/ob mice improves glucose-induced insulin secretion. Khan, A., Narangoda, S., Ahren, B., Holm, C., Sundler, F., Efendic, S. Int. J. Obes. Relat. Metab. Disord. (2001) [Pubmed]
  23. Inhibitory effect of tumor necrosis factor on gene expression of hormone sensitive lipase in 3T3-L1 adipocytes. Sumida, M., Sekiya, K., Okuda, H., Tanaka, Y., Shiosaka, T. J. Biochem. (1990) [Pubmed]
  24. Hormone-sensitive lipase is a cholesterol esterase of the intestinal mucosa. Grober, J., Lucas, S., Sörhede-Winzell, M., Zaghini, I., Mairal, A., Contreras, J.A., Besnard, P., Holm, C., Langin, D. J. Biol. Chem. (2003) [Pubmed]
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