Gene Review:
Nr4a2 - nuclear receptor subfamily 4, group A,...
Mus musculus
Synonyms:
HZF-3, NOT, NUR-related factor 1, Nuclear receptor subfamily 4 group A member 2, Nurr1, ...
Misler,
Missale,
Zhang,
Páez-Pereda,
Kovalovsky,
Hoffer,
Post,
Hopfner,
Ikenaka,
Losa,
Pirih,
Tetradis,
Bezouglaia,
Pagotto,
You,
Arzt,
Jung,
Hida,
Tsingotjidou,
Uhl,
Grübler,
Stalla,
Stalla,
Nervina,
Bezouglaia,
Aghaloo,
Russell,
Bäckman,
Xing,
Nakahira,
Eells,
Kim,
Nikodem,
Nishino,
Tetradis,
Theodoropoulou,
Perlmann,
- Dopamine neuron agenesis in Nurr1-deficient mice. Zetterström, R.H., Solomin, L., Jansson, L., Hoffer, B.J., Olson, L., Perlmann, T. Science (1997)
- The role of Nurr1 in the development of dopaminergic neurons and Parkinson's disease. Jankovic, J., Chen, S., Le, W.D. Prog. Neurobiol. (2005)
- Congenital hypoventilation and impaired hypoxic response in Nurr1 mutant mice. Nsegbe, E., Wallén-Mackenzie, A., Dauger, S., Roux, J.C., Shvarev, Y., Lagercrantz, H., Perlmann, T., Herlenius, E. J. Physiol. (Lond.) (2004)
- Age-dependent dopaminergic dysfunction in Nurr1 knockout mice. Jiang, C., Wan, X., He, Y., Pan, T., Jankovic, J., Le, W. Exp. Neurol. (2005)
- Reduction of dopamine-related transcription factors Nurr1 and NGFI-B in the prefrontal cortex in schizophrenia and bipolar disorders. Xing, G., Zhang, L., Russell, S., Post, R. Schizophr. Res. (2006)
- Inhibition of Nur77/Nurr1 leads to inefficient clonal deletion of self-reactive T cells. Zhou, T., Cheng, J., Yang, P., Wang, Z., Liu, C., Su, X., Bluethmann, H., Mountz, J.D. J. Exp. Med. (1996)
- Retinoic acid prevents experimental Cushing syndrome. Páez-Pereda, M., Kovalovsky, D., Hopfner, U., Theodoropoulou, M., Pagotto, U., Uhl, E., Losa, M., Stalla, J., Grübler, Y., Missale, C., Arzt, E., Stalla, G.K. J. Clin. Invest. (2001)
- Elevated locomotor activity without altered striatal dopamine contents in Nurr1 heterozygous mice after acute exposure to methamphetamine. Bäckman, C., You, Z.B., Perlmann, T., Hoffer, B.J. Behav. Brain Res. (2003)
- Dopaminergic properties and experimental anti-parkinsonian effects of IPX750 in rodent models of Parkinson disease. Jiang, C., Wan, X., Jankovic, J., Christian, S.T., Pristupa, Z.B., Niznik, H.B., Sundsmo, J.S., Le, W. Clinical neuropharmacology. (2004)
- Regulation of the osteopontin gene by the orphan nuclear receptor NURR1 in osteoblasts. Lammi, J., Huppunen, J., Aarnisalo, P. Mol. Endocrinol. (2004)
- Orphan nuclear receptor Nurr1 is essential for Ret expression in midbrain dopamine neurons and in the brain stem. Wallén A, A., Castro, D.S., Zetterström, R.H., Karlén, M., Olson, L., Ericson, J., Perlmann, T. Mol. Cell. Neurosci. (2001)
- Dopamine biosynthesis is selectively abolished in substantia nigra/ventral tegmental area but not in hypothalamic neurons in mice with targeted disruption of the Nurr1 gene. Castillo, S.O., Baffi, J.S., Palkovits, M., Goldstein, D.S., Kopin, I.J., Witta, J., Magnuson, M.A., Nikodem, V.M. Mol. Cell. Neurosci. (1998)
- Temporally induced Nurr1 can induce a non-neuronal dopaminergic cell type in embryonic stem cell differentiation. Sonntag, K.C., Simantov, R., Kim, K.S., Isacson, O. Eur. J. Neurosci. (2004)
- Decreased ethanol preference and wheel running in Nurr1-deficient mice. Werme, M., Hermanson, E., Carmine, A., Buervenich, S., Zetterström, R.H., Thorén, P., Ogren, S.O., Olson, L., Perlmann, T., Brené, S. Eur. J. Neurosci. (2003)
- Retinoid X receptor heterodimerization and developmental expression distinguish the orphan nuclear receptors NGFI-B, Nurr1, and Nor1. Zetterström, R.H., Solomin, L., Mitsiadis, T., Olson, L., Perlmann, T. Mol. Endocrinol. (1996)
- Adult mice with reduced Nurr1 expression: an animal model for schizophrenia. Rojas, P., Joodmardi, E., Hong, Y., Perlmann, T., Ogren, S.O. Mol. Psychiatry (2007)
- Identification of Dlk1, Ptpru and Klhl1 as novel Nurr1 target genes in meso-diencephalic dopamine neurons. Jacobs, F.M., van der Linden, A.J., Wang, Y., von Oerthel, L., Sul, H.S., Burbach, J.P., Smidt, M.P. Development (2009)
- Differential regulation of midbrain dopaminergic neuron development by Wnt-1, Wnt-3a, and Wnt-5a. Castelo-Branco, G., Wagner, J., Rodriguez, F.J., Kele, J., Sousa, K., Rawal, N., Pasolli, H.A., Fuchs, E., Kitajewski, J., Arenas, E. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Pleiotrophin mRNA is highly expressed in neural stem (progenitor) cells of mouse ventral mesencephalon and the product promotes production of dopaminergic neurons from embryonic stem cell-derived nestin-positive cells. Jung, C.G., Hida, H., Nakahira, K., Ikenaka, K., Kim, H.J., Nishino, H. FASEB J. (2004)
- Parathyroid hormone induces expression of the nuclear orphan receptor Nurr1 in bone cells. Tetradis, S., Bezouglaia, O., Tsingotjidou, A. Endocrinology (2001)
- PGC-1alpha is induced by parathyroid hormone and coactivates Nurr1-mediated promoter activity in osteoblasts. Nervina, J.M., Magyar, C.E., Pirih, F.Q., Tetradis, S. Bone (2006)
- Neuropilin1 is a direct downstream target of Nurr1 in the developing brain stem. Hermanson, E., Borgius, L., Bergsland, M., Joodmardi, E., Perlmann, T. J. Neurochem. (2006)
- Parathyroid hormone induces the NR4A family of nuclear orphan receptors in vivo. Pirih, F.Q., Aghaloo, T.L., Bezouglaia, O., Nervina, J.M., Tetradis, S. Biochem. Biophys. Res. Commun. (2005)
- Neural precursors derived from embryonic stem cells, but not those from fetal ventral mesencephalon, maintain the potential to differentiate into dopaminergic neurons after expansion in vitro. Chung, S., Shin, B.S., Hwang, M., Lardaro, T., Kang, U.J., Isacson, O., Kim, K.S. Stem Cells (2006)
- Reduced tyrosine hydroxylase and GTP cyclohydrolase mRNA expression, tyrosine hydroxylase activity, and associated neurochemical alterations in Nurr1-null heterozygous mice. Eells, J.B., Misler, J.A., Nikodem, V.M. Brain Res. Bull. (2006)
- One-step induction of neurons from mouse embryonic stem cells in serum-free media containing vitamin B12 and heparin. Yamazoe, H., Kobori, M., Murakami, Y., Yano, K., Satoh, M., Mizuseki, K., Sasai, Y., Iwata, H. Cell transplantation. (2006)
- Regulation of osteoblast differentiation by Nurr1 in MC3T3-E1 cell line and mouse calvarial osteoblasts. Lee, M.K., Choi, H., Gil, M., Nikodem, V.M. J. Cell. Biochem. (2006)
- Generation of tyrosine hydroxylase-immunoreactive neurons in ventral mesencephalic tissue of Nurr1 deficient mice. Tornqvist, N., Hermanson, E., Perlmann, T., Stromberg, I. Brain Res. Dev. Brain Res. (2002)
- Cooperative transcription activation by Nurr1 and Pitx3 induces embryonic stem cell maturation to the midbrain dopamine neuron phenotype. Martinat, C., Bacci, J.J., Leete, T., Kim, J., Vanti, W.B., Newman, A.H., Cha, J.H., Gether, U., Wang, H., Abeliovich, A. Proc. Natl. Acad. Sci. U.S.A. (2006)