Gene Review:
Stat6 - signal transducer and activator of...
Mus musculus
Synonyms:
Signal transducer and transcription activator 6
Nevalainen,
Chen,
Wick,
Urban,
Kosonen,
Zhang,
Li,
Lahesmaa,
Finkelman,
Dunnick,
Linehan,
Schopf,
Uckun,
Aittokallio,
Shea-Donohue,
Berton,
Morris,
Fu,
Madden,
Gildea,
Cetkovic-Cvrlje,
Lund,
Strait,
Wei,
Barnstable,
- Pivotal role of signal transducer and activator of transcription (Stat)4 and Stat6 in the innate immune response during sepsis. Matsukawa, A., Kaplan, M.H., Hogaboam, C.M., Lukacs, N.W., Kunkel, S.L. J. Exp. Med. (2001)
- Interleukin 13 gene transfer in liver ischemia and reperfusion injury: role of Stat6 and TLR4 pathways in cytoprotection. Ke, B., Shen, X.D., Gao, F., Busuttil, R.W., Kupiec-Weglinski, J.W. Hum. Gene Ther. (2004)
- Interleukin-4 receptor alpha chain and STAT6 signaling inhibit gamma interferon but not Th2 cytokine expression within schistosome granulomas. Metwali, A., Blum, A., Elliott, D.E., Weinstock, J.V. Infect. Immun. (2002)
- Differential requirement of signal transducer and activator of transcription-4 (Stat4) and Stat6 in a thyrotropin receptor-289-adenovirus-induced model of Graves' hyperthyroidism. Land, K.J., Gudapati, P., Kaplan, M.H., Seetharamaiah, G.S. Endocrinology (2006)
- Essential role of Stat6 in IL-4 signalling. Takeda, K., Tanaka, T., Shi, W., Matsumoto, M., Minami, M., Kashiwamura, S., Nakanishi, K., Yoshida, N., Kishimoto, T., Akira, S. Nature (1996)
- Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene. Shimoda, K., van Deursen, J., Sangster, M.Y., Sarawar, S.R., Carson, R.T., Tripp, R.A., Chu, C., Quelle, F.W., Nosaka, T., Vignali, D.A., Doherty, P.C., Grosveld, G., Paul, W.E., Ihle, J.N. Nature (1996)
- Th2 cells are required for the Schistosoma mansoni egg-induced granulomatous response. Kaplan, M.H., Whitfield, J.R., Boros, D.L., Grusby, M.J. J. Immunol. (1998)
- Effect of targeted disruption of signal transducer and activator of transcription (Stat)4 and Stat6 genes on the autoimmune diabetes development induced by multiple low doses of streptozotocin. Cetkovic-Cvrlje, M., Uckun, F.M. Clin. Immunol. (2005)
- Stat6-deficient mice develop airway hyperresponsiveness and peribronchial fibrosis during chronic fungal asthma. Blease, K., Schuh, J.M., Jakubzick, C., Lukacs, N.W., Kunkel, S.L., Joshi, B.H., Puri, R.K., Kaplan, M.H., Hogaboam, C.M. Am. J. Pathol. (2002)
- Abrogation of lung inflammation in sensitized Stat6-deficient mice is dependent on the allergen inhalation procedure. Trifilieff, A., El-Hasim, A., Corteling, R., Owen, C.E. Br. J. Pharmacol. (2000)
- Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis. Quelle, F.W., Shimoda, K., Thierfelder, W., Fischer, C., Kim, A., Ruben, S.M., Cleveland, J.L., Pierce, J.H., Keegan, A.D., Nelms, K. Mol. Cell. Biol. (1995)
- Quantitative gene expression profiling implicates genes for susceptibility and resistance to alveolar bone loss. Hart, G.T., Shaffer, D.J., Akilesh, S., Brown, A.C., Moran, L., Roopenian, D.C., Baker, P.J. Infect. Immun. (2004)
- Th1 cells regulate hematopoietic progenitor cell homeostasis by production of oncostatin M. Broxmeyer, H.E., Bruns, H.A., Zhang, S., Cooper, S., Hangoc, G., McKenzie, A.N., Dent, A.L., Schindler, U., Naeger, L.K., Hoey, T., Kaplan, M.H. Immunity (2002)
- DNA binding activity of cytoplasmic phosphorylated Stat6 is masked by an interaction with a detergent-sensitive factor. Daines, M.O., Andrews, R.P., Chen, W., El-Zayaty, S.A., Hershey, G.K. J. Biol. Chem. (2003)
- Interleukin-4- and interleukin-13-mediated host protection against intestinal nematode parasites. Finkelman, F.D., Shea-Donohue, T., Morris, S.C., Gildea, L., Strait, R., Madden, K.B., Schopf, L., Urban, J.F. Immunol. Rev. (2004)
- Consequences of Stat6 deletion on Sis/PDGF- and IL-4-induced proliferation and transcriptional activation in murine fibroblasts. Kriebel, P., Patel, B.K., Nelson, S.A., Grusby, M.J., LaRochelle, W.J. Oncogene (1999)
- Signal transducer and activator of transcription factor 6 (Stat6)-deficient mice are protected from antigen-induced airway hyperresponsiveness and mucus production. Kuperman, D., Schofield, B., Wills-Karp, M., Grusby, M.J. J. Exp. Med. (1998)
- Analysis of the life cycle of stat6. Continuous cycling of STAT6 is required for IL-4 signaling. Andrews, R.P., Ericksen, M.B., Cunningham, C.M., Daines, M.O., Hershey, G.K. J. Biol. Chem. (2002)
- Dependence of IL-4, IL-13, and nematode-induced alterations in murine small intestinal smooth muscle contractility on Stat6 and enteric nerves. Zhao, A., McDermott, J., Urban, J.F., Gause, W., Madden, K.B., Yeung, K.A., Morris, S.C., Finkelman, F.D., Shea-Donohue, T. J. Immunol. (2003)
- Ectopic expression of activated Stat6 induces the expression of Th2-specific cytokines and transcription factors in developing Th1 cells. Kurata, H., Lee, H.J., O'Garra, A., Arai, N. Immunity (1999)
- An IL-4R alpha allelic variant, I50, acts as a gain-of-function variant relative to V50 for Stat6, but not Th2 differentiation. Stephenson, L., Johns, M.H., Woodward, E., Mora, A.L., Boothby, M. J. Immunol. (2004)
- NF-kappaB elements associated with the Stat6 site in the germline gamma1 immunoglobulin promoter are not necessary for the transcriptional response to CD40 ligand. Berton, M.T., Linehan, L.A., Wick, K.R., Dunnick, W.A. Int. Immunol. (2004)
- Repression of an interleukin-4-responsive promoter requires cooperative BCL-6 function. Harris, M.B., Mostecki, J., Rothman, P.B. J. Biol. Chem. (2005)
- Stat5a regulates T helper cell differentiation by several distinct mechanisms. Kagami , S., Nakajima, H., Suto, A., Hirose, K., Suzuki, K., Morita, S., Kato, I., Saito, Y., Kitamura, T., Iwamoto, I. Blood (2001)
- Stat5a inhibits IL-12-induced Th1 cell differentiation through the induction of suppressor of cytokine signaling 3 expression. Takatori, H., Nakajima, H., Kagami, S., Hirose, K., Suto, A., Suzuki, K., Kubo, M., Yoshimura, A., Saito, Y., Iwamoto, I. J. Immunol. (2005)
- Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment. Ouyang, W., Löhning, M., Gao, Z., Assenmacher, M., Ranganath, S., Radbruch, A., Murphy, K.M. Immunity (2000)
- Increased susceptibility of Stat4-deficient and enhanced resistance in Stat6-deficient mice to infection with Trypanosoma cruzi. Tarleton, R.L., Grusby, M.J., Zhang, L. J. Immunol. (2000)
- Stat6 signaling promotes protective immunity against Trichinella spiralis through a mast cell- and T cell-dependent mechanism. Urban, J.F., Schopf, L., Morris, S.C., Orekhova, T., Madden, K.B., Betts, C.J., Gamble, H.R., Byrd, C., Donaldson, D., Else, K., Finkelman, F.D. J. Immunol. (2000)
- Stat6 signaling suppresses VLA-4 expression by CD8+ T cells and limits their ability to infiltrate tumor lesions in vivo. Sasaki, K., Zhao, X., Pardee, A.D., Ueda, R., Fujita, M., Sehra, S., Kaplan, M.H., Kane, L.P., Okada, H., Storkus, W.J. J. Immunol. (2008)
- Expression and activation of STAT proteins during mouse retina development. Zhang, S.S., Wei, J.Y., Li, C., Barnstable, C.J., Fu, X.Y. Exp. Eye Res. (2003)
- Cutting edge: spontaneous rejection of poorly immunogenic P1.HTR tumors by Stat6-deficient mice. Kacha, A.K., Fallarino, F., Markiewicz, M.A., Gajewski, T.F. J. Immunol. (2000)
- Helminth regulation of host IL-4Ralpha/Stat6 signaling: mechanism underlying NOS-2 inhibition by Trichinella spiralis. Bian, K., Zhong, M., Harari, Y., Lai, M., Weisbrodt, N., Murad, F. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Transcriptional repression of Stat6-dependent interleukin-4-induced genes by BCL-6: specific regulation of iepsilon transcription and immunoglobulin E switching. Harris, M.B., Chang, C.C., Berton, M.T., Danial, N.N., Zhang, J., Kuehner, D., Ye, B.H., Kvatyuk, M., Pandolfi, P.P., Cattoretti, G., Dalla-Favera, R., Rothman, P.B. Mol. Cell. Biol. (1999)
- Identification of novel IL-4/Stat6-regulated genes in T lymphocytes. Chen, Z., Lund, R., Aittokallio, T., Kosonen, M., Nevalainen, O., Lahesmaa, R. J. Immunol. (2003)