The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

Nisoxetina     3-(2-methoxyphenoxy)-N- methyl-3-phenyl...

Synonyms: Nisoxetine, Nisoxetinum, Compound 89218, CHEMBL295467, SureCN124289, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of NISOXETINE HYDROCHLORIDE

 

Psychiatry related information on NISOXETINE HYDROCHLORIDE

 

High impact information on NISOXETINE HYDROCHLORIDE

  • Analyses of functional chimeras delineate a segment spanning transmembrane domains 5-7 of the norepinephrine transporter of primary importance for high affinity binding of tricyclic and nontricyclic antidepressants (e.g., Ki < 20nM desipramine or nisoxetine) [8].
  • To confirm that the protection observed in the NET KO mice was due to the lack of NET, we treated wild-type mice with the specific NET inhibitor, nisoxetine, and then challenged them with MPTP [9].
  • Scatchard analysis revealed that nisoxetine bound with high affinity to a single class of binding sites in the membranes (dissociation constant = 13.8 +/- 0.4 nM) [10].
  • We investigated the interaction of nisoxetine with the human norepinephrine transporter by examining the binding of this ligand to the placental brush border membranes [10].
  • The binding capacity (Bmax) for binding defined by 0.1 microM nisoxetine varied between brain regions, with very low density in the striatum (Bmax not possible to determine), 60-90 fmol/mg of protein in cortical areas and cerebellum, and 120 fmol/mg of protein in the hypothalamus [11].
 

Biological context of NISOXETINE HYDROCHLORIDE

 

Anatomical context of NISOXETINE HYDROCHLORIDE

  • Effect of nisoxetine on uptake of catecholamines in synaptosomes isolated from discrete regions of rat brain [17].
  • Likewise, nisoxetine (10(-5)m) increased (1.3-fold) NE concentrations in the transudates but not in the effluents of sham animals [18].
  • Receptor binding studies indicated that chronic (22 day) treatment with clomipramine, desipramine or nisoxetine reduced the affinity of opiate [3H]naloxone) receptors in the spinal cord [19].
  • Consistent with expression of a functional SERT, specific uptake of (3)H-serotonin in macrophages was sodium dependent and inhibited by fluoxetine (IC(50) 6.9 nM) and desipramine (IC(50) 32 nM) but not by nisoxetine or reserpine [20].
  • 3. NE transport in rat trophoblasts is sensitive to NET-specific antagonists, desipramine (DS) and nisoxetine (NX), but not to the dopamine-transporter (DAT) specific antagonist, GBR12909 or to the serotonin (5HT) transporter (SERT) specific antagonist paroxetine (PX) [21].
 

Associations of NISOXETINE HYDROCHLORIDE with other chemical compounds

 

Gene context of NISOXETINE HYDROCHLORIDE

 

Analytical, diagnostic and therapeutic context of NISOXETINE HYDROCHLORIDE

References

  1. 6-hydroxydopamine-induced apoptosis is mediated via extracellular auto-oxidation and caspase 3-dependent activation of protein kinase Cdelta. Hanrott, K., Gudmunsen, L., O'Neill, M.J., Wonnacott, S. J. Biol. Chem. (2006) [Pubmed]
  2. Characterization of the inhibitory effect of some antidepressant drugs on the outward transport of norepinephrine in the ischemic myocardium. Carlsson, L., Abrahamsson, T. J. Pharmacol. Exp. Ther. (1988) [Pubmed]
  3. Nonexocytotic noradrenaline release and ventricular fibrillation in ischemic rat hearts. Kurz, T., Offner, B., Schreieck, J., Richardt, G., Tölg, R., Schömig, A. Naunyn Schmiedebergs Arch. Pharmacol. (1995) [Pubmed]
  4. Atomoxetine blocks motor hyperactivity in neonatal 6-hydroxydopamine-lesioned rats: implications for treatment of attention-deficit hyperactivity disorder. Moran-Gates, T., Zhang, K., Baldessarini, R.J., Tarazi, F.I. Int. J. Neuropsychopharmacol. (2005) [Pubmed]
  5. Alpha 1-and alpha 2-adrenoceptors of the circular myometrium from the dioestrous guinea-pig. Haynes, J., Pennefather, J.N. Clin. Exp. Pharmacol. Physiol. (1988) [Pubmed]
  6. Monoaminergic mechanisms and experimental cataplexy. Foutz, A.S., Delashaw, J.B., Guilleminault, C., Dement, W.C. Ann. Neurol. (1981) [Pubmed]
  7. Depression of REM sleep in cats by nisoxetine, a potential antidepressant drug. Slater, I.H., Jones, G.T., Moore, R.A. Psychopharmacology communications. (1976) [Pubmed]
  8. Structural domains of catecholamine transporter chimeras involved in selective inhibition by antidepressants and psychomotor stimulants. Buck, K.J., Amara, S.G. Mol. Pharmacol. (1995) [Pubmed]
  9. Reduced MPTP toxicity in noradrenaline transporter knockout mice. Rommelfanger, K.S., Weinshenker, D., Miller, G.W. J. Neurochem. (2004) [Pubmed]
  10. Sodium- and chloride-dependent, cocaine-sensitive, high-affinity binding of nisoxetine to the human placental norepinephrine transporter. Jayanthi, L.D., Prasad, P.D., Ramamoorthy, S., Mahesh, V.B., Leibach, F.H., Ganapathy, V. Biochemistry (1993) [Pubmed]
  11. [3H]desipramine binding to rat brain tissue: binding to both noradrenaline uptake sites and sites not related to noradrenaline neurons. Bäckström, I.T., Ross, S.B., Marcusson, J.O. J. Neurochem. (1989) [Pubmed]
  12. Down-regulation of norepinephrine transporters on PC12 cells by transporter inhibitors. Zhu, M.Y., Ordway, G.A. J. Neurochem. (1997) [Pubmed]
  13. Effect of monoamine uptake inhibitors on norepinephrine-stimulated phosphatidylinositol hydrolysis in rat cortex. Mosaddeghi, M., Moerschbaecher, J.M., Gonzales, R.A. Biochem. Pharmacol. (1989) [Pubmed]
  14. Comparison of the effects of sibutramine and other monoamine reuptake inhibitors on food intake in the rat. Jackson, H.C., Needham, A.M., Hutchins, L.J., Mazurkiewicz, S.E., Heal, D.J. Br. J. Pharmacol. (1997) [Pubmed]
  15. Effects of the selective norepinephrine uptake inhibitor nisoxetine on prodynorphin gene expression in rat CNS. Di Benedetto, M., Feliciani, D., D'Addario, C., Izenwasser, S., Candeletti, S., Romualdi, P. Brain Res. Mol. Brain Res. (2004) [Pubmed]
  16. Sibutramine: a novel anti-obesity drug. A review of the pharmacological evidence to differentiate it from d-amphetamine and d-fenfluramine. Heal, D.J., Aspley, S., Prow, M.R., Jackson, H.C., Martin, K.F., Cheetham, S.C. Int. J. Obes. Relat. Metab. Disord. (1998) [Pubmed]
  17. Effect of nisoxetine on uptake of catecholamines in synaptosomes isolated from discrete regions of rat brain. Wong, D.T., Bymaster, F.P. Biochem. Pharmacol. (1976) [Pubmed]
  18. Norepinephrine concentrations in the epicardial transudate reflect early changes in adrenergic activity in the isolated perfused heart. Lorbar, M., Skalova, K., Nabi, A., Chung, E.S., Fenton, R.A., Dobson, J.G., Meyer, T.E. J. Mol. Cell. Cardiol. (2000) [Pubmed]
  19. Effect of chronic treatment with tricyclic antidepressants upon antinociception induced by intrathecal injection of morphine and monoamines. Kellstein, D.E., Malseed, R.T., Ossipov, M.H., Goldstein, F.J. Neuropharmacology (1988) [Pubmed]
  20. Peritoneal macrophages express the serotonin transporter. Rudd, M.L., Nicolas, A.N., Brown, B.L., Fischer-Stenger, K., Stewart, J.K. J. Neuroimmunol. (2005) [Pubmed]
  21. Characterization of cocaine and antidepressant-sensitive norepinephrine transporters in rat placental trophoblasts. Jayanthi, L.D., Vargas, G., DeFelice, L.J. Br. J. Pharmacol. (2002) [Pubmed]
  22. Amphetamine-like effects of anorectics and related compounds in pigeons. Evans, S.M., Johanson, C.E. J. Pharmacol. Exp. Ther. (1987) [Pubmed]
  23. Human placental monoamine transporters as targets for amphetamines. Ramamoorthy, J.D., Ramamoorthy, S., Leibach, F.H., Ganapathy, V. Am. J. Obstet. Gynecol. (1995) [Pubmed]
  24. Activation and desensitization by cyclic antidepressant drugs of alpha2-autoreceptors, alpha2-heteroreceptors and 5-HT1A-autoreceptors regulating monamine synthesis in the rat brain in vivo. Esteban, S., Lladó, J., Sastre-Coll, A., García-Sevilla, J.A. Naunyn Schmiedebergs Arch. Pharmacol. (1999) [Pubmed]
  25. A PET imaging agent with fast kinetics: synthesis and in vivo evaluation of the serotonin transporter ligand [11C]2-[2-dimethylaminomethylphenylthio)]-5-fluorophenylamine ([11C]AFA). Huang, Y., Narendran, R., Bae, S.A., Erritzoe, D., Guo, N., Zhu, Z., Hwang, D.R., Laruelle, M. Nucl. Med. Biol. (2004) [Pubmed]
  26. Dopamine uptake through the norepinephrine transporter in brain regions with low levels of the dopamine transporter: evidence from knock-out mouse lines. Morón, J.A., Brockington, A., Wise, R.A., Rocha, B.A., Hope, B.T. J. Neurosci. (2002) [Pubmed]
  27. Cocaine mechanisms: enhanced cocaine, fluoxetine and nisoxetine place preferences following monoamine transporter deletions. Hall, F.S., Li, X.F., Sora, I., Xu, F., Caron, M., Lesch, K.P., Murphy, D.L., Uhl, G.R. Neuroscience (2002) [Pubmed]
  28. S-[18F]fluoromethyl-(+)-McN5652, a PET tracer for the serotonin transporter: evaluation in rats. Marjamäki, P., Zessin, J., Eskola, O., Grönroos, T., Haaparanta, M., Bergman, J., Lehikoinen, P., Forsback, S., Brust, P., Steinbach, J., Solin, O. Synapse (2003) [Pubmed]
  29. Nisoxetine infusion into the olfactory bulb enhances the capacity for male rats to identify conspecifics. Shang, Y., Dluzen, D.E. Neuroscience (2001) [Pubmed]
  30. [3H]nisoxetine: a radioligand for quantitation of norepinephrine uptake sites by autoradiography or by homogenate binding. Tejani-Butt, S.M. J. Pharmacol. Exp. Ther. (1992) [Pubmed]
  31. A comparison of the acute effects of zotepine and other antipsychotics on rat cortical dopamine release, in vivo. Rowley, H.L., Needham, P.L., Kilpatrick, I.C., Heal, D.J. Naunyn Schmiedebergs Arch. Pharmacol. (2000) [Pubmed]
  32. The effect of nisoxetine (Lilly compound 94939), a potential antidepressant, on biogenic amine uptake in man. Lemberger, L., Terman, S., Rowe, H., Billings, R. British journal of clinical pharmacology. (1976) [Pubmed]
  33. Castration increases nisoxetine-evoked norepinephrine levels in vivo within the olfactory bulb of male rats. Shang, Y., Dluzen, D.E. Neurosci. Lett. (2002) [Pubmed]
  34. Evaluation of the role of norepinephrine in the reinforcing effects of psychomotor stimulants in rhesus monkeys. Woolverton, W.L. Pharmacol. Biochem. Behav. (1987) [Pubmed]
 
WikiGenes - Universities