Gene Review:
Bhlhe40 - basic helix-loop-helix family, member e40
Mus musculus
Synonyms:
Bhlhb2, C130042M06Rik, CR8, Class B basic helix-loop-helix protein 2, Class E basic helix-loop-helix protein 40, ...
- Stra13 homodimers repress transcription through class B E-box elements. St-Pierre, B., Flock, G., Zacksenhaus, E., Egan, S.E. J. Biol. Chem. (2002)
- Overexpression of Stra13, a novel retinoic acid-inducible gene of the basic helix-loop-helix family, inhibits mesodermal and promotes neuronal differentiation of P19 cells. Boudjelal, M., Taneja, R., Matsubara, S., Bouillet, P., Dolle, P., Chambon, P. Genes Dev. (1997)
- Defective T cell activation and autoimmune disorder in Stra13-deficient mice. Sun, H., Lu, B., Li, R.Q., Flavell, R.A., Taneja, R. Nat. Immunol. (2001)
- Impaired lymphocyte development and function in Clast5/Stra13/DEC1-transgenic mice. Seimiya, M., Wada, A., Kawamura, K., Sakamoto, A., Ohkubo, Y., Okada, S., Hatano, M., Tokuhisa, T., Watanabe, T., Saisho, H., Tagawa, M., O-Wang, J. Eur. J. Immunol. (2004)
- A novel autofeedback loop of Dec1 transcription involved in circadian rhythm regulation. Kawamoto, T., Noshiro, M., Sato, F., Maemura, K., Takeda, N., Nagai, R., Iwata, T., Fujimoto, K., Furukawa, M., Miyazaki, K., Honma, S., Honma, K., Kato, Y. Biochem. Biophys. Res. Commun. (2004)
- mSharp-1/DEC2, a basic helix-loop-helix protein functions as a transcriptional repressor of E box activity and Stra13 expression. Azmi, S., Sun, H., Ozog, A., Taneja, R. J. Biol. Chem. (2003)
- Clast5/Stra13 is a negative regulator of B lymphocyte activation. Seimiya, M., Bahar, R., Wang, Y., Kawamura, K., Tada, Y., Okada, S., Hatano, M., Tokuhisa, T., Saisho, H., Watanabe, T., Tagawa, M., O-Wang, J. Biochem. Biophys. Res. Commun. (2002)
- 57Arg in the bHLH transcription factor DEC2 is essential for the suppression of CLOCK/BMAL2-mediated transactivation. Kondo, J., Sato, F., Fujimoto, K., Kusumi, T., Imanaka, T., Kawamoto, T., Uk, B., Noshiro, M., Kato, Y., Sato, T., Kijima, H. Int. J. Mol. Med. (2006)
- Stra13, a prostaglandin E2-induced gene, regulates the cellular redox state of podocytes. Bek, M.J., Wahle, S., Müller, B., Benzing, T., Huber, T.B., Kretzler, M., Cohen, C., Busse-Grawitz, A., Pavenstädt, H. FASEB J. (2003)
- Basic helix-loop-helix protein DEC1 promotes chondrocyte differentiation at the early and terminal stages. Shen, M., Yoshida, E., Yan, W., Kawamoto, T., Suardita, K., Koyano, Y., Fujimoto, K., Noshiro, M., Kato, Y. J. Biol. Chem. (2002)
- Molecular cloning and characterization of DEC2, a new member of basic helix-loop-helix proteins. Fujimoto, K., Shen, M., Noshiro, M., Matsubara, K., Shingu, S., Honda, K., Yoshida, E., Suardita, K., Matsuda, Y., Kato, Y. Biochem. Biophys. Res. Commun. (2001)
- The expression of antiapoptotic protein survivin is transcriptionally upregulated by DEC1 primarily through multiple sp1 binding sites in the proximal promoter. Li, Y., Xie, M., Yang, J., Yang, D., Deng, R., Wan, Y., Yan, B. Oncogene (2006)
- Inhibition of PPAR gamma 2 gene expression by the HIF-1-regulated gene DEC1/Stra13: a mechanism for regulation of adipogenesis by hypoxia. Yun, Z., Maecker, H.L., Johnson, R.S., Giaccia, A.J. Dev. Cell (2002)
- Dec1 and Dec2 expression is disrupted in the suprachiasmatic nuclei of Clock mutant mice. Butler, M.P., Honma, S., Fukumoto, T., Kawamoto, T., Fujimoto, K., Noshiro, M., Kato, Y., Honma, K. J. Biol. Rhythms (2004)
- Cytokine response gene 8 (CR8) regulates the cell cycle G1-S phase transition and promotes cellular survival. Beadling, C., Cereseto, A., Fan, W., Naramura, M., Smith, K.A. Oncogene (2001)
- Constitutively active signal transducer and activator of transcription 5 can replace the requirement for growth hormone in adipogenesis of 3T3-F442A preadipocytes. Shang, C.A., Waters, M.J. Mol. Endocrinol. (2003)
- The transcription factor DEC1 (stra13, SHARP2) is associated with the hypoxic response and high tumour grade in human breast cancers. Chakrabarti, J., Turley, H., Campo, L., Han, C., Harris, A.L., Gatter, K.C., Fox, S.B. Br. J. Cancer (2004)