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Gene Review

TAPBP  -  TAP binding protein (tapasin)

Homo sapiens

Synonyms: NGS-17, NGS17, TAP-associated protein, TAP-binding protein, TAPA, ...
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Disease relevance of TAPBP

  • Liver disease after TPN [1].
  • Postoperative TPN-induced lactic acidosis [2].
  • In the high-risk stratified group as defined by admission nutritional assessment and calculated PNI (greater than or equal to 50%), adequate preoperative TPN reduced postoperative complications 2.5-fold (p < 0.01), postoperative major sepsis six-fold (p < 0.005) and mortality five-fold (p < 0.01) [3].
  • Significant reductions in major wound, infectious, and postoperative complications were noted in these patients who received at least 5 days of preoperative TPN compared with postoperative TPN or the non-TPN groups (4% vs. 24% and 23%) [4].
  • A review of operative therapy in 244 patients with esophageal cancer from 1960 to 1980 was done to evaluate the impact of TPN in 72 patients treated from 1973 to 1980 with 43 non-TPN patients treated during the same period and to 129 patients operated upon before 1973 [4].

Psychiatry related information on TAPBP


High impact information on TAPBP


Chemical compound and disease context of TAPBP

  • Backgroud: Short bowel syndrome (SBS) can lead to intestinal failure and require total or supplemental parenteral nutrition (TPN or PN, respectively) [11].
  • In the EEN group, hyperglycemia (serum glucose, >200 mg/dL) was observed in 4.7% of the patients vs. 9.1% in the TPN group (p = NS) [12].
  • Combined growth hormone/insulin-like growth factor I in addition to glutamine-supplemented TPN results in net protein anabolism in critical illness [13].
  • Although there are no consistent signs and symptoms characteristic of TPN-associated Se deficiency in addition to the low blood selenium levels, some patients will experience leg muscle pain and altered serum transaminase and creatine kinase activities [14].
  • Met-depleting TPN appears to play a role as a biomodulator of 5-FU in human gastric cancer [15].

Biological context of TAPBP

  • Alkylation of methionine in human heart TPN-dependent isocitrate dehydrogenase [16].
  • Using primed constant isotopic infusions, we investigated the effects of recombinant human insulin-like growth factor-I (IGF-I) infusion on protein kinetics in both fasted and parenterally fed (TPN) lambs [17].
  • Intravenous TPN caused greater bacterial translocation in all small intestinal segments and the cecum when compared with chow (p <.05) [18].
  • Following termination of TPN or ad libitum food intake, and while receiving chemotherapy, the majority of the children who had previously received TPN lost significant weight [19].
  • The plateau in energy expenditure in response to TPN infusion may be useful as a guideline for nutritional therapy [20].

Anatomical context of TAPBP

  • Although a variety of cDNA fragments were identified as modulated by GM-CSF with the use of DD-PCR, one fragment in particular, NGS-17 (neutrophil GM-CSF-stimulated fragment #17), was characterized [21].
  • OBJECTIVE: The authors determined the effect of glutamine-supplementation of TPN on postoperative peripheral blood T-cell response and proinflammatory cytokine production in patients undergoing colorectal resection [22].
  • SUMMARY BACKGROUND DATA: Several vital tissues, including the immune system, are very dependent on glutamine; however, this amino acid, which may be essential in conditions of stress, only now is becoming formulated suitably for incorporation into TPN [22].
  • It is interesting to note that patients on prolonged TPN, in particular those with a short small intestine, have weak cholesterolemia, reflecting a lowering of HDL and LDL not masked by elevated LP-X [23].
  • Similarly, the fractional synthetic rates of protein in cardiac muscle, diaphragm, adductor muscle, psoas muscle, and hepatic tissue were increased (P less than 0.05) compared to those in animals that received only TPN [17].

Associations of TAPBP with chemical compounds

  • Human heart TPN-specific isocitrate dehydrogenase. Purification by a rapid three-step procedure [24].
  • The coenzymes TPN and TPNH have no effects on epsilon, while the carboxylic acid substrates L-malate and pyruvate and the inhibitors D-malate and oxalate significantly decrease epsilon [25].
  • The ability of selenious acid to reverse selenium deficiency in eight adult home TPN patients was assessed [26].
  • The Ra of leucine decreased (P less than 0.01) from 3.9 +/- 0.8 to 2.5 +/- 0.47 mumol/kg.min during IGF-I and TPN infusion [17].
  • These compounds thus bind to both enzyme-triphosphopyridine nucleotide (E-TPN) and enzyme-reduced triphosphopyridine nucleotide (E-TPNH), but only malate analogues prevent release of TPN, while pyruvate analogues prevent release of TPNH [27].

Physical interactions of TAPBP

  • A ternary complex between heavy chain, ERp57, and tapasin was observed and shown to be stabilized by a disulfide between both tapasinheavy chain and tapasin-ERp57 [28].

Analytical, diagnostic and therapeutic context of TAPBP

  • Since TPN allows total and complete control of exogenous nutrients, it should be used to explore alternative therapies in the form of nutrient composition [7].
  • Intestinal transplantation has become a standard treatment for intestinal failure in patients with life-threatening complications of TPN [29].
  • A set of independent variables was also evaluated, including age, gender, APACHE III scores, the presence of preexisting medical conditions, the use of invasive monitoring (Swan-Ganz catheters, central and arterial lines), and the use of antibiotics, low-dose dopamine (LDD) for renal protection, vasopressors, TPN, and enteral feeding [30].
  • The patient data have been compared with data obtained from 32 normal volunteers, and in addition the metabolic response of the trauma patient to total nutritional support (TPN) has been assessed [31].
  • Lean body mass increased in the TPN group (+9 +/- 3%) and decreased in the control group (-5 +/- 3%; P < 0.004) while body cell mass increased in the former (+15 +/- 4%) and decreased in the latter (-12 +/- 6%; P < 0.002) [32].


  1. Liver disease after TPN. Freund, U. Gastroenterology (1982) [Pubmed]
  2. Postoperative TPN-induced lactic acidosis. Kitamura, K., Takahashi, T., Yamaguchi, T., Hagiwara, A., Taniguchi, H., Tanaka, H., Hashimoto, S. Lancet (1992) [Pubmed]
  3. Reduction of operative morbidity and mortality by combined preoperative and postoperative nutritional support. Mullen, J.L., Buzby, G.P., Matthews, D.C., Smale, B.F., Rosato, E.F. Ann. Surg. (1980) [Pubmed]
  4. Parenteral nutrition in esophageal cancer patients. Daly, J.M., Massar, E., Giacco, G., Frazier, O.H., Mountain, C.F., Dudrick, S.J., Copeland, E.M. Ann. Surg. (1982) [Pubmed]
  5. Ethical issues in total parenteral nutrition. Fry, S.T. Nutrition (Burbank, Los Angeles County, Calif.) (1990) [Pubmed]
  6. Studies on early enteral nutrition for patients with gastric cancer from the view of immunity. Tanabe, H. Nippon geka hokan. Archiv für japanische Chirurgie. (1993) [Pubmed]
  7. Hyperalimentation in cancer. Souba, W.W., Copeland, E.M. CA: a cancer journal for clinicians. (1989) [Pubmed]
  8. Tap: a novel cellular protein that interacts with tip of herpesvirus saimiri and induces lymphocyte aggregation. Yoon, D.W., Lee, H., Seol, W., DeMaria, M., Rosenzweig, M., Jung, J.U. Immunity (1997) [Pubmed]
  9. Bloodstream infections associated with a needleless intravenous infusion system in patients receiving home infusion therapy. Danzig, L.E., Short, L.J., Collins, K., Mahoney, M., Sepe, S., Bland, L., Jarvis, W.R. JAMA (1995) [Pubmed]
  10. Glutamine and the preservation of gut integrity. van der Hulst, R.R., van Kreel, B.K., von Meyenfeldt, M.F., Brummer, R.J., Arends, J.W., Deutz, N.E., Soeters, P.B. Lancet (1993) [Pubmed]
  11. Synergistic effect of supplemental enteral nutrients and exogenous glucagon-like peptide 2 on intestinal adaptation in a rat model of short bowel syndrome. Liu, X., Nelson, D.W., Holst, J.J., Ney, D.M. Am. J. Clin. Nutr. (2006) [Pubmed]
  12. Early postoperative enteral nutrition improves gut oxygenation and reduces costs compared with total parenteral nutrition. Braga, M., Gianotti, L., Gentilini, O., Parisi, V., Salis, C., Di Carlo, V. Crit. Care Med. (2001) [Pubmed]
  13. Combined growth hormone/insulin-like growth factor I in addition to glutamine-supplemented TPN results in net protein anabolism in critical illness. Carroll, P.V., Jackson, N.C., Russell-Jones, D.L., Treacher, D.F., Sönksen, P.H., Umpleby, A.M. Am. J. Physiol. Endocrinol. Metab. (2004) [Pubmed]
  14. Selenium in pediatric nutrition. Litov, R.E., Combs, G.F. Pediatrics (1991) [Pubmed]
  15. Synergistic effect of methionine-depleting total parenteral nutrition with 5-fluorouracil on human gastric cancer: a randomized, prospective clinical trial. Goseki, N., Yamazaki, S., Shimojyu, K., Kando, F., Maruyama, M., Endo, M., Koike, M., Takahashi, H. Jpn. J. Cancer Res. (1995) [Pubmed]
  16. Alkylation of methionine in human heart TPN-dependent isocitrate dehydrogenase. Seelig, G.F., Colman, R.F. J. Biol. Chem. (1979) [Pubmed]
  17. Synergistic effect of insulin-like growth factor-I administration on the protein-sparing effects of total parenteral nutrition in fasted lambs. Koea, J.B., Douglas, R.G., Breier, B.H., Shaw, J.H., Gluckman, P.D. Endocrinology (1992) [Pubmed]
  18. Elemental and intravenous total parenteral nutrition diet-induced gut barrier failure is intestinal site specific and can be prevented by feeding nonfermentable fiber. Mosenthal, A.C., Xu, D., Deitch, E.A. Crit. Care Med. (2002) [Pubmed]
  19. Comparison of morbidity in children requiring abdominal radiation and chemotherapy, with and without total parenteral nutrition. Ghavimi, F., Shils, M.E., Scott, B.F., Brown, M., Tamaroff, M. J. Pediatr. (1982) [Pubmed]
  20. Metabolic and thermogenic response to continuous and cyclic total parenteral nutrition in traumatised and infected patients. Forsberg, E., Soop, M., Lepapea, A., Thörne, A. Clinical nutrition (Edinburgh, Scotland) (1994) [Pubmed]
  21. Granulocyte-macrophage colony-stimulating factor modulates tapasin expression in human neutrophils. El Ouakfaoui, S., Heitz, D., Paquin, R., Beaulieu, A.D. J. Leukoc. Biol. (1999) [Pubmed]
  22. Glutamine-supplemented total parenteral nutrition enhances T-lymphocyte response in surgical patients undergoing colorectal resection. O'Riordain, M.G., Fearon, K.C., Ross, J.A., Rogers, P., Falconer, J.S., Bartolo, D.C., Garden, O.J., Carter, D.C. Ann. Surg. (1994) [Pubmed]
  23. Phospholipid-rich particles in commercial parenteral fat emulsions. An overview. Bach, A.C., Férézou, J., Frey, A. Prog. Lipid Res. (1996) [Pubmed]
  24. Human heart TPN-specific isocitrate dehydrogenase. Purification by a rapid three-step procedure. Seelig, G.F., Colman, R.F. J. Biol. Chem. (1977) [Pubmed]
  25. Mechanism of malic enzyme from pigeon liver. Magnetic resonance and kinetic studies of the role of Mn2+. Hsu, R.Y., Mildvan, A.S., Chang, G., Fung, C. J. Biol. Chem. (1976) [Pubmed]
  26. Utilizing selenious acid to reverse selenium deficiency in total parenteral nutrition patients. Baptista, R.J., Bistrian, B.R., Blackburn, G.L., Miller, D.G., Champagne, C.D., Buchanan, L. Am. J. Clin. Nutr. (1984) [Pubmed]
  27. Inhibition and alternate-substrate studies on the mechanism of malic enzyme. Schimerlik, M.I., Cleland, W.W. Biochemistry (1977) [Pubmed]
  28. Formation of a major histocompatibility complex class I tapasin disulfide indicates a change in spatial organization of the peptide-loading complex during assembly. Chambers, J.E., Jessop, C.E., Bulleid, N.J. J. Biol. Chem. (2008) [Pubmed]
  29. Cost and quality of life after intestinal transplantation. Sudan, D. Gastroenterology (2006) [Pubmed]
  30. Analysis of the effect of conversion from open to closed surgical intensive care unit. Ghorra, S., Reinert, S.E., Cioffi, W., Buczko, G., Simms, H.H. Ann. Surg. (1999) [Pubmed]
  31. An integrated analysis of glucose, fat, and protein metabolism in severely traumatized patients. Studies in the basal state and the response to total parenteral nutrition. Shaw, J.H., Wolfe, R.R. Ann. Surg. (1989) [Pubmed]
  32. Efficacy of 2-month total parenteral nutrition in AIDS patients: a controlled randomized prospective trial. The French Multicenter Total Parenteral Nutrition Cooperative Group Study. Melchior, J.C., Chastang, C., Gelas, P., Carbonnel, F., Zazzo, J.F., Boulier, A., Cosnes, J., Boulétreau, P., Messing, B. AIDS (1996) [Pubmed]
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