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Gene Review

TRAM1  -  translocation associated membrane protein 1

Homo sapiens

Synonyms: PNAS8, TRAM, TRAMP, Translocating chain-associated membrane protein 1
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Disease relevance of TRAM1

  • CONCLUSION: The extensive curvilinear or tram-track calcification found in the colon in patients with schistosomiasis japonica is calcification of deposited eggs [1].
  • EXPERIENCE: Following unilateral or bilateral TRAM reconstruction, four consecutive breast cancer survivors underwent successful laparoscopic-assisted vaginal hysterectomy with oophorectomy using the periumbilical incision for trocar placement [2].
  • Sixty percent or more of the clinical fellows felt they would be uncomfortable performing vaginal radical hysterectomies, splenectomies, radical vaginectomies, laparoscopic lymph node dissection (LND), scalene LND, skin grafts, creation of neovagina, tram flaps, and ureterovaginal fistula repairs by the end of their fellowship [3].
  • The rate of hernia formation in the bilateral TRAM flap patients (5.4 percent) was similar to that of unilateral patients (3.9 percent, p = 0.80) [4].
  • A preoperative delay procedure can decrease the likelihood of TRAM flap failure or fat necrosis, but the required extent of this delay procedure is not clearly defined [5].

Psychiatry related information on TRAM1

  • By contrast, delayed TRAM patients noted significantly greater gains in body image compared with women choosing delayed expander-implant reconstruction [6].

High impact information on TRAM1

  • Protein translocation. Travelling by TRAM [7].
  • In mammalian cells, the Sec61 complex and translocating chain-associated membrane protein (TRAM) are necessary and sufficient to direct the biogenesis, in the appropriate topology, of all secretory and membrane proteins examined thus far [8].
  • Further investigation of other TLR ligands showed that AdTRAMdn was also able to inhibit signaling initiated by lipoteichoic acid, a TLR2 ligand, in SFs and HUVECs and lipoteichoic acid and macrophage-activating lipopeptide 2 signaling was also inhibited in TRAM(-/-) murine embryonic fibroblasts [9].
  • To investigate a potential role for TRAM in LPS signaling in human M-CSF-derived macrophages, we engineered an adenoviral construct expressing dominant-negative TRAM-C117H (AdTRAMdn) [9].
  • Selective Use of TRAM in Lipopolysaccharide (LPS) and Lipoteichoic Acid (LTA) Induced NF-{kappa}B Activation and Cytokine Production in Primary Human Cells: TRAM Is an Adaptor for LPS and LTA Signaling [9].

Biological context of TRAM1

  • Blood circulation within the conventional TRAM flap is not generous, and the contralateral random portion of the flap may result in fat or skin necrosis [10].
  • Successful pregnancies following TRAM flap surgery [11].
  • The purpose of this study was to evaluate the intraoperative changes in physiologic blood pressure following vascular delay of the TRAM flap [12].
  • TRAM, a predicted RNA-binding domain, common to tRNA uracil methylation and adenine thiolation enzymes [13].
  • The microvascular histology of both donor and recipient vessels was studied in 38 patients (40 flaps) undergoing breast reconstruction with free TRAM flaps [14].

Anatomical context of TRAM1

  • The optic nerve tram-track sign [15].
  • In five patients, calcifications resembling tram tracks were found in the sigmoid colon [1].
  • Secretion of newly synthesized proteins across the mammalian rough endoplasmic reticulum (translocation) is supported by the membrane proteins Sec61p and TRAM, but may also include accessory factors, depending on the particular translocation substrate [16].
  • Rectus abdominis muscle innervation: implications for TRAM flap elevation [17].
  • Assessment of the abdominal wall after pedicled TRAM flap surgery: 5- to 7-year follow-up of 150 consecutive patients [18].

Associations of TRAM1 with chemical compounds

  • BACKGROUND: Low-profile second-generation THORP titanium plates combined with soft tissues free flaps (forearm or TRAM) can be used for oromandibular reconstruction in patients with SCC in advanced stage (stage III-IV) [19].
  • During five winter months in late 2001 and early 2002, in-vehicle monitoring was performed in nine popular public transportation modes: tram, public light bus, air-conditioned bus, non-air-conditioned bus, taxi, ferry and three railway systems (Mass Transit Railway-MTR, Kowloon-Canton Railway-KCR and Light Rail Transit-LRT) [20].
  • Twenty-three patients were operated on by an uninfiltrated free TRAM technique, and 79 had 0.5% lignocaine with adrenaline infiltrated along the incision lines before the operation [21].
  • The effect of intravenous dopamine and dobutamine on blood circulation during a microvascular TRAM flap operation [22].

Analytical, diagnostic and therapeutic context of TRAM1


  1. Intestinal schistosomiasis japonica: CT-pathologic correlation. Lee, R.C., Chiang, J.H., Chou, Y.H., Rubesin, S.E., Wu, H.P., Jeng, W.C., Hsu, C.C., Tiu, C.M., Chang, T. Radiology. (1994) [Pubmed]
  2. Laparoscopy in patients following transverse rectus abdominis myocutaneous flap reconstruction. Muller, C.Y., Coleman, R.L., Adams, W.P. Obstetrics and gynecology. (2000) [Pubmed]
  3. Factors affecting fellowship satisfaction among gynecologic oncology fellows. Scribner, D.R., Baldwin, J., Gold, M.A. Gynecol. Oncol. (2001) [Pubmed]
  4. A comparison of morbidity from bilateral, unipedicled and unilateral, unipedicled TRAM flap breast reconstructions. Paige, K.T., Bostwick, J., Bried, J.T., Jones, G. Plast. Reconstr. Surg. (1998) [Pubmed]
  5. TRAM flap perforator ligation and the delay phenomenon: development of an endoscopic/laparoscopic delay procedure. Restifo, R.J., Ahmed, S.S., Rosser, J., Zahir, K., Zink, J., Lalikos, J.A., Thomson, J.G. Plast. Reconstr. Surg. (1998) [Pubmed]
  6. Prospective analysis of psychosocial outcomes in breast reconstruction: one-year postoperative results from the Michigan Breast Reconstruction Outcome Study. Wilkins, E.G., Cederna, P.S., Lowery, J.C., Davis, J.A., Kim, H.M., Roth, R.S., Goldfarb, S., Izenberg, P.H., Houin, H.P., Shaheen, K.W. Plast. Reconstr. Surg. (2000) [Pubmed]
  7. Protein translocation. Travelling by TRAM. Walter, P. Nature (1992) [Pubmed]
  8. Regulation of protein topology by trans-acting factors at the endoplasmic reticulum. Hegde, R.S., Voigt, S., Lingappa, V.R. Mol. Cell (1998) [Pubmed]
  9. Selective Use of TRAM in Lipopolysaccharide (LPS) and Lipoteichoic Acid (LTA) Induced NF-{kappa}B Activation and Cytokine Production in Primary Human Cells: TRAM Is an Adaptor for LPS and LTA Signaling. Sacre, S.M., Lundberg, A.M., Andreakos, E., Taylor, C., Feldmann, M., Foxwell, B.M. J. Immunol. (2007) [Pubmed]
  10. Extended transverse rectus abdominis musculocutaneous flap. Takayanagi, S., Ohtsuka, M. Plast. Reconstr. Surg. (1989) [Pubmed]
  11. Successful pregnancies following TRAM flap surgery. Chen, L., Hartrampf, C.R., Bennett, G.K. Plast. Reconstr. Surg. (1993) [Pubmed]
  12. TRAM flap vascular delay for high-risk breast reconstruction. Codner, M.A., Bostwick, J., Nahai, F., Bried, J.T., Eaves, F.F. Plast. Reconstr. Surg. (1995) [Pubmed]
  13. TRAM, a predicted RNA-binding domain, common to tRNA uracil methylation and adenine thiolation enzymes. Anantharaman, V., Koonin, E.V., Aravind, L. FEMS Microbiol. Lett. (2001) [Pubmed]
  14. Incidence and significance of microscopic pathological lesions found in pedicle and recipient vessels used in microsurgical breast reconstruction. El-Mrakby, H.H., McLean, N.R., Hodgkinson, P.D., Soames, J.V. Microsurgery. (2003) [Pubmed]
  15. The optic nerve tram-track sign. Kanamalla, U.S. Radiology. (2003) [Pubmed]
  16. A complex of chaperones and disulfide isomerases occludes the cytosolic face of the translocation protein Sec61p and affects translocation of the prion protein. Stockton, J.D., Merkert, M.C., Kellaris, K.V. Biochemistry (2003) [Pubmed]
  17. Rectus abdominis muscle innervation: implications for TRAM flap elevation. Hammond, D.C., Larson, D.L., Severinac, R.N., Marcias, M. Plast. Reconstr. Surg. (1995) [Pubmed]
  18. Assessment of the abdominal wall after pedicled TRAM flap surgery: 5- to 7-year follow-up of 150 consecutive patients. Mizgala, C.L., Hartrampf, C.R., Bennett, G.K. Plast. Reconstr. Surg. (1994) [Pubmed]
  19. Primary oromandibular reconstruction using free flaps and thorp plates in cancer patients: a 5-year experience. Poli, T., Ferrari, S., Bianchi, B., Sesenna, E. Head & neck. (2003) [Pubmed]
  20. Commuter exposure to aromatic VOCs in public transportation modes in Hong Kong. Lau, W.L., Chan, L.Y. Sci. Total Environ. (2003) [Pubmed]
  21. Breast reconstruction with free transverse rectus abdominis myocutaneous flaps in hospitals unaccustomed to microsurgery: original retrospective study. Salmi, A.M. Scandinavian journal of plastic and reconstructive surgery and hand surgery / Nordisk plastikkirurgisk forening [and] Nordisk klubb for handkirurgi. (2005) [Pubmed]
  22. The effect of intravenous dopamine and dobutamine on blood circulation during a microvascular TRAM flap operation. Suominen, S., Svartling, N., Silvasti, M., Niemi, T., Kuokkanen, H., Asko-Seljavaara, S. Annals of plastic surgery. (2004) [Pubmed]
  23. Remission rates following preoperative chemotherapy and radiation therapy in patients with breast cancer. Aryus, B., Audretsch, W., Gogolin, F., Gripp, S., Königshausen, T., Lammering, G., Rohn, R., Hartmann, K.A. Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]. (2000) [Pubmed]
  24. DIEP versus TRAM for breast reconstruction. Allen, R.J. Plast. Reconstr. Surg. (2003) [Pubmed]
  25. A comparison of outcomes using three different methods of breast reconstruction. Kroll, S.S., Baldwin, B. Plast. Reconstr. Surg. (1992) [Pubmed]
  26. Double-pedicle TRAM flap for unilateral breast reconstruction. Wagner, D.S., Michelow, B.J., Hartrampf, C.R. Plast. Reconstr. Surg. (1991) [Pubmed]
  27. The early management of flap necrosis in breast reconstruction. Kroll, S.S. Plast. Reconstr. Surg. (1991) [Pubmed]
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