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Vipr1  -  vasoactive intestinal peptide receptor 1

Rattus norvegicus

Synonyms: PACAP type II receptor, PACAP-R-2, PACAP-R2, Pituitary adenylate cyclase-activating polypeptide type II receptor, RATVASREC, ...
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High impact information on Vipr1


Biological context of Vipr1


Anatomical context of Vipr1


Associations of Vipr1 with chemical compounds


Physical interactions of Vipr1


Regulatory relationships of Vipr1

  • The PACAP-induced catecholamine output responses were inhibited by the PACAP type I receptor antagonist PACAP- (6-38) (30-3,000 nM) but were resistant to the PACAP type II receptor antagonist [Lys1,Pro2,5,Ara3,4,Tyr6]-vasoactive intestinal peptide (LPAT-VIP; 30-3,000 nM) [20].

Analytical, diagnostic and therapeutic context of Vipr1


  1. Molecular cloning of a novel transcriptional repressor protein of the rat type 1 vasoactive intestinal peptide receptor gene. Pei, L. J. Biol. Chem. (1998) [Pubmed]
  2. Direct evidence for functional coupling of the vasoactive intestinal peptide receptor to Gi3 in native lung membranes. Diehl, N.L., Kermode, J.C., Shreeve, S.M. Mol. Pharmacol. (1996) [Pubmed]
  3. Identification of vasoactive intestinal peptide receptor subtypes in the lacrimal gland and their signal-transducing components. Hodges, R.R., Zoukhri, D., Sergheraert, C., Zieske, J.D., Dartt, D.A. Invest. Ophthalmol. Vis. Sci. (1997) [Pubmed]
  4. Solubilization and hydrodynamic characterization of guanine nucleotide sensitive vasoactive intestinal peptide-receptor complexes from rat intestine. Calvo, J.R., Couvineau, A., Guijarro, L., Laburthe, M. Biochemistry (1989) [Pubmed]
  5. Genomic organization and chromosomal location of the mouse vasoactive intestinal polypeptide 1 (VPAC1) receptor. Hashimoto, H., Nishino, A., Shintani, N., Hagihara, N., Copeland, N.G., Jenkins, N.A., Yamamoto, K., Matsuda, T., Ishihara, T., Nagata, S., Baba, A. Genomics (1999) [Pubmed]
  6. Regional distribution of guanine nucleotide-sensitive and guanine nucleotide-insensitive vasoactive intestinal peptide receptors in rat brain. Hill, J.M., Harris, A., Hilton-Clarke, D.I. Neuroscience (1992) [Pubmed]
  7. Differential effect of arachidonic acid on the vasoactive intestinal peptide receptor/effector system in rat prostatic epithelium during sexual maturation. Carmena, M.J., Hueso, C., Solano, R.M., Prieto, J.C. Peptides (1992) [Pubmed]
  8. Chromosomal assignment of 11 loci in the rat by mouse-rat somatic hybrids and linkage. Deng, A.Y., Gu, L., Rapp, J.P., Szpirer, C., Szpirer, J. Mamm. Genome (1994) [Pubmed]
  9. Vasoactive intestinal peptide receptor on liver plasma membranes: characterization as a glycoprotein. Nguyen, T.D., Williams, J.A., Gray, G.M. Biochemistry (1986) [Pubmed]
  10. Characterization of the vasoactive intestinal peptide receptor in rat submandibular gland: radioligand binding assay in membrane preparations. Turner, J.T., Bylund, D.B. J. Pharmacol. Exp. Ther. (1987) [Pubmed]
  11. Tumor-promoting phorbol esters interfere with the vasoactive intestinal peptide receptor/effector system in rat prostatic epithelial cells. Escudero, F., Carmena, M.J., Prieto, J.C. Biochem. Biophys. Res. Commun. (1987) [Pubmed]
  12. Vasoactive intestinal peptide receptor antagonists in rat seminal vesicle membranes. Rodríguez-Pena, M.S., Guijarro, L.G., Prieto, J.C. Eur. J. Pharmacol. (1991) [Pubmed]
  13. Vasoactive intestinal peptide receptor localization in rat forebrain by autoradiography. De Souza, E.B., Seifert, H., Kuhar, M.J. Neurosci. Lett. (1985) [Pubmed]
  14. The effect of streptozotocin diabetes on the vasoactive intestinal peptide receptor/effector system in membranes from rat ventral prostate. Carmena, M.J., Clemente, C., Guijarro, L.G., Prieto, J.C. Endocrinology (1992) [Pubmed]
  15. Excitatory action of pituitary adenylate cyclase activating polypeptide on rat sympathetic preganglionic neurons in vivo and in vitro. Lai, C.C., Wu, S.Y., Lin, H.H., Dun, N.J. Brain Res. (1997) [Pubmed]
  16. Lindane effect upon the vasoactive intestinal peptide receptor/effector system in rat enterocytes. Carrero, I., Fernández-Moreno, M.D., Pérez-Albarsanz, M.A., Prieto, J.C. Biochem. Biophys. Res. Commun. (1989) [Pubmed]
  17. Effects of chronic ethanol ingestion on the vasoactive intestinal peptide receptor-effector system from rat seminal vesicle membranes. Juarranz, M.G., Marinero, M.J., Bodega, G., Prieto, J.C., Guijarro, L.G. Alcohol. Clin. Exp. Res. (1999) [Pubmed]
  18. Effects of GTP analogs and dithiothreitol on the binding properties of the vascular vasoactive intestinal peptide receptor. Huang, M., Rorstad, O.P. Can. J. Physiol. Pharmacol. (1989) [Pubmed]
  19. The influence of vasoactive intestinal peptide receptors in dispersed acini from rat submandibular gland on cyclic AMP production and mucin release. Turner, J.T., Camden, J.M. Arch. Oral Biol. (1990) [Pubmed]
  20. Role of endogenous PACAP in catecholamine secretion from the rat adrenal gland. Fukushima, Y., Hikichi, H., Mizukami, K., Nagayama, T., Yoshida, M., Suzuki-Kusaba, M., Hisa, H., Kimura, T., Satoh, S. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2001) [Pubmed]
  21. Influence of castration and testosterone treatment on the vasoactive intestinal peptide receptor/effector system in rat prostatic epithelial cells. Carmena, M.J., Recio, M.N., Prieto, J.C. Biochim. Biophys. Acta (1988) [Pubmed]
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