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Gene Review

Gata1  -  GATA binding protein 1

Rattus norvegicus

Synonyms: Eryf1, Erythroid transcription factor, GATA-1, GATA-binding factor 1, GF-1, ...
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Disease relevance of Gata1

  • Rat GATA-1 expressed as a GST-fusion protein in E. coli bound to the GAT(A/T) motif in the serine dehydratase gene [1].
  • Hypoxia for 6 h increased transcription factors CREB, NF-kappaB, and GATA DNA binding activities [2].
  • These sequences contain two M-CAT elements, which have previously been demonstrated to mediate inducible expression during alpha1-adrenergic-stimulated hypertrophy in cultured neonatal cardiac myocytes, and a GATA element [3].
  • Although recent studies have suggested a role for cardiac-specific zinc finger GATA factors in the transcriptional pathways that modulate cardiac hypertrophy, it is unknown whether these factors are also involved in cardiac ET-1 transcription and if so, how these factors are modulated during this process [4].
  • Among 15 WT1-expressing leukemias, GATA-1, which is an erythroid-specific transcription factor and might regulate WT1 expression, was also expressed in 13 cases (p < 0.05) [5].

High impact information on Gata1

  • Mutations introduced into consensus binding sites for AP-1 or GATA transcription factors abolished the pressure overload response but had no effect on AT1aR promoter activity in control animals [6].
  • A GATA element within beta-MHC sequences -303/-197 plays a role in the transcriptional activation of this gene by aortic constriction [3].
  • Polymerase chain reaction amplification of cDNA from pig gastric mucosa demonstrated the presence of zinc-finger proteins called GATA-GT1, GATA-GT2, and GATA-GT3, each having zinc-finger sequences similar to previously characterized GATA-binding proteins [7].
  • GATA-GT1 and -GT2 were expressed predominantly in the gastric mucosa and at much lower levels in the intestine (GATA-GT2, also in testis), their tissue distributions being distinct from those of GATA-1, -2, or -3 [7].
  • These results clearly suggest that GATA-GT1 and GATA-GT2 are involved in gene regulation specifically in the gastric epithelium and represent two additional members of the GATA-binding protein family [7].

Biological context of Gata1

  • Cloning and functional characterization of the rat alpha2B-adrenergic receptor gene promoter region: Evidence for binding sites for erythropoiesis-related transcription factors GATA1 and NF-E2 [8].
  • Identical interactions were observed with a target transgene consisting of a single GATA site upstream of a minimal promoter [9].
  • By screening a fetal liver cDNA library, we isolated a rat homolog of GATA-1 [1].
  • These results are consistent with tethering of one GATA factor to the Fabp1 promoter through interaction with a second GATA factor to produce increased target gene activation [9].
  • Transfection of GATA2 alone or with Ets, which binds adjacent to GATA, resulted in differentiation of BE2 cells in parallel with increased PDGF beta-receptor expression [10].

Anatomical context of Gata1

  • Expression of GATA-binding transcription factors in rat hepatocytes [1].
  • For example, prohypertrophic transcription factors belonging to the nuclear factor of activated T cells (NFAT) and GATA families are subject to CRM1-dependent nuclear export but are rapidly relocalized to the nucleus in response to cues for hypertrophic growth [11].
  • We suggest that GATA repeats of Bkm bring about a coordinated decondensation of the W and Y sex chromosomes in the germ cells in response to BBP, which may serve as a "switch" for the activation of the genes present on the W and Y sex chromosomes [12].
  • Furthermore, the coregulator of GATA, FOG2, markedly suppresses the GATA-induced increase in myocytes, but enhances it in PC12 cells [13].
  • An upstream regulatory region containing a GATA-1 site is necessary for activity in PC12 and glial cells but not in neuroblastoma cells [14].

Associations of Gata1 with chemical compounds


Other interactions of Gata1

  • Since brain natriuretic peptide (BNP) is activated early in cardiac growth and development, we evaluated whether it could serve as a target gene for GATA-binding protein-mediated induction [18].
  • Moreover, the exposure of renal cortex to LC versus HC conditions revealed a high differential expression of a PKA-dominated pathway involving CBP interacting protein, GATA-1 and CREB transcription factors in the LC model [19].
  • For 30% of the identified proteins, new isoforms indicative of alternative transcription were detected (e.g., GATA1, ATF6alpha, MTA1, MLH1, MYO1C, UBF, SYCP2, EIF3S10, MAP3K4, ZFP99) [20].
  • Changes in nuclear receptor transcription factors (THRalpha1, RORalpha4, HNF4alpha, NUR77), other transcription factors (GATA1, AP-2alpha, OCT1, ATF6alpha, ZFP161, ZNF354A, PDCD2), and transcription cofactors (PC4, PCAF, MTA1, TCEA1, JMY) are indicative of major, co-ordinated changes in transcription [20].

Analytical, diagnostic and therapeutic context of Gata1

  • Gel mobility shift assays were used to analyze the transacting factors that interact with the GATA motifs of the B-type natriuretic peptide promoter [21].
  • Sequences surrounding both proximal and distal promoters lack typical TATA or CCAAT boxes but contain cis-elements for multiple myocardium-relevant nuclear regulators including Sp1, GATA, and CREB, findings consistent with enhanced cardiac basal alpha(1a)AR expression seen in Northern blots and reporter constructs [22].
  • Sequence analysis and electrophoretic mobility shift experiments suggest that GnSE response elements interact, in these two regions, with GATA- and LIM-related factors, respectively [23].
  • Post-embedding immunogold techniques with the use of anti-Sap polyclonal and the specifically generated monoclonal antibody GF1 showed that Sap was essentially localized in the cell wall of C. albicans early during infection, in a cytological pattern mirroring Sap localization in C. albicans cells grown in Sap-inductive media in vitro [24].


  1. Expression of GATA-binding transcription factors in rat hepatocytes. Matsuda, K., Kobune, Y., Noda, C., Ichihara, A. FEBS Lett. (1994) [Pubmed]
  2. Reoxygenation after severe hypoxia induces cardiomyocyte hypertrophy in vitro: activation of CREB downstream of GSK3beta. El Jamali, A., Freund, C., Rechner, C., Scheidereit, C., Dietz, R., Bergmann, M.W. FASEB J. (2004) [Pubmed]
  3. cis-Acting sequences that mediate induction of beta-myosin heavy chain gene expression during left ventricular hypertrophy due to aortic constriction. Hasegawa, K., Lee, S.J., Jobe, S.M., Markham, B.E., Kitsis, R.N. Circulation (1997) [Pubmed]
  4. Phosphorylation of GATA-4 is involved in alpha 1-adrenergic agonist-responsive transcription of the endothelin-1 gene in cardiac myocytes. Morimoto, T., Hasegawa, K., Kaburagi, S., Kakita, T., Wada, H., Yanazume, T., Sasayama, S. J. Biol. Chem. (2000) [Pubmed]
  5. WT1 contributes to leukemogenesis: expression patterns in 7,12-dimethylbenz[a]anthracene (DMBA)-induced leukemia. Osaka, M., Koami, K., Sugiyama, T. Int. J. Cancer (1997) [Pubmed]
  6. Angiotensin II type1a receptor gene expression in the heart: AP-1 and GATA-4 participate in the response to pressure overload. Herzig, T.C., Jobe, S.M., Aoki, H., Molkentin, J.D., Cowley, A.W., Izumo, S., Markham, B.E. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  7. Gastric DNA-binding proteins recognize upstream sequence motifs of parietal cell-specific genes. Tamura, S., Wang, X.H., Maeda, M., Futai, M. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  8. Cloning and functional characterization of the rat alpha2B-adrenergic receptor gene promoter region: Evidence for binding sites for erythropoiesis-related transcription factors GATA1 and NF-E2. Schaak, S., Cussac, D., Labialle, S., Mignotte, V., Paris, H. Biochem. Pharmacol. (2005) [Pubmed]
  9. Cooperative interactions among intestinal GATA factors in activating the rat liver fatty acid binding protein gene. Divine, J.K., Staloch, L.J., Haveri, H., Rowley, C.W., Heikinheimo, M., Simon, T.C. Am. J. Physiol. Gastrointest. Liver Physiol. (2006) [Pubmed]
  10. Activity of a novel PDGF beta-receptor enhancer during the cell cycle and upon differentiation of neuroblastoma. Kaneko, M., Yang, W., Matsumoto, Y., Watt, F., Funa, K. Exp. Cell Res. (2006) [Pubmed]
  11. The CRM1 nuclear export receptor controls pathological cardiac gene expression. Harrison, B.C., Roberts, C.R., Hood, D.B., Sweeney, M., Gould, J.M., Bush, E.W., McKinsey, T.A. Mol. Cell. Biol. (2004) [Pubmed]
  12. Biological significance of minisatellites. Singh, L. Electrophoresis (1995) [Pubmed]
  13. GATA and FOG2 transcription factors differentially regulate the promoter for Kv4.2 K(+) channel gene in cardiac myocytes and PC12 cells. Jia, Y., Takimoto, K. Cardiovasc. Res. (2003) [Pubmed]
  14. Mechanism of promoter activity of the beta-amyloid precursor protein gene in different cell lines: identification of a specific 30 bp fragment in the proximal promoter region. Ge, Y.W., Ghosh, C., Song, W., Maloney, B., Lahiri, D.K. J. Neurochem. (2004) [Pubmed]
  15. Molecular characterization of the 5' regulatory region of rat sodium-dependent multivitamin transporter gene. Chatterjee, N.S., Rubin, S.A., Said, H.M. Am. J. Physiol., Cell Physiol. (2001) [Pubmed]
  16. Transcriptional activation of the BNP gene by lipopolysaccharide is mediated through GATA elements in neonatal rat cardiac myocytes. Tomaru Ki, K., Arai, M., Yokoyama, T., Aihara, Y., Sekiguchi Ki, K., Tanaka, T., Nagai, R., Kurabayashi, M. J. Mol. Cell. Cardiol. (2002) [Pubmed]
  17. Isolation of CHO-K1 clones defective in cAMP-dependent proteolysis, as determined by the stability of exogenously expressed GATA-6. Maeda, M., Ishida, A., Ni, L., Kobayashi, A. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  18. Regulation of rat brain natriuretic peptide transcription. A potential role for GATA-related transcription factors in myocardial cell gene expression. Thuerauf, D.J., Hanford, D.S., Glembotski, C.C. J. Biol. Chem. (1994) [Pubmed]
  19. Gene profiling the effects of calcium deficiency versus 1,25-dihydroxyvitamin D induced hypercalcemia in rat kidney cortex. Bajwa, A., Horst, R.L., Beckman, M.J. Arch. Biochem. Biophys. (2005) [Pubmed]
  20. Proteomics profiling of nuclear proteins for kidney fibroblasts suggests hypoxia, meiosis, and cancer may meet in the nucleus. Shakib, K., Norman, J.T., Fine, L.G., Brown, L.R., Godovac-Zimmermann, J. Proteomics (2005) [Pubmed]
  21. Mitogen-activated protein kinases p38 and ERK 1/2 mediate the wall stress-induced activation of GATA-4 binding in adult heart. Tenhunen, O., Sármán, B., Kerkelä, R., Szokodi, I., Papp, L., Tóth, M., Ruskoaho, H. J. Biol. Chem. (2004) [Pubmed]
  22. Cloning and characterization of the rat alpha 1a-adrenergic receptor gene promoter. Demonstration of cell specificity and regulation by hypoxia. Michelotti, G.A., Bauman, M.J., Smith, M.P., Schwinn, D.A. J. Biol. Chem. (2003) [Pubmed]
  23. Proximal cis-acting elements, including steroidogenic factor 1, mediate the efficiency of a distal enhancer in the promoter of the rat gonadotropin-releasing hormone receptor gene. Pincas, H., Amoyel, K., Counis, R., Laverrière, J.N. Mol. Endocrinol. (2001) [Pubmed]
  24. Ultrastructural localization of the secretory aspartyl proteinase in Candida albicans cell wall in vitro and in experimentally infected rat vagina. Stringaro, A., Crateri, P., Pellegrini, G., Arancia, G., Cassone, A., De Bernardis, F. Mycopathologia (1997) [Pubmed]
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