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Gene Review

Sds  -  serine dehydratase

Rattus norvegicus

Synonyms: L-serine deaminase, L-serine dehydratase/L-threonine deaminase, L-threonine dehydratase, RATSDHE1, SDH, ...
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Disease relevance of Sds


Psychiatry related information on Sds


High impact information on Sds


Chemical compound and disease context of Sds

  • Serine hydroxymethyltransferase activity was present in hepatomas, whereas other enzymes of serine utilization (serine dehydratase and serine aminotransferase) were absent [8].
  • PEPCK, which is localized to the proximal tubules under the normal condition, spreads throughout the entire cortex to the outer medullary rays by acidosis, whereas SDH does not change regardless of treatment with dexamethasone or NH(4)Cl [9].
  • We conclude that the enhanced regulatory effect of epinephrine counteracting insulin on SDH gene transcription in liver of newborn dogs may be one of the mechanisms responsible for the neonatal insulin resistance which contributes to neonatal hyperglycemia [10].

Biological context of Sds


Anatomical context of Sds


Associations of Sds with chemical compounds


Regulatory relationships of Sds


Other interactions of Sds


Analytical, diagnostic and therapeutic context of Sds


  1. Crystal structure of serine dehydratase from rat liver. Yamada, T., Komoto, J., Takata, Y., Ogawa, H., Pitot, H.C., Takusagawa, F. Biochemistry (2003) [Pubmed]
  2. The peptide sequences near the bound pyridoxal phosphate are conserved in serine dehydratase from rat liver, and threonine dehydratases from yeast and Escherichia coli. Ogawa, H., Konishi, K., Fujioka, M. Biochim. Biophys. Acta (1989) [Pubmed]
  3. Effect of pyridoxine availability on the activity of serine dehydratase of normal liver, host liver, and three Morris hepatomas. Tryfiates, G.P. J. Natl. Cancer Inst. (1975) [Pubmed]
  4. Nutritional regulation and tissue-specific expression of the serine dehydratase gene in rat. Ogawa, H., Fujioka, M., Su, Y., Kanamoto, R., Pitot, H.C. J. Biol. Chem. (1991) [Pubmed]
  5. Immunochemical studies of serine dehydratase and ornithine aminotransferase regulation in rat liver in vivo. Morris, J.E., Peraino, C. J. Biol. Chem. (1976) [Pubmed]
  6. The effect of o,p'-DDT feeding and food deprivation on plasma and liver amino acids and liver serine dehydratase in rats. Story, D.L., Freedland, R.A. Toxicol. Appl. Pharmacol. (1979) [Pubmed]
  7. Isolation and nucleotide sequence of the cDNA for rat liver serine dehydratase mRNA and structures of the 5' and 3' flanking regions of the serine dehydratase gene. Ogawa, H., Miller, D.A., Dunn, T., Su, Y., Burcham, J.M., Peraino, C., Fujioka, M., Babcock, K., Pitot, H.C. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  8. Enzymic imbalance in serine metabolism in rat hepatomas. Snell, K., Weber, G. Biochem. J. (1986) [Pubmed]
  9. Localization and hormonal control of serine dehydratase during metabolic acidosis differ markedly from those of phosphoenolpyruvate carboxykinase in rat kidney. Masuda, T., Ogawa, H., Matsushima, T., Kawamata, S., Sasahara, M., Kuroda, K., Suzuki, Y., Takata, Y., Yamazaki, M., Takusagawa, F., Pitot, H.C. Int. J. Biochem. Cell Biol. (2003) [Pubmed]
  10. Effects of insulin, epinephrine, and glucose on regulation of transcription of the serine dehydratase gene in newborn dogs. Feng, B.C., Li, J., Kliegman, R.M. Biochem. Mol. Med. (1996) [Pubmed]
  11. Evidence for a dimeric structure of rat liver serine dehydratase. Ogawa, H., Gomi, T., Takusagawa, F., Masuda, T., Goto, T., Kan, T., Huh, N.H. Int. J. Biochem. Cell Biol. (2002) [Pubmed]
  12. Organization and structure of the 5' flanking region of the rat serine dehydratase gene. Noda, C., Ohguri, M., Matsuda, K., Nakamura, T., Hasegawa, A., Yagi, S., Ichihara, A. J. Biochem. (1990) [Pubmed]
  13. Requirements of both glucocorticoids and glucagon as co-inducers for activation of transcription of the serine dehydratase gene in cultured rat hepatocytes. Noda, C., Yakiyama, M., Nakamura, T., Ichihara, A. J. Biol. Chem. (1988) [Pubmed]
  14. Hormonal and nutritional effects on the binding of 125I-labeled anti-serine dehydratase Fab' to rat tissue polysomes. McLaughlin, C.A., Pitot, H.C. Biochemistry (1976) [Pubmed]
  15. Experimental hypersensitivity pneumonitis in the rat: histopathology and T-cell subset compartmentalization. Richerson, H.B., Coon, J.D., Lubaroff, D. Am. J. Respir. Cell Mol. Biol. (1991) [Pubmed]
  16. Diurnal rhythms of rat liver serine dehydratase, D-site binding protein, and 3-hydroxy-3-methylglutaryl coenzyme A reductase mRNA levels are altered by destruction of the suprachiasmatic nucleus of the hypothalamus. Ogawa, H., Ansai, Y. Arch. Biochem. Biophys. (1995) [Pubmed]
  17. Serine dehydratase activity in the liver and extrahepatic organs of fed and 24-hour fasted rats. Palou, A., Remesar, X., Arola, L., Alemany, M. Rev. Esp. Fisiol. (1980) [Pubmed]
  18. Sequential phenotypic changes in hyperplastic areas during hepatocarcinogenesis in the rat. Kitagawa, T. Cancer Res. (1976) [Pubmed]
  19. Flux of the L-serine metabolism in rat liver. The predominant contribution of serine dehydratase. Xue, H.H., Fujie, M., Sakaguchi, T., Oda, T., Ogawa, H., Kneer, N.M., Lardy, H.A., Ichiyama, A. J. Biol. Chem. (1999) [Pubmed]
  20. Expression of GATA-binding transcription factors in rat hepatocytes. Matsuda, K., Kobune, Y., Noda, C., Ichihara, A. FEBS Lett. (1994) [Pubmed]
  21. Hormonal regulation of serine dehydratase gene expression in liver and kidney of the adrenalectomized rat. Kanamoto, R., Su, Y., Pitot, H.C. Mol. Endocrinol. (1991) [Pubmed]
  22. Reciprocal modulation of growth and differentiated functions of mature rat hepatocytes in primary culture by cell--cell contact and cell membranes. Nakamura, T., Yoshimoto, K., Nakayama, Y., Tomita, Y., Ichihara, A. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  23. Induction of enzymes by glucagon, glucose repression, adenosine 3',5'-monophosphate concentration during carcinogenesis and in Morris 6918A hepatoma. Sudilovsky, O., Gunter, R. Cancer Res. (1975) [Pubmed]
  24. Stimulation of tyrosine aminotransferase activity by dl-alpha-methyltryptophan. Oravec, M. J. Biol. Chem. (1975) [Pubmed]
  25. Control of hepatic utilization of serine, glycine and threonine in fed and starved rats. Remesy, C., Fafournoux, P., Demigne, C. J. Nutr. (1983) [Pubmed]
  26. Metabolic evidence for adaptation to a high protein diet in rats. Jean, C., Rome, S., Mathé, V., Huneau, J.F., Aattouri, N., Fromentin, G., Achagiotis, C.L., Tomé, D. J. Nutr. (2001) [Pubmed]
  27. Consumption of carbohydrate or medium- or long-chain triglycerides by unfed rats exerts different protein-sparing effects. Takada, R., Saitoh, M. J. Nutr. (1995) [Pubmed]
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