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Gene Review

Nf2  -  neurofibromin 2 (merlin)

Rattus norvegicus

Synonyms: Merlin, Moesin-ezrin-radixin-like protein, Neurofibromin-2, Schwannomin
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Disease relevance of Nf2


High impact information on Nf2


Chemical compound and disease context of Nf2


Biological context of Nf2


Anatomical context of Nf2


Associations of Nf2 with chemical compounds

  • Although C3T caused dose-dependent morphological abnormalities, FAK, paxillin, and schwannomin were able to coimmunoprecipitate with beta(1) integrin [10].

Other interactions of Nf2


Analytical, diagnostic and therapeutic context of Nf2


  1. Characterization of the rat neurofibromatosis 2 gene and its involvement in asbestos-induced mesothelioma. Kleymenova, E.V., Bianchi, A.A., Kley, N., Pylev, L.N., Walker, C.L. Mol. Carcinog. (1997) [Pubmed]
  2. Expression of the neurofibromatosis 2 tumor suppressor gene product, merlin, in Schwann cells. Scherer, S.S., Gutmann, D.H. J. Neurosci. Res. (1996) [Pubmed]
  3. Merlin, the neurofibromatosis type 2 gene product, and beta1 integrin associate in isolated and differentiating Schwann cells. Obremski, V.J., Hall, A.M., Fernandez-Valle, C. J. Neurobiol. (1998) [Pubmed]
  4. Neurofibromatosis 2 (NF2) tumor suppressor merlin inhibits phosphatidylinositol 3-kinase through binding to PIKE-L. Rong, R., Tang, X., Gutmann, D.H., Ye, K. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  5. Functional analysis of neurofibromatosis 2 (NF2) missense mutations. Gutmann, D.H., Hirbe, A.C., Haipek, C.A. Hum. Mol. Genet. (2001) [Pubmed]
  6. Expression of the neurofibromatosis 2 (NF2) gene isoforms during rat embryonic development. Gutmann, D.H., Wright, D.E., Geist, R.T., Snider, W.D. Hum. Mol. Genet. (1995) [Pubmed]
  7. Characterization of chicken Nf2/merlin indicates regulatory roles in cell proliferation and migration. Chen, Y., Gutmann, D.H., Haipek, C.A., Martinsen, B.J., Bronner-Fraser, M., Krull, C.E. Dev. Dyn. (2004) [Pubmed]
  8. Ezrin, radixin, and moesin are components of Schwann cell microvilli. Scherer, S.S., Xu, T., Crino, P., Arroyo, E.J., Gutmann, D.H. J. Neurosci. Res. (2001) [Pubmed]
  9. Analysis of molecular domains of epitope-tagged merlin isoforms in Cos-7 cells and primary rat Schwann cells. Xu, L., Gonzalez-Agosti, C., Beauchamp, R., Pinney, D., Sterner, C., Ramesh, V. Exp. Cell Res. (1998) [Pubmed]
  10. Formation of a beta1 integrin signaling complex in Schwann cells is independent of rho. Taylor, A.R., Geden, S.E., Fernandez-Valle, C. Glia (2003) [Pubmed]
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