The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

SFN  -  stratifin

Homo sapiens

Synonyms: 14-3-3 protein sigma, Epithelial cell marker protein 1, HME1, Stratifin, YWHAS
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of SFN


High impact information on SFN

  • We further demonstrate that mice that are compound heterozygotes for mutations in Irf6 and the gene encoding the cell cycle regulator protein stratifin (Sfn; also known as 14-3-3sigma) show similar defects of keratinizing epithelia [5].
  • In this report, we demonstrate that the interaction of epithelial cell marker E-cadherin with integrin alpha(E)(CD103)beta(7), often expressed by tumor-infiltrating lymphocytes (TILs), plays a major role in effective tumor cell lysis [6].
  • Hypermethylation of 14-3-3 sigma (stratifin) is an early event in breast cancer [7].
  • Furthermore, proteomic profiling of HLCECs and human conjunctival epithelial cells (HCECs) identified a 14-3-3 protein (stratifin) preferentially expressed by HLCECs [8].
  • In keratinocytes, 14-3-3sigma (stratifin) is involved in terminal differentiation and its cell cycle function in this cell type might diverge from the one it fulfills in other cellular backgrounds [9].

Chemical compound and disease context of SFN


Biological context of SFN


Anatomical context of SFN


Associations of SFN with chemical compounds


Regulatory relationships of SFN

  • In conclusion, stratifin stimulates fibroblast MMP-1 levels through the activation of c-fos and MAPK pathway [11].
  • The results of a dose-response experiment showed that stratifin stimulates the expression of stromelysin-1 (MMP-3) mRNA by dermal fibroblasts in a concentration-dependent fashion [17].

Other interactions of SFN

  • Furthermore, SB significantly blocked the stratifin induction of MMP-1 protein levels (***p<0.005, n=3) [11].
  • Our results indicate that stratifin markedly increase Elk4/Sap1 mRNA expression in a time-dependent fashion [11].
  • Upon DNA damage induced by cisplatin, stratifin mediated a nuclear export of DeltaNp63alpha into cytoplasm and then RACK1 targeted latter into a proteasome degradation pathway possibly serving as an E3 ubiquitin ligase [1].
  • Immunofluorescence staining of keratinocytes showed that two of these proteins (IEF SSPs 9124 and 9126) localize to the Golgi apparatus, while stratifin is distributed diffusely in the cytoplasm [12].
  • Our initial attempt using the candidate gene approach did not yield any somatic mutations in the 14-3-3sigma gene (official gene symbol, SFN), a mediator of G2 arrest by TP53 [18].

Analytical, diagnostic and therapeutic context of SFN


  1. RACK1 and stratifin target DeltaNp63alpha for a proteasome degradation in head and neck squamous cell carcinoma cells upon DNA damage. Fomenkov, A., Zangen, R., Huang, Y.P., Osada, M., Guo, Z., Fomenkov, T., Trink, B., Sidransky, D., Ratovitski, E.A. Cell Cycle (2004) [Pubmed]
  2. Complementary DNA cloning of a novel epithelial cell marker protein, HME1, that may be down-regulated in neoplastic mammary cells. Prasad, G.L., Valverius, E.M., McDuffie, E., Cooper, H.L. Cell Growth Differ. (1992) [Pubmed]
  3. Subcutaneous fat necrosis of the newborn. Repiso-Jiménez, J.B., Márquez, J., Sotillo, I., García-Bravo, B., Camacho, F. Journal of the European Academy of Dermatology and Venereology : JEADV. (1999) [Pubmed]
  4. Claudin-4, mitogen-activated protein kinase kinase 4, and stratifin are markers of gastric adenocarcinoma precursor lesions. Cunningham, S.C., Kamangar, F., Kim, M.P., Hammoud, S., Haque, R., Iacobuzio-Donahue, C.A., Maitra, A., Ashfaq, R., Hustinx, S., Heitmiller, R.E., Choti, M.A., Lillemoe, K.D., Cameron, J.L., Yeo, C.J., Schulick, R.D., Montgomery, E. Cancer Epidemiol. Biomarkers Prev. (2006) [Pubmed]
  5. Irf6 is a key determinant of the keratinocyte proliferation-differentiation switch. Richardson, R.J., Dixon, J., Malhotra, S., Hardman, M.J., Knowles, L., Boot-Handford, R.P., Shore, P., Whitmarsh, A., Dixon, M.J. Nat. Genet. (2006) [Pubmed]
  6. {alpha}E{beta}7 integrin interaction with E-cadherin promotes antitumor CTL activity by triggering lytic granule polarization and exocytosis. Floc'h, A.L., Jalil, A., Vergnon, I., Chansac, B.l.e. .M., Lazar, V., Bismuth, G., Chouaib, S., Mami-Chouaib, F. J. Exp. Med. (2007) [Pubmed]
  7. Hypermethylation of 14-3-3 sigma (stratifin) is an early event in breast cancer. Umbricht, C.B., Evron, E., Gabrielson, E., Ferguson, A., Marks, J., Sukumar, S. Oncogene (2001) [Pubmed]
  8. Regulation of corneal angiogenesis in limbal stem cell deficiency. Ma, D.H., Chen, J.K., Zhang, F., Lin, K.Y., Yao, J.Y., Yu, J.S. Progress in retinal and eye research (2006) [Pubmed]
  9. Radiation response and cell cycle regulation of p53 rescued malignant keratinocytes. Niemantsverdriet, M., Jongmans, W., Backendorf, C. Exp. Cell Res. (2005) [Pubmed]
  10. Folic acid targeting of protein conjugates into ascites tumour cells from ovarian cancer patients. Ward, C.M., Acheson, N., Seymour, L.W. Journal of drug targeting. (2000) [Pubmed]
  11. Stratifin-induced matrix metalloproteinase-1 in fibroblast is mediated by c-fos and p38 mitogen-activated protein kinase activation. Lam, E., Kilani, R.T., Li, Y., Tredget, E.E., Ghahary, A. J. Invest. Dermatol. (2005) [Pubmed]
  12. Molecular cloning and expression of the transformation sensitive epithelial marker stratifin. A member of a protein family that has been involved in the protein kinase C signalling pathway. Leffers, H., Madsen, P., Rasmussen, H.H., Honoré, B., Andersen, A.H., Walbum, E., Vandekerckhove, J., Celis, J.E. J. Mol. Biol. (1993) [Pubmed]
  13. The localization and distribution of corticotropin-releasing hormone in the human placenta and fetal membranes throughout gestation. Riley, S.C., Walton, J.C., Herlick, J.M., Challis, J.R. J. Clin. Endocrinol. Metab. (1991) [Pubmed]
  14. Increased expression of epidermal fatty acid binding protein, cofilin, and 14-3-3-sigma (stratifin) detected by two-dimensional gel electrophoresis, mass spectrometry and microsequencing of drug-resistant human adenocarcinoma of the pancreas. Sinha, P., Hütter, G., Köttgen, E., Dietel, M., Schadendorf, D., Lage, H. Electrophoresis (1999) [Pubmed]
  15. Immunohistochemical characterization of cellular immunoglobulins and epithelial marker antigens in Warthin's tumor. Korsrud, F.R., Brandtzaeg, P. Hum. Pathol. (1984) [Pubmed]
  16. Transcriptome profiling of the tubular porcine conceptus identifies the differential regulation of growth and developmentally associated genes. Blomberg, l.e. .A., Garrett, W.M., Guillomot, M., Miles, J.R., Sonstegard, T.S., Van Tassell, C.P., Zuelke, K.A. Mol. Reprod. Dev. (2006) [Pubmed]
  17. Fibroblast extracellular matrix gene expression in response to keratinocyte-releasable stratifin. Ghaffari, A., Li, Y., Karami, A., Ghaffari, M., Tredget, E.E., Ghahary, A. J. Cell. Biochem. (2006) [Pubmed]
  18. Frequent allelic imbalance suggests involvement of a tumor suppressor gene at 1p36 in the pathogenesis of human lung cancers. Nomoto, S., Haruki, N., Tatematsu, Y., Konishi, H., Mitsudomi, T., Takahashi, T., Takahashi, T. Genes Chromosomes Cancer (2000) [Pubmed]
  19. Differentiated keratinocyte-releasable stratifin (14-3-3 sigma) stimulates MMP-1 expression in dermal fibroblasts. Ghahary, A., Marcoux, Y., Karimi-Busheri, F., Li, Y., Tredget, E.E., Kilani, R.T., Lam, E., Weinfeld, M. J. Invest. Dermatol. (2005) [Pubmed]
  20. Metallothionein as an epithelial proliferative compartment marker for DNA flow cytometry. Meskel, H.H., Cherian, M.G., Martinez, V.J., Veinot, L.A., Frei, J.V. Mod. Pathol. (1993) [Pubmed]
  21. EGF receptor-related protein (ERRP) inhibits invasion of colon cancer cells and tubule formation by endothelial cells in vitro. Rishi, A.K., Parikh, R., Wali, A., Durko, L., Zhang, L., Yu, Y., Majumdar, A.P. Anticancer Res. (2006) [Pubmed]
WikiGenes - Universities