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Chemical Compound Review

Ratironina     2-amino-3-[4-(4-hydroxy-3- iodo-phenoxy)-3...

Synonyms: Rathyronine, Thrithyrone, Rathyroninum, Detrothyronin, CHEMBL789, ...
 
 
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Disease relevance of liothyronine

 

Psychiatry related information on liothyronine

  • Influence of L-triiodothyronine on memory following repeated electroconvulsive shock in rats: implications for human electroconvulsive therapy [5].
  • The influence of L-triiodothyronine (T3) on the effects of repeated administration of desipramine or electroconvulsive shock on alpha 2- and beta-adrenoceptor function in the brain of the rat: implications for the potentiation of antidepressant therapy by T3 [6].
  • Whereas administration of lithium carbonate (60 mg/kg) to normal rats for 10 days, beginning from the 20th day of age, produced no significant effect, this antimanic drug significantly decreased the observed increase in spontaneous locomotor activity in l-triiodothyronine-treated rats [7].
  • Decreases (to percentage of baseline, prefood deprivation value) in circulating T3 (42%), T4 (38%), FT3 (30%), and FT4 (24%) concentrations were maximal after 2, 4, 2, and 4 days of food deprivation, respectively (P < 0.05) [8].
  • We tested the hypothesis considering the role of hypothalamic-pituitary-thyroid axis (HPT), L-triiodothyronine (L-T3) uptake into erythrocytes, and the role of membrane lipids in the development and treatment of affective disorders [9].
 

High impact information on liothyronine

 

Chemical compound and disease context of liothyronine

 

Biological context of liothyronine

 

Anatomical context of liothyronine

 

Associations of liothyronine with other chemical compounds

 

Gene context of liothyronine

  • Therefore, it may be speculated that Oatp14 plays a role in maintaining the concentration of T4 and, ultimately, T3 in the brain by transporting T4 from the circulating blood to the brain [34].
  • On day 7, T4 and T3 were still lower in the septic group, whereas IL-1 beta, sIL-2R and IL-6 were still elevated [35].
  • In contrast, the decline of TSH by treatment with L-triiodothyronine was severely blunted in SRC-1(-/-) mice [36].
  • TRH injection induced a definite rise in serum TSH and T3 in controls, but not in L-T4 treated newborns [37].
  • Thyrotropin or L-triiodothyronine did not imitate and hypophysectomy did not reduce the effects of TRH, indicating that the pituitary is not essential for its antagonism of pentobarbital [38].
 

Analytical, diagnostic and therapeutic context of liothyronine

References

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