The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Ratironina     2-amino-3-[4-(4-hydroxy-3- iodo-phenoxy)-3...

Synonyms: Rathyronine, Thrithyrone, Rathyroninum, Detrothyronin, CHEMBL789, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of liothyronine


Psychiatry related information on liothyronine

  • Influence of L-triiodothyronine on memory following repeated electroconvulsive shock in rats: implications for human electroconvulsive therapy [5].
  • The influence of L-triiodothyronine (T3) on the effects of repeated administration of desipramine or electroconvulsive shock on alpha 2- and beta-adrenoceptor function in the brain of the rat: implications for the potentiation of antidepressant therapy by T3 [6].
  • Whereas administration of lithium carbonate (60 mg/kg) to normal rats for 10 days, beginning from the 20th day of age, produced no significant effect, this antimanic drug significantly decreased the observed increase in spontaneous locomotor activity in l-triiodothyronine-treated rats [7].
  • Decreases (to percentage of baseline, prefood deprivation value) in circulating T3 (42%), T4 (38%), FT3 (30%), and FT4 (24%) concentrations were maximal after 2, 4, 2, and 4 days of food deprivation, respectively (P < 0.05) [8].
  • We tested the hypothesis considering the role of hypothalamic-pituitary-thyroid axis (HPT), L-triiodothyronine (L-T3) uptake into erythrocytes, and the role of membrane lipids in the development and treatment of affective disorders [9].

High impact information on liothyronine


Chemical compound and disease context of liothyronine


Biological context of liothyronine


Anatomical context of liothyronine


Associations of liothyronine with other chemical compounds


Gene context of liothyronine

  • Therefore, it may be speculated that Oatp14 plays a role in maintaining the concentration of T4 and, ultimately, T3 in the brain by transporting T4 from the circulating blood to the brain [34].
  • On day 7, T4 and T3 were still lower in the septic group, whereas IL-1 beta, sIL-2R and IL-6 were still elevated [35].
  • In contrast, the decline of TSH by treatment with L-triiodothyronine was severely blunted in SRC-1(-/-) mice [36].
  • TRH injection induced a definite rise in serum TSH and T3 in controls, but not in L-T4 treated newborns [37].
  • Thyrotropin or L-triiodothyronine did not imitate and hypophysectomy did not reduce the effects of TRH, indicating that the pituitary is not essential for its antagonism of pentobarbital [38].

Analytical, diagnostic and therapeutic context of liothyronine


  1. Fibronectin expression in the normal and hypertrophic rat heart. Mamuya, W.S., Brecher, P. J. Clin. Invest. (1992) [Pubmed]
  2. Frequency of euthyroid sick syndrome as assessed by free thyroxine index and a direct free thyroxine assay. A limitation of FT4 assays. Vermaak, W.J., Kalk, W.J., Zakolski, W.J. Lancet (1983) [Pubmed]
  3. Induction of amino acid transport by L-triiodothyronine in cultured growth hormone-producing rat pituitary tumor cells (GC cells). Surks, M.I., Fels, E.C., DeFesi, C.R. J. Biol. Chem. (1984) [Pubmed]
  4. Beneficial effects of a novel thyromimetic on lipoprotein metabolism. Taylor, A.H., Stephan, Z.F., Steele, R.E., Wong, N.C. Mol. Pharmacol. (1997) [Pubmed]
  5. Influence of L-triiodothyronine on memory following repeated electroconvulsive shock in rats: implications for human electroconvulsive therapy. Stern, R.A., Whealin, J.M., Mason, G.A., Noonan, L.R., Silva, S.G., Arruda, J.E., Prange, A.J. Biol. Psychiatry (1995) [Pubmed]
  6. The influence of L-triiodothyronine (T3) on the effects of repeated administration of desipramine or electroconvulsive shock on alpha 2- and beta-adrenoceptor function in the brain of the rat: implications for the potentiation of antidepressant therapy by T3. Heal, D.J., Bristow, L.J., Elliott, J.M., Bloomfield, J.G., Catto, L.C., Atterwill, C.K. Neuropharmacology (1987) [Pubmed]
  7. Lithium: modification of behavioral activity and brain biogenic amines in developing hyperthyroid rats. Rastoge, R.B., Singhal, R.L. J. Pharmacol. Exp. Ther. (1977) [Pubmed]
  8. Effect of food deprivation on baseline iodothyronine and cortisol concentrations in healthy, adult horses. Messer, N.T., Johnson, P.J., Refsal, K.R., Nachreiner, R.F., Ganjam, V.K., Krause, G.F. Am. J. Vet. Res. (1995) [Pubmed]
  9. Red blood cell triiodothyronine uptake as membrane parameter of depression. Kalisová-Stárková, L., Fisar, Z., Paclt, I., Hanus, Z., Vevera, J. Physiological research / Academia Scientiarum Bohemoslovaca. (2006) [Pubmed]
  10. L-triiodothyronine stimulates growth by means of an autocrine factor in a cultured growth-hormone-producing cell line. Miller, M.J., Fels, E.C., Shapiro, L.E., Surks, M.I. J. Clin. Invest. (1987) [Pubmed]
  11. Ontogenesis of iodothyronine-5'-deiodinase. Induction of 5'-deiodinating activity by insulin, glucocorticoid, and thyroxine in cultured fetal mouse liver. Sato, K., Mimura, H., Han, D.C., Tsushima, T., Shizume, K. J. Clin. Invest. (1984) [Pubmed]
  12. L-triiodothyronine and L-reverse-triiodothyronine generation in the human polymorphonuclear leukocyte. Woeber, K.A. J. Clin. Invest. (1978) [Pubmed]
  13. Stimulation of hepatic mitochondrial alpha-glycerophosphate dehydrogenase and malic enzyme by L-triiodothyronine. Characteristics of the response with specific nuclear thyroid hormone binding sites fully saturated. Oppenheimer, J.H., Silva, E., Schwartz, H.L., Surks, M.I. J. Clin. Invest. (1977) [Pubmed]
  14. In vitro binding of L-triiodothyronine to receptors in rat liver nuclei. Kinectics of binding, extraction properties, and lack of requirement for cytosol proteins. Surks, M.I., Koerner, D.H., Oppenheimer, J.H. J. Clin. Invest. (1975) [Pubmed]
  15. Contractile and fatigue properties of thyrotoxic rat skeletal muscle. Fitts, R.H., Brimmer, C.J., Troup, J.P., Unsworth, B.R. Muscle Nerve (1984) [Pubmed]
  16. Interference between estradiol and L-triiodothyronine in the control of the proliferation of a pituitary tumor cell line. Zhou-Li, F., Skalli, M., Albaladéjo, V., Joly-Pharaboz, M.O., Nicolas, B., André, J. J. Steroid Biochem. Mol. Biol. (1993) [Pubmed]
  17. Nutritional and metabolic effects of gonadotropin-releasing hormone agonist treatment for prostate cancer. Tayek, J.A., Heber, D., Byerley, L.O., Steiner, B., Rajfer, J., Swerdloff, R.S. Metab. Clin. Exp. (1990) [Pubmed]
  18. Effect of cortisone or L-triiodothyronine administration to pregnant rats on the activity of fetal intestinal disaccharidases and lysosomal acid beta-galactosidase. Jumawan, J., Celano, P., Horowitz, C., Lau, H., Koldovsky, O. Biol. Neonate (1977) [Pubmed]
  19. Lithium suppresses elevated behavioural activity and brain catecholamines in developing hyperthyroid rats. Rastogi, R.B., Singhal, R.L. Can. J. Physiol. Pharmacol. (1977) [Pubmed]
  20. Incorporation of nascent myosin heavy chains into thick filaments of cardiac myocytes in thyroid-treated rabbits. Wenderoth, M.P., Eisenberg, B.R. J. Cell Biol. (1987) [Pubmed]
  21. Characteristics of a negative thyroid hormone response element. Carr, F.E., Wong, N.C. J. Biol. Chem. (1994) [Pubmed]
  22. Binding of nuclear proteins to the rat liver S14 gene is influenced by thyroid state. Wong, N.C., Deschamps, B.J., Yeomans, Z.A., Cannon, P.D. J. Biol. Chem. (1990) [Pubmed]
  23. Reversible alteration of the visual evoked potential in hypothyroidism. Ladenson, P.W., Stakes, J.W., Ridgway, E.C. Am. J. Med. (1984) [Pubmed]
  24. Effects of thyroid hormone on the arrhythmogenic activity of pulmonary vein cardiomyocytes. Chen, Y.C., Chen, S.A., Chen, Y.J., Chang, M.S., Chan, P., Lin, C.I. J. Am. Coll. Cardiol. (2002) [Pubmed]
  25. Synergistic growth factors enhance rat liver proliferation and enable retroviral gene transfer via a peripheral vein. Forbes, S.J., Themis, M., Alison, M.R., Sarosi, I., Coutelle, C., Hodgson, H.J. Gastroenterology (2000) [Pubmed]
  26. Effect of amiodarone on the expression of myosin isoforms and cellular growth of cardiac muscle cells in culture. Nag, A.C., Lee, M.L., Shepard, D. Circ. Res. (1990) [Pubmed]
  27. L-triiodothyronine augments erythropoietic growth factor release from peripheral blood and bone marrow leukocytes. Dainiak, N., Sutter, D., Kreczko, S. Blood (1986) [Pubmed]
  28. High affinity L-triiodothyronine binding to right-side-out and inside-out vesicles from rat and human erythrocyte membrane. Angel, R.C., Botta, J.A., Farias, R.N. J. Biol. Chem. (1989) [Pubmed]
  29. Raised total thyroxine and free thyroxine index but normal free thyroxine. A serum abnormality due to inherited increased affinity of iodothyronines for serum binding protein. Hennemann, G., Docter, R., Krenning, E.P., Bos, G., Otten, M., Visser, T.J. Lancet (1979) [Pubmed]
  30. Behavioral and endocrine responses of schizophrenic patients to TRH (protirelin). Prange, A.J., Loosen, P.T., Wilson, I.C., Meltzer, H.Y., Fang, V.S. Arch. Gen. Psychiatry (1979) [Pubmed]
  31. Growth of a human breast cancer cell line in serum-free hormone-supplemented medium. Allegra, J.C., Lippman, M.E. Cancer Res. (1978) [Pubmed]
  32. Selective affinity labeling of a 27-kDa integral membrane protein in rat liver and kidney with N-bromoacetyl derivatives of L-thyroxine and 3,5,3'-triiodo-L-thyronine. Köhrle, J., Rasmussen, U.B., Rokos, H., Leonard, J.L., Hesch, R.D. J. Biol. Chem. (1990) [Pubmed]
  33. Familial thyroid hormone resistance. Brooks, M.H., Barbato, A.L., Collins, S., Garbincius, J., Neidballa, R.G., Hoffman, D. Am. J. Med. (1981) [Pubmed]
  34. Functional characterization of rat brain-specific organic anion transporter (Oatp14) at the blood-brain barrier: high affinity transporter for thyroxine. Sugiyama, D., Kusuhara, H., Taniguchi, H., Ishikawa, S., Nozaki, Y., Aburatani, H., Sugiyama, Y. J. Biol. Chem. (2003) [Pubmed]
  35. Activation of the hypothalamo-pituitary-adrenal axis in response to septic or non-septic diseases--implications for the euthyroid sick syndrome. Mönig, H., Arendt, T., Meyer, M., Kloehn, S., Bewig, B. Intensive care medicine. (1999) [Pubmed]
  36. Mice deficient in the steroid receptor co-activator 1 (SRC-1) are resistant to thyroid hormone. Weiss, R.E., Xu, J., Ning, G., Pohlenz, J., O'Malley, B.W., Refetoff, S. EMBO J. (1999) [Pubmed]
  37. L-thyroxine treatment of preterm newborns: clinical and endocrine effects. Vanhole, C., Aerssens, P., Naulaers, G., Casneuf, A., Devlieger, H., Van den Berghe, G., de Zegher, F. Pediatr. Res. (1997) [Pubmed]
  38. Effects of thyrotropin-releasing hormone (TRH) on the actions of pentobarbital and other centrally acting drugs. Breese, G.R., Cott, J.M., Cooper, B.R., Prange, A.J., Lipton, M.A., Plotnikoff, N.P. J. Pharmacol. Exp. Ther. (1975) [Pubmed]
  39. Thyroid hormone stimulates de novo growth hormone synthesis in cultured GH1 cells: evidence for the accumulation of a rate limiting RNA species in the induction process. Samuels, H.H., Shapiro, L.E. Proc. Natl. Acad. Sci. U.S.A. (1976) [Pubmed]
  40. Chromatin structure and methylation state of a thyroid hormone-responsive gene in rat liver. Jump, D.B., Wong, N.C., Oppenheimer, J.H. J. Biol. Chem. (1987) [Pubmed]
  41. Appearance of mania in drug-resistant bipolar depressed patients after treatment with L-triiodothyronine. Evans, D.L., Strawn, S.K., Haggerty, J.J., Garbutt, J.C., Burnett, G.B., Pedersen, C.A. The Journal of clinical psychiatry. (1986) [Pubmed]
  42. Diabetes, hypophysectomy, or thyroidectomy reduces nuclear L-triiodothyronine-binding capacity of rat lung. Das, D.K., Ganguly, M. Endocrinology (1981) [Pubmed]
  43. 3,3',5'-Triiodothyronine (reverse T3) and 3,3',5-triiodothyronine (T3) in fetal and adult sheep: studies of metabolic clearance rates, production rates, serum binding, and thyroidal content relative to thyroxine. Chopra, I.J., Sack, J., Fisher, D.A. Endocrinology (1975) [Pubmed]
WikiGenes - Universities