The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

FADS1  -  fatty acid desaturase 1

Homo sapiens

Synonyms: D5D, Delta(5) desaturase, Delta(5) fatty acid desaturase, Delta-5 desaturase, FADS6, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of FADS1

  • Fads in the treatment of low back pain [1].
  • Models of contagion arise broadly in both the biological and the social sciences, with applications ranging from the transmission of infectious diseases to the spread of cultural fads [2].
  • Whether these are fads or truly represent important changes in the way peo-ple eat and that ultimately will lead to a lower rate of obesity and improved health is impossible to know [3].
  • However, D5D did not localize well to renal cell carcinoma xenografts in vivo despite its highly restrictive in vitro reactivity [4].
  • Moreover, the rtxC product was highly homologous to the fatty acid desaturase of Pseudomonas syringae and included the copper-binding signature and eight histidine residues conserved in membrane-bound desaturase [5].

Psychiatry related information on FADS1

  • Gluttony and indiscriminate eating were characteristic of FTD, whereas patients with semantic dementia were more likely to exhibit food fads [6].
  • Family therapy, unlike many fleeting therapeutic fads, has flourished in established mental health circles for the past 25 years [7].
  • The strongest desires to improve skills were in the areas of obesity, poor dietary patterns, sports nutrition, food fads, supplement misuse, alternative diets, and eating disorders [8].
  • We must recognize that adolescence is a critical period of life, and food fads may deeply change the dietary habits acquired within the familiar group [9].
  • The most frequently reported behavioral symptoms were food fads, irritability, depression, and preoccupation with puzzles; cognitive deficits included word-finding difficulties, reduced comprehension, difficulty with person identification, and reduced conversation [10].

High impact information on FADS1

  • Hitchhiking fads en route to peroxisomes [11].
  • The tomato suppressor of prosystemin-mediated responses2 gene encodes a fatty acid desaturase required for the biosynthesis of jasmonic acid and the production of a systemic wound signal for defense gene expression [12].
  • Common genetic variants of the FADS1 FADS2 gene cluster and their reconstructed haplotypes are associated with the fatty acid composition in phospholipids [13].
  • RESULTS: High activity of estimated SCD-1 (odds ratio=1.29, p<0.05) and D6D (odds ratio=1.35, p<0.05), as well as low estimated D5D activity (odds ratio=0.71, p<0.001) predicted the development of metabolic syndrome (as defined by the National Cholesterol Education Program) [14].
  • This trend risks replicating both the rejuvenation fads of a century ago and the recent experience in estrogen therapy for menopause that has been propelled for decades by advocacy substituting for reliable scientific evidence [15].

Chemical compound and disease context of FADS1


Biological context of FADS1


Anatomical context of FADS1

  • Specificity testing against 33 human tumor cell lines revealed D5D to have no specific reactivity with 17 specimens of normal adult or fetal kidney [20].
  • A clone for a plastid omega-3 fatty acid desaturase (FAD) was isolated from a leaf cDNA library of hot pepper (Capsicum annuum L.). The nucleotide sequence of a 1,317 bp open reading frame in the CachFAD showed 80.9% homology with that of tobacco plant [21].

Associations of FADS1 with chemical compounds

  • FAD synthetase (FADS) (EC is a key enzyme in the metabolic pathway that converts riboflavin into the redox cofactor FAD [22].
  • The expressed protein accounted for more than 40% of the total protein extracted from the cell culture; 10% of it was recovered in a soluble and nearly pure form by Triton X-100 treatment of the insoluble cell fraction. hFADS2 possesses FADS activity and has a strict requirement for MgCl(2), as demonstrated in a spectrophotometric assay [22].
  • Delta-6 Desaturase (D6D) and Delta-5 desaturase (D5D) are the key enzymes for the synthesis of highly unsaturated fatty acids (HUFAs), such as arachidonic acid (20:4, n -6) and docosahexaenoic acid (22:6, n -3), that are incorporated in phospholipids (PLs) and perform essential physiological functions [23].
  • Fentanyl, fads, and folly: who will adopt the therapeutic orphans [24]?
  • Treatment of VA-deficient rats with all-trans-retinoic acid lowered the level of expression of D5D mRNA toward that of VA-sufficient rats [19].

Other interactions of FADS1


Analytical, diagnostic and therapeutic context of FADS1


  1. Fads in the treatment of low back pain. Deyo, R.A. N. Engl. J. Med. (1991) [Pubmed]
  2. Universal behavior in a generalized model of contagion. Dodds, P.S., Watts, D.J. Phys. Rev. Lett. (2004) [Pubmed]
  3. Diet options of obesity: fad or famous? Balart, L.A. Gastroenterol. Clin. North Am. (2005) [Pubmed]
  4. Biodistribution and radioimmunoscintigraphy studies of renal cell carcinoma using tumor-preferential monoclonal antibodies and F(ab')2 fragments. Chiou, R.K. J. Urol. (1989) [Pubmed]
  5. DNA sequence and mutational analysis of rhizobitoxine biosynthesis genes in Bradyrhizobium elkanii. Yasuta, T., Okazaki, S., Mitsui, H., Yuhashi, K., Ezura, H., Minamisawa, K. Appl. Environ. Microbiol. (2001) [Pubmed]
  6. Distinct behavioural profiles in frontotemporal dementia and semantic dementia. Snowden, J.S., Bathgate, D., Varma, A., Blackshaw, A., Gibbons, Z.C., Neary, D. J. Neurol. Neurosurg. Psychiatr. (2001) [Pubmed]
  7. Family therapy: the making of a mental health movement. Brodkin, A.M. The American journal of orthopsychiatry. (1980) [Pubmed]
  8. Adolescent nutrition: self-perceived deficiencies and needs of practitioners working with youth. Story, M., Blum, R.W. Journal of the American Dietetic Association. (1988) [Pubmed]
  9. Adolescence: macronutrient needs. Giovannini, M., Agostoni, C., Gianní, M., Bernardo, L., Riva, E. European journal of clinical nutrition. (2000) [Pubmed]
  10. Left/right asymmetry of atrophy in semantic dementia: behavioral-cognitive implications. Thompson, S.A., Patterson, K., Hodges, J.R. Neurology (2003) [Pubmed]
  11. Hitchhiking fads en route to peroxisomes. Subramani, S. J. Cell Biol. (2002) [Pubmed]
  12. The tomato suppressor of prosystemin-mediated responses2 gene encodes a fatty acid desaturase required for the biosynthesis of jasmonic acid and the production of a systemic wound signal for defense gene expression. Li, C., Liu, G., Xu, C., Lee, G.I., Bauer, P., Ling, H.Q., Ganal, M.W., Howe, G.A. Plant Cell (2003) [Pubmed]
  13. Common genetic variants of the FADS1 FADS2 gene cluster and their reconstructed haplotypes are associated with the fatty acid composition in phospholipids. Schaeffer, L., Gohlke, H., Müller, M., Heid, I.M., Palmer, L.J., Kompauer, I., Demmelmair, H., Illig, T., Koletzko, B., Heinrich, J. Hum. Mol. Genet. (2006) [Pubmed]
  14. Fatty acid composition of serum lipids predicts the development of the metabolic syndrome in men. Warensjö, E., Risérus, U., Vessby, B. Diabetologia (2005) [Pubmed]
  15. Andropause: invention, prevention, rejuvenation. Handelsman, D.J., Liu, P.Y. Trends Endocrinol. Metab. (2005) [Pubmed]
  16. Inherited and acquired risk factors in colonic neoplasia and modulation by chemopreventive interventions. Lipkin, M., Yang, K., Edelmann, W., Newmark, H., Fan, K.H., Risio, M., Kucherlapati, R. J. Cell. Biochem. Suppl. (1996) [Pubmed]
  17. Plasmid omega-3 fatty acid desaturase cDNA from Ricinus communis. van de Loo, F.J., Somerville, C. Plant Physiol. (1994) [Pubmed]
  18. Further characterization of auxin-regulated mRNAs in hypocotyl sections of mung bean [Vigna radiata (L.) Wilczek]: sequence homology to genes for fatty-acid desaturases and atypical late-embryogenesis-abundant protein, and the mode of expression of the mRNAs. Yamamoto, K.T. Planta (1994) [Pubmed]
  19. Fatty acid delta(5)-desaturase mRNA is regulated by dietary vitamin A and exogenous retinoic acid in liver of adult rats. Zolfaghari, R., Cifelli, C.J., Banta, M.D., Ross, A.C. Arch. Biochem. Biophys. (2001) [Pubmed]
  20. A highly restricted antigen for renal cell carcinoma defined by a monoclonal antibody. Moon, T.D., Vessella, R.L., Palme, D.F., Nowak, J.A., Lange, P.H. Hybridoma (1985) [Pubmed]
  21. CDNA cloning of chloroplast omega-3 fatty acid desaturase from Capsicum annuum and its expression upon wounding. Kwon, J.H., Lee, Y.M., An, C.S. Mol. Cells (2000) [Pubmed]
  22. Over-expression in Escherichia coli, purification and characterization of isoform 2 of human FAD synthetase. Galluccio, M., Brizio, C., Torchetti, E.M., Ferranti, P., Gianazza, E., Indiveri, C., Barile, M. Protein Expr. Purif. (2007) [Pubmed]
  23. Gene regulation of mammalian desaturases. Nakamura, M.T., Nara, T.Y. Biochem. Soc. Trans. (2002) [Pubmed]
  24. Fentanyl, fads, and folly: who will adopt the therapeutic orphans? Kauffman, R.E. J. Pediatr. (1991) [Pubmed]
  25. Monitoring the expression profiles of doxorubicin-resistant K562 human leukemia cells by serial analysis of gene expression. Ichikawa, Y., Hirokawa, M., Aiba, N., Fujishima, N., Komatsuda, A., Saitoh, H., Kume, M., Miura, I., Sawada, K. Int. J. Hematol. (2004) [Pubmed]
  26. Maternal low protein diet in rats programmes fatty acid desaturase activities in the offspring. Ozanne, S.E., Martensz, N.D., Petry, C.J., Loizou, C.L., Hales, C.N. Diabetologia (1998) [Pubmed]
  27. Fads, flaws, fallacies, and foolishness in evaluation of rehabilitation programs. Parker, R.M. Journal of rehabilitation. (1980) [Pubmed]
  28. Oral health issues for women athletes. Ranalli, D.N., Rye, L.A. Dent. Clin. North Am. (2001) [Pubmed]
  29. Fads and fashions of early breast cancer clinical trials in the United States over the past decade (1971-1981). Gelman, R. Experientia Suppl. (1982) [Pubmed]
WikiGenes - Universities