Disease relevance of MARK1

• Selected items from the history of pathology. Mark Akenside, MD (1721-1770): first recorded description of multiple neurofibromatosis [1].
• Thirty seven patients with confirmed gastro-oesophageal reflux disease who had a Belsey Mark IV antireflux procedure were evaluated preoperatively and three to six months postoperatively including endoscopy, lower oesophageal sphincter manometry, and 24 hour ambulatory pH metry [2].
• Here, Mark Woolhouse and Steve Chandiwana make use of a theoretical framework in discussing current understanding of schistisome-snail epidemiological patterns in the field, and then consider the implications of the analysis for the control of schistosomiasis [3].
• George M. Cober Lecturer: Mark T. Keating. Molecular basis of the long-QT syndrome associated with deafness [4].
• Correspondence re: Tatusuo Tomita, Timothy Dalton, Simon Kwok, Saing Lee, Mark Noble, and Masahiro Chiga. Profile of prostatic-specific antigen in prostatic carcinomas. Mod Pathol 6:259, 1993 [5].

Psychiatry related information on MARK1

• Microtubule affinity-regulating kinase 1 (MARK1) is activated by electroconvulsive shock in the rat hippocampus [6].
• "Plain question and plain answer make the shortest road out of most perplexities." Mark Twain-Life on the Mississippi. A new methodology for the measurement of the neural substrates of human social interaction is described [7].
• Moos; and (5) A Broader View of Change in Drinking Behavior, by discussant Mark L [8].
• In particular, the paper focuses on Mark Goldman's model of drug expectancies, Albert Bandura's model of self-efficacy, Thomas Wills's model of stress and coping and Stephen Tiffany's cognitive-processing model of drug urges and cravings [9].
• Rethinking medical decision making. Interview by Mark Hagland [10].

High impact information on MARK1

• In this review Ross Kinloch, Mark Treherne, Mike Furness and Iradj Hajimohamadreza will focus on the current literature describing the pharmacology of apoptosis, with particular reference to the therapeutic potential that could arise from the development of pro- and anti-apoptotic drugs [11].
• In this article, Mark Robertson and colleagues propose that the properties of angiotensin AT1 receptors may be explained by a similar model, but without the need to evoke an allosteric site [12].
• Methotrexate hepatotoxicity and the premature reporting of Mark Twain's death: both greatly exaggerated [13].
• Correspondence re: Mark J. Ratain et al., Limited Sampling Models for Amonafide (NSC 308847) Pharmacokinetics [14].
• Here, Steve Paterson and Mark Viney examine the interface between epidemiology and population genetics [15].

Chemical compound and disease context of MARK1

• Reply to invited letter concerning: Long-term results of the Belsey Mark IV antireflux operation in relation to the severity of esophagitis (J Thorac Cardiovasc Surg 1990;100:624-5) [16].
• The CT patterns of 295 glioblastomas examined with pre- and postcontrast scans using an EMI scanner Mark I (Matrix 160/160) have been reviewed and compared with the CT appearances of other brain tumors, metastases and abscesses [17].
• Interview with Mark Klempner, MD, principal investigator, National Emerging Infectious Diseases Laboratories, and associate provost for research, Boston University School of Medicine [18].

Biological context of MARK1

• MARK1 was maximally activated between 2 and 5 min after ECS, and Tau phosphorylation at Ser262 was also increased at 2 min and lasted to 1 h after ECS [6].
• Here, Mark Booth describes how attributable risk analysis techniques based on 232 tables can be used to address these problems, and how they were applied to estimate the public health impact of Schistosoma japonicum infections in three villages in China [19].
• In this article, Allen Hightower, Patrick Lommie and Mark Eberhard discuss these issues and their implications for the epidemiology of filarial infection [20].
• In this article john Kelly and Mark Blaxter discuss two simple procedures that allow recombinant clones to be characterized rapidly on the basis of both the parasite DNA sequences that they carry and the parasite antigens that they produce [21].
• On presentation of the Friedenwald Award of the Association for Research in Vision and Ophthalmology to Dr. Mark O. M. Tso [22].

Anatomical context of MARK1

• MARK1 activation and subsequent Tau phosphorylation in the hippocampus after ECS was confirmed by an in-gel kinase assay using tau protein as a substrate [6].
• While studying phosphorylated proteins in the rat brain after ECS, we observed a 100-kDa protein that cross-reacted with anti-phospho-p70 S6 kinase antibody, which was subsequently purified and identified as microtubule affinity-regulating kinase 1 (MARK1) [6].
• In this review, Timothy Lee, Mark Swieter and Dean Befus point out that much of the confusion about the role of mast cells in immunity stems from methods and interpretations which are inadequate for the diversity of roles played by these cells in host responses to parasites [23].
• Reciprocal Modifications of CLIC4 in Tumor Epithelium and Stroma Mark Malignant Progression of Multiple Human Cancers [24].
• The initial debate was provoked by Martin Cline's misadventures in 1980 and rekindled in 1983 by congressional resolution against germ-line intervention sponsored by Senator Mark Hatfield [25].

Associations of MARK1 with chemical compounds

• Within the framework of this interpretation, which is based on a vibrational analysis of biliverdin dimethyl ester (Smith, K. Matysik, J., Hlldebrandt, P., & Mark, F. (1993) J. Phys. Chem. 97, 11887-11900), a consistent model is proposed to describe the molecular events in the chromophore during the photocycle [26].
• The 2 MAB-based systems detected vWD but could not specifically identify qualitative vWF defects, although the recently modified Mark II kit was more effective for the latter compared with the original Mark I kit [27].
• We conclude the Fortec vaporizer is as efficient in delivering isoflurane in O2 as previous reports have shown the Fluotec Mark III to be in its delivery of halothane [28].
• STUDY OBJECTIVE: We sought to determine the feasibility of discharging Mark 1 atropine and pralidoxime autoinjectors into small, sterile vials to facilitate the potential intramuscular injection of these antidotes, particularly pralidoxime, on a milligram per kilogram basis to small children [29].
• Buck; (2) The Ionic Mechanism of Serotonin Potentiation of Ethanol Excitation of Ventral Tegmental Area Neurons, by Mark S [30].

Other interactions of MARK1

• The adult statures of a sample of 71 Canadian boys from the Saskatchewan Longitudinal Growth Study were predicted using the original TW Mark 1 and the new TW Mark 2 prediction equations [31].
• In order to investigate the physiologic stimuli which are involved in the activation of MARK1, SH-SY 5Y cells were treated with brain-derived neurotrophic factor or 60 mm KCl [6].

Analytical, diagnostic and therapeutic context of MARK1

• The Mark 2 aid was shown to give improved results over the Mark 1 aid in transmitting voice intonation, but gave no help in an isolated word lipreading test [32].
• The introduction of frequency modulated recording systems for ambulatory electrocardiographic monitoring (Oxford Medilog mark 2 and Cardiodyne cassette recorders) prompted comparison with a conventional direct recording type of recorder (Oxford Medilog mark 1) [33].
• Since the first selective kappa-agonists are now entering clinical trials, this is an opportune moment for Mark Millan to review the pharmacology of drugs of this type in the control of nociception and their therapeutic potential as analgesics [34].
• As part of this federal effort, an assessment of the "state of the art" for targeted drug therapeutics to the liver and gene therapy was undertaken through the conference, cochaired by Dr. Mark Zern (Thomas Jefferson Medical College) and Dr. Flossie Wong-Staal (University of California, San Diego, CA) [35].
• In 30 of 37 patients the Belsey Mark IV fundoplication was judged successful based on symptom relief and healing of oesophagitis [2].

References