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Gene Review

Impact  -  impact RWD domain protein

Rattus norvegicus

Synonyms: Imprinted and ancient gene protein homolog, Protein IMPACT
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Disease relevance of Impact


High impact information on Impact


Biological context of Impact


Anatomical context of Impact

  • These findings suggest that omega-3 fatty acids are the components of the enteral IED, Impact (Novartis Corp), which produce the increased blood flow to the terminal ileum and its contiguous gut-associated lymphoid tissue [13].
  • (Ang, K.K., Jiang, G.L., Guttenberger, R., Thames, H.D., Stephens, L.C., Smith, C.D. and Feng, Y. Impact of spinal cord repair kinetics on the practice of altered fractionation schedules. Radiother. Oncol. 25: 287-294, 1992) in the spinal cord of Sprague-Dawley rats [14].
  • Sustained P450 expression and prodrug activation in bolus cyclophosphamide-treated cultured tumor cells. Impact of prodrug schedule on P450 gene-directed enzyme prodrug therapy [15].
  • CONCLUSION: The pulmonary histopathologic effects of aspiration of Impact were severe peribronchial inflammatory cell infiltration (greater than aspiration of Biosorb and Pulmocare), abundant alveolar histiocytes, and alveolar edema in comparison with aspiration of saline, even though Impact had the lowest lipid content of all studied formulas [16].

Associations of Impact with chemical compounds


Analytical, diagnostic and therapeutic context of Impact

  • RESULTS: Allograft survival was extended by combining Impact with CsA (45.3+/-19 days) and Rapa (165.3+/-52 days), but not FK506 (12.4+/-3.2 days) [9].
  • Microdialysis sampling for hepatic metabolism studies. Impact of microdialysis probe design and implantation technique on liver tissue [22].
  • INTERVENTIONS: Previously undernourished rats were subjected to either massive bowel resection (n = 30) or laparotomy (n = 26) and fed four enteral hypocaloric diets for 7 days: Alitraq (n = 7 in each group), Impact (n = 8 and 7), Enrich (n = 8 and 6), and Elemental (n = 7 and 6) [23].
  • Objective of this study was the characterization of traumatic brain injury induced by a "Controlled Cortical Impact" with magnetic resonance imaging techniques [24].


  1. 52: PSEF 2006 Scientific Essay Contest Annual Bernard G. Sarnat, MD Junior Award, Basic Science - The Impact of Gradual Blood Flow Increase on Ischemia- Reperfusion Injury in the Rat Cremaster Microcirculation Model. Ozmen, S. Plast. Reconstr. Surg. (2006) [Pubmed]
  2. Expression of ob mRNA and its encoded protein in rodents. Impact of nutrition and obesity. Frederich, R.C., Löllmann, B., Hamann, A., Napolitano-Rosen, A., Kahn, B.B., Lowell, B.B., Flier, J.S. J. Clin. Invest. (1995) [Pubmed]
  3. Genetic contamination of Dahl SS/Jr rats. Impact on studies of salt-sensitive hypertension. St Lezin, E.M., Pravenec, M., Wong, A., Wang, J.M., Merriouns, T., Newton, S., Stec, D.E., Roman, R.J., Lau, D., Morris, R.C. Hypertension (1994) [Pubmed]
  4. Port-site metastases. Impact of local tissue trauma and gas leakage. Tseng, L.N., Berends, F.J., Wittich, P., Bouvy, N.D., Marquet, R.L., Kazemier, G., Bonjer, H.J. Surgical endoscopy. (1998) [Pubmed]
  5. The impact-acceleration model of head injury: injury severity predicts motor and cognitive performance after trauma. Beaumont, A., Marmarou, A., Czigner, A., Yamamoto, M., Demetriadou, K., Shirotani, T., Marmarou, C., Dunbar, J. Neurol. Res. (1999) [Pubmed]
  6. Impaired pancreatic beta cell function in the fetal GK rat. Impact of diabetic inheritance. Serradas, P., Gangnerau, M.N., Giroix, M.H., Saulnier, C., Portha, B. J. Clin. Invest. (1998) [Pubmed]
  7. Restoration of cell-to-cell communication in thyroid cell lines by transfection with and stable expression of the connexin-32 gene. Impact on cell proliferation and tissue-specific gene expression. Statuto, M., Audebet, C., Tonoli, H., Selmi-Ruby, S., Rousset, B., Munari-Silem, Y. J. Biol. Chem. (1997) [Pubmed]
  8. Phosphorylation of native 97-kDa 3-hydroxy-3-methylglutaryl-coenzyme A reductase from rat liver. Impact on activity and degradation of the enzyme. Parker, R.A., Miller, S.J., Gibson, D.M. J. Biol. Chem. (1989) [Pubmed]
  9. Nutritional immunomodulation leads to enhanced allograft survival in combination with cyclosporine A and rapamycin, but not FK506. Gibson, S.W., Valente, J.F., Alexander, J.W., Custer, D.A., Li, B.G., Frede, S., Babcock, G.F., Ogle, C.K. Transplantation (2000) [Pubmed]
  10. Comparative genomics approach toward critical determinants for the imprinting of an evolutionarily conserved gene Impact. Okamura, K., Sakaki, Y., Ito, T. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  11. The Impact of Aging, Dietary Restriction, and Glucocorticoids on ApoE Gene Expression in Rat Brain. Ruzdijic, S., Perovic, M., Mladenovic, A., Milanovic, D., Rakic, L., Petanceska, S., Kanazir, S. Ann. N. Y. Acad. Sci. (2005) [Pubmed]
  12. Iobitridol, a new nonionic low-osmolality contrast agent, and iohexol. Impact on renal histology in the rat. Beaufils, H., Idée, J.M., Berthommier, C., Balut, C., Bourbouze, R., Nimier, K., Chicandre-Jouanneau, C., Bonnemain, B. Investigative radiology. (1995) [Pubmed]
  13. Omega-3 fatty acids in immune-enhancing enteral diets selectively increase blood flow to the ileum by a bile acid dependent mechanism. Matheson, P.J., Lusco, V., Wilson, M.A., Garrison, R.N. Surgery (2002) [Pubmed]
  14. Kinetics of repair in the spinal cord of the rat. Landuyt, W., Fowler, J., Ruifrok, A., Stüben, G., van der Kogel, A., van der Schueren, E. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. (1997) [Pubmed]
  15. Sustained P450 expression and prodrug activation in bolus cyclophosphamide-treated cultured tumor cells. Impact of prodrug schedule on P450 gene-directed enzyme prodrug therapy. Schwartz, P.S., Chen, C.S., Waxman, D.J. Cancer Gene Ther. (2003) [Pubmed]
  16. Histopathologic effects of lipid content of enteral solutions after pulmonary aspiration in rats. Takil, A., Umuroğlu, T., Göğüş, Y.F., Eti, Z., Yildizeli, B., Ahiskali, R. Nutrition (Burbank, Los Angeles County, Calif.) (2003) [Pubmed]
  17. Differential Impact of Atorvastatin vs Pravastatin on Progressive Insulin Resistance and Left Ventricular Diastolic Dysfunction in a Rat Model of Type II Diabetes. Chen, Y., Ohmori, K., Mizukawa, M., Yoshida, J., Zeng, Y., Zhang, L., Shinomiya, K., Kosaka, H., Kohno, M. Circ. J. (2007) [Pubmed]
  18. Melatonin receptors in discrete brain areas of the male rat. Impact of aging on density and on circadian rhythmicity. Laudon, M., Nir, I., Zisapel, N. Neuroendocrinology (1988) [Pubmed]
  19. Influence of cholestyramine on the pharmacokinetics of rosiglitazone and its metabolite, desmethylrosiglitazone, after oral and intravenous dosing of rosiglitazone: Impact on oral bioavailability, absorption, and metabolic disposition in rats. Muzeeb, S., Venkatesh, P., Mullangi, R., Srinivas, N.R. Xenobiotica (2006) [Pubmed]
  20. Arginine, fish oil, and donor-specific transfusions independently improve cardiac allograft survival in rats given subtherapeutic doses of cyclosporin. Alexander, J.W., Levy, A., Custer, D., Valente, J.F., Babcock, G., Ogle, C.K., Schroeder, T.J. JPEN. Journal of parenteral and enteral nutrition. (1998) [Pubmed]
  21. Tumor oxygenation under normobaric and hyperbaric hyperoxia. Impact of various inspiratory CO2 concentrations. Thews, O., Kelleher, D.K., Vaupel, P. Adv. Exp. Med. Biol. (1997) [Pubmed]
  22. Microdialysis sampling for hepatic metabolism studies. Impact of microdialysis probe design and implantation technique on liver tissue. Davies, M.I., Lunte, C.E. Drug Metab. Dispos. (1995) [Pubmed]
  23. Effect of four enteral foods on the small bowel of undernourished rats after midgut resection. Gómez de Segura, I.A., Vázquez, P., García, P., Candela, C.G., Cos, A., Gancedo, P.G., López, J.M., De Miguel, E. The European journal of surgery = Acta chirurgica. (1999) [Pubmed]
  24. Magnetic resonance imaging studies with cluster algorithm for characterization of brain edema after controlled cortical impact injury (CCII). Stroop, R., Thomale, U.W., Päuser, S., Bernarding, J., Vollmann, W., Wolf, K.J., Lanksch, W.R., Unterberg, A.W. Acta Neurochir. Suppl. (1998) [Pubmed]
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