Disease relevance of Impact

• 52: PSEF 2006 Scientific Essay Contest Annual Bernard G. Sarnat, MD Junior Award, Basic Science - The Impact of Gradual Blood Flow Increase on Ischemia- Reperfusion Injury in the Rat Cremaster Microcirculation Model [1].
• Expression of ob mRNA and its encoded protein in rodents. Impact of nutrition and obesity [2].
• Genetic contamination of Dahl SS/Jr rats. Impact on studies of salt-sensitive hypertension [3].
• Port-site metastases. Impact of local tissue trauma and gas leakage [4].
• This study examines neuropsychological dysfunction after varying severities of the Impact Acceleration Model of diffuse traumatic brain injury [5].

High impact information on Impact

• Impaired pancreatic beta cell function in the fetal GK rat. Impact of diabetic inheritance [6].
• Restoration of cell-to-cell communication in thyroid cell lines by transfection with and stable expression of the connexin-32 gene. Impact on cell proliferation and tissue-specific gene expression [7].
• Phosphorylation of native 97-kDa 3-hydroxy-3-methylglutaryl-coenzyme A reductase from rat liver. Impact on activity and degradation of the enzyme [8].
• Rats were fed ad libitum with Impact diet (fortified with fish oil, arginine, and RNA) or standard rat food [9].
• Mean graft survival in the Rapa/Impact group met criteria for functional tolerance [9].

Biological context of Impact

• The Impact is an evolutionarily conserved gene subjected to genomic imprinting in mouse but not in human [10].
• Comparative genomics approach toward critical determinants for the imprinting of an evolutionarily conserved gene Impact [10].
• It thus seems that lineage-specific enhancement of gene expression rather than the tandem repeat per se played a critical role in the evolution of imprinting of Impact [10].
• The Impact of Aging, Dietary Restriction, and Glucocorticoids on ApoE Gene Expression in Rat Brain [11].
• Iobitridol, a new nonionic low-osmolality contrast agent, and iohexol. Impact on renal histology in the rat [12].

Anatomical context of Impact

• These findings suggest that omega-3 fatty acids are the components of the enteral IED, Impact (Novartis Corp), which produce the increased blood flow to the terminal ileum and its contiguous gut-associated lymphoid tissue [13].
• (Ang, K.K., Jiang, G.L., Guttenberger, R., Thames, H.D., Stephens, L.C., Smith, C.D. and Feng, Y. Impact of spinal cord repair kinetics on the practice of altered fractionation schedules. Radiother. Oncol. 25: 287-294, 1992) in the spinal cord of Sprague-Dawley rats [14].
• Sustained P450 expression and prodrug activation in bolus cyclophosphamide-treated cultured tumor cells. Impact of prodrug schedule on P450 gene-directed enzyme prodrug therapy [15].
• CONCLUSION: The pulmonary histopathologic effects of aspiration of Impact were severe peribronchial inflammatory cell infiltration (greater than aspiration of Biosorb and Pulmocare), abundant alveolar histiocytes, and alveolar edema in comparison with aspiration of saline, even though Impact had the lowest lipid content of all studied formulas [16].

Associations of Impact with chemical compounds

• Differential Impact of Atorvastatin vs Pravastatin on Progressive Insulin Resistance and Left Ventricular Diastolic Dysfunction in a Rat Model of Type II Diabetes [17].
• Melatonin receptors in discrete brain areas of the male rat. Impact of aging on density and on circadian rhythmicity [18].
• Influence of cholestyramine on the pharmacokinetics of rosiglitazone and its metabolite, desmethylrosiglitazone, after oral and intravenous dosing of rosiglitazone: Impact on oral bioavailability, absorption, and metabolic disposition in rats [19].
• BACKGROUND: Dietary supplementation with a fish oil and arginine-enriched immunoenhancing diet (Impact; Sandoz Nutrition, Minneapolis, MN) in a rat cardiac allograft model using donor-specific transfusion (DST) and cyclosporin (CsA) resulted in significant prolongation of cardiac allograft survival with many animals developing long-term tolerance [20].
• Tumor oxygenation under normobaric and hyperbaric hyperoxia. Impact of various inspiratory CO2 concentrations [21].

Analytical, diagnostic and therapeutic context of Impact

• RESULTS: Allograft survival was extended by combining Impact with CsA (45.3+/-19 days) and Rapa (165.3+/-52 days), but not FK506 (12.4+/-3.2 days) [9].
• Microdialysis sampling for hepatic metabolism studies. Impact of microdialysis probe design and implantation technique on liver tissue [22].
• INTERVENTIONS: Previously undernourished rats were subjected to either massive bowel resection (n = 30) or laparotomy (n = 26) and fed four enteral hypocaloric diets for 7 days: Alitraq (n = 7 in each group), Impact (n = 8 and 7), Enrich (n = 8 and 6), and Elemental (n = 7 and 6) [23].
• Objective of this study was the characterization of traumatic brain injury induced by a "Controlled Cortical Impact" with magnetic resonance imaging techniques [24].

References