Gene Review:
Slc12a3 - solute carrier family 12 (sodium/chloride...
Rattus norvegicus
Synonyms:
NCC, Na-Cl symporter, Solute carrier family 12 member 3, TSC, Thiazide-sensitive sodium-chloride cotransporter, ...
- Increased renal alpha-ENaC and NCC abundance and elevated blood pressure are independent of hyperaldosteronism in vasopressin escape. Tiwari, S., Packer, R.K., Hu, X., Sugimura, Y., Verbalis, J.G., Ecelbarger, C.A. Am. J. Physiol. Renal Physiol. (2006)
- Sodium retention in rats with liver cirrhosis is associated with increased renal abundance of NaCl cotransporter (NCC). Yu, Z., Serra, A., Sauter, D., Loffing, J., Ackermann, D., Frey, F.J., Frey, B.M., Vogt, B. Nephrol. Dial. Transplant. (2005)
- Upregulation of renal BSC1 and TSC in prenatally programmed hypertension. Manning, J., Beutler, K., Knepper, M.A., Vehaskari, V.M. Am. J. Physiol. Renal Physiol. (2002)
- Increased blood pressure, aldosterone activity, and regional differences in renal ENaC protein during vasopressin escape. Song, J., Hu, X., Khan, O., Tian, Y., Verbalis, J.G., Ecelbarger, C.A. Am. J. Physiol. Renal Physiol. (2004)
- Altered expression of renal AQPs and Na(+) transporters in rats with lithium-induced NDI. Kwon, T.H., Laursen, U.H., Marples, D., Maunsbach, A.B., Knepper, M.A., Frokiaer, J., Nielsen, S. Am. J. Physiol. Renal Physiol. (2000)
- Sleep deprivation in the rat: XVI. Effects in a light-dark cycle. Tsai, L.L., Bergmann, B.M., Rechtschaffen, A. Sleep. (1992)
- The renal thiazide-sensitive Na-Cl cotransporter as mediator of the aldosterone-escape phenomenon. Wang, X.Y., Masilamani, S., Nielsen, J., Kwon, T.H., Brooks, H.L., Nielsen, S., Knepper, M.A. J. Clin. Invest. (2001)
- Estradiol enhances thiazide-sensitive NaCl cotransporter density in the apical plasma membrane of the distal convoluted tubule in ovariectomized rats. Verlander, J.W., Tran, T.M., Zhang, L., Kaplan, M.R., Hebert, S.C. J. Clin. Invest. (1998)
- The thiazide-sensitive Na-Cl cotransporter is an aldosterone-induced protein. Kim, G.H., Masilamani, S., Turner, R., Mitchell, C., Wade, J.B., Knepper, M.A. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Affinity-defining domains in the Na-Cl cotransporter: a different location for Cl- and thiazide binding. Moreno, E., Cristóbal, P.S., Rivera, M., Vázquez, N., Bobadilla, N.A., Gamba, G. J. Biol. Chem. (2006)
- WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1. Moriguchi, T., Urushiyama, S., Hisamoto, N., Iemura, S., Uchida, S., Natsume, T., Matsumoto, K., Shibuya, H. J. Biol. Chem. (2005)
- Regulation of blood pressure, the epithelial sodium channel (ENaC), and other key renal sodium transporters by chronic insulin infusion in rats. Song, J., Hu, X., Riazi, S., Tiwari, S., Wade, J.B., Ecelbarger, C.A. Am. J. Physiol. Renal Physiol. (2006)
- A novel fluid resuscitation therapy for hemorrhagic shock. Roy, J.W., Graham, M.C., Griffin, A.M., Gainer, J.L. Shock (1998)
- The effect of trans sodium crocetinate (TSC) in a rat oleic acid model of acute lung injury. Gainer, J.L., Stennett, A.K., Murray, R.J. Pulmonary pharmacology & therapeutics. (2005)
- Trans-sodium crocetinate does not affect oxygen uptake in rats during treadmill running. Kemi, O.J., Ellingsen, O. Scand. J. Clin. Lab. Invest. (2005)
- Renal tubule-specific transcription and chromosomal localization of rat thiazide-sensitive Na-Cl cotransporter gene. Taniyama, Y., Sato, K., Sugawara, A., Uruno, A., Ikeda, Y., Kudo, M., Ito, S., Takeuchi, K. J. Biol. Chem. (2001)
- Altered expression of renal apical plasma membrane Na+ transporters in the early phase of genetic hypertension. Capasso, G., Rizzo, M., Evangelista, C., Ferrari, P., Geelen, G., Lang, F., Bianchi, G. Am. J. Physiol. Renal Physiol. (2005)
- Time course of renal Na-K-ATPase, NHE3, NKCC2, NCC, and ENaC abundance changes with dietary NaCl restriction. Masilamani, S., Wang, X., Kim, G.H., Brooks, H., Nielsen, J., Nielsen, S., Nakamura, K., Stokes, J.B., Knepper, M.A. Am. J. Physiol. Renal Physiol. (2002)
- N-Glycosylation at two sites critically alters thiazide binding and activity of the rat thiazide-sensitive Na(+):Cl(-) cotransporter. Hoover, R.S., Poch, E., Monroy, A., Vázquez, N., Nishio, T., Gamba, G., Hebert, S.C. J. Am. Soc. Nephrol. (2003)
- A transient post-translationally modified form of cartilage type II collagen is ignored by self-reactive T cells. Yamada, H., Dzhambazov, B., Bockermann, R., Blom, T., Holmdahl, R. J. Immunol. (2004)
- Thiazide-sensitive NaCl-cotransporter in the intestine: possible role of hydrochlorothiazide in the intestinal Ca2+ uptake. Bazzini, C., Vezzoli, V., Sironi, C., Dossena, S., Ravasio, A., De Biasi, S., Garavaglia, M., Rodighiero, S., Meyer, G., Fascio, U., Fürst, J., Ritter, M., Bottà, G., Paulmichl, M. J. Biol. Chem. (2005)
- Sarcomere dynamics in a spontaneous contraction wave and its effect on the following, electrically triggered twitch in rat myocyte. Comparison with the rested state twitch. Tameyasu, T., Kasugai, H., Tanaka, M., Harada, H. J. Gen. Physiol. (1994)
- Redistribution of distal tubule Na+-Cl- cotransporter (NCC) in response to a high-salt diet. Sandberg, M.B., Maunsbach, A.B., McDonough, A.A. Am. J. Physiol. Renal Physiol. (2006)
- Regulation of NHE3, NKCC2, and NCC abundance in kidney during aldosterone escape phenomenon: role of NO. Turban, S., Wang, X.Y., Knepper, M.A. Am. J. Physiol. Renal Physiol. (2003)
- Altered expression of major renal Na transporters in rats with bilateral ureteral obstruction and release of obstruction. Li, C., Wang, W., Kwon, T.H., Knepper, M.A., Nielsen, S., Frøkiaer, J. Am. J. Physiol. Renal Physiol. (2003)
- Angiotensin II AT1 receptor blockade decreases vasopressin-induced water reabsorption and AQP2 levels in NaCl-restricted rats. Kwon, T.H., Nielsen, J., Knepper, M.A., Frøkiaer, J., Nielsen, S. Am. J. Physiol. Renal Physiol. (2005)
- Altered expression of renal NHE3, TSC, BSC-1, and ENaC subunits in potassium-depleted rats. Elkjaer, M.L., Kwon, T.H., Wang, W., Nielsen, J., Knepper, M.A., Frøkiaer, J., Nielsen, S. Am. J. Physiol. Renal Physiol. (2002)