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Gene Review

ADI1  -  acireductone dioxygenase 1

Homo sapiens

Synonyms: 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase, APL1, ARD, Acireductone dioxygenase (Fe(2+)-requiring), FLJ10913, ...
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Disease relevance of ADI1

  • The C-terminal part of MTCBP-1 is identical to Sip-L, which is reported to be important for human hepatitis C virus replication [1].
  • GERD is the most common ARD (2.9% overall prevalence) [2].
  • Four hundred and thirty subjects with chronic viral hepatitis (n=185), autoimmune liver diseases (n=181), autoimmune rheumatic diseases (ARD, n=31) and healthy (n=33) were tested [3].
  • Nuclear hADI1 expression significantly altered the splicing pattern of the adenovirus E1A mini-gene, which generates multiple alternatively spliced transcripts [4].
  • Of infants born during the study period, 995 tested positive for HIV antibody, and 151 infants (15 percent) were hospitalized with an ARD within 12 months of birth [5].

High impact information on ADI1


Chemical compound and disease context of ADI1

  • Patients underwent dobutamine echocardiography (DE) and rest scintigraphic studies before revascularization and DE at 3 to 4 months. alpha- and ss-receptor density (ARD and BRD) and extent of fibrosis were quantified from the myocardial biopsies [9].

Biological context of ADI1


Anatomical context of ADI1

  • We have described preliminary experiments designed to show the correlation between the blood glucose assay (BGA) and the aqueous humor glucose concentration as determined by chemical assay (AGA) and by optical rotation determination (ARD) [13].
  • Having seen five patients with both SLE and thyroid disease (case reports available on request) in a short period of time, we have undertaken a survey of the association between the ARD and endocrine disorders [14].
  • Three myeloma cell lines (U266, ARH77, and ARD) were treated with TMPyP4 for 3-4 weeks [15].
  • We recommend that these three tests - ART, ARD, and ARL - be used as a group and describe how they are implemented in the audiologic diagnosis of acoustic tumors and other lesions affecting the auditory system in the cerebellopontine angle and brain stem [16].
  • The objective of this study was to determine if calculation of the sinus of Valsalva to annulus ratio (SOV/Ann) effectively screens for root dilatation (ARD) during two-dimensional (2D) echocardiography in young patients (1 month-15 years) with suspected or confirmed Marfan syndrome [17].

Associations of ADI1 with chemical compounds


Co-localisations of ADI1

  • Indeed, hADI1 specifically co-localized with the splicing factor U1-70K to the nucleus but not with another splicing factor, SC35 [4].

Regulatory relationships of ADI1

  • MTCBP-1 expressed in cells formed a complex with MT1-MMP and co-localized at the membrane [1].
  • U1-70K over-expression induced nuclear accumulation of hADI1 [4].

Other interactions of ADI1

  • Thus, MTCBP-1 may have multiple functions other than the regulation of MT1-MMP, which presumably depends on the subcellular compartment [1].
  • Thus, hADI1 may have acquired a novel role in nuclear mRNA processing possibly by modulating U1-70K-related functions, an activity negatively regulated by a non-classical NES sequence [4].
  • Comparison of exon structure (including the uncharacterised APL-1 gene), construction of phylogenetic trees, and analysis of the protein sequence alignment of known homologues of the APP super-family were performed to reconstruct the evolution of the family and to assess the functional significance of conserved protein sequences between homologues [20].

Analytical, diagnostic and therapeutic context of ADI1

  • BACKGROUND: Acute and chronic renal dysfunction (ARD, CRD) are common complications after liver transplantation and are associated with poor outcome [21].
  • The Antimicrobial Removal Device (ARD; Marion Scientific) was evaluated in vitro with simulated blood culture samples in fresh blood and clinically with samples from potentially septic patients to test its ability to remove antimicrobial agents and recover bacteria from blood culture specimens containing these drugs [22].
  • The 151 ARD cases had a total of 240 hospitalizations, accounting for 5,772 patient days [5].
  • A water-deficit-suppressed gene, OsARD encoding an aci-reductone-dioxygenase-like protein, was identified from rice (Oryza sativa L.). Northern blot and reverse transcriptase-polymerase chain reaction (RT-PCR) analysis revealed that the OsARD expression is regulated by abiotic stresses and phytohormones [23].
  • We studied the effect of ADI-1 on the prolongation of canine renal allografts [24].


  1. Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein-1 is a new member of the Cupin superfamily. A possible multifunctional protein acting as an invasion suppressor down-regulated in tumors. Uekita, T., Gotoh, I., Kinoshita, T., Itoh, Y., Sato, H., Shiomi, T., Okada, Y., Seiki, M. J. Biol. Chem. (2004) [Pubmed]
  2. Costs of acid-related disorders to a health maintenance organization. Levin, T.R., Schmittdiel, J.A., Kunz, K., Henning, J.M., Henke, C.J., Colby, C.J., Selby, J.V. Am. J. Med. (1997) [Pubmed]
  3. Cytochrome P450 2A6: a new hepatic autoantigen in patients with chronic hepatitis C virus infection. Dalekos, G.N., Obermayer-Straub, P., Bartels, M., Maeda, T., Kayser, A., Braun, S., Loges, S., Schmidt, E., Gershwin, M.E., Manns, M.P. J. Hepatol. (2003) [Pubmed]
  4. Regulated nucleo-cytoplasmic shuttling of human aci-reductone dioxygenase (hADI1) and its potential role in mRNA processing. Gotoh, I., Uekita, T., Seiki, M. Genes Cells (2007) [Pubmed]
  5. Hospitalization of HIV-seropositive newborns with AIDS-related disease within the first year of life. Glebatis, D.M., Novick, L.F., Stacy, A. American journal of public health. (1991) [Pubmed]
  6. Nickel uptake and utilization by microorganisms. Mulrooney, S.B., Hausinger, R.P. FEMS Microbiol. Rev. (2003) [Pubmed]
  7. Aliphatic carbon-carbon bond cleavage reactivity of a mononuclear Ni(II) cis-beta-keto-enolate complex in the presence of base and O2: a model reaction for acireductone dioxygenase (ARD). Szajna, E., Arif, A.M., Berreau, L.M. J. Am. Chem. Soc. (2005) [Pubmed]
  8. Mechanisms and Rates of Birth and Death of Dispersed Duplicated Genes during the Evolution of a Multigene Family in Diploid and Tetraploid Wheats. Akhunov, E.D., Akhunova, A.R., Dvorak, J. Mol. Biol. Evol. (2007) [Pubmed]
  9. Altered adrenergic receptor density in myocardial hibernation in humans: A possible mechanism of depressed myocardial function. Shan, K., Bick, R.J., Poindexter, B.J., Nagueh, S.F., Shimoni, S., Verani, M.S., Keng, F., Reardon, M.J., Letsou, G.V., Howell, J.F., Zoghbi, W.A. Circulation (2000) [Pubmed]
  10. Membrane-type 1 matrix metalloproteinase cytoplasmic tail binding protein-1 (MTCBP-1) acts as an eukaryotic aci-reductone dioxygenase (ARD) in the methionine salvage pathway. Hirano, W., Gotoh, I., Uekita, T., Seiki, M. Genes Cells (2005) [Pubmed]
  11. One protein, two enzymes revisited: a structural entropy switch interconverts the two isoforms of acireductone dioxygenase. Ju, T., Goldsmith, R.B., Chai, S.C., Maroney, M.J., Pochapsky, S.S., Pochapsky, T.C. J. Mol. Biol. (2006) [Pubmed]
  12. Telomerase inhibition and cell growth arrest after telomestatin treatment in multiple myeloma. Shammas, M.A., Shmookler Reis, R.J., Li, C., Koley, H., Hurley, L.H., Anderson, K.C., Munshi, N.C. Clin. Cancer Res. (2004) [Pubmed]
  13. Noninvasive glucose monitoring of the aqueous humor of the eye: Part II. Animal studies and the scleral lens. March, W.F., Rabinovitch, B., Adams, R.L. Diabetes Care (1982) [Pubmed]
  14. The endocrinologic associations of the autoimmune rheumatic diseases. Gordon, T., Isenberg, D. Semin. Arthritis Rheum. (1987) [Pubmed]
  15. Telomerase inhibition and cell growth arrest by G-quadruplex interactive agent in multiple myeloma. Shammas, M.A., Shmookler Reis, R.J., Akiyama, M., Koley, H., Chauhan, D., Hideshima, T., Goyal, R.K., Hurley, L.H., Anderson, K.C., Munshi, N.C. Mol. Cancer Ther. (2003) [Pubmed]
  16. Acoustic reflex testing in otoneurology. Clemis, J.D. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. (1984) [Pubmed]
  17. A new on-line method for predicting aortic root dilatation during two-dimensional echocardiography in pediatric patients with Marfan syndrome using the sinus of valsalva to annulus ratio. Mart, C.R., Khan, S.A., Smith, F.C., Kavey, R.E. Pediatric cardiology. (2003) [Pubmed]
  18. The immediate-early ethylene response gene OsARD1 encodes an acireductone dioxygenase involved in recycling of the ethylene precursor S-adenosylmethionine. Sauter, M., Lorbiecke, R., Ouyang, B., Pochapsky, T.C., Rzewuski, G. Plant J. (2005) [Pubmed]
  19. Recovery of fish communities in the Finniss River, northern Australia, following remediation of the Rum Jungle uranium/copper mine site. Jeffree, R.A., Twining, J.R., Thomson, J. Environ. Sci. Technol. (2001) [Pubmed]
  20. What the evolution of the amyloid protein precursor supergene family tells us about its function. Coulson, E.J., Paliga, K., Beyreuther, K., Masters, C.L. Neurochem. Int. (2000) [Pubmed]
  21. Early kidney dysfunction post liver transplantation predicts late chronic kidney disease. Velidedeoglu, E., Bloom, R.D., Crawford, M.D., Desai, N.M., Campos, L., Abt, P.L., Markmann, J.W., Mange, K.C., Olthoff, K.M., Shaked, A., Markmann, J.F. Transplantation (2004) [Pubmed]
  22. Evaluation of new blood culture processing systems. Moody, J.A., Fasching, C.E., Shanholtzer, C.J., Gerding, D.N., Peterson, L.R. J. Clin. Microbiol. (1984) [Pubmed]
  23. Identification and characterization of a novel water-deficit-suppressed gene OsARD encoding an aci-reductone-dioxygenase-like protein in rice. Lin, T., He, X., Yang, L., Shou, H., Wu, P. Gene (2005) [Pubmed]
  24. Characterization of anti-canine cytokine monoclonal antibodies specific for IFN-gamma: effect of anti-IFN-gamma on renal transplant rejection. Fuller, L., Carreno, M., Esquenazi, V., Zucker, K., Zheng, S., Roth, D., Burke, G., Nery, J., Asthana, D., Olson, L. Tissue Antigens (1994) [Pubmed]
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