Disease relevance of ADI1

• The C-terminal part of MTCBP-1 is identical to Sip-L, which is reported to be important for human hepatitis C virus replication [1].
• GERD is the most common ARD (2.9% overall prevalence) [2].
• Four hundred and thirty subjects with chronic viral hepatitis (n=185), autoimmune liver diseases (n=181), autoimmune rheumatic diseases (ARD, n=31) and healthy (n=33) were tested [3].
• Nuclear hADI1 expression significantly altered the splicing pattern of the adenovirus E1A mini-gene, which generates multiple alternatively spliced transcripts [4].
• Of infants born during the study period, 995 tested positive for HIV antibody, and 151 infants (15 percent) were hospitalized with an ARD within 12 months of birth [5].

High impact information on ADI1

• To date, nine nickel-containing enzymes are known: urease, NiFe-hydrogenase, carbon monoxide dehydrogenase, acetyl-CoA decarbonylase/synthase, methyl coenzyme M reductase, certain superoxide dismutases, some glyoxylases, aci-reductone dioxygenase, and methylenediurease [6].
• In human tumor cell lines MTCBP-1 expression was significantly low compared with non-transformed fibroblasts, and enforced expression of MTCBP-1 inhibited the activity of MT1-MMP in promoting cell migration and invasion [1].
• MTCBP-1 showed significant homology to the bacterial aci-reductone dioxygenase, which is an enzyme in methionine metabolism [1].
• Aliphatic carbon-carbon bond cleavage reactivity of a mononuclear Ni(II) cis-beta-keto-enolate complex in the presence of base and O2: a model reaction for acireductone dioxygenase (ARD) [7].
• The ancestral gene, ALP-A1, is on chromosome 1A and encodes an aci-reductone dioxygenase-like protein [8].

Chemical compound and disease context of ADI1

• Patients underwent dobutamine echocardiography (DE) and rest scintigraphic studies before revascularization and DE at 3 to 4 months. alpha- and ss-receptor density (ARD and BRD) and extent of fibrosis were quantified from the myocardial biopsies [9].

Biological context of ADI1

• Re-expression of either the YMR009w or MTCBP-1 gene restored the cell growth [10].
• Since it is difficult to speculate the functions of cupin proteins simply based on their sequence homology, we examined whether the eukaryotic ARD homologs surely function in the methionine metabolism [10].
• Thus, MTCBP-1 isolated as a binding protein for MT1-MMP was demonstrated to function as an ARD-like enzyme in the MTA cycle in yeast [10].
• Paramagnetism of Fe(2+) renders the active site of ARD' inaccessible to standard NMR methods [11].
• Telomere length, apoptosis, and gene expression changes were monitored as described in detail in "Materials and Methods." RESULTS: Telomestatin treatment led to inhibition of telomerase activity, reduction in telomere length, and apoptotic cell death in ARD, MM1S, and ARP myeloma cells [12].

Anatomical context of ADI1

• We have described preliminary experiments designed to show the correlation between the blood glucose assay (BGA) and the aqueous humor glucose concentration as determined by chemical assay (AGA) and by optical rotation determination (ARD) [13].
• Having seen five patients with both SLE and thyroid disease (case reports available on request) in a short period of time, we have undertaken a survey of the association between the ARD and endocrine disorders [14].
• Three myeloma cell lines (U266, ARH77, and ARD) were treated with TMPyP4 for 3-4 weeks [15].
• We recommend that these three tests - ART, ARD, and ARL - be used as a group and describe how they are implemented in the audiologic diagnosis of acoustic tumors and other lesions affecting the auditory system in the cerebellopontine angle and brain stem [16].
• The objective of this study was to determine if calculation of the sinus of Valsalva to annulus ratio (SOV/Ann) effectively screens for root dilatation (ARD) during two-dimensional (2D) echocardiography in young patients (1 month-15 years) with suspected or confirmed Marfan syndrome [17].

Associations of ADI1 with chemical compounds

• If Fe(2+) is bound (ARD'), the same substrates yield methylthioketobutyrate and formate [11].
• The immediate-early ethylene response gene OsARD1 encodes an acireductone dioxygenase involved in recycling of the ethylene precursor S-adenosylmethionine [18].
• In two independent differential screens for submergence-induced genes and for 1-aminocyclopropane-1-carboxylic acid (ACC)-induced genes from deepwater rice (Oryza sativa L.) we identified an acireductone dioxygenase (ARD) [18].
• Nuclear export of hADI1 was not mediated by CRM1, a major transporter that binds to leucine-rich NES [4].
• The Finniss River in the wet-dry tropics of northern Australia has received acid rock drainage (ARD) contaminants from the Rum Jungle uranium/copper mine site over more than four decades [19].

Co-localisations of ADI1

• Indeed, hADI1 specifically co-localized with the splicing factor U1-70K to the nucleus but not with another splicing factor, SC35 [4].

Regulatory relationships of ADI1

• MTCBP-1 expressed in cells formed a complex with MT1-MMP and co-localized at the membrane [1].
• U1-70K over-expression induced nuclear accumulation of hADI1 [4].

Other interactions of ADI1

• Thus, MTCBP-1 may have multiple functions other than the regulation of MT1-MMP, which presumably depends on the subcellular compartment [1].
• Thus, hADI1 may have acquired a novel role in nuclear mRNA processing possibly by modulating U1-70K-related functions, an activity negatively regulated by a non-classical NES sequence [4].
• Comparison of exon structure (including the uncharacterised APL-1 gene), construction of phylogenetic trees, and analysis of the protein sequence alignment of known homologues of the APP super-family were performed to reconstruct the evolution of the family and to assess the functional significance of conserved protein sequences between homologues [20].

Analytical, diagnostic and therapeutic context of ADI1

• BACKGROUND: Acute and chronic renal dysfunction (ARD, CRD) are common complications after liver transplantation and are associated with poor outcome [21].
• The Antimicrobial Removal Device (ARD; Marion Scientific) was evaluated in vitro with simulated blood culture samples in fresh blood and clinically with samples from potentially septic patients to test its ability to remove antimicrobial agents and recover bacteria from blood culture specimens containing these drugs [22].
• The 151 ARD cases had a total of 240 hospitalizations, accounting for 5,772 patient days [5].
• A water-deficit-suppressed gene, OsARD encoding an aci-reductone-dioxygenase-like protein, was identified from rice (Oryza sativa L.). Northern blot and reverse transcriptase-polymerase chain reaction (RT-PCR) analysis revealed that the OsARD expression is regulated by abiotic stresses and phytohormones [23].
• We studied the effect of ADI-1 on the prolongation of canine renal allografts [24].

References