Gene Review:
Park2 - Parkinson disease (autosomal recessive,...
Mus musculus
Synonyms:
E3 ubiquitin-protein ligase parkin, PRKN, Prkn
- Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons. Goldberg, M.S., Fleming, S.M., Palacino, J.J., Cepeda, C., Lam, H.A., Bhatnagar, A., Meloni, E.G., Wu, N., Ackerson, L.C., Klapstein, G.J., Gajendiran, M., Roth, B.L., Chesselet, M.F., Maidment, N.T., Levine, M.S., Shen, J. J. Biol. Chem. (2003)
- Susceptibility to rotenone is increased in neurons from parkin null mice and is reduced by minocycline. Casarejos, M.J., Menéndez, J., Solano, R.M., Rodríguez-Navarro, J.A., García de Yébenes, J., Mena, M.A. J. Neurochem. (2006)
- DJ-1 and Parkin Modulate Dopamine-dependent Behavior and Inhibit MPTP-induced Nigral Dopamine Neuron Loss in Mice. Paterna, J.C., Leng, A., Weber, E., Feldon, J., Büeler, H. Mol. Ther. (2007)
- Neurotoxicity and behavioral deficits associated with Septin 5 accumulation in dopaminergic neurons. Son, J.H., Kawamata, H., Yoo, M.S., Kim, D.J., Lee, Y.K., Kim, S., Dawson, T.M., Zhang, H., Sulzer, D., Yang, L., Beal, M.F., Degiorgio, L.A., Chun, H.S., Baker, H., Peng, C. J. Neurochem. (2005)
- Down-regulation of parkin protein in transient focal cerebral ischemia: A link between stroke and degenerative disease? Mengesdorf, T., Jensen, P.H., Mies, G., Aufenberg, C., Paschen, W. Proc. Natl. Acad. Sci. U.S.A. (2002)
- Effects of cinnarizine, a calcium antagonist that produces human parkinsonism, in parkin knock out mice. Serrano, A., Menéndez, J., Casarejos, M.J., Solano, R.M., Gallego, E., Sánchez, M., Mena, M.A., García de Yebenes, J. Neuropharmacology (2005)
- Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. Kitada, T., Asakawa, S., Hattori, N., Matsumine, H., Yamamura, Y., Minoshima, S., Yokochi, M., Mizuno, Y., Shimizu, N. Nature (1998)
- Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons. Petrucelli, L., O'Farrell, C., Lockhart, P.J., Baptista, M., Kehoe, K., Vink, L., Choi, P., Wolozin, B., Farrer, M., Hardy, J., Cookson, M.R. Neuron (2002)
- 14-3-3eta is a novel regulator of parkin ubiquitin ligase. Sato, S., Chiba, T., Sakata, E., Kato, K., Mizuno, Y., Hattori, N., Tanaka, K. EMBO J. (2006)
- Parkin-deficient mice are not a robust model of parkinsonism. Perez, F.A., Palmiter, R.D. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Midbrain neuronal cultures from parkin mutant mice are resistant to nitric oxide-induced toxicity. Solano, R.M., Menéndez, J., Casarejos, M.J., Rodríguez-Navarro, J.A., García de Yébenes, J., Mena, M.A. Neuropharmacology (2006)
- Parkin suppresses the expression of monoamine oxidases. Jiang, H., Jiang, Q., Liu, W., Feng, J. J. Biol. Chem. (2006)
- Parkin attenuates manganese-induced dopaminergic cell death. Higashi, Y., Asanuma, M., Miyazaki, I., Hattori, N., Mizuno, Y., Ogawa, N. J. Neurochem. (2004)
- Parkin-deficient mice are not more sensitive to 6-hydroxydopamine or methamphetamine neurotoxicity. Perez, F.A., Curtis, W.R., Palmiter, R.D. BMC neuroscience [electronic resource]. (2005)
- Differential effects of l-DOPA on monoamine metabolism, cell survival and glutathione production in midbrain neuronal-enriched cultures from parkin knockout and wild-type mice. Casarejos, M.J., Solano, R.M., Menéndez, J., Rodríguez-Navarro, J.A., Correa, C., García de Yébenes, J., Mena, M.A. J. Neurochem. (2005)
- Proteomic analysis of parkin knockout mice: alterations in energy metabolism, protein handling and synaptic function. Periquet, M., Corti, O., Jacquier, S., Brice, A. J. Neurochem. (2005)
- It's a double knock-out! The quaking mouse is a spontaneous deletion of parkin and parkin co-regulated gene (PACRG). Lockhart, P.J., O'Farrell, C.A., Farrer, M.J. Mov. Disord. (2004)
- Inclusion body formation and neurodegeneration are parkin independent in a mouse model of alpha-synucleinopathy. von Coelln, R., Thomas, B., Andrabi, S.A., Lim, K.L., Savitt, J.M., Saffary, R., Stirling, W., Bruno, K., Hess, E.J., Lee, M.K., Dawson, V.L., Dawson, T.M. J. Neurosci. (2006)
- Mitochondria mass is low in mouse substantia nigra dopamine neurons: Implications for Parkinson's disease. Liang, C.L., Wang, T.T., Luby-Phelps, K., German, D.C. Exp. Neurol. (2007)
- Cannabinoid CB(1) receptors in the basal ganglia and motor response to activation or blockade of these receptors in parkin-null mice. González, S., Mena, M.A., Lastres-Becker, I., Serrano, A., de Yébenes, J.G., Ramos, J.A., Fernández-Ruiz, J. Brain Res. (2005)
- Parkin expression in the adult mouse brain. Stichel, C.C., Augustin, M., Kühn, K., Zhu, X.R., Engels, P., Ullmer, C., Lübbert, H. Eur. J. Neurosci. (2000)