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Gene Review

NCOA5  -  nuclear receptor coactivator 5

Homo sapiens

Synonyms: CIA, Coactivator independent of AF-2, KIAA1637, NCoA-5, Nuclear receptor coactivator 5, ...
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Disease relevance of NCOA5

  • Five late deaths occurred (2 TAA, 2 SRA, 1 CIA), three of which (2 TAA, 1 SRA) were aneurysm related [1].
  • T derived colony inhibitory activity (Td/CIA) was obtained from unstimulated T cells from aplastic anemia patients (SAA), or from PWM primed normal T cells [2].
  • METHODS: A prospective study was conducted in patients with thoracoabdominal, suprarenal, or common iliac aneurysms (TAA, SRA, or CIA) at high risk for open surgical repair [1].
  • The susceptibility of human herpes simplex virus (HSV) to acyclovir (ACV) was determined with the use of a single dose of the drug (1 and 2 micrograms of ACV per ml for HSV-1 and HSV-2, respectively) in two rapid assays: a rapid cytopathic effect inhibitory assay (Rapid CIA) and a rapid dye uptake assay (Rapid DUA) [3].
  • The CIA method seems to be reliable and practicable in estimating the actual surface of psoriasis [4].

Psychiatry related information on NCOA5

  • The CIA (Consciousness, Intuition. Anticipation, professional psychometric testing) is a set of tests covering three essential values to determine one's suitability and fitness for work at sea developed in order to recognize and improve potentials of professional seafarers [5].

High impact information on NCOA5

  • Biogenesis of cytosolic and nuclear Fe/S proteins is facilitated by the cytosolic iron-sulfur protein assembly (CIA) apparatus [6].
  • No difference was noted in the course of CIA in the injected knee joints between Ad5E1mIL-4 and the control vector, but radiographic analysis revealed impressive reduction of joint erosion and more compact bone structure in the Ad5E1mIL-4 group [7].
  • The tumor suppressor effect of CC3 has been suggested to result from inhibition of nuclear transport by binding to importin betas or by regulating transcription through interaction in a complex with co-activator independent of AF-2 function (CIA) and the c-myc gene [8].
  • These structural results, in conjunction with data from earlier mutagenesis work on the nucleotide binding motif, suggest that NADPH binding is important for the biological activity of CC3, including interaction with importins and with the CIA/c-myc system [8].
  • DA.F344(Cia5d) rats had a significantly lower median arthritis severity index in PIA, but not in CIA, compared with DA [9].

Chemical compound and disease context of NCOA5


Biological context of NCOA5


Anatomical context of NCOA5

  • Generation of CFUC suppressor T cells in vitro: VII. T derived colony inhibitory activity (Td/CIA) has no suppressor effect on in vitro immunoglobulin production [2].
  • Td/CIA was then added to normal peripheral blood T and B cells, primed with PWM, to test whether it would interfere with in vitro immunoglobulin (Ig) production [2].
  • In the deeper interfollicular areas granulocytes were more abundant in CIA than in HOA [15].
  • On the basis of our results we speculate that CIA have a malfunctioning defence, thereby facilitating long-standing infections deep in the adenoid [15].
  • This may be the main reason for development of middle ear disease and an indication for adenoidectomy in patients with CIA [15].

Associations of NCOA5 with chemical compounds

  • Non-tumor-promoting 1-oleoyl-2-acetyl-sn-glycerol and bryostatin 1 showed relatively strong binding to all CIA peptides of novel PKCs (delta, epsilon, and eta) [16].
  • The MTD for CIA was established at the first dose level of carboplatin (4.0 mg/ml per min) [13].
  • The CIA Factor Assessment is a psychological testing and related research activities carried out under auspices of Wartsila Land and Sea Academy at WLSA Regional Training Centre in the Philippines in June 2003 [5].
  • In both rats and mice, cyclosporine A and several disease modifying anti-arthritic drugs failed to the prevent the development of CIA that was potentiated by IL-1 [17].

Analytical, diagnostic and therapeutic context of NCOA5

  • 82% agreement was seen between CIA-RA and western blot; CIA was more sensitive to envelope antibody and western blot was more sensitive to core antibody [18].
  • A novel chromatin immunoprecipitation and array (CIA) analysis identifies a 460-kb CENP-A-binding neocentromere DNA [19].
  • CIA obtains the same microspheres/cell average as manual microscopic counting and an analytical precision of 5% [11].
  • Bulky DNA adducts were determined by 32P-postlabelling, and polycyclic aromatic hydrocarbon (PAH)-DNA adducts were detected by (+/-)-7beta, 8alpha-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene-DNA chemiluminescence immunoassay (BPDE-DNA CIA) in smaller subsets of tissue samples subject to availability of DNA [20].
  • CONCLUSIONS: Branch vessel technology has made it technically feasible to preserve critical end-organ perfusion in the setting of CIA, SRA, and TAA aneurysms [1].


  1. Beyond the aortic bifurcation: Branched endovascular grafts for thoracoabdominal and aortoiliac aneurysms. Greenberg, R.K., West, K., Pfaff, K., Foster, J., Skender, D., Haulon, S., Sereika, J., Geiger, L., Lyden, S.P., Clair, D., Svensson, L., Lytle, B. J. Vasc. Surg. (2006) [Pubmed]
  2. Generation of CFUC suppressor T cells in vitro: VII. T derived colony inhibitory activity (Td/CIA) has no suppressor effect on in vitro immunoglobulin production. Bacigalupo, A., Mingari, M.C., Melioli, G., Frassoni, F., Podestá, M., Moretta, L., Van Lint, M.T., Marmont, A.M. Exp. Hematol. (1983) [Pubmed]
  3. Rapid screening tests for determining in vitro susceptibility of herpes simplex virus clinical isolates. de la Iglesia, P., Melón, S., López, B., Rodriguez, M., Blanco, M.I., Mellado, P., de Oña, M. J. Clin. Microbiol. (1998) [Pubmed]
  4. Application of machine vision to assess involved surface in patients with psoriasis. Savolainen, L., Kontinen, J., Röning, J., Oikarinen, A. Br. J. Dermatol. (1997) [Pubmed]
  5. Psychological evaluation of seafarers. Jezewska, M. International maritime health. (2003) [Pubmed]
  6. Iron-sulfur protein biogenesis in eukaryotes: components and mechanisms. Lill, R., M??hlenhoff, U. Annu. Rev. Cell Dev. Biol. (2006) [Pubmed]
  7. IL-4 gene therapy for collagen arthritis suppresses synovial IL-17 and osteoprotegerin ligand and prevents bone erosion. Lubberts, E., Joosten, L.A., Chabaud, M., van Den Bersselaar, L., Oppers, B., Coenen-De Roo, C.J., Richards, C.D., Miossec, P., van Den Berg, W.B. J. Clin. Invest. (2000) [Pubmed]
  8. Crystal structure of CC3 (TIP30): implications for its role as a tumor suppressor. El Omari, K., Bird, L.E., Nichols, C.E., Ren, J., Stammers, D.K. J. Biol. Chem. (2005) [Pubmed]
  9. The non-MHC quantitative trait locus Cia5 contains three major arthritis genes that differentially regulate disease severity, pannus formation, and joint damage in collagen- and pristane-induced arthritis. Brenner, M., Meng, H.C., Yarlett, N.C., Joe, B., Griffiths, M.M., Remmers, E.F., Wilder, R.L., Gulko, P.S. J. Immunol. (2005) [Pubmed]
  10. Protection against chemotherapy toxicity by IV hyperalimentation. Issell, B.F., Valdivieso, M., Zaren, H.A., Dudrick, S.J., Freireich, E.J., Copeland, E.W., Bodey, G.P. Cancer treatment reports. (1978) [Pubmed]
  11. Computer image analysis method for rapid quantitation of macrophage phagocytosis. Odeyale, C.O., Hook, G.R. J. Leukoc. Biol. (1990) [Pubmed]
  12. Purification and characterization of an adenotin-like adenosine binding protein from human platelets. Fein, T., Schulze, E., Bär, J., Schwabe, U. Naunyn Schmiedebergs Arch. Pharmacol. (1994) [Pubmed]
  13. A phase I trial of AUC-directed carboplatin with infusional doxorubicin and ifosfamide plus G-CSF in patients with advanced gynecologic malignancies. Lopez, A.M., Ketchum, M., Nichols, H., Xu, M.J., Peng, Y.M., Dorr, R., Alberts, D.S. Cancer Chemother. Pharmacol. (2000) [Pubmed]
  14. Human leukocyte antigen-DRB1*1502 (DR2Dw12) transgene reduces incidence and severity of arthritis in mice. Gonzalez-Gay, M.A., Zanelli, E., Khare, S.D., Krco, C.J., Zhou, P., Inoko, H., Griffiths, M.M., Luthra, H.S., David, C.S. Hum. Immunol. (1996) [Pubmed]
  15. Abundance of intraepithelial gamma delta T cells in hypertrophic obstructive but not in chronically infected adenoids. Olofsson, K., Hellström, S., Hammarström, M.L. Clin. Exp. Immunol. (1996) [Pubmed]
  16. Establishment of a binding assay for protein kinase C isozymes using synthetic C1 peptides and development of new medicinal leads with protein kinase C isozyme and C1 domain selectivity. Irie, K., Nakahara, A., Nakagawa, Y., Ohigashi, H., Shindo, M., Fukuda, H., Konishi, H., Kikkawa, U., Kashiwagi, K., Saito, N. Pharmacol. Ther. (2002) [Pubmed]
  17. Interleukin 1 mediated acceleration of type II collagen-induced arthritis: effects of anti-inflammatory or anti-arthritic drugs. Hom, J.T., Gliszczynski, V.L., Cole, H.W., Bendele, A.M. Agents Actions (1991) [Pubmed]
  18. Serological markers in early stages of human immunodeficiency virus infection in haemophiliacs. Allain, J.P., Laurian, Y., Paul, D.A., Senn, D. Lancet (1986) [Pubmed]
  19. A novel chromatin immunoprecipitation and array (CIA) analysis identifies a 460-kb CENP-A-binding neocentromere DNA. Lo, A.W., Magliano, D.J., Sibson, M.C., Kalitsis, P., Craig, J.M., Choo, K.H. Genome Res. (2001) [Pubmed]
  20. DNA adducts in tumour, normal peripheral lung and bronchus, and peripheral blood lymphocytes from smoking and non-smoking lung cancer patients: correlations between tissues and detection by 32P-postlabelling and immunoassay. Gyorffy, E., Anna, L., Gyori, Z., Segesdi, J., Minárovits, J., Soltész, I., Kostic, S., Csekeo, A., Poirier, M.C., Schoket, B. Carcinogenesis (2004) [Pubmed]
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