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Gene Review

HTATIP2  -  HIV-1 Tat interactive protein 2, 30kDa

Homo sapiens

Synonyms: 30 kDa HIV-1 TAT-interacting protein, CC3, FLJ26963, HIV-1 TAT-interactive protein 2, Oxidoreductase HTATIP2, ...
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Disease relevance of HTATIP2


High impact information on HTATIP2


Biological context of HTATIP2

  • Previous biochemical studies indicated that CC3 has protein kinase activity, and a structural similarity to cAMP-dependent protein kinase catalytic subunit was proposed [6].
  • The tumor suppressor effect of CC3 has been suggested to result from inhibition of nuclear transport by binding to importin betas or by regulating transcription through interaction in a complex with co-activator independent of AF-2 function (CIA) and the c-myc gene [6].
  • By contrast, bioinformatics studies suggested a relationship of CC3 to the short chain dehydrogenase reductase family [6].
  • CC3 and TC3 have opposing functions in apoptosis and represent a novel dual regulator of cell death [7].
  • These results indicate that expression of CC3 has a dual effect on phenotype of tumor cells ultimately inhibiting their metastatic potential [2].

Anatomical context of HTATIP2

  • The proapoptotic activity of CC3 in SCLC cells is induced by a wide variety of signals and involves disruption of the mitochondrial membrane potential (Deltapsim) [7].
  • CC3 RNA is absent in a subset of SCLC cell lines known as variant (v-SCLC) that are derived from tumors characterized by highly aggressive metastatic behavior [8].
  • Expression of CC3 in three different tumor cell lines significantly diminished their angiogenic character as manifested in the in vitro proliferation and migration assays with endothelial cells of both macro- and microvascular origin [2].
  • 6. CC3 interneurons were excitatory, and they were inhibited by the ipsilateral Müller cell I1 [9].
  • Recently, we identified unique nuclear matrix proteins (NMPs) specific for colon cancer (CC2, CC3, CC4, CC5) [10].

Associations of HTATIP2 with chemical compounds

  • Comparison of our structural model with that of known SDRs reveals that TIP30/CC3 contains several well-conserved features, including a beta alpha beta fold at the amino terminus, which we predict binds NADP(H) [3].
  • TIP30/CC3 contains characteristic motifs at the catalytic site of SDRs, including a serine, tyrosine, and lysine that are important in catalyzing hydride transfer between substrate and cofactor [3].
  • Combination of equimolar concentrations of motapizone and CC3 (0.34 microM) or rolipram (0.005 microM) showed an additive effect [11].
  • However, if rolipram or CC3 were given in combination with motapizone, methacholine-induced bronchoconstriction was concentration-dependently attenuated [11].
  • From extensive calculations on formic acid and methylamine, different basis sets and electron correlation treatments are benchmarked using a hierarchy of coupled cluster (CC) methods, consisting of CCS, CC2, CCSD, CCSDR(3), and CC3, in combination with augmented correlation consistent basis sets [12].

Regulatory relationships of HTATIP2


Other interactions of HTATIP2


Analytical, diagnostic and therapeutic context of HTATIP2


  1. TIP30 has an intrinsic kinase activity required for up-regulation of a subset of apoptotic genes. Xiao, H., Palhan, V., Yang, Y., Roeder, R.G. EMBO J. (2000) [Pubmed]
  2. Metastasis suppressor CC3 inhibits angiogenic properties of tumor cells in vitro. NicAmhlaoibh, R., Shtivelman, E. Oncogene (2001) [Pubmed]
  3. Three-dimensional model of human TIP30, a coactivator for HIV-1 Tat-activated transcription, and CC3, a protein associated with metastasis suppression. Baker, M.E., Yan, L., Pear, M.R. Cell. Mol. Life Sci. (2000) [Pubmed]
  4. TIP30 regulates apoptosis-related genes in its apoptotic signal transduction pathway. Shi, M., Zhang, X., Wang, P., Zhang, H.W., Zhang, B.H., Wu, M.C. World J. Gastroenterol. (2005) [Pubmed]
  5. A cofactor, TIP30, specifically enhances HIV-1 Tat-activated transcription. Xiao, H., Tao, Y., Greenblatt, J., Roeder, R.G. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  6. Crystal structure of CC3 (TIP30): implications for its role as a tumor suppressor. El Omari, K., Bird, L.E., Nichols, C.E., Ren, J., Stammers, D.K. J. Biol. Chem. (2005) [Pubmed]
  7. Alternatively spliced products CC3 and TC3 have opposing effects on apoptosis. Whitman, S., Wang, X., Shalaby, R., Shtivelman, E. Mol. Cell. Biol. (2000) [Pubmed]
  8. A link between metastasis and resistance to apoptosis of variant small cell lung carcinoma. Shtivelman, E. Oncogene (1997) [Pubmed]
  9. Identification of interneurons with contralateral, caudal axons in the lamprey spinal cord: synaptic interactions and morphology. Buchanan, J.T. J. Neurophysiol. (1982) [Pubmed]
  10. Colon cancer specific nuclear matrix protein alterations in human colonic adenomatous polyps. Brünagel, G., Schoen, R.E., Getzenberg, R.H. J. Cell. Biochem. (2004) [Pubmed]
  11. Airway relaxant and anti-inflammatory properties of a PDE4 inhibitor with low affinity for the high-affinity rolipram binding site. Martin, C., Göggel, R., Dal Piaz, V., Vergelli, C., Giovannoni, P., Ernst, M., Uhlig, S. Naunyn Schmiedebergs Arch. Pharmacol. (2002) [Pubmed]
  12. Theoretical study of the electronic gas-phase spectrum of glycine, alanine, and related amines and carboxylic acids. Osted, A., Kongsted, J., Christiansen, O. The journal of physical chemistry. A, Molecules, spectroscopy, kinetics, environment & general theory. (2005) [Pubmed]
  13. Overexpression of CC3/TIP30 is associated with HER-2/neu status in breast cancer. Zhang, D.H., Wong, L.L., Tai, L.K., Koay, E.S., Hewitt, R.E. J. Cancer Res. Clin. Oncol. (2005) [Pubmed]
  14. Differentially expressed CC3/TIP30 and rab11 along in vivo and in vitro intestinal epithelial cell crypt-villus axis. Lindfors, K., Halttunen, T., Kainulainen, H., Mäki, M. Life Sci. (2001) [Pubmed]
  15. Integration of HPV-16 DNA in cervical carcinoma cell line CC3/CUHK3 and its xenografts. Yiu, K.C., Huang, D.P., Chan, M.K., Ng, A.Y., Chew, E.C., Wong, F.W., Lee, J.C. Anticancer Res. (1990) [Pubmed]
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