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Gene Review

Dapk1  -  death associated protein kinase 1

Mus musculus

Synonyms: 2310039H24Rik, 2810425C21Rik, AI642003, D13Ucla1, DAP kinase 1, ...
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Disease relevance of Dapk1


High impact information on Dapk1


Chemical compound and disease context of Dapk1


Biological context of Dapk1


Anatomical context of Dapk1


Associations of Dapk1 with chemical compounds


Regulatory relationships of Dapk1


Analytical, diagnostic and therapeutic context of Dapk1

  • To elucidate the contribution of DAPK activity to apoptosis in renal ischemia-reperfusion (IR) injury, wild-type (WT) mice and DAPK-mutant mice, which express a DAPK deletion mutant that lacks a portion of the kinase domain, were subjected to renal pedicle clamping and reperfusion [1].
  • We have shown that the kinase domain of DAPK is crucial for the induction of renal tubular cell apoptosis in chronic obstructive uropathy (COU) created by unilateral ureteral ligation [2].
  • Upon incubation with C(6)-Cer, DAP kinase levels are elevated as early as 1 h after treatment, reaching levels 2-3-fold higher than untreated cells after 4 h [9].


  1. Deletion of the kinase domain in death-associated protein kinase attenuates tubular cell apoptosis in renal ischemia-reperfusion injury. Kishino, M., Yukawa, K., Hoshino, K., Kimura, A., Shirasawa, N., Otani, H., Tanaka, T., Owada-Makabe, K., Tsubota, Y., Maeda, M., Ichinose, M., Takeda, K., Akira, S., Mune, M. J. Am. Soc. Nephrol. (2004) [Pubmed]
  2. The kinase domain of death-associated protein kinase is inhibitory for tubulointerstitial fibrosis in chronic obstructive nephropathy. Yukawa, K., Kishino, M., Hoshino, K., Shirasawa, N., Kimura, A., Tsubota, Y., Owada-Makabe, K., Bai, T., Tanaka, T., Ueyama, T., Ichinose, M., Takeda, K., Akira, S., Maeda, M. Int. J. Mol. Med. (2005) [Pubmed]
  3. DAP kinase links the control of apoptosis to metastasis. Inbal, B., Cohen, O., Polak-Charcon, S., Kopolovic, J., Vadai, E., Eisenbach, L., Kimchi, A. Nature (1997) [Pubmed]
  4. The tumor suppressor DAPK inhibits cell motility by blocking the integrin-mediated polarity pathway. Kuo, J.C., Wang, W.J., Yao, C.C., Wu, P.R., Chen, R.H. J. Cell Biol. (2006) [Pubmed]
  5. Aberrant promoter hypermethylation of the death-associated protein kinase gene is early and frequent in murine lung tumors induced by cigarette smoke and tobacco carcinogens. Pulling, L.C., Vuillemenot, B.R., Hutt, J.A., Devereux, T.R., Belinsky, S.A. Cancer Res. (2004) [Pubmed]
  6. Immune-related mechanisms participating in resistance and susceptibility to glutamate toxicity. Schori, H., Yoles, E., Wheeler, L.A., Raveh, T., Kimchi, A., Schwartz, M. Eur. J. Neurosci. (2002) [Pubmed]
  7. Methylation-associated silencing of death-associated protein kinase gene in laryngeal squamous cell cancer. Kong, W.J., Zhang, S., Guo, C., Zhang, S., Wang, Y., Zhang, D. Laryngoscope (2005) [Pubmed]
  8. Identification of a new form of death-associated protein kinase that promotes cell survival. Jin, Y., Blue, E.K., Dixon, S., Hou, L., Wysolmerski, R.B., Gallagher, P.J. J. Biol. Chem. (2001) [Pubmed]
  9. Death-associated protein (DAP) kinase plays a central role in ceramide-induced apoptosis in cultured hippocampal neurons. Pelled, D., Raveh, T., Riebeling, C., Fridkin, M., Berissi, H., Futerman, A.H., Kimchi, A. J. Biol. Chem. (2002) [Pubmed]
  10. Uncoordinated regulation of stress fibers and focal adhesions by DAP kinase. Kuo, J.C., Lin, J.R., Staddon, J.M., Hosoya, H., Chen, R.H. J. Cell. Sci. (2003) [Pubmed]
  11. DRAK2, a lymphoid-enriched DAP kinase, regulates the TCR activation threshold during thymocyte selection. Friedrich, M.L., Wen, B.G., Bain, G., Kee, B.L., Katayama, C., Murre, C., Hedrick, S.M., Walsh, C.M. Int. Immunol. (2005) [Pubmed]
  12. The death associated protein (DAP) kinase homologue Dlk/ZIP kinase induces p19ARF- and p53-independent apoptosis. Kögel, D., Reimertz, C., Düssmann, H., Mech, P., Scheidtmann, K.H., Prehn, J.H. Eur. J. Cancer (2003) [Pubmed]
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