Gene Review:
MAP3K12 - mitogen-activated protein kinase kinase...
Homo sapiens
Synonyms:
DLK, Dual leucine zipper bearing kinase, Leucine-zipper protein kinase, MAPK-upstream kinase, MEKK12, ...
- Mixed lineage kinase 3 inhibits phorbol myristoyl acetate-induced DNA synthesis but not osteopontin expression in rat mesangial cells. Parameswaran, N., Hall, C.S., Bock, B.C., Sparks, H.V., Gallo, K.A., Spielman, W.S. Mol. Cell. Biochem. (2002)
- The mitogen-activated protein kinase kinase kinase dual leucine zipper-bearing kinase (DLK) acts as a key regulator of keratinocyte terminal differentiation. Robitaille, H., Proulx, R., Robitaille, K., Blouin, R., Germain, L. J. Biol. Chem. (2005)
- Inhibition of mixed-lineage kinase (MLK) activity during G2-phase disrupts microtubule formation and mitotic progression in HeLa cells. Cha, H., Dangi, S., Machamer, C.E., Shapiro, P. Cell. Signal. (2006)
- Mixed lineage kinase-c-jun N-terminal kinase signaling pathway: a new therapeutic target in Parkinson's disease. Silva, R.M., Kuan, C.Y., Rakic, P., Burke, R.E. Mov. Disord. (2005)
- Usefulness of AgNOR counts in diagnosing epithelial dysplasia. Ray, J.G., Chattopadhyay, A., Caplan, D.J. J. Oral Pathol. Med. (2003)
- Mixed-lineage kinases: a target for the prevention of neurodegeneration. Wang, L.H., Besirli, C.G., Johnson, E.M. Annu. Rev. Pharmacol. Toxicol. (2004)
- The MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosis. Xu, Z., Maroney, A.C., Dobrzanski, P., Kukekov, N.V., Greene, L.A. Mol. Cell. Biol. (2001)
- Two distinct signaling pathways regulate peroxynitrite-induced apoptosis in PC12 cells. Shacka, J.J., Sahawneh, M.A., Gonzalez, J.D., Ye, Y.Z., D'Alessandro, T.L., Estévez, A.G. Cell Death Differ. (2006)
- The mixed lineage kinase DLK utilizes MKK7 and not MKK4 as substrate. Merritt, S.E., Mata, M., Nihalani, D., Zhu, C., Hu, X., Holzman, L.B. J. Biol. Chem. (1999)
- Inhibition of mixed lineage kinase 3 attenuates MPP+-induced neurotoxicity in SH-SY5Y cells. Mathiasen, J.R., McKenna, B.A., Saporito, M.S., Ghadge, G.D., Roos, R.P., Holskin, B.P., Wu, Z.L., Trusko, S.P., Connors, T.C., Maroney, A.C., Thomas, B.A., Thomas, J.C., Bozyczko-Coyne, D. Brain Res. (2004)
- MRK, a mixed lineage kinase-related molecule that plays a role in gamma-radiation-induced cell cycle arrest. Gross, E.A., Callow, M.G., Waldbaum, L., Thomas, S., Ruggieri, R. J. Biol. Chem. (2002)
- SP3 acts as a positive regulator on the core promoter of human ZPK gene. Itoh, A., Wang, Z., Ito, Y., Reddy, U.R., Itoh, T. Biochem. Biophys. Res. Commun. (2004)
- Characterization of dual leucine zipper-bearing kinase, a mixed lineage kinase present in synaptic terminals whose phosphorylation state is regulated by membrane depolarization via calcineurin. Mata, M., Merritt, S.E., Fan, G., Yu, G.G., Holzman, L.B. J. Biol. Chem. (1996)
- Molecular cloning and functional expression of a cDNA encoding a new member of mixed lineage protein kinase from human brain. Sakuma, H., Ikeda, A., Oka, S., Kozutsumi, Y., Zanetta, J.P., Kawasaki, T. J. Biol. Chem. (1997)
- Localization of the mixed-lineage kinase DLK/MUK/ZPK to the Golgi apparatus in NIH 3T3 cells. Douziech, M., Laberge, G., Grondin, G., Daigle, N., Blouin, R. J. Histochem. Cytochem. (1999)
- Inhibition of membrane depolarisation-induced transcriptional activity of cyclic AMP response element binding protein (CREB) by the dual-leucine-zipper-bearing kinase in a pancreatic islet beta cell line. Oetjen, E., Lechleiter, A., Blume, R., Nihalani, D., Holzman, L., Knepel, W. Diabetologia (2006)
- Identification of structural and functional domains in mixed lineage kinase dual leucine zipper-bearing kinase required for complex formation and stress-activated protein kinase activation. Nihalani, D., Merritt, S., Holzman, L.B. J. Biol. Chem. (2000)
- The mixed lineage kinase leucine-zipper protein kinase exhibits a differentiation-associated localization in normal human skin and induces keratinocyte differentiation upon overexpression. Germain, L., Fradette, J., Robitaille, H., Guignard, R., Grondin, G., Nadeau, A., Blouin, R. J. Invest. Dermatol. (2000)
- Localization of the human zipper protein kinase gene (ZPK) to chromosome 12q13 by fluorescence in situ hybridization and somatic cell hybrid analysis. Reddy, U.R., Nycum, L., Slavc, I., Biegel, J.A. Genomics (1995)
- Identification, molecular cloning, and characterization of dual leucine zipper bearing kinase. A novel serine/threonine protein kinase that defines a second subfamily of mixed lineage kinases. Holzman, L.B., Merritt, S.E., Fan, G. J. Biol. Chem. (1994)
- The c-Jun N-terminal kinase activator dual leucine zipper kinase regulates axon growth and neuronal migration in the developing cerebral cortex. Hirai, S., Cui, d.e. .F., Miyata, T., Ogawa, M., Kiyonari, H., Suda, Y., Aizawa, S., Banba, Y., Ohno, S. J. Neurosci. (2006)
- Lamellar keratitis following laser-assisted in situ keratomileusis. Chao, C.W., Azar, D.T. Ophthalmology clinics of North America. (2002)