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Gene Review

Myh10  -  myosin, heavy chain 10, non-muscle

Rattus norvegicus

Synonyms: Cellular myosin heavy chain, type B, MCH-B, Myosin heavy chain 10, Myosin heavy chain, non-muscle IIb, Myosin-10, ...
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Disease relevance of Myh10

  • Expression of the contractile protein isoforms, especially SMemb, should serve as a new marker for the subsequent glomerular hypertrophy and sclerosis [1].
  • In the anti-GBM nephritis rats, SMemb expression was increased in epithelial cells [2].
  • However, the expression profile was shifted from alpha-SM actin to SMemb dominant pattern over the course of glomerulonephritis [2].
  • CONCLUSIONS: In rats with PAN nephrosis, findings suggest that restriction of dietary protein leads to a reduction in glomerular SMemb expression [3].
  • In contrast, glomerular SMemb mRNA increased on days 2 and 4 (before and soon after the onset of proteinuria, respectively), but declined on day 8 (the peak of proteinuria) [4].

High impact information on Myh10


Chemical compound and disease context of Myh10

  • 1. We investigated the glomerular expression of three types of myosin heavy-chain isoforms, including S-myosin heavy-chain 40 (SM1), S-myosin heavy-chain 29 (SM2) and FS-myosin heavy-chain 34 (SMemb) in puromycin aminonucleoside nephrosis [4].
  • The SMemb isoform was barely detectable in normal glomeruli, but substantial amounts of SMemb were demonstrated in the glomeruli of rats with puromycin aminonucleoside nephrosis [4].
  • These data suggest that SMemb is a molecular marker for phenotypic alteration and that the beneficial effect of enalapril on proteinuria and renal function may be, at least in part, associated with reducing SMemb mRNA expression in diabetic glomeruli [7].

Biological context of Myh10


Anatomical context of Myh10


Associations of Myh10 with chemical compounds


Regulatory relationships of Myh10


Other interactions of Myh10

  • Thus, we investigated the effect of AII on the mesangial expression of SMemb and synthesis of fibronectin [12].

Analytical, diagnostic and therapeutic context of Myh10

  • RESULTS: Semiquantitative immunohistochemical evaluation and Western blot analysis showed that AII significantly enhanced glomerular expression of SMemb (0.87 +/- 0.33 vs. 0.40 +/- 0.19 for immunohistochemical grading, p < 0.05; 2.55 +/- 0.88 vs. 1.16 +/- 0.75 for Western blot analysis, p < 0.05) [12].
  • In all models examined, mesangial and epithelial expression of SMemb was confirmed by immunoelectron microscopy, and enhanced expression of SMemb mRNA in glomeruli was verified by RNase protection assay [2].
  • However, the low-protein diet did not affect SMemb mRNA and protein levels in the glomeruli of control rats [3].
  • To evaluate the role of SMemb in the development of kidney rejection, we examined its expression in rat kidney transplantation models [15].
  • In Northern blot analysis, SMemb mRNA was not detected in control glomeruli, whereas it was transiently upregulated in glomeruli on day 48 in rats with focal glomerulosclerosis [16].


  1. Phenotypic modulation of the mesangium reflected by contractile proteins in diabetes. Makino, H., Kashihara, N., Sugiyama, H., Kanao, K., Sekikawa, T., Okamoto, K., Maeshima, Y., Ota, Z., Nagai, R. Diabetes (1996) [Pubmed]
  2. Expression of a nonmuscle myosin heavy chain in glomerular cells differentiates various types of glomerular disease in rats. Hiroi, J., Kimura, K., Aikawa, M., Tojo, A., Suzuki, Y., Nagamatsu, T., Omata, M., Yazaki, Y., Nagai, R. Kidney Int. (1996) [Pubmed]
  3. Effect of a low-protein diet on expression of non-muscle type myosin heavy-chain isoforms in glomeruli of rats with puromycin aminonucleoside nephrosis. Koide, H., Nakamura, T., Kimura, K., Ebihara, I., Nagai, R., Tomino, Y. Nephrol. Dial. Transplant. (1996) [Pubmed]
  4. Glomerular expression of smooth-muscle myosin heavy-chain isoforms in aminonucleoside nephrosis in rats. Nakamura, T., Kimura, K., Ebihara, I., Takahashi, T., Tomino, Y., Aikawa, M., Yazaki, Y., Nagai, R., Koide, H. Clin. Sci. (1995) [Pubmed]
  5. Nonmuscle and smooth muscle myosin heavy chain expression in rejected cardiac allografts. A study in rat and monkey models. Suzuki, J., Isobe, M., Aikawa, M., Kawauchi, M., Shiojima, I., Kobayashi, N., Tojo, A., Suzuki, T., Kimura, K., Nishikawa, T., Sakai, T., Sekiguchi, M., Yazaki, Y., Nagai, R. Circulation (1996) [Pubmed]
  6. Contractile responses of smooth muscle cells differentiated from rat neural stem cells. Oishi, K., Ogawa, Y., Gamoh, S., Uchida, M.K. J. Physiol. (Lond.) (2002) [Pubmed]
  7. Effects of enalapril treatment on gene expression of smooth muscle myosin heavy chain isoforms in glomeruli of diabetic rats. Nakamura, T., Ebihara, I., Fukui, M., Makita, Y., Tomino, Y., Kimura, K., Nagai, R., Yazaki, Y., Koide, H. Renal physiology and biochemistry. (1995) [Pubmed]
  8. Molecular cloning and functional analysis of the promoter region of rat nonmuscle myosin heavy chain-B gene. Yam, J.W., Chan, K.W., Li, N., Hsiao, W.L. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  9. Pulmonary expression of vascular endothelial growth factor and myosin isoforms in rats with congenital diaphragmatic hernia. Okazaki, T., Sharma, H.S., Aikawa, M., Yamataka, A., Nagai, R., Miyano, T., Tibboel, D. J. Pediatr. Surg. (1997) [Pubmed]
  10. Different effects of amlodipine and enalapril on the mitogen-activated protein kinase/extracellular signal-regulated kinase kinase-extracellular signal-regulated kinase pathway for induction of vascular smooth muscle cell differentiation in vivo. Umemoto, S., Kawahara, S., Hashimoto, R., Umeji, K., Matsuda, S., Tanaka, M., Kubo, M., Matsuzaki, M. Hypertens. Res. (2006) [Pubmed]
  11. B2 exon splicing of nonmuscle myosin heavy chain IIB is differently regulated in developing and adult rat brain. Miyazaki, T., Watanabe, M., Yamagishi, A., Takahashi, M. Neurosci. Res. (2000) [Pubmed]
  12. Angiotensin II enhances glomerular expression of a nonmuscle myosin heavy chain, SMemb, with extracellular matrix accumulation. Mise, N., Kimura, K., Kurabayashi, M., Nagai, R., Okuda, T., Ohba, S., Suzuki, N., Miyashita, K., Kamijo, A., Tojo, A., Goto, A., Omata, M. Nephron (2002) [Pubmed]
  13. Hypertensive glomerular damage as revealed by the expression of alpha-smooth muscle actin and non-muscle myosin. Kimura, K., Suzuki, N., Ohba, S., Nagai, R., Hiroi, J., Mise, N., Tojo, A., Nagaoka, A., Hirata, Y., Goto, A., Yazaki, Y., Omata, M. Kidney Int. Suppl. (1996) [Pubmed]
  14. Embryonic smooth muscle myosin heavy chain SMemb is expressed in pressure-overloaded cardiac fibroblasts. Shiojima, I., Aikawa, M., Suzuki, J., Yazaki, Y., Nagai, R. Japanese heart journal. (1999) [Pubmed]
  15. Expression of nonmuscle myosin heavy chain B (SMemb) in rat allogeneic kidney transplantation. Watanabe, Y., Yoshimura, R., Wada, S., Chargui, J., Suzuki, J., Kishimoto, T., Isobe, M. Nephron (2002) [Pubmed]
  16. Glomerular nonmuscle-type myosin heavy-chain isoform gene expression in glomerulosclerosis. Ebihara, I., Kimura, K., Nakamura, T., Tomino, Y., Yazaki, Y., Nagai, R., Koide, H. Nephron (1998) [Pubmed]
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