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Gene Review

BCL2L12  -  BCL2-like 12 (proline rich)

Homo sapiens

Synonyms: BPR, Bcl-2-like protein 12, Bcl-2-related proline-rich protein, Bcl2-L-12
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Disease relevance of BCL2L12

  • Our results indicate that BCL2L12 positive breast tumors are mainly of lower stage (I/II) or grade (I/II) (p=0.02 or p=0.04 respectively) [1].
  • In the present study, the expression of the BCL2L12 gene was analyzed in colon cancer by RT-PCR [2].
  • Bacterial cellulose (BC) was produced by Acetobacter xylinum BPR 2001 and its acetan nonproducing mutant EP1 in corn steep liquor-fructose medium in a 10-l jar fermentor supplemented with different agar concentrations ranging from 0% to 1.0% (w/v) [3].

Psychiatry related information on BCL2L12

  • The first one is comprised of 100 normal subjects with a negative familial affective history (NFH); the second of 37 individuals, with positive affective family history (PFH); and a third of 40 subjects, with at least one sib or first-degree kin with bipolar disorder type I according to the DSM-IV (BPR) [4].

High impact information on BCL2L12

  • The incidence of treatment failure during the first 6 months, including BPR, death, graft loss, and early withdrawal without prior BPR, was significantly decreased: AZA, 50%, compared with MMF 2 g, 38.2% (P=0.0287), and MMF 3 g, 34.8% (P=0.0045) [5].
  • RESULTS: During the first 6 months, the incidence of biopsy-proven acute graft rejection (BPR) was reduced by approximately 50% in the MMF 2 g (19.7%) and MMF 3 g (15.9%) groups compared with the AZA group (35.5%) [5].
  • The BCL2L12 protein contains one BH2 homology domain, one proline-rich region similar to the TC21 protein and, five consensus PXXP tetrapeptide sequences [6].
  • Molecular cloning, physical mapping, and expression analysis of a novel gene, BCL2L12, encoding a proline-rich protein with a highly conserved BH2 domain of the Bcl-2 family [6].
  • We also identified one splice variant of BCL2L12 that is primarily expressed in skeletal muscle [6].

Chemical compound and disease context of BCL2L12

  • A gene fragment encoding a putative pyrroloquinoline quinone glucose dehydrogenase (PQQ GDH) was cloned from a bacterial cellulose (BC)-forming acetic acid bacterium, Gluconacetobacter xylinus (=Acetobacter xylinum) strain BPR 2001, which was isolated as a high BC producer when using fructose as the carbon source [7].

Biological context of BCL2L12


Anatomical context of BCL2L12


Associations of BCL2L12 with chemical compounds

  • Here, we report the identification, cloning, physical mapping, and expression pattern of BCL2L12, a novel gene that encodes a BCL2-like proline-rich protein [6].
  • AAs in the AZA group experienced BPR/TF earlier than AAs in the MMF 3 g group (median onset at 64 days vs. > 183 days, P=0.0012) [12].
  • The minimum inhibitory concentration (MIC) and bactericidal activity of green tea catechin against black-pigmented, Gram-negative anaerobic rods (BPR) were measured [13].
  • In the in vivo experiment, the pocket depth (PD) and the proportion of BPR were markedly decreased in the catechin group with mechanical treatment at week 8 compared with the baseline with significant difference [13].
  • The rate of conversion from glucose to BC under these cultivation conditions was equivalent to that of strain BPR 2001 cultivated with fructose as the carbon source [7].

Other interactions of BCL2L12


Analytical, diagnostic and therapeutic context of BCL2L12

  • Our results support the idea that after long-term clinical studies, mRNA expression analysis of BCL2L12 and other members of the BCL2 gene family may serve as useful molecular markers predicting chemotherapy response in breast cancer [14].
  • RESULTS: AAs in the AZA group had the highest biopsy-proven rejection/treatment failure (BPR/TF) rate (57.5% vs. 43.5% for non-AAs) [12].
  • By setting the region of interest on the distraction segment and contralateral normal area, we calculated the perfusion index (PI), the uptake ratio of the blood-pool image (BPR), and the uptake ratio of the delayed image (DR) [15].


  1. Expression of BCL2L12, a new member of apoptosis-related genes, in breast tumors. Talieri, M., Diamandis, E.P., Katsaros, N., Gourgiotis, D., Scorilas, A. Thromb. Haemost. (2003) [Pubmed]
  2. Expression analysis of BCL2L12, a new member of apoptosis-related genes, in colon cancer. Mathioudaki, K., Scorilas, A., Papadokostopoulou, A., Xynopoulos, D., Arnogianaki, N., Agnanti, N., Talieri, M. Biol. Chem. (2004) [Pubmed]
  3. Improvement of bacterial cellulose production by addition of agar in a jar fermentor. Bae, S., Sugano, Y., Shoda, M. J. Biosci. Bioeng. (2004) [Pubmed]
  4. The cyclothymic temperament in healthy controls and familially at risk individuals for mood disorder: endophenotype for genetic studies? Chiaroni, P., Hantouche, E.G., Gouvernet, J., Azorin, J.M., Akiskal, H.S. Journal of affective disorders. (2005) [Pubmed]
  5. A blinded, long-term, randomized multicenter study of mycophenolate mofetil in cadaveric renal transplantation: results at three years. Tricontinental Mycophenolate Mofetil Renal Transplantation Study Group. Mathew, T.H. Transplantation (1998) [Pubmed]
  6. Molecular cloning, physical mapping, and expression analysis of a novel gene, BCL2L12, encoding a proline-rich protein with a highly conserved BH2 domain of the Bcl-2 family. Scorilas, A., Kyriakopoulou, L., Yousef, G.M., Ashworth, L.K., Kwamie, A., Diamandis, E.P. Genomics (2001) [Pubmed]
  7. Cellulose production from glucose using a glucose dehydrogenase gene (gdh)-deficient mutant of Gluconacetobacter xylinus and its use for bioconversion of sweet potato pulp. Shigematsu, T., Takamine, K., Kitazato, M., Morita, T., Naritomi, T., Morimura, S., Kida, K. J. Biosci. Bioeng. (2005) [Pubmed]
  8. mRNA expression analysis of a variety of apoptosis-related genes, including the novel gene of the BCL2-family, BCL2L12, in HL-60 leukemia cells after treatment with carboplatin and doxorubicin. Floros, K.V., Thomadaki, H., Katsaros, N., Talieri, M., Scorilas, A. Biol. Chem. (2004) [Pubmed]
  9. Cisplatin-induced apoptosis in HL-60 human promyelocytic leukemia cells: differential expression of BCL2 and novel apoptosis-related gene BCL2L12. Floros, K.V., Thomadaki, H., Lallas, G., Katsaros, N., Talieri, M., Scorilas, A. Ann. N. Y. Acad. Sci. (2003) [Pubmed]
  10. Prognostic value of the apoptosis related genes BCL2 and BCL2L12 in breast cancer. Thomadaki, H., Talieri, M., Scorilas, A. Cancer Lett. (2007) [Pubmed]
  11. Topotecan and methotrexate alter expression of the apoptosis-related genes BCL2, FAS and BCL2L12 in leukemic HL-60 cells. Floros, K.V., Talieri, M., Scorilas, A. Biol. Chem. (2006) [Pubmed]
  12. Immunosuppressive therapy in high-risk transplant patients: dose-dependent efficacy of mycophenolate mofetil in African-American renal allograft recipients. U.S. Renal Transplant Mycophenolate Mofetil Study Group. Neylan, J.F. Transplantation (1997) [Pubmed]
  13. Improvement of periodontal status by green tea catechin using a local delivery system: a clinical pilot study. Hirasawa, M., Takada, K., Makimura, M., Otake, S. J. Periodont. Res. (2002) [Pubmed]
  14. Treatment of MCF-7 cells with taxol and etoposide induces distinct alterations in the expression of apoptosis-related genes BCL2, BCL2L12, BAX, CASPASE-9 and FAS. Thomadaki, H., Talieri, M., Scorilas, A. Biol. Chem. (2006) [Pubmed]
  15. Predicting the outcome of distraction osteogenesis by 3-phase bone scintigraphy. Kawano, M., Taki, J., Tsuchiya, H., Tomita, K., Tonami, N. J. Nucl. Med. (2003) [Pubmed]
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