Disease relevance of Pulmonary Valve

• Three other siblings probably had small a ventricular septal defect and another one probably had mild pulmonary valve stenosis [1].
• Severe congestive heart failure in mild pulmonic stenosis due to dysplastic pulmonary valve associated with cardiomyopathy [2].
• The proportion of 22qdel for each CTM was: tetralogy of Fallot (14/100), pulmonary atresia with ventricular septal defect (11/61), tetralogy of Fallot with absent pulmonary valves (6/16), interrupted aortic arch (10/22), truncus arteriosus (9/29), and complex transpositions of the great arteries (4/33) [3].
• Data on 111 lesions, in addition to pulmonary valve, aortic valve, branch pulmonary stenosis, native coarctation and recoarctation, were submitted to the Valvuloplasty and Angioplasty of Congenital Anomalies Registry [4].
• In 3 patients who had successful tricuspid and pulmonary valve replacements, signs and symptoms of right ventricular failure disappeared and plasma ANP levels declined and normalized [5].

High impact information on Pulmonary Valve

• Fetal aortic and pulmonary valve; ductus arteriosus (DA); and right (RPA), left (LPA), and distal (DPA) pulmonary artery blood velocity waveforms were obtained by Doppler ultrasound before, during, and after maternal administration of either 60% oxygen or room air [6].
• In all animals, the TEL persisted in the pulmonary valve position after 8 to 10 weeks, and all polyglycolic acid polymer had been degraded [7].
• Angiograms of 30 patients with congenital pulmonary valve atresia, ventricular septal defect, and large systemic-pulmonary collateral arteries (SPCAs) were evaluated [8].
• NFATc1 mediates vascular endothelial growth factor-induced proliferation of human pulmonary valve endothelial cells [9].
• We examined the mechanisms by which NFATc1 is activated and translocated to the nucleus in human pulmonary valve endothelial cells to gain a better understanding of its potential role(s) in post-natal valvular repair as well as valve development [9].

Chemical compound and disease context of Pulmonary Valve

• A 3 French (3F) coaxial polyurethane catheter was utilized for catheterization of the pulmonary artery in patients with complex congenital heart disease with concomitant stenosis or atresia of the pulmonary valve, with or without Blalock-Taussig shunts [10].
• In the patients with valval pulmonic stenosis, the systolic BP difference across the pulmonary valve decreased an average of 17 mm Hg (range, 0 to 20 mm Hg) in the resting state and decreased an average of 33 mm Hg (range, 19 to 56 mm Hg) in a state of isoproterenol hydrochloride-induced stress [11].
• A 17-month-old boy developed grand mal seizures secondary to lidocaine toxicity during balloon dilatation of a congenital pulmonary valve stenosis [12].

Biological context of Pulmonary Valve

• Cell fate analysis using the Tbx1 enhancer suggests that SHF-derived Tbx1-expressing cells contribute extensively to the right ventricular myocardium as well as the OFT during early development and ultimately give rise to the right ventricular infundibulum, pulmonary trunk, and pulmonary valves [13].
• Cardiac phenotypes were: truncus arteriosus (17), interrupted aortic arch (18), tetralogy of Fallot with or without pulmonary valve atresia (55), tetralogy of Fallot with absent pulmonary valves (5), ventricular septal defect with malalignment of the conal septum (9) [14].

Anatomical context of Pulmonary Valve

• Similarly, polyurethane films with direct attachment of antivector antibodies to the surface were used in sheep pulmonary valve leaflet replacement studies, simulating the blood contacting environment of a prosthetic heart valve cusp [15].
• Nitinol stents were placed in the pulmonary valve and main pulmonary artery in five pigs by using MR imaging guidance [16].
• Aortic and pulmonary valves with an intact endothelium showed a spontaneous ability to release prostacyclin [17].
• Glutaraldehyde-fixed bovine jugular vein as a substitute for the pulmonary valve in the Ross operation [18].
• In four fetuses pulsed Doppler echocardiography played a primary or a definitive diagnostic role: One fetus had a complete atrioventricular canal, another lacked the pulmonary valve, the third had transposition of the great vessels without ventricular septal defect, and the fourth had high cardiac output failure caused by placental chorioangioma [19].

Associations of Pulmonary Valve with chemical compounds

• Prevention of calcification in glutaraldehyde-treated porcine aortic and pulmonary valves [20].
• Symptoms of cardiac failure disappeared following pulmonary valve replacement and steroid therapy [21].
• METHODS: Porcine (n = 3) and sheep (n = 3) pulmonary valve conduits were acellularized by trypsin/EDTA digestion and then implanted into healthy sheep in pulmonary valve position using extracorporeal bypass support [22].
• METHODS: Between July 2002 and May 2004, a total of 50 Ross operations was performed with the Matrix P for pulmonary valve replacement [23].
• The luminal layer of studied pulmonary valves exhibited a strong staining reaction with anti-SLA class I and class II antibodies [24].

Gene context of Pulmonary Valve

• Transient congenital hypoparathyroidism: possible association with anomalies of the pulmonary valve [25].
• To test whether this apparent protection from leukocyte invasion might be an inherent feature of the valve endothelium, leukocyte adhesion molecule expression and function were analyzed in human pulmonary valve endothelial cells (HPVEC) [26].
• Six of eight subjects with PTPN11/SHP2 mutations had pulmonary valve stenosis while no mutations were identified in those subjects (N = 4) with hypertrophic cardiomyopathy [27].
• Familial pulmonary valve stenosis, atrial septal defect, and unique electrocardiogram abnormalities [28].
• Except for one woman (Ability Index 3) who developed dilated cardiomyopathy without aortic or pulmonary valve disease 6 months after delivery, the women remained in Ability Index 1 after pregnancy [29].

Analytical, diagnostic and therapeutic context of Pulmonary Valve

• Three patients with subpulmonic ventricular septal defect and pulmonary valve fluttering by echocardiography are presented [30].
• Simultaneous device closure of muscular ventricular septal defect and pulmonary valve balloon dilatation [31].
• Hemodynamic characteristics of the Matrix P decellularized xenograft for pulmonary valve replacement during the Ross operation [23].
• Despite parenteral antimicrobial therapy, the patient developed recurrent pulmonary emboli with enlargement of the vegetative mass, necessitating surgical debridement and replacement of the pulmonary valve [32].
• Patients with a conduit inserted at initial operation, with absent pulmonary valve syndrome or with a more than moderate ventricular septal defect at reoperation were excluded from the study [33].

References