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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Embolectomy

  • According to our strategy, 98 patients met the diagnostic criteria of pulmonary embolism: 75 patients (all shock index <1) were treated with heparin alone, 16 (seven had a shock index > or =1) with thrombolysis, four (all shock index > or =1) with catheter fragmentation, and three (all shock index > or =1) with surgical embolectomy [1].
  • For those patients who survive embolectomy, prognosis is most closely correlated with the TNM staging of the primary lung tumor ignoring the tumor embolus [2].
  • Adequate heparin therapy significantly improved results after embolectomy, but had no such effect after surgical treatment of thrombosis [3].
  • PATIENTS/METHODS: Serial sections of thrombi obtained during valve replacement surgery or embolectomy from 22 patients with atrial fibrillation were stained with antibodies against fibrin, integrin beta3, or tissue factor and analyzed with NIH-image [4].
  • The patient underwent brachial artery embolectomy, proximal and distal aneurysm ligation, and placement of a carotid to axillary artery polytef bypass graft [5].

High impact information on Embolectomy

  • Pulmonary embolectomy after intravenous thrombolysis with alteplase [6].
  • Pulmonary embolectomy was done in 0.2% of cases of PE; interruption of the vena cava was done in 4.4% of cases of PE and in 2% of cases of DVT [7].
  • The authors conclude that the keys to successful treatment of ASE include high dose heparin which is maintained through the perioperative period, embolectomy without preoperative angiography, and maintenance of long-term oral anticoagulation [8].
  • Bilateral superficial femoral arteries were deendothelialized with a 2F arterial embolectomy catheter. rTM (145 microg/kg; 2.0 microg/mL in circulation) or Tris-hydrochloride vehicle control was administered intravenously during the procedure, then either discontinued (group A) or administered twice daily for an additional 48 hours (group B) [9].
  • Intra-arterial lignocaine in embolectomy [10].

Biological context of Embolectomy

  • Different treatment strategies, such as i.v. and i.a. fibrinolysis, adjunctive application of GP IIb/IIIa inhibitors, PTA/stenting and mechanical embolectomy are addressed in detail [11].

Anatomical context of Embolectomy


Associations of Embolectomy with chemical compounds

  • Four weeks after embolectomy, the vessels were perfusion-fixed in situ with 2% glutaraldehyde and were excised [17].
  • Artificial secretions were removed by suction (using 12- or 18-French suction catheters) or by means of a balloon-tipped catheter (6-French Fogarty arterial embolectomy catheter) in 20 experiments performed on five dogs anesthetized with halothane [18].
  • The functional recovery of gas exchange would be signaled by an increase in pulmonary CO2 elimination and decrease in CO2 retention; such data could guide the course of operative embolectomy [19].
  • RESULTS: No significant differences were noted in the contractile response to NE after embolectomy [20].
  • We report two patients in whom subcutaneous lepirudin was used for long term anticoagulation after heart transplant or surgical pulmonary embolectomy because treatment with LMWH or warfarin was contraindicated, unsuccessful, or impractical [21].

Gene context of Embolectomy


Analytical, diagnostic and therapeutic context of Embolectomy


  1. Novel management strategy for patients with suspected pulmonary embolism. Kucher, N., Luder, C.M., Dörnhöfer, T., Windecker, S., Meier, B., Hess, O.M. Eur. Heart J. (2003) [Pubmed]
  2. Prognostic significance of massive bronchogenic tumor embolus. Heitmiller, R.F. Ann. Thorac. Surg. (1992) [Pubmed]
  3. Acute nontraumatic extremity ischaemia in Sweden. A one-year survey. Dryjski, M., Swedenborg, J. Acta chirurgica Scandinavica. (1985) [Pubmed]
  4. Atrial fibrillation and thrombosis: immunohistochemical differences between in situ and embolized thrombi. Wysokinski, W.E., Owen, W.G., Fass, D.N., Patrzalek, D.D., Murphy, L., McBane, R.D. J. Thromb. Haemost. (2004) [Pubmed]
  5. Idiopathic multiple systemic aneurysms in a child. Fee, H., McGough, E. Am. J. Dis. Child. (1983) [Pubmed]
  6. Pulmonary embolectomy after intravenous thrombolysis with alteplase. Jolliet, P., Magnin, C., Unger, P.F. Lancet (1990) [Pubmed]
  7. The epidemiology of diagnosed pulmonary embolism and deep venous thrombosis in the elderly. Kniffin, W.D., Baron, J.A., Barrett, J., Birkmeyer, J.D., Anderson, F.A. Arch. Intern. Med. (1994) [Pubmed]
  8. Aortic saddle embolus. A twenty-year experience. Busuttil, R.W., Keehn, G., Milliken, J., Paredero, V.M., Baker, J.D., Machleder, H.I., Moore, W.S., Barker, W.F. Ann. Surg. (1983) [Pubmed]
  9. Recombinant human thrombomodulin inhibits arterial neointimal hyperplasia after balloon injury. Li, J.M., Singh, M.J., Itani, M., Vasiliu, C., Hendricks, G., Baker, S.P., Hale, J.E., Rohrer, M.J., Cutler, B.S., Nelson, P.R. J. Vasc. Surg. (2004) [Pubmed]
  10. Intra-arterial lignocaine in embolectomy. Campbell, W.B., Ballard, P.K. The British journal of surgery. (1996) [Pubmed]
  11. Acute vertebrobasilar occlusion: current treatment strategies. Eckert, B. Neurol. Res. (2005) [Pubmed]
  12. The importance of the subendothelial connective tissue to the permeability of the neointimal barrier. Collatz Christensen, B., Chemnitz, J. Atherosclerosis (1983) [Pubmed]
  13. Protective effects of methyl prednisolone and dimethyl sulfoxide in experimental middle cerebral artery embolectomy. Laha, R.K., Dujovny, M., Barrionuevo, P.J., DeCastro, S.C., Hellstrom, H.R., Maroon, J.C. J. Neurosurg. (1978) [Pubmed]
  14. Hypermyoglobinemia after successful arterial embolectomy. Andersen, P.T., Møller-Petersen, J., Henneberg, E.W., Egeblad, K. Surgery (1987) [Pubmed]
  15. Surgical therapy for acute superior mesenteric artery embolism. Bingol, H., Zeybek, N., Cingöz, F., Yilmaz, A.T., Tatar, H., Sen, D. Am. J. Surg. (2004) [Pubmed]
  16. Early experience of intra-ureteric capsaicin infusion in loin pain haematuria syndrome. Armstrong, T., McLean, A.D., Hayes, M., Morgans, B.T., Tulloch, D.N. BJU international. (2000) [Pubmed]
  17. Early myointimal hyperplasia after balloon catheter embolectomy: effect of shear forces and multiple withdrawals. Schwarcz, T.H., Dobrin, P.B., Mrkvicka, R., Skowron, L., Cole, M.B. J. Vasc. Surg. (1988) [Pubmed]
  18. Removal of tracheal secretions in anesthetized dogs: balloon catheters versus suction. Leiman, B.C., Katz, J., Stanley, T.H., Butler, B.D. Anesth. Analg. (1987) [Pubmed]
  19. Carbon dioxide elimination measures resolution of experimental pulmonary embolus in dogs. Breen, P.H., Mazumdar, B., Skinner, S.C. Anesth. Analg. (1996) [Pubmed]
  20. The impact of balloon embolectomy on the function and morphology of the endothelium. Jerius, H., Bagwell, D., Beall, A., Brophy, C. J. Surg. Res. (1997) [Pubmed]
  21. Outpatient management of venous thromboembolic disease with subcutaneous lepirudin: a case report. Begelman, S.M., Deitcher, S.R. J. Thromb. Thrombolysis (2002) [Pubmed]
  22. Combined pulmonary tumour embolectomy and extended right hepatectomy with inferior vena cava resection for advanced hepatocellular carcinoma. Uemoto, S., Fleming, W., Keogh, B.E., Habib, N.A. The British journal of surgery. (1995) [Pubmed]
  23. Caught in the act: impending paradoxical embolism. Fabricius, A.M., Krüger, M., Hanke, M., Mohr, F.W. Asian cardiovascular & thoracic annals. (2002) [Pubmed]
  24. Anticipated diagnosis of left atrial myxoma following histological investigation of limb embolectomy specimens: a report of two cases. Val-Bernal, J.F., Acebo, E., Gómez-Román, J.J., Garijo, M.F. Pathol. Int. (2003) [Pubmed]
  25. MERCI 1: a phase 1 study of Mechanical Embolus Removal in Cerebral Ischemia. Gobin, Y.P., Starkman, S., Duckwiler, G.R., Grobelny, T., Kidwell, C.S., Jahan, R., Pile-Spellman, J., Segal, A., Vinuela, F., Saver, J.L. Stroke (2004) [Pubmed]
  26. Infected ventricular septal defect. Windsor, H.M., Noble, N., Chang, V.P. The Australian and New Zealand journal of surgery. (1981) [Pubmed]
  27. Cardiorespiratory failure secondary to peripheral pulmonary emboli. Survival following a combination of prolonged extracorporeal membrane oxygenator support and pulmonary embolectomy. Cooper, J.D., Teasdale, S., Nelems, J.M., Glynn, M.F., MacGregor, D.C., Duffin, J., Scott, A.A. J. Thorac. Cardiovasc. Surg. (1976) [Pubmed]
  28. Treatment of heparin-associated thrombocytopenia and thrombosis with low molecular weight heparin (CY 216). Leroy, J., Leclerc, M.H., Delahousse, B., Guérois, C., Foloppe, P., Gruel, Y., Toulemonde, F. Semin. Thromb. Hemost. (1985) [Pubmed]
  29. Arterial embolectomy: a 34-year experience with 400 cases. Panetta, T., Thompson, J.E., Talkington, C.M., Garrett, W.V., Smith, B.L. Surg. Clin. North Am. (1986) [Pubmed]
  30. Repair in arterial tissue. Electron microscopy of Evans blue vital stained embolectomy catheter lesion of the rabbit thoracic aorta. Christensen, B.C., Chemnitz, J., Tkocz, I. Acta pathologica et microbiologica Scandinavica. Section A, Pathology. (1976) [Pubmed]
  31. Management of neglected embolic occlusions in lower-limb arteries using arterial lavage. Hachem, M.M., Grillo, I.A. Cardiovascular surgery (London, England) (1995) [Pubmed]
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