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Chemical Compound Review

NSC-27685     5-butan-2-yl-5-ethyl-2- sulfanylidene-1,3...

Synonyms: NSC-32372, AC1MHU0C, NSC27685, NSC32372, LS-23947, ...
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Disease relevance of Inactin

  • To examine the role of plasma extravasation in CsA-induced hypovolemia, intravascular plasma volumes (PV), blood volumes, [125I]albumin disappearance, and changes in hematocrit (Hct) were measured in Inactin-anesthetized rats subjected to minimal surgery [1].
  • DESIGN: Male Sprague-Dawley rats (n = 15, body weight 350-420 g) were anesthetized with thiobutabarbital sodium (Inactin, 100 mg/kg intraperitoneally) [2].
  • The relative importance of endothelial derived relaxing factor (EDRF)/nitric oxide (NO) in maintaining kidney function in normal condition and in acute renal failure (ARF) were evaluated in inactin anesthetized rats [3].
  • In Inactin anaesthetized rats, hypothermia at 28 degrees C decreased GFR by 50% but failed to alter efferent renal sympathetic nerve activity (ERSNA) [4].
  • Tubular transit time was measured in the conscious state and during inactin anesthesia in control rats as well as in unilaterally nephrectomized rats with compensatory hypertrophy [5].

High impact information on Inactin


Chemical compound and disease context of Inactin


Biological context of Inactin


Anatomical context of Inactin


Associations of Inactin with other chemical compounds


Gene context of Inactin

  • Inhibition of NOS with N(omega)-nitro-l-arginine methyl ester (l-NAME; 50 mg/kg iv) in Inactin-anesthetized WT and nNOS(-/-) mice increased arterial blood pressure by 28-31 mmHg and significantly decreased blood flow in the renal cortex (18-24%) and the renal medulla (13-18%) [28].
  • METHODS: AT1A receptor-deficient mice and their wild-type controls were anesthetized with inactin and ketamine, and were prepared to allow intravenous infusions of solutions and measurements of aortic pressure and urine collections [29].
  • Administration of endothelin to inactin-anesthetized rats resulted in a significant renal vasoconstriction as evidenced by a reduction in both renal plasma flow and glomerular filtration rate [30].
  • Male Munich-Wistar rats, normal Han:SPRD rats, and heterozygous Han:SPRD rats with autosomal-dominant polycystic kidney disease were anesthetized with Inactin and solutions containing SF were administered by constant intravenous infusion [31].
  • In male rats anesthetized with Inactin, continuous infusion of OT (125 ng/kg x h) increased plasma OT to about 70 pg/ml; renal Na+ excretion increased 10-fold, and urine volume and K+ excretion also were elevated [32].

Analytical, diagnostic and therapeutic context of Inactin


  1. Effect of cyclosporine on endothelial albumin leakage in rats. Moore, L.C., Mason, J., Feld, L., Van Liew, J.B., Kaskel, F.J. J. Am. Soc. Nephrol. (1992) [Pubmed]
  2. The angiotensin II AT1 receptor antagonist irbesartan prevents thromboxane A2-induced vasoconstriction in the rat hind-limb vascular bed in vivo. Fukuhara, M., Neves, L.A., Li, P., Diz, D.I., Ferrario, C.M., Brosnihan, K.B. J. Hypertens. (2001) [Pubmed]
  3. Inhibition of endothelial derived relaxing factor (EDRF) aggravates ischemic acute renal failure in anesthetized rats. Chintala, M.S., Chiu, P.J., Vemulapalli, S., Watkins, R.W., Sybertz, E.J. Naunyn Schmiedebergs Arch. Pharmacol. (1993) [Pubmed]
  4. Influence of the sympathetic nervous system on renal function during hypothermia. Broman, M., Källskog, O., Kopp, U.C., Wolgast, M. Acta Physiol. Scand. (1998) [Pubmed]
  5. Intravital microscopical studies of the tubular urine flow in the conscious rat. Steinhausen, M., Hill, E., Parekh, N. Pflugers Arch. (1976) [Pubmed]
  6. Gastric mucosal smooth muscles may explain oscillations in glandular pressure: role of vasoactive intestinal peptide. Synnerstad, I., Ekblad, E., Sundler, F., Holm, L. Gastroenterology (1998) [Pubmed]
  7. Renal function in mice: effects of volume expansion and angiotensin II. Cervenka, L., Mitchell, K.D., Navar, L.G. J. Am. Soc. Nephrol. (1999) [Pubmed]
  8. Inhibition of 20-HETE production contributes to the vascular responses to nitric oxide. Alonso-Galicia, M., Drummond, H.A., Reddy, K.K., Falck, J.R., Roman, R.J. Hypertension (1997) [Pubmed]
  9. Long-term ouabain administration produces hypertension in rats. Yuan, C.M., Manunta, P., Hamlyn, J.M., Chen, S., Bohen, E., Yeun, J., Haddy, F.J., Pamnani, M.B. Hypertension (1993) [Pubmed]
  10. Effect of enalapril treatment on the pressure-natriuresis curve in spontaneously hypertensive rats. McLennan, G.P., Kline, R.L., Mercer, P.F. Hypertension (1991) [Pubmed]
  11. The effects of anesthesia on the excretion of an isotonic saline load in the rat. Knight, T.F., Sansom, S., Hawk, L., Frankfurt, S.J., Weinman, E.J. Pflugers Arch. (1978) [Pubmed]
  12. Augmented pulmonary vascular and venous constrictions to N(G)-nitro-L-arginine methyl ester in rats with monocrotaline-induced pulmonary hypertension. Leung, S.W., Cheng, X., Lim, S.L., Pang, C.C. Pharmacology (2003) [Pubmed]
  13. Effect of hyperthermia on blood levels of corticosterone and certain metabolites in rats during thiobutabarbital anaesthesia. Torlińska, T., Paluszak, J., Waliszewska, A., Banach, R. Acta physiologica Polonica. (1984) [Pubmed]
  14. Nitric oxide modulation of glutamatergic, baroreflex, and cardiopulmonary transmission in the nucleus of the solitary tract. Dias, A.C., Vitela, M., Colombari, E., Mifflin, S.W. Am. J. Physiol. Heart Circ. Physiol. (2005) [Pubmed]
  15. Cardiovascular activity of rasagiline, a selective and potent inhibitor of mitochondrial monoamine oxidase B: comparison with selegiline. Abassi, Z.A., Binah, O., Youdim, M.B. Br. J. Pharmacol. (2004) [Pubmed]
  16. Propofol anesthesia compared to awake reduces infarct size in rats. Gelb, A.W., Bayona, N.A., Wilson, J.X., Cechetto, D.F. Anesthesiology (2002) [Pubmed]
  17. A glomerular defect in prehypertensive Dahl S rats, which limits their capacity to increase GFR. Tobian, L., Johnson, M.A., Hanlon, S., Bartemes, K. Am. J. Hypertens. (1989) [Pubmed]
  18. Arginine vasopressin-induced natriuresis in the anaesthetized rat: involvement of V1 and V2 receptors. Smith, C.P., Balment, R.J. J. Endocrinol. (1993) [Pubmed]
  19. Omeprazole induces high intraglandular pressure in the rat gastric mucosa. Synnerstad, I., Holm, L. Gastroenterology (1997) [Pubmed]
  20. Mechanism of matrix accumulation and glomerulosclerosis in spontaneously hypertensive rats. Camp, T.M., Smiley, L.M., Hayden, M.R., Tyagi, S.C. J. Hypertens. (2003) [Pubmed]
  21. Melatonin in the duodenal lumen is a potent stimulant of mucosal bicarbonate secretion. Sjöblom, M., Flemström, G. J. Pineal Res. (2003) [Pubmed]
  22. Pharmacological evidence that the sympathetic nervous system mediates the increase in renin secretion produced by immobilization and head-up tilt in rats. Golin, R.M., Gotoh, E., Said, S.I., Ganong, W.F. Neuropharmacology (1988) [Pubmed]
  23. Stimulation of endogenous endothelin release in the anesthetized rat. Pollock, D.M., Divish, B.J., Opgenorth, T.J. J. Cardiovasc. Pharmacol. (1993) [Pubmed]
  24. Renal effects of rilmenidine in anesthetized rats: importance of renal nerves. Kline, R.L., Cechetto, D.F. J. Pharmacol. Exp. Ther. (1993) [Pubmed]
  25. Glucocorticoids reduce responses to AMPA receptor activation and blockade in nucleus tractus solitarius. Shank, S.S., Scheuer, D.A. Am. J. Physiol. Heart Circ. Physiol. (2003) [Pubmed]
  26. Role of the paraventricular nucleus in renal excretory responses to acute volume expansion: role of nitric oxide. Li, Y.F., Mayhan, W.G., Patel, K.P. Am. J. Physiol. Heart Circ. Physiol. (2003) [Pubmed]
  27. Prevention and complete reversal of cyclosporine A-induced renal vasoconstriction and nephrotoxicity in the rat by fenoldopam. Brooks, D.P., Drutz, D.J., Ruffolo, R.R. J. Pharmacol. Exp. Ther. (1990) [Pubmed]
  28. Renal cortical and medullary blood flow responses to L-NAME and ANG II in wild-type, nNOS null mutant, and eNOS null mutant mice. Mattson, D.L., Meister, C.J. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2005) [Pubmed]
  29. Renal function in the AT1A receptor knockout mouse during normal and volume-expanded conditions. Cervenka, L., Mitchell, K.D., Oliverio, M.I., Coffman, T.M., Navar, L.G. Kidney Int. (1999) [Pubmed]
  30. Prevention of cyclosporine A-induced renal vasoconstriction by the endothelin receptor antagonist SB 209670. Brooks, D.P., Contino, L.C. Eur. J. Pharmacol. (1995) [Pubmed]
  31. Two-photon in vivo microscopy of sulfonefluorescein secretion in normal and cystic rat kidneys. Tanner, G.A., Sandoval, R.M., Dunn, K.W. Am. J. Physiol. Renal Physiol. (2004) [Pubmed]
  32. Sodium excretion and renin secretion after continuous versus pulsatile infusion of oxytocin in rats. Sjöquist, M., Huang, W., Jacobsson, E., Skøtt, O., Stricker, E.M., Sved, A.F. Endocrinology (1999) [Pubmed]
  33. Prostaglandin E2 and aggressive factors increase the gland luminal pressure in the rat gastric mucosa in vivo. Synnerstad, I., Holm, L. Gastroenterology (1998) [Pubmed]
  34. Intraluminal acid and gastric mucosal integrity: the importance of blood-borne bicarbonate. Synnerstad, I., Johansson, M., Nylander, O., Holm, L. Am. J. Physiol. Gastrointest. Liver Physiol. (2001) [Pubmed]
  35. Peptide changes in the parabrachial nucleus following cervical vagal stimulation. Saleh, T.M., Cechetto, D.F. J. Comp. Neurol. (1996) [Pubmed]
  36. Effect of general anaesthesia on renal haemodynamics in the rat. Koeppen, B.M., Katz, A.I., Lindheimer, M.D. Clin. Sci. (1979) [Pubmed]
  37. Disparate effects of thrombin receptor activating peptide on platelets and peripheral vasculature in rats. Chintala, M.S., Chiu, P.J., Bernadino, V., Tetzloff, G.G., Tedesco, R., Sabin, C., Watkins, R.W., Sybertz, E.J. Eur. J. Pharmacol. (1998) [Pubmed]
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