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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Sarcoma, Experimental

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Disease relevance of Sarcoma, Experimental


High impact information on Sarcoma, Experimental


Chemical compound and disease context of Sarcoma, Experimental


Biological context of Sarcoma, Experimental


Anatomical context of Sarcoma, Experimental

  • Laminin complexes secreted by cultured cells contained a approximately 300 kD heavy chain which did not immunoreact with immunoreagents raised against either the classical laminin complex secreted by EHS tumor cells or the merosin heavy chain [20].

Gene context of Sarcoma, Experimental

  • Specific binding of basic fibroblast growth factor to basement membrane-like structures and to purified heparan sulfate proteoglycan of the EHS tumor [21].
  • Nidogen, obtained from the EHS tumor or in recombinant form, binds exclusively to the protein core in a heparin-insensitive manner [22].
  • A novel acidic glycoprotein, BM-40, with Mr = 40,000, was purified from the basement-membrane-producing mouse EHS tumor and characterized with regard to its unique chemical and antigenic properties [23].
  • A large, low-density form of heparan sulfate proteoglycan was isolated from the Engelbreth-Holm-Swarm (EHS) tumor and demonstrated to bind in immobilized-ligand assays to laminin fragment E3, collagen type IV, fibronectin and nidogen [22].
  • A polyclonal antibody prepared against basal lamina HSPG from Engelbreth-Holm-Swarm (EHS) tumor cells (gift of Dr. John Hassell) was used as a positive control [24].

Analytical, diagnostic and therapeutic context of Sarcoma, Experimental


  1. Autoantibodies to the laminin P1 fragment in HgCl2-induced membranous glomerulopathy. Aten, J., Veninga, A., Coers, W., Sonnenberg, A., Timpl, R., Claessen, N., van Eendenburg, J.D., de Heer, E., Weening, J.J. Am. J. Pathol. (1995) [Pubmed]
  2. Epidermolysis bullosa acquisita antigen, a major cutaneous basement membrane component, is synthesized by human dermal fibroblasts and other cutaneous tissues. Woodley, D.T., Briggaman, R.A., Gammon, W.R., Falk, R.J., Reese, M.J., Tomsick, R.S., O'Keefe, E.J. J. Invest. Dermatol. (1986) [Pubmed]
  3. Structural variability of BM-40/SPARC/osteonectin glycosylation: implications for collagen affinity. Kaufmann, B., Müller, S., Hanisch, F.G., Hartmann, U., Paulsson, M., Maurer, P., Zaucke, F. Glycobiology (2004) [Pubmed]
  4. Isolated lung perfusion with doxorubicin prolongs survival in a rodent model of pulmonary metastases. Abolhoda, A., Brooks, A., Nawata, S., Kaneda, Y., Cheng, H., Burt, M.E. Ann. Thorac. Surg. (1997) [Pubmed]
  5. Lack of association between tumor hypoxia, GLUT-1 expression and glucose uptake in experimental sarcomas. Thews, O., Kelleher, D.K., Esser, N., Kraus, S., Vaupel, P. Adv. Exp. Med. Biol. (2003) [Pubmed]
  6. Antibodies to basement membrane collagen and to laminin are present in sera from patients with poststreptococcal glomerulonephritis. Kefalides, N.A., Pegg, M.T., Ohno, N., Poon-King, T., Zabriskie, J., Fillit, H. J. Exp. Med. (1986) [Pubmed]
  7. Macrophage functions are regulated by murine decidual and tumor extracellular matrices. McKay, D.B., Vazquez, M.A., Redline, R.W., Lu, C.Y. J. Clin. Invest. (1992) [Pubmed]
  8. Role of insulin in development of cancer cachexia in nongrowing sarcoma-bearing mice: special reference to muscle wasting. Svaninger, G., Drott, C., Lundholm, K. J. Natl. Cancer Inst. (1987) [Pubmed]
  9. Basement membrane components are potent promoters of rat intestinal epithelial cell differentiation in vitro. Hahn, U., Stallmach, A., Hahn, E.G., Riecken, E.O. Gastroenterology (1990) [Pubmed]
  10. The mushroom Marasmius oreades lectin is a blood group type B agglutinin that recognizes the Galalpha 1,3Gal and Galalpha 1,3Galbeta 1,4GlcNAc porcine xenotransplantation epitopes with high affinity. Winter, H.C., Mostafapour, K., Goldstein, I.J. J. Biol. Chem. (2002) [Pubmed]
  11. Metastatic melanoma cell heparanase. Characterization of heparan sulfate degradation fragments produced by B16 melanoma endoglucuronidase. Nakajima, M., Irimura, T., Di Ferrante, N., Nicolson, G.L. J. Biol. Chem. (1984) [Pubmed]
  12. Characterization of a novel glycoprotein isolated from the basement membrane matrix of the Engelbreth-Holm-Swarm tumor. Robinson, L.K., Murrah, V.A., Moyer, M.P., Rohrbach, D.H. J. Biol. Chem. (1989) [Pubmed]
  13. Effects of streptozotocin diabetes, glucose, and insulin on the metabolism of type IV collagen and proteoglycan in murine basement membrane-forming EHS tumor tissue. Pihlajaniemi, T., Myllylä, R., Kivirikko, K.I., Tryggvason, K. J. Biol. Chem. (1982) [Pubmed]
  14. An abundant chick gizzard integrin is the avian alpha 1 beta 1 integrin heterodimer and functions as a divalent cation-dependent collagen IV receptor. Syfrig, J., Mann, K., Paulsson, M. Exp. Cell Res. (1991) [Pubmed]
  15. DL-threo-beta-Fluoroaspartate and DL-threo-beta-fluoroasparagine: selective cytotoxic agents for mammalian cells in culture. Stern, A.M., Foxman, B.M., Tashjian, A.H., Abeles, R.H. J. Med. Chem. (1982) [Pubmed]
  16. Influence of cyclophosphamide on the antibody response evoked by an experimental sarcoma in rats. Husberg, B.S., Ericsson, H. Transplantation (1978) [Pubmed]
  17. Heparan sulfate proteoglycan of human colon: partial molecular cloning, cellular expression, and mapping of the gene (HSPG2) to the short arm of human chromosome 1. Dodge, G.R., Kovalszky, I., Chu, M.L., Hassell, J.R., McBride, O.W., Yi, H.F., Iozzo, R.V. Genomics (1991) [Pubmed]
  18. Vimentin cDNA clones covering the complete intermediate-filament protein are found in an EHS tumor cDNA library. Wood, L., Theriault, N., Vogeli, G. Gene (1989) [Pubmed]
  19. An alternatively spliced exon in the extracellular domain of the human alpha 6 integrin subunit--functional analysis of the alpha 6 integrin variants. Delwel, G.O., Kuikman, I., Sonnenberg, A. Cell Adhes. Commun. (1995) [Pubmed]
  20. Angiotensin-II-induced expression of laminin complex and laminin A-chain-related transcripts in vascular smooth muscle cells. Regenass, S., Resink, T.J., Kern, F., Bühler, F.R., Hahn, A.W. J. Vasc. Res. (1994) [Pubmed]
  21. Specific binding of basic fibroblast growth factor to basement membrane-like structures and to purified heparan sulfate proteoglycan of the EHS tumor. Vigny, M., Ollier-Hartmann, M.P., Lavigne, M., Fayein, N., Jeanny, J.C., Laurent, M., Courtois, Y. J. Cell. Physiol. (1988) [Pubmed]
  22. Basement-membrane heparan sulfate proteoglycan binds to laminin by its heparan sulfate chains and to nidogen by sites in the protein core. Battaglia, C., Mayer, U., Aumailley, M., Timpl, R. Eur. J. Biochem. (1992) [Pubmed]
  23. Purification and tissue distribution of a small protein (BM-40) extracted from a basement membrane tumor. Dziadek, M., Paulsson, M., Aumailley, M., Timpl, R. Eur. J. Biochem. (1986) [Pubmed]
  24. Changes in histochemical distribution of cell surface heparan sulfate proteoglycan in mouse uterus during the estrous cycle and early pregnancy. Potter, S.W., Morris, J.E. Anat. Rec. (1992) [Pubmed]
  25. Characterization of native laminin from bovine kidney and comparison with other laminin variants. Lindblom, A., Marsh, T., Fauser, C., Engel, J., Paulsson, M. Eur. J. Biochem. (1994) [Pubmed]
  26. Synthesis of digoxigenin-labeled cRNA probes for nonisotopic in situ hybridization using reverse transcription polymerase chain reaction. Young, I.D., Stewart, R.J., Ailles, L., Mackie, A., Gore, J. Biotechnic & histochemistry : official publication of the Biological Stain Commission. (1993) [Pubmed]
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