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Gene Review

NID1  -  nidogen 1

Homo sapiens

Synonyms: Entactin, NID, NID-1, Nidogen-1, entactin
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Disease relevance of NID1


Psychiatry related information on NID1

  • Our data suggest that nidogen-2 and nidogen-1, as is known for mouse development, could well participate in cell biological functions during human development [3].

High impact information on NID1


Chemical compound and disease context of NID1


Biological context of NID1


Anatomical context of NID1


Associations of NID1 with chemical compounds

  • The laminin-nidogen complex is a ligand for a specific splice isoform of the transmembrane protein tyrosine phosphatase LAR [11].
  • A distinct interaction was also observed with nidogen but this was only partially blocked by EDTA [12].
  • Urokinase binding to laminin-nidogen. Structural requirements and interactions with heparin [18].
  • Thioflavin T fluorometric assay and electron microscopy revealed that entactin significantly inhibited Abeta1-40 (Abeta40) fibril formation at an Abeta40:entactin molar ratio of 50:1 [19].
  • The binding of entactin to either the A alpha chain or the B beta chain was divalent cation-independent [20].

Physical interactions of NID1


Enzymatic interactions of NID1


Regulatory relationships of NID1


Other interactions of NID1

  • Indirect immunofluorescent antibody staining revealed high expression of LAR in a punctate pattern, throughout the length of these cellular processes observed on laminin-nidogen [11].
  • We propose that the ability of entactin to induce random structure is linked to the inhibition of Abeta fibril formation [19].
  • Nonscarred regions showed decreased staining of the epithelial BM for entactin/nidogen, fibronectin, alpha 3-alpha 5 chains of type IV collagen, and chains of laminin-1 [24].
  • The extracellular matrix laminin-nidogen complex was identified as a ligand for the LAR-FnIII domain 5 (Fn5) using a series of GST-LAR-FnIII domain fusion proteins and testing them in in vitro ligand-binding assays [11].
  • Interactions with some non-collagenous protein ligands were even stronger, with matrilin-2 binding to fibrillin-2, fibronectin and laminin-1-nidogen-1 complexes, with K (D) values in the range of 10(-8)-10(-11) M [25].

Analytical, diagnostic and therapeutic context of NID1


  1. Nidogen 1 and 2 gene promoters are aberrantly methylated in human gastrointestinal cancer. Ulazzi, L., Sabbioni, S., Miotto, E., Veronese, A., Angusti, A., Gafà, R., Manfredini, S., Farinati, F., Sasaki, T., Lanza, G., Negrini, M. Mol. Cancer (2007) [Pubmed]
  2. Human nidogen: cDNA cloning, cellular expression, and mapping of the gene to chromosome Iq43. Olsen, D.R., Nagayoshi, T., Fazio, M., Mattei, M.G., Passage, E., Weil, D., Timpl, R., Chu, M.L., Uitto, J. Am. J. Hum. Genet. (1989) [Pubmed]
  3. Nidogen-1 and nidogen-2 are found in basement membranes during human embryonic development. Miosge, N., Holzhausen, S., Zelent, C., Sprysch, P., Herken, R. Histochem. J. (2001) [Pubmed]
  4. Functional domains of cell adhesion molecules. Yamada, Y., Kleinman, H.K. Curr. Opin. Cell Biol. (1992) [Pubmed]
  5. Collagen COL4A3 knockout: a mouse model for autosomal Alport syndrome. Cosgrove, D., Meehan, D.T., Grunkemeyer, J.A., Kornak, J.M., Sayers, R., Hunter, W.J., Samuelson, G.C. Genes Dev. (1996) [Pubmed]
  6. Leukocyte response integrin and integrin-associated protein act as a signal transduction unit in generation of a phagocyte respiratory burst. Zhou, M., Brown, E.J. J. Exp. Med. (1993) [Pubmed]
  7. Entactin stimulates neutrophil adhesion and chemotaxis through interactions between its Arg-Gly-Asp (RGD) domain and the leukocyte response integrin. Senior, R.M., Gresham, H.D., Griffin, G.L., Brown, E.J., Chung, A.E. J. Clin. Invest. (1992) [Pubmed]
  8. Basement-membrane heparan sulfate proteoglycan binds to laminin by its heparan sulfate chains and to nidogen by sites in the protein core. Battaglia, C., Mayer, U., Aumailley, M., Timpl, R. Eur. J. Biochem. (1992) [Pubmed]
  9. Overexpression of matrix metalloproteinase-10 and matrix metalloproteinase-3 in human diabetic corneas: a possible mechanism of basement membrane and integrin alterations. Saghizadeh, M., Brown, D.J., Castellon, R., Chwa, M., Huang, G.H., Ljubimova, J.Y., Rosenberg, S., Spirin, K.S., Stolitenko, R.B., Adachi, W., Kinoshita, S., Murphy, G., Windsor, L.J., Kenney, M.C., Ljubimov, A.V. Am. J. Pathol. (2001) [Pubmed]
  10. Abnormal expression and distribution of nidogen in Hirschsprung's disease. Parikh, D.H., Leibl, M., Tam, P.K., Edgar, D. J. Pediatr. Surg. (1995) [Pubmed]
  11. The laminin-nidogen complex is a ligand for a specific splice isoform of the transmembrane protein tyrosine phosphatase LAR. O'Grady, P., Thai, T.C., Saito, H. J. Cell Biol. (1998) [Pubmed]
  12. Binding of mouse and human fibulin-2 to extracellular matrix ligands. Sasaki, T., Göhring, W., Pan, T.C., Chu, M.L., Timpl, R. J. Mol. Biol. (1995) [Pubmed]
  13. Integrin-associated protein immunoglobulin domain is necessary for efficient vitronectin bead binding. Lindberg, F.P., Gresham, H.D., Reinhold, M.I., Brown, E.J. J. Cell Biol. (1996) [Pubmed]
  14. Characterization of a conduit system containing laminin-5 in the human thymus: a potential transport system for small molecules. Drumea-Mirancea, M., Wessels, J.T., Müller, C.A., Essl, M., Eble, J.A., Tolosa, E., Koch, M., Reinhardt, D.P., Sixt, M., Sorokin, L., Stierhof, Y.D., Schwarz, H., Klein, G. J. Cell. Sci. (2006) [Pubmed]
  15. Basement membrane abnormalities in human eyes with diabetic retinopathy. Ljubimov, A.V., Burgeson, R.E., Butkowski, R.J., Couchman, J.R., Zardi, L., Ninomiya, Y., Sado, Y., Huang, Z.S., Nesburn, A.B., Kenney, M.C. J. Histochem. Cytochem. (1996) [Pubmed]
  16. Adhesion of cultured human kidney mesangial cells to native entactin: role of integrin receptors. Yi, X.Y., Wayner, E.A., Kim, Y., Fish, A.J. Cell Adhes. Commun. (1998) [Pubmed]
  17. Vascular anomalies in lipoid proteinosis (hyalinosis cutis et mucosae): basement membrane components and ultrastructure. Mirancea, N., Hausser, I., Beck, R., Metze, D., Fusenig, N.E., Breitkreutz, D. J. Dermatol. Sci. (2006) [Pubmed]
  18. Urokinase binding to laminin-nidogen. Structural requirements and interactions with heparin. Stephens, R.W., Aumailley, M., Timpl, R., Reisberg, T., Tapiovaara, H., Myöhänen, H., Murphy-Ullrich, J., Vaheri, A. Eur. J. Biochem. (1992) [Pubmed]
  19. Entactin-induced inhibition of human amyloid beta-protein fibril formation in vitro. Kiuchi, Y., Isobe, Y., Fukushima, K. Neurosci. Lett. (2001) [Pubmed]
  20. Potential role of entactin in hemostasis. Specific interaction of entactin with fibrinogen A alpha and B beta chains. Wu, C., Chung, A.E. J. Biol. Chem. (1991) [Pubmed]
  21. An interaction between basement membrane and Alzheimer amyloid precursor proteins suggests a role in the pathogenesis of Alzheimer's disease. Narindrasorasak, S., Altman, R.A., Gonzalez-DeWhitt, P., Greenberg, B.D., Kisilevsky, R. Lab. Invest. (1995) [Pubmed]
  22. Activity of MMP-19 inhibits capillary-like formation due to processing of nidogen-1. Titz, B., Dietrich, S., Sadowski, T., Beck, C., Petersen, A., Sedlacek, R. Cell. Mol. Life Sci. (2004) [Pubmed]
  23. Cardiac electrophysiological consequences of neuromuscular incapacitating device discharges. Nanthakumar, K., Billingsley, I.M., Masse, S., Dorian, P., Cameron, D., Chauhan, V.S., Downar, E., Sevaptsidis, E. J. Am. Coll. Cardiol. (2006) [Pubmed]
  24. Abnormalities of the extracellular matrix in keratoconus corneas. Kenney, M.C., Nesburn, A.B., Burgeson, R.E., Butkowski, R.J., Ljubimov, A.V. Cornea (1997) [Pubmed]
  25. Matrilin-2 interacts with itself and with other extracellular matrix proteins. Piecha, D., Wiberg, C., Mörgelin, M., Reinhardt, D.P., Deák, F., Maurer, P., Paulsson, M. Biochem. J. (2002) [Pubmed]
  26. Human nidogen gene: structural and functional characterization of the 5'-flanking region. Fazio, M.J., O'Leary, J., Kähäri, V.M., Chen, Y.Q., Saitta, B., Uitto, J. J. Invest. Dermatol. (1991) [Pubmed]
  27. Genomic sequences and structural organization of the human nidogen gene (NID). Zimmermann, K., Hoischen, S., Hafner, M., Nischt, R. Genomics (1995) [Pubmed]
  28. Human trophoblast cell adhesion to extracellular matrix protein, entactin. Yang, Y., Todt, J.C., Svinarich, D.M., Qureshi, F., Jacques, S.M., Graham, C.H., Chung, A.E., Gonik, B., Yelian, F.D. Am. J. Reprod. Immunol. (1996) [Pubmed]
  29. Human nidogen: complete amino acid sequence and structural domains deduced from cDNAs, and evidence for polymorphism of the gene. Nagayoshi, T., Sanborn, D., Hickok, N.J., Olsen, D.R., Fazio, M.J., Chu, M.L., Knowlton, R., Mann, K., Deutzmann, R., Timpl, R. DNA (1989) [Pubmed]
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