Disease relevance of IOPHENDYLATE

• The authors studied the Pantopaque radiograms of a hematoma cavity in 46 patients following early surgical treatment for the lateral type of hypertensive intracerebral hematoma [1].
• Correlation between the location of hematoma and its clinical symptoms in the lateral type of hypertensive intracerebral hemorrhage. Observations on Pantopaque radiography of the hematoma cavity in cases of early surgical treatment [1].
• Lipiodol and Pantopaque are not absorbed and residual medium in the spinal canal can cause arachnoiditis [2].
• The radiologic investigation of patients with suspected acoustic neurilemmomas may include specialized plain films, thin-section tomography, CT scanning with intravenous contrast enhancement, Pantopaque cisternography, radionuclide scanning, angiography, and pneumoencephalography [3].
• Although Pantopaque will probably not be used as an MR contrast agent, it is important to recognize this property so that its high signal is not mistaken for fat or hemorrhage in the subarachnoid space on MR images [4].

High impact information on IOPHENDYLATE

• MR images of two dogs--one injected with Pantopaque in the cervical subarachnoid space and the other with Amipaque--confirmed that the high signal arose from the Pantopaque [4].
• The Pantopaque appeared as a linear band of high signal intensity along the dependent portion of the spinal canal on MR images obtained with a repetition time of 500 msec and an echo time of 30 msec [4].
• Thin section tomography, high resolution computed tomography, posterior fossa computed tomography, and cerebellopontine angle cisternography using Pantopaque (iophendylate) demonstrated bone erosions and soft tissue masses conforming to the course of the facial nerve [5].
• Arachnoiditis resulting from administration of intrathecal iophendylate (Pantopaque) was compared with that from metrizamide (Amipaque) in 16 monkeys [6].
• During injection, it was noted that Myodil injected before the alcohol spread along the pituitary stalk and the walls of the third ventricle [7].

Chemical compound and disease context of IOPHENDYLATE

• No apparent protection against Pantopaque arachnoiditis was provided by either intrathecal or intramuscular methylprednisolone [8].
• A large traumatic arteriovenous malformation of the scalp was embolized with Pantopaque-saturated Gelfoam pledgets, which made fluoroscopic monitoring of the radiopaque emboli possible [9].
• One patient with a left frontal arteriovenous malformation had embolization with an isobutyl-2-cyanoacrylate/pantopaque/acetic acid mixture; severe pleuritic chest pain developed 2 days later [10].
• The most useful sign of recurrent disc prolapse was anterior indentation of the iophendylate (Myodil) column opposite a disc space [11].
• Late sequelae (adhesive arachnoiditis) have been reported following myelography with the oily contrast medium (Pantopaque) and with the ionic water-soluble contrast media methiodal sodium (Abrodil, Conturex, Kontrast U) meglumine iothalamate (Conray Meglumine) and meglumine iocarmate (Bis-Conray, Dimer-X) [12].

Biological context of IOPHENDYLATE

• Positive contrast material (Pantopaque) was preferred in cervical and thoracic trauma manifesting bony deformity, in cervical trauma without bony deformity (in the prone position), in delineating the thoracic spinal cord in the frontal projection, and in lumbar spinal injuries [13].
• If Pantopaque myelography in patients in the supine position shows the Arnold-Chiari malformation, hydromyelia can be established as a cause of central cord deficit even if myelography shows the cord size to be normal [14].

Anatomical context of IOPHENDYLATE

• Following injections of iodophendylate (Pantopaque) in adult rats, the contrast medium was shown to be refrained in the dilated cerebral ventricles for at least 180 days [15].
• Morphological damage following Pantopaque was more severe and widespread in both choroid plexus and ependyma suggesting that, of the two agents, Conray may have the greater clinical potential provided that the associated convulsions are controlled by appropriate measures [16].
• Ultrastructural effects of Conray 60 and Pantopaque on ependyma and choroid plexus following intraventricular injections [16].
• Conray was not detected with the light or electron microscope; however, Pantopaque was presumptively localized as electron-dense masses associated with lipid-like bodies at the ventricular interface of both choroidal and ependymal epithelium [16].
• Metrizamide computerized tomography scanning and Pantopaque myelography have been the radiographic tests most commonly used to evaluate the foramen magnum [17].

Associations of IOPHENDYLATE with other chemical compounds

• The combined effort involves the exposure of the lesion at craniotomy, standard arteriotomy, and fluoroscopically monitored intravascular infusion of contrast material followed by the injection of bucrylate (IBCA, Ethicon, Somerville, NJ) mixed with tantalum or Pantopaque into the feeding vessels and into the interstices of the malformation [18].
• An experimental evaluation of response to contrast media: Pantopaque, iopamidol, and iohexol in the subarachnoid space [8].
• The possibility that prophylactic intrathecal injections of methylprednisolone acetate while performing Pantopaque myelography help avoid serious complications is discussed [19].

Gene context of IOPHENDYLATE

• Also described is the behavior of this contrast material when using in vitro imaging data obtained from a CSF/Pantopaque phantom [20].
• Histological studies and CSF analyses show that it is much less irriating than Pantopaque [21].

Analytical, diagnostic and therapeutic context of IOPHENDYLATE

• This technique is reliable and offers advantages over Pantopaque and/or gas myelography [22].
• Only 13% of a control group of 15 renal cysts which were percutaneously punctured but did not have Pantopaque instilled showed a 50% or more decrease in cyst volume [23].
• After 126 myelographies or cisternographies with ioglunide, routine electroencephalograms (EEG) and brain potential frequency analyses were performed in 109 and 73 patients, respectively [24].
• However, CT revealed an intrathecal collection of iophendylate (Pantopaque), which was subsequently removed via a lumbar puncture [25].
• Fluoroscopy during the procedure revealed diffuse residual intrathecal iophendylate (Pantopaque) dye [26].

References