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Gene Review

Icam5  -  intercellular adhesion molecule 5,...

Mus musculus

Synonyms: CD50, ICAM-3, ICAM-5, Icam3, Intercellular adhesion molecule 5, ...
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Disease relevance of Icam5

  • To investigate the fate of ICAM-5 during focal brain injury, we induced hypoxia-ischemia (HI) damage in adult mice by right common carotid artery ligation followed by hypoxia [1].
  • In addition to binding human immunodeficiency virus (HIV), this type II membrane protein binds with high affinity to the adhesion molecules ICAM-3 and -2 to promote important dendritic cell interactions with naive T cells and endothelial cells, respectively [2].
  • At high doses SR 95195 induced clonic seizures in mice (threshold convulsant dose: 150 mg kg-1; CD50: 160 mg kg-1 i.p.) which were antagonized by Ro 15-1788 [3].
  • Ehrlich ascites tumour cells grown in mice have a cell-surface trypsin-like neutral protease (TLNP) which is not inhibited by high-mol.-wt inhibitors of trypsin [4].
  • The percentage of animals rendered cataleptic by administration of either GABA uptake inhibitor was reduced by treatment for as few as 4 days and treatment with SKF(R)-89976A for 14 days resulted in a 4-fold increase in the CD50 for induction of catalepsy [5].

Psychiatry related information on Icam5


High impact information on Icam5

  • This third ligand, designated ICAM-3 based on its functional relatedness to ICAM-1 and -2, is a highly glycosylated protein of 124,000 Mr. It is well expressed on all leukocytes and absent from endothelial cells [8].
  • An ICAM-related neuronal glycoprotein, telencephalin, with brain segment-specific expression [9].
  • TLN is an example of a dendrite-associated cell adhesion molecule involved in the brain's segmental organization, cell-cell interactions during dendritic development, and maintenance of functional neuronal networks [9].
  • Telencephalin (TLN) is a 130 kd glycoprotein expressed exclusively in neurons of the telencephalon, the most rostral brain segment [9].
  • The structural similarity of TLN with ICAMs provides a new and strong link between immunoglobulin superfamily molecules in the nervous and immune systems [9].

Chemical compound and disease context of Icam5


Biological context of Icam5

  • The loss of Icam3 in rodent genomes might be relevant for rodent-specific properties of the T-cell-mediated immune response [14].
  • The Tlcn gene spanned about 6.3 kb and consisted of 11 exons [15].
  • A conserved amino acid motif including residues E37 and T38 form an integrin binding site (IBS) in ICAM-3 [16].
  • Point mutation of Ser(487), Ser(489), and Ser(496) to alanine in the juxtamembrane region of ICAM-3 significantly impaired both ERM binding and polarization of ICAM-3 [17].
  • Almost the same ICAM gene clusters were found in rodent genome, but only the ICAM-3 was not present [18].

Anatomical context of Icam5


Associations of Icam5 with chemical compounds

  • The intercellular adhesion molecule-3 (ICAM-3) is a counter receptor for the integrin LFA-1 that supports cell-cell adhesion dependent functions [16].
  • Protein-protein binding assays demonstrated a phosphatidylinositol 4,5-bisphosphate-induced association between ICAM-3 and the amino-terminal domain of ERM proteins [17].
  • Our results underscore the key role of specific serine residues within the cytoplasmic region of ICAM-3 for its ERM-directed positioning at the trailing edge of motile lymphocytes [17].
  • The CD50 of 7.0 mg/kg i.v. falls between that of picrotoxin and pentylenetetrazol [21].
  • (-)Nicotine was the most potent agonist tested, with a CD50 of 7.9 X 10(-9) mol [22].

Physical interactions of Icam5


Regulatory relationships of Icam5

  • Six out of nine ICAM-3 Mab described blocked the interaction with LFA-1 to varying degrees [16].

Other interactions of Icam5

  • Genomic organization and chromosomal localization of the mouse telencephalin gene, a neuronal member of the ICAM family [15].
  • This motif has also been shown to function as an IBS in ICAM-3 and VCAM-1 and hence many form a common site of contact in all CAMs of this type [16].
  • Pretreatment with anti-LFA-1 antibodies before HI injury or LFA-1 receptor knockout mice with HI injury had markedly reduced levels of serum ICAM-5 [1].
  • This residue, Q75, is predicted to locate in a model of ICAM-3 to the same site as RGD in the immunoglobulin-like domain of fibronectin that binds several integrins [16].

Analytical, diagnostic and therapeutic context of Icam5


  1. Release of the neuronal glycoprotein ICAM-5 in serum after hypoxic-ischemic injury. Guo, H., Tong, N., Turner, T., Epstein, L.G., McDermott, M.P., Kilgannon, P., Gelbard, H.A. Ann. Neurol. (2000) [Pubmed]
  2. Molecular characterization of the murine SIGNR1 gene encoding a C-type lectin homologous to human DC-SIGN and DC-SIGNR. Parent, S.A., Zhang, T., Chrebet, G., Clemas, J.A., Figueroa, D.J., Ky, B., Blevins, R.A., Austin, C.P., Rosen, H. Gene (2002) [Pubmed]
  3. A 7-phenyl substituted triazolopyridazine has inverse agonist activity at the benzodiazepine receptor site. Biziere, K., Bourguignon, J.J., Chambon, J.P., Heaulme, M., Perio, A., Tebib, S., Wermuth, C.G. Br. J. Pharmacol. (1987) [Pubmed]
  4. beta-Naphthylamidase activity of the cell surface of ehrlich ascites cells. Reversible control of enzyme activity by metal ions and thiols. Short, A.K., Steven, F.S., Griffin, M.M., Itzhaki, S. Br. J. Cancer (1981) [Pubmed]
  5. Biochemical and behavioral studies following subchronic administration of GABA uptake inhibitors in mice. Karbon, E.W., Enna, S.J., Ferkany, J.W. Neuropharmacology (1991) [Pubmed]
  6. Seizure susceptibility in DBA and C57 mice: the effects of various convulsants. Engstrom, F.L., Woodbury, D.M. Epilepsia (1988) [Pubmed]
  7. Decreased susceptibility to local anesthetics-induced convulsions after paradoxical sleep deprivation. Vale, N.B., Leite, J.R. Psychopharmacology (Berl.) (1988) [Pubmed]
  8. Intercellular adhesion molecule 3, a third adhesion counter-receptor for lymphocyte function-associated molecule 1 on resting lymphocytes. de Fougerolles, A.R., Springer, T.A. J. Exp. Med. (1992) [Pubmed]
  9. An ICAM-related neuronal glycoprotein, telencephalin, with brain segment-specific expression. Yoshihara, Y., Oka, S., Nemoto, Y., Watanabe, Y., Nagata, S., Kagamiyama, H., Mori, K. Neuron (1994) [Pubmed]
  10. Further studies on anti- and proconvulsant effects of inhibitors of nitric oxide synthase in rodents. Alexander, C.B., Ellmore, T.M., Kokate, T.G., Kirkby, R.D. Eur. J. Pharmacol. (1998) [Pubmed]
  11. Proconvulsant and anticonvulsant effects of Evans blue dye in rodents. Dürmüller, N., Smith, S.E., Meldrum, B.S. Neuroreport (1993) [Pubmed]
  12. The role of nitric oxide in chemically- and electrically-induced seizures in mice. Przegaliñski, E., Baran, L., Siwanowicz, J. Neurosci. Lett. (1996) [Pubmed]
  13. Acute toxicity (LD50 and CD50) of lidocaine and prilocaine in combination with adrenaline and felypressin. Volpato, M.C., Ranali, J., Amaral, I.M., Demetrio, C.G., Chalita, L.V. Indian journal of dental research : official publication of Indian Society for Dental Research. (1999) [Pubmed]
  14. Comparative human-mouse-rat sequence analysis of the ICAM gene cluster on HSA 19p13.2 and a 185-kb porcine region from SSC 2q. Leeb, T., Müller, M. Gene (2004) [Pubmed]
  15. Genomic organization and chromosomal localization of the mouse telencephalin gene, a neuronal member of the ICAM family. Sugino, H., Yoshihara, Y., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Mori, K. Genomics (1997) [Pubmed]
  16. LFA-1 binding site in ICAM-3 contains a conserved motif and non-contiguous amino acids. Sadhu, C., Lipsky, B., Erickson, H.P., Hayflick, J., Dick, K.O., Gallatin, W.M., Staunton, D.E. Cell Adhes. Commun. (1994) [Pubmed]
  17. A novel serine-rich motif in the intercellular adhesion molecule 3 is critical for its ezrin/radixin/moesin-directed subcellular targeting. Serrador, J.M., Vicente-Manzanares, M., Calvo, J., Barreiro, O., Montoya, M.C., Schwartz-Albiez, R., Furthmayr, H., Lozano, F., Sánchez-Madrid, F. J. Biol. Chem. (2002) [Pubmed]
  18. ICAM-3, a ligand for DC-SIGN, was duplicated from ICAM-1 in mammalian evolution, but was lost in the rodent genome. Sugino, H. FEBS Lett. (2005) [Pubmed]
  19. A novel phenylalanine-based targeting signal directs telencephalin to neuronal dendrites. Mitsui, S., Saito, M., Hayashi, K., Mori, K., Yoshihara, Y. J. Neurosci. (2005) [Pubmed]
  20. Dendrite-associated cell adhesion molecule, telencephalin, promotes neurite outgrowth in mouse embryo. Tamada, A., Yoshihara, Y., Mori, K. Neurosci. Lett. (1998) [Pubmed]
  21. Reduction of gamma-aminobutyric acid (GABA)-mediated transmission by a convulsant benzodiazepine. Schlosser, W., Franco, S. J. Pharmacol. Exp. Ther. (1979) [Pubmed]
  22. Mediation of nicotine-induced convulsions by central nicotinic receptors of the 'C6' type. Caulfield, M.P., Higgins, G.A. Neuropharmacology (1983) [Pubmed]
  23. Epitope mapping and functional properties of anti-intercellular adhesion molecule-3 (CD50) monoclonal antibodies. Bossy, D., Buckley, C.D., Holness, C.L., Littler, A.J., Murray, N., Collins, I., Simmons, D.L. Eur. J. Immunol. (1995) [Pubmed]
  24. Nitrous oxide antagonizes CNS stimulation by laudanosine in mice. Avramov, M.N., Mori, K. British journal of anaesthesia. (1990) [Pubmed]
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