The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

KISS1  -  KiSS-1 metastasis-suppressor

Homo sapiens

Synonyms: HH13, KiSS-1, Kisspeptin-1, Metastasis-suppressor KiSS-1, PP5098
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of KISS1


High impact information on KISS1


Chemical compound and disease context of KISS1


Biological context of KISS1


Anatomical context of KISS1

  • Overexpression of AP-2alpha into highly metastatic breast cell lines did not alter KiSS-1 promoter-driven luciferase gene activity [13].
  • These transcriptional expression profiles are in favor of a predominant role of INSL4, KiSS-1 and KiSS-1R in the control of the invasive and migratory properties of trophoblast cells [3].
  • To further study the role of GPR54 signaling in the onset of primate puberty, we used the monkey to examine the ability of kisspeptin-10 to elicit the release of gonadotropin-releasing hormone (GnRH) precociously, and we describe the expression of GPR54 and KiSS-1 in the hypothalamus during the peripubertal period [8].
  • Parental, vector-only transfectants and KiSS-1 transfectant clones were injected into the mammary fat pads of athymic nude mice and assessed for tumor growth and spontaneous metastasis to regional lymph nodes and lungs [12].
  • We observed complete loss of KiSS-1 in all invasive tumors under study as compared to their respective normal urothelium [14].

Associations of KISS1 with chemical compounds

  • Kisspeptin administration evoked robust LH and testosterone bursts and enhanced postgonadectomy LH concentrations, despite prevailing attenuation of gonadotropic axis in diabetic animals [15].
  • We propose that photoperiod, via melatonin, modulates KiSS-1 signaling to drive the reproductive axis [16].
  • Expression of hypothalamic KiSS-1 system and rescue of defective gonadotropic responses by kisspeptin in streptozotocin-induced diabetic male rats [15].
  • The excitatory neuronal systems most prevalently involved in this process use glutamate and the peptide kisspeptin for neurotransmission/neuromodulation, whereas the most important inhibitory inputs are provided by gamma-aminobutyric acid (GABA)ergic and opiatergic neurons [17].
  • The pattern of distribution of kp10 immunoreactivity in the hypothalamus suggests a role for kisspeptin in the estrogen-dependent regulation of GnRH and LH secretion in the ewe [18].

Physical interactions of KISS1

  • Although MMP-9 expression is regulated by AP-1, Sp1, and Ets transcription factors, KiSS-1 did not alter the binding of these factors to the MMP-9 promoter [19].

Regulatory relationships of KISS1

  • CRSP3 transfectant cells had up-regulated KISS1 and TXNIP expression and were suppressed for metastasis [1].
  • Furthermore, we demonstrated that AP-2alpha directly interacted with Sp1 to form transcription complexes at two tandem Sp1-binding sites of the promoter to activate KiSS-1 transcription [13].
  • We demonstrate that KiSS-1 expression is regulated by Sp1 elements within the first 100-bp region of the KiSS-1 promoter and that targeted deletion of a single GC-rich region spanning -93 to -58 interrupts Sp1- and DRIP-130-modulated transcriptional control of KiSS-1 expression [20].

Other interactions of KISS1


Analytical, diagnostic and therapeutic context of KISS1


  1. Melanoma metastasis suppression by chromosome 6: evidence for a pathway regulated by CRSP3 and TXNIP. Goldberg, S.F., Miele, M.E., Hatta, N., Takata, M., Paquette-Straub, C., Freedman, L.P., Welch, D.R. Cancer Res. (2003) [Pubmed]
  2. Reduced metastasis-suppressor gene mRNA-expression in breast cancer brain metastases. Stark, A.M., Tongers, K., Maass, N., Mehdorn, H.M., Held-Feindt, J. J. Cancer Res. Clin. Oncol. (2005) [Pubmed]
  3. Transcriptional expression of genes involved in cell invasion and migration by normal and tumoral trophoblast cells. Janneau, J.L., Maldonado-Estrada, J., Tachdjian, G., Miran, I., Motté, N., Saulnier, P., Sabourin, J.C., Coté, J.F., Simon, B., Frydman, R., Chaouat, G., Bellet, D. J. Clin. Endocrinol. Metab. (2002) [Pubmed]
  4. Two novel missense mutations in g protein-coupled receptor 54 in a patient with hypogonadotropic hypogonadism. Semple, R.K., Achermann, J.C., Ellery, J., Farooqi, I.S., Karet, F.E., Stanhope, R.G., O'rahilly, S., Aparicio, S.A. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  5. Hypertrophy and increased kisspeptin gene expression in the hypothalamic infundibular nucleus of postmenopausal women and ovariectomized monkeys. Rometo, A.M., Krajewski, S.J., Voytko, M.L., Rance, N.E. J. Clin. Endocrinol. Metab. (2007) [Pubmed]
  6. Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor. Ohtaki, T., Shintani, Y., Honda, S., Matsumoto, H., Hori, A., Kanehashi, K., Terao, Y., Kumano, S., Takatsu, Y., Masuda, Y., Ishibashi, Y., Watanabe, T., Asada, M., Yamada, T., Suenaga, M., Kitada, C., Usuki, S., Kurokawa, T., Onda, H., Nishimura, O., Fujino, M. Nature (2001) [Pubmed]
  7. KiSS-1, a novel human malignant melanoma metastasis-suppressor gene. Lee, J.H., Miele, M.E., Hicks, D.J., Phillips, K.K., Trent, J.M., Weissman, B.E., Welch, D.R. J. Natl. Cancer Inst. (1996) [Pubmed]
  8. Increased hypothalamic GPR54 signaling: a potential mechanism for initiation of puberty in primates. Shahab, M., Mastronardi, C., Seminara, S.B., Crowley, W.F., Ojeda, S.R., Plant, T.M. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  9. KiSS1 suppresses metastasis in human ovarian cancer via inhibition of protein kinase C alpha. Jiang, Y., Berk, M., Singh, L.S., Tan, H., Yin, L., Powell, C.T., Xu, Y. Clin. Exp. Metastasis (2005) [Pubmed]
  10. AXOR12, a novel human G protein-coupled receptor, activated by the peptide KiSS-1. Muir, A.I., Chamberlain, L., Elshourbagy, N.A., Michalovich, D., Moore, D.J., Calamari, A., Szekeres, P.G., Sarau, H.M., Chambers, J.K., Murdock, P., Steplewski, K., Shabon, U., Miller, J.E., Middleton, S.E., Darker, J.G., Larminie, C.G., Wilson, S., Bergsma, D.J., Emson, P., Faull, R., Philpott, K.L., Harrison, D.C. J. Biol. Chem. (2001) [Pubmed]
  11. Loss of expression of the metastasis suppressor gene KiSS1 during melanoma progression and its association with LOH of chromosome 6q16.3-q23. Shirasaki, F., Takata, M., Hatta, N., Takehara, K. Cancer Res. (2001) [Pubmed]
  12. Suppression of metastasis in human breast carcinoma MDA-MB-435 cells after transfection with the metastasis suppressor gene, KiSS-1. Lee, J.H., Welch, D.R. Cancer Res. (1997) [Pubmed]
  13. Regulation of KiSS-1 metastasis suppressor gene expression in breast cancer cells by direct interaction of transcription factors activator protein-2alpha and specificity protein-1. Mitchell, D.C., Abdelrahim, M., Weng, J., Stafford, L.J., Safe, S., Bar-Eli, M., Liu, M. J. Biol. Chem. (2006) [Pubmed]
  14. Tumor suppressor role of KiSS-1 in bladder cancer: loss of KiSS-1 expression is associated with bladder cancer progression and clinical outcome. Sanchez-Carbayo, M., Capodieci, P., Cordon-Cardo, C. Am. J. Pathol. (2003) [Pubmed]
  15. Expression of hypothalamic KiSS-1 system and rescue of defective gonadotropic responses by kisspeptin in streptozotocin-induced diabetic male rats. Castellano, J.M., Navarro, V.M., Fernández-Fernández, R., Roa, J., Vigo, E., Pineda, R., Dieguez, C., Aguilar, E., Pinilla, L., Tena-Sempere, M. Diabetes (2006) [Pubmed]
  16. Kisspeptin mediates the photoperiodic control of reproduction in hamsters. Revel, F.G., Saboureau, M., Masson-Pévet, M., Pévet, P., Mikkelsen, J.D., Simonneaux, V. Curr. Biol. (2006) [Pubmed]
  17. Minireview: the neuroendocrine regulation of puberty: is the time ripe for a systems biology approach? Ojeda, S.R., Lomniczi, A., Mastronardi, C., Heger, S., Roth, C., Parent, A.S., Matagne, V., Mungenast, A.E. Endocrinology (2006) [Pubmed]
  18. Kisspeptin immunoreactive cells of the ovine preoptic area and arcuate nucleus co-express estrogen receptor alpha. Franceschini, I., Lomet, D., Cateau, M., Delsol, G., Tillet, Y., Caraty, A. Neurosci. Lett. (2006) [Pubmed]
  19. KiSS-1 represses 92-kDa type IV collagenase expression by down-regulating NF-kappa B binding to the promoter as a consequence of Ikappa Balpha -induced block of p65/p50 nuclear translocation. Yan, C., Wang, H., Boyd, D.D. J. Biol. Chem. (2001) [Pubmed]
  20. Transcriptional regulation of KiSS-1 gene expression in metastatic melanoma by specificity protein-1 and its coactivator DRIP-130. Mitchell, D.C., Stafford, L.J., Li, D., Bar-Eli, M., Liu, M. Oncogene (2007) [Pubmed]
  21. KISS1 metastasis suppression and emergent pathways. Harms, J.F., Welch, D.R., Miele, M.E. Clin. Exp. Metastasis (2003) [Pubmed]
  22. Chromosome localization and genomic structure of the KiSS-1 metastasis suppressor gene (KISS1). West, A., Vojta, P.J., Welch, D.R., Weissman, B.E. Genomics (1998) [Pubmed]
  23. Downregulation of KiSS-1 expression is responsible for tumor invasion and worse prognosis in gastric carcinoma. Dhar, D.K., Naora, H., Kubota, H., Maruyama, R., Yoshimura, H., Tonomoto, Y., Tachibana, M., Ono, T., Otani, H., Nagasue, N. Int. J. Cancer (2004) [Pubmed]
WikiGenes - Universities