Gene Review:
ICOS - inducible T-cell co-stimulator
Homo sapiens
Synonyms:
AILIM, Activation-inducible lymphocyte immunomediatory molecule, CD278, CVID1, Inducible T-cell costimulator
Kroczek,
Hamelmann,
Adeniyi,
Akalin,
Dikman,
Murphy,
Bromberg,
Hancock,
Schmidt,
Rakocevic,
Raju,
Dalakas,
Okamoto,
Saito,
Yamanaka,
Tomatsu,
Kamatani,
Ogiuchi,
Uchiyama,
Yagi,
Sakamoto,
Tezuka,
Tsuji,
Hori,
Tamatani,
Yoshinaga,
Whoriskey,
Khare,
Sarmiento,
Guo,
Horan,
Shih,
Zhang,
Coccia,
Kohno,
Tafuri-Bladt,
Brankow,
Campbell,
Chang,
Chiu,
Dai,
Duncan,
Elliott,
Hui,
McCabe,
Scully,
Shahinian,
Shaklee,
Van,
Mak,
Senaldi,
- Evidence for unique association signals in SLE at the CD28-CTLA4-ICOS locus in a family-based study. Graham, D.S., Wong, A.K., McHugh, N.J., Whittaker, J.C., Vyse, T.J. Hum. Mol. Genet. (2006)
- The diabetes susceptibility locus Idd5.1 on mouse chromosome 1 regulates ICOS expression and modulates murine experimental autoimmune encephalomyelitis. Greve, B., Vijayakrishnan, L., Kubal, A., Sobel, R.A., Peterson, L.B., Wicker, L.S., Kuchroo, V.K. J. Immunol. (2004)
- Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency. Grimbacher, B., Hutloff, A., Schlesier, M., Glocker, E., Warnatz, K., Dräger, R., Eibel, H., Fischer, B., Schäffer, A.A., Mages, H.W., Kroczek, R.A., Peter, H.H. Nat. Immunol. (2003)
- Hyperexpression of inducible costimulator and its contribution on lamina propria T cells in inflammatory bowel disease. Sato, T., Kanai, T., Watanabe, M., Sakuraba, A., Okamoto, S., Nakai, T., Okazawa, A., Inoue, N., Totsuka, T., Yamazaki, M., Kroczek, R.A., Fukushima, T., Ishii, H., Hibi, T. Gastroenterology (2004)
- Tadalafil, a further innovation in the treatment of sexual dysfunction. Pomerol, J.M., Rabasseda, X. Drugs of today (Barcelona, Spain : 1998) (2003)
- ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28. Hutloff, A., Dittrich, A.M., Beier, K.C., Eljaschewitsch, B., Kraft, R., Anagnostopoulos, I., Kroczek, R.A. Nature (1999)
- T-cell co-stimulation through B7RP-1 and ICOS. Yoshinaga, S.K., Whoriskey, J.S., Khare, S.D., Sarmiento, U., Guo, J., Horan, T., Shih, G., Zhang, M., Coccia, M.A., Kohno, T., Tafuri-Bladt, A., Brankow, D., Campbell, P., Chang, D., Chiu, L., Dai, T., Duncan, G., Elliott, G.S., Hui, A., McCabe, S.M., Scully, S., Shahinian, A., Shaklee, C.L., Van, G., Mak, T.W., Senaldi, G. Nature (1999)
- American Urological Association--94th annual meeting. 1-6 May 1999, Dallas, USA. Adeniyi, A. IDrugs : the investigational drugs journal. (1999)
- Signatures of strong population differentiation shape extended haplotypes across the human CD28, CTLA4, and ICOS costimulatory genes. Butty, V., Roy, M., Sabeti, P., Besse, W., Benoist, C., Mathis, D. Proc. Natl. Acad. Sci. U.S.A. (2007)
- Modulation of TCR-induced transcriptional profiles by ligation of CD28, ICOS, and CTLA-4 receptors. Riley, J.L., Mao, M., Kobayashi, S., Biery, M., Burchard, J., Cavet, G., Gregson, B.P., June, C.H., Linsley, P.S. Proc. Natl. Acad. Sci. U.S.A. (2002)
- Induction, binding specificity and function of human ICOS. Beier, K.C., Hutloff, A., Dittrich, A.M., Heuck, C., Rauch, A., Büchner, K., Ludewig, B., Ochs, H.D., Mages, H.W., Kroczek, R.A. Eur. J. Immunol. (2000)
- ICOS cooperates with CD28, IL-2, and IFN-gamma and modulates activation of human na??ve CD4(+) T cells. Mesturini, R., Nicola, S., Chiocchetti, A., Bernardone, I.S., Castelli, L., Bensi, T., Ferretti, M., Comi, C., Dong, C., Rojo, J.M., Yagi, J., Dianzani, U. Eur. J. Immunol. (2006)
- Eminent role of ICOS costimulation for T cells interacting with plasmacytoid dendritic cells. Janke, M., Witsch, E.J., Mages, H.W., Hutloff, A., Kroczek, R.A. Immunology (2006)
- Expression and function of the co-stimulator H4/ICOS on activated T cells of patients with rheumatoid arthritis. Okamoto, T., Saito, S., Yamanaka, H., Tomatsu, T., Kamatani, N., Ogiuchi, H., Uchiyama, T., Yagi, J. J. Rheumatol. (2003)
- Structural basis of inducible costimulator ligand costimulatory function: determination of the cell surface oligomeric state and functional mapping of the receptor binding site of the protein. Chattopadhyay, K., Bhatia, S., Fiser, A., Almo, S.C., Nathenson, S.G. J. Immunol. (2006)
- AILIM/ICOS-mediated elongation of activated T cells is regulated by both the PI3-kinase/Akt and Rho family cascade. Nukada, Y., Okamoto, N., Konakahara, S., Tezuka, K., Ohashi, K., Mizuno, K., Tsuji, T. Int. Immunol. (2006)
- Upregulated inducible co-stimulator (ICOS) and ICOS-ligand in inclusion body myositis muscle: significance for CD8+ T cell cytotoxicity. Schmidt, J., Rakocevic, G., Raju, R., Dalakas, M.C. Brain (2004)
- Amgen redux: ICOS Corporation. Wells, W.A. Chem. Biol. (1999)
- PI3-kinase and MAP-kinase signaling cascades in AILIM/ICOS- and CD28-costimulated T-cells have distinct functions between cell proliferation and IL-10 production. Okamoto, N., Tezuka, K., Kato, M., Abe, R., Tsuji, T. Biochem. Biophys. Res. Commun. (2003)
- ICOS costimulation requires IL-2 and can be prevented by CTLA-4 engagement. Riley, J.L., Blair, P.J., Musser, J.T., Abe, R., Tezuka, K., Tsuji, T., June, C.H. J. Immunol. (2001)
- ICOS-induced B7h shedding on B cells is inhibited by TLR7/8 and TLR9. Logue, E.C., Bakkour, S., Murphy, M.M., Nolla, H., Sha, W.C. J. Immunol. (2006)
- AILIM/ICOS: its expression and functional analysis with monoclonal antibodies. Sakamoto, S., Tezuka, K., Tsuji, T., Hori, N., Tamatani, T. Hybrid. Hybridomics (2001)
- Characterization of human inducible costimulator ligand expression and function. Aicher, A., Hayden-Ledbetter, M., Brady, W.A., Pezzutto, A., Richter, G., Magaletti, D., Buckwalter, S., Ledbetter, J.A., Clark, E.A. J. Immunol. (2000)
- Glomerular infiltration by CXCR3+ ICOS+ activated T cells in chronic allograft nephropathy with transplant glomerulopathy. Akalin, E., Dikman, S., Murphy, B., Bromberg, J.S., Hancock, W.W. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. (2003)
- Program death-1 engagement upon TCR activation has distinct effects on costimulation and cytokine-driven proliferation: attenuation of ICOS, IL-4, and IL-21, but not CD28, IL-7, and IL-15 responses. Bennett, F., Luxenberg, D., Ling, V., Wang, I.M., Marquette, K., Lowe, D., Khan, N., Veldman, G., Jacobs, K.A., Valge-Archer, V.E., Collins, M., Carreno, B.M. J. Immunol. (2003)
- T-cell costimulatory molecules: optimal targets for the treatment of allergic airway disease with monoclonal antibodies. Kroczek, R., Hamelmann, E. J. Allergy Clin. Immunol. (2005)
- Inducible CO-stimulator molecule, a candidate gene for defective isotype switching, is normal in patients with hyper-IgM syndrome of unknown molecular diagnosis. Lee, W.I., Zhu, Q., Gambineri, E., Jin, Y., Welcher, A.A., Ochs, H.D. J. Allergy Clin. Immunol. (2003)
- Endothelial inducible costimulator ligand expression is increased during human cardiac allograft rejection and regulates endothelial cell-dependent allo-activation of CD8+ T cells in vitro. Klingenberg, R., Autschbach, F., Gleissner, C., Giese, T., Wambsganss, N., Sommer, N., Richter, G., Katus, H.A., Dengler, T.J. Eur. J. Immunol. (2005)