The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

SureCN880     4-hydroxy-4-methyl-oxan-2-one

Synonyms: Divalonic acid, AGN-PC-0069K3, AG-K-69990, BSPBio_000740, M4667_SIGMA, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Mevalonic acid lactone


High impact information on Mevalonic acid lactone


Chemical compound and disease context of Mevalonic acid lactone


Biological context of Mevalonic acid lactone


Anatomical context of Mevalonic acid lactone


Associations of Mevalonic acid lactone with other chemical compounds


Gene context of Mevalonic acid lactone

  • To investigate whether the Pex5(-/-) fetuses are able to synthesise their own isoprenoids, fibroblasts derived from these mice were incubated with radiolabeled mevalonolactone as a substrate for isoprenoid synthesis [19].
  • The incorporation of mevalonolactone into pregnenolone and its sulfate ester was time- and concentration-dependent and blocked by aminoglutethimide, a competitive inhibitor of cytochrome P450 side-chain cleavage (P450scc) enzyme [20].
  • Metabolic labeling of parathyroid cells with mevalonolactone demonstrated that DARPP-32 is isoprenylated [21].
  • After transection of nervus corporis allati 1 (NCA-1), the rate of mevalonolactone-stimulated JH synthesis was maintained at the preoperative levels although the spontaneous rate of JH biosynthesis decreased rapidly [22].

Analytical, diagnostic and therapeutic context of Mevalonic acid lactone


  1. Regulation of pregnenolone synthesis in C6-2B glioma cells by 4'-chlorodiazepam. Guarneri, P., Papadopoulos, V., Pan, B., Costa, E. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  2. Regulation of cholesterol 7 alpha-hydroxylase by hepatic 7 alpha-hydroxylated bile acid flux and newly synthesized cholesterol supply. Shefer, S., Nguyen, L.B., Salen, G., Ness, G.C., Tint, G.S., Batta, A.K., Hauser, S., Rani, I. J. Biol. Chem. (1991) [Pubmed]
  3. In vivo modulation of rat liver 3-hydroxy-3-methylglutaryl-coenzyme A reductase, reductase kinase, and reductase kinase kinase by mevalonolactone. Beg, Z.H., Stonik, J.A., Brewer, H.B. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  4. In vivo regulation of rat liver 3-hydroxy-3-methylglutaryl-coenzyme A reductase: enzyme phosphorylation as an early regulatory response after intragastric administration of mevalonolactone. Arebalo, R.E., Hardgrave, J.E., Noland, B.J., Scallen, T.J. Proc. Natl. Acad. Sci. U.S.A. (1980) [Pubmed]
  5. Suppression of autoimmune retinal disease by lovastatin does not require Th2 cytokine induction. Gegg, M.E., Harry, R., Hankey, D., Zambarakji, H., Pryce, G., Baker, D., Adamson, P., Calder, V., Greenwood, J. J. Immunol. (2005) [Pubmed]
  6. Feedback regulation of hepatic 3-hydroxy-3-methylglutaryl-CoA reductase activity by dietary cholesterol is not due to altered mRNA levels. Ness, G.C., Keller, R.K., Pendleton, L.C. J. Biol. Chem. (1991) [Pubmed]
  7. Bile acid synthesis. VI. Regulation of cholesterol 7 alpha-hydroxylase by taurocholate and mevalonate. Pandak, W.M., Vlahcevic, Z.R., Chiang, J.Y., Heuman, D.M., Hylemon, P.B. J. Lipid Res. (1992) [Pubmed]
  8. Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase. Ness, G.C. Mol. Cell. Biochem. (1983) [Pubmed]
  9. Rapid modulation of rat hepatocyte HMG-CoA reductase activity by cyclic AMP or cyclic GMP. Henneberg, R., Rodwell, V.W. Physiological chemistry and physics and medical NMR. (1985) [Pubmed]
  10. Lovastatin inhibits brain endothelial cell Rho-mediated lymphocyte migration and attenuates experimental autoimmune encephalomyelitis. Greenwood, J., Walters, C.E., Pryce, G., Kanuga, N., Beraud, E., Baker, D., Adamson, P. FASEB J. (2003) [Pubmed]
  11. HMG-CoA reductase inhibition aborts functional differentiation and triggers apoptosis in cultured primary human monocytes: a potential mechanism of statin-mediated vasculoprotection. Vamvakopoulos, J.E., Green, C. BMC cardiovascular disorders [electronic resource]. (2003) [Pubmed]
  12. Properties of purified rat hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase and regulation of enzyme activity. Edwards, P.A., Lemongello, D., Kane, J., Shechter, I., Fogelman, A.M. J. Biol. Chem. (1980) [Pubmed]
  13. Independent regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase and chylomicron remnant receptor activities in rat liver. Wade, D.P., Soutar, A.K., Gibbons, G.F. Biochem. J. (1984) [Pubmed]
  14. Improved methods for the study of hepatic HMG CoA reductase: one-step isolation of mevalonolactone and rapid preparation of endoplasmic reticulum. Goodwin, C.D., Margolis, S. J. Lipid Res. (1976) [Pubmed]
  15. Cholesterol depletion induces autophagy. Cheng, J., Ohsaki, Y., Tauchi-Sato, K., Fujita, A., Fujimoto, T. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  16. Isoprenoid biosynthesis in multiple sclerosis. Steen, G., Axelsson, H., Bowallius, M., Holthuis, N., Molander, B.M. Acta neurologica Scandinavica. (1985) [Pubmed]
  17. Control of 3-hydroxy-3-methylglutaryl coenzyme A reductase by endogenously synthesized sterols in vitro and in vivo. Edwards, P.A., Popják, G., Fogelman, A.M., Edmond, J. J. Biol. Chem. (1977) [Pubmed]
  18. Regulation of cholesterol synthesis in primary rat hepatocyte culture cells. Possible regulatory site at sterol demethylation. Havel, C., Hansbury, E., Scallen, T.J., Watson, J.A. J. Biol. Chem. (1979) [Pubmed]
  19. Isoprenoid biosynthesis is not compromised in a Zellweger syndrome mouse model. Vanhorebeek, I., Baes, M., Declercq, P.E. Biochim. Biophys. Acta (2001) [Pubmed]
  20. Neurosteroidogenesis in rat retinas. Guarneri, P., Guarneri, R., Cascio, C., Pavasant, P., Piccoli, F., Papadopoulos, V. J. Neurochem. (1994) [Pubmed]
  21. DARPP-32 (dopamine and cAMP-regulated phosphoprotein, M(r) 32,000) is a membrane protein in the bovine parathyroid. Matovcik, L.M., Hemmings, H.C., Kinder, B.K. FEBS Lett. (1995) [Pubmed]
  22. Evidence for regulation of juvenile hormone biosynthesis operating before mevalonate in locust corpora allata. Couillaud, F. Mol. Cell. Endocrinol. (1991) [Pubmed]
  23. Ethanol enhances de novo synthesis of high density lipoprotein cholesterol. Cluette, J.E., Mulligan, J.J., Noring, R., Doyle, K., Hojnacki, J. Proc. Soc. Exp. Biol. Med. (1984) [Pubmed]
  24. Adaptive changes in coenzyme Q biosynthesis to myocardial reperfusion in young and aged rats. Muscari, C., Biagetti, L., Stefanelli, C., Giordano, E., Guarnieri, C., Caldarera, C.M. J. Mol. Cell. Cardiol. (1995) [Pubmed]
  25. Feasibility of an immunoassay for mevalonolactone. Spencer, T.A., Clark, D.S., Johnson, G.A., Erickson, S.K., Curtiss, L.K. Bioorg. Med. Chem. (1997) [Pubmed]
  26. Determination of mevalonolactone in capsules by capillary gas-liquid chromatography. Lindemann, C.J., Singh, M.M., Ramjit, H.G., Bell, C., Ip, D.P. Journal of pharmaceutical and biomedical analysis. (1991) [Pubmed]
WikiGenes - Universities