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Chemical Compound Review

Bouin's fluid     ethanoic acid; methanal; 2,4,6-trinitrophenol

Synonyms: AC1L3XQJ, 37330-50-0, Bouin's solution, acetic acid; formaldehyde; picric acid
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Disease relevance of picric acid


High impact information on picric acid


Chemical compound and disease context of picric acid


Biological context of picric acid


Anatomical context of picric acid

  • An immunocytochemical technique has been developed for the identification in situ of immunoglobulin-producing cells in tissues fixed in Bouin's solution and embedded in paraffin [17].
  • On cryostat sections of fresh-frozen mammary tissue post-fixed in acetone, or on paraffin sections also from mammary tissue fixed in Bouin's solution, the MAb reacted preferentially with glandular epithelial cells and staining was restricted to the nuclei [18].
  • Fetuses were individually weighed, and two-thirds of them were fixed in Bouin's solution and examined for soft-tissue anomalies [19].
  • On Day 11, monkeys were castrated, and one-half of a testis was fixed in Bouin's fluid [20].
  • Serial sections (8-10 micron-thick) prepared from corpora lutea that had been fixed in Bouin's solution and embedded in paraffin were immunostained for neurophysin or oxytocin using the peroxidase-antiperoxidase (PAP) procedure [21].

Associations of picric acid with other chemical compounds


Gene context of picric acid


Analytical, diagnostic and therapeutic context of picric acid


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  2. Immunocytochemical localization of luteinizing hormone-releasing hormone (LHRH) in Vibratome-sectioned brain. Joseph, S.A., Piekut, D.T., Knigge, K.M. J. Histochem. Cytochem. (1981) [Pubmed]
  3. Comparative genomic hybridization study of paraffin-embedded dedifferentiated liposarcoma fixed with Holland Bouin's fluid. Hostein, I., Coindre, J.M., Derré, J., Mariani, O., Chibon, F., Aurias, A. Diagn. Mol. Pathol. (2003) [Pubmed]
  4. Antibodies to hepatocyte membrane antigens in chronic liver disease: detection by immunofluorescence after Bouin's fixation. Lee, W.M., Shelton, L.L., Galbraith, R.M. J. Histochem. Cytochem. (1983) [Pubmed]
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  12. Localization of secretory, membrane-associated and cytoskeletal proteins in rat testis using an improved immunocytochemical protocol that employs polyester wax. Oke, B.O., Suarez-Quian, C.A. Biol. Reprod. (1993) [Pubmed]
  13. Localization of 3 beta-hydroxysteroid dehydrogenase in the chicken ovarian follicle shifts from the theca layer to granulosa layer with follicular maturation. Nitta, H., Mason, J.I., Bahr, J.M. Biol. Reprod. (1993) [Pubmed]
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  15. Decidual sialylation shows species-specific differences in the pregnant mouse and rat. Jones, C.J., Kimber, S.J., Illingworth, I., Aplin, J.D. J. Reprod. Fertil. (1996) [Pubmed]
  16. Ontogenetic development of S-antigen- and rod-opsin immunoreactions in retinal and pineal photoreceptors of Xenopus laevis in relation to the onset of melatonin-dependent color-change mechanisms. Korf, B., Rollag, M.D., Korf, H.W. Cell Tissue Res. (1989) [Pubmed]
  17. Immunoglobulin-producing cells in the inflammatory infiltrates of cutaneous tumors. Immunocytologic identification in situ. Bustamante, R., Schmitt, D., Pillet, C., Thivolet, J. J. Invest. Dermatol. (1977) [Pubmed]
  18. Differential expression of isopeptide bonds N epsilon (gamma-glutamyl) lysine in benign and malignant human breast lesions: an immunohistochemical study. Roch, A.M., Noel, P., el Alaoui, S., Charlot, C., Quash, G. Int. J. Cancer (1991) [Pubmed]
  19. Comparative inhalation teratogenicity of four glycol ether solvents and an amino derivative in rats. Nelson, B.K., Setzer, J.V., Brightwell, W.S., Mathinos, P.R., Kuczuk, M.H., Weaver, T.E., Goad, P.T. Environ. Health Perspect. (1984) [Pubmed]
  20. Pulsatile stimulation with recombinant single chain human luteinizing hormone elicits precocious sertoli cell proliferation in the juvenile male rhesus monkey (Macaca mulatta). Ramaswamy, S., Plant, T.M., Marshall, G.R. Biol. Reprod. (2000) [Pubmed]
  21. Immunocytochemical localization of neurophysin and oxytocin in ovine corpora lutea. Sawyer, H.R., Moeller, C.L., Kozlowski, G.P. Biol. Reprod. (1986) [Pubmed]
  22. Determination of the specific gravity of human pineal. Bhatnagar, K.P., Veling, M., Ouseph, P.J., Nettleton, G.S. J. Pineal Res. (1991) [Pubmed]
  23. Regulation of laminin 1-induced pancreatic beta-cell differentiation by alpha6 integrin and alpha-dystroglycan. Jiang, F.X., Georges-Labouesse, E., Harrison, L.C. Mol. Med. (2001) [Pubmed]
  24. Evidence of gap junctions in the stable nonobstructed human bladder. John, H., Wang, X., Wehrli, E., Hauri, D., Maake, C. J. Urol. (2003) [Pubmed]
  25. Mitochondrial-dependent apoptosis in experimental rodent abdominal aortic aneurysms. Sinha, I., Sinha-Hikim, A.P., Hannawa, K.K., Henke, P.K., Eagleton, M.J., Stanley, J.C., Upchurch, G.R. Surgery (2005) [Pubmed]
  26. Light microscopy and computer three-dimensional reconstruction of the blood capillaries of the enamel organ of rat molar tooth germs. Cerri, P.S., de Faria, F.P., Villa, R.G., Katchburian, E. J. Anat. (2004) [Pubmed]
  27. Epidermal growth factor, transforming growth factor-alpha, and epidermal growth factor receptor localization in the baboon (Papio anubis) uterus during the menstrual cycle and early pregnancy. Slowey, M.J., Verhage, H.G., Fazleabas, A.T. J. Soc. Gynecol. Investig. (1994) [Pubmed]
  28. Distribution of phosphate-independent MAP2 epitopes revealed with monoclonal antibodies in microwave-denatured human nervous system tissues. Trojanowski, J.Q., Schuck, T., Schmidt, M.L., Lee, V.M. J. Neurosci. Methods (1989) [Pubmed]
  29. Detection of the synovial sarcoma translocation t(X;18) (SYT;SSX) in paraffin-embedded tissues using reverse transcriptase-polymerase chain reaction: a reliable and powerful diagnostic tool for pathologists. A molecular analysis of 221 mesenchymal tumors fixed in different fixatives. Guillou, L., Coindre, J., Gallagher, G., Terrier, P., Gebhard, S., de Saint Aubain Somerhausen, N., Michels, J., Jundt, G., Vince, D.R., Collin, F., Trassard, M., Le Doussal, V., Benhattar, J. Hum. Pathol. (2001) [Pubmed]
  30. Immunoblotting of keratin polypeptides extracted from tissues preserved in standard histologic fixatives. Clark, R.K., Damjanov, I. J. Histochem. Cytochem. (1986) [Pubmed]
  31. Oxytocin in baboon (Papio anubis) corpus luteum. Khan-Dawood, F.S. Biol. Reprod. (1987) [Pubmed]
  32. Hepatic membrane antibodies: studies of prevalence and specificity. Lee, W.M., Martin, K.L., Shelton, L.L., Galbraith, R.M. Clin. Exp. Immunol. (1985) [Pubmed]
  33. Immunocytochemical localization of nerve growth factor: effects of fixation. Hazen-Martin, D.J., Simson, J.A. J. Histochem. Cytochem. (1984) [Pubmed]
  34. Needle biopsy of testes: a safe outpatient procedure. Cohen, M.S., Warner, R.S. Urology (1987) [Pubmed]
  35. The importance of tissue fixation for light microscopic immunohistochemical localization of peroxisomal proteins: the superiority of Carnoy's fixative over Baker's formalin and Bouin's solution. Lehmann, T., Völkl, A., Fahimi, H.D. Histochem. Cell Biol. (1995) [Pubmed]
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