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Chemical Compound Review

Beclomet     [2-[ (8S,9S,10S,11S,13S,14S,16S,17R )-9...

Synonyms: Beconase, Vanceril, Aerobec, Aldecin, Beclazone, ...
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Disease relevance of Beconase


High impact information on Beconase


Chemical compound and disease context of Beconase


Biological context of Beconase


Anatomical context of Beconase


Associations of Beconase with other chemical compounds


Gene context of Beconase

  • Indirect assessments have shown a superior lung deposition of HFA-BDP (Ventolair/Qvar) compared to CFC-BDP (Aerobec) [23].
  • Mean (range) whole lung deposition of drug from the Respimat SMI (51.6 [46-57]% of the metered dose) was significantly (p < 0.001) greater than that from the Turbuhaler DPI used with both fast and slow inhaled flow rates (28.5 [24-33]% and 17.8 [14-22]%, respectively) or from the Becloforte pMDI (8.9 [6-12]%) [24].
  • The nasal application of beclomethasone diproprionate (Beconase) in allergic rhinitis [25].
  • In general, preschool children and infants should not be prescribed inhaled corticosteroids above 200 microg beclometasone dipropionate equivalent twice a day, or regular oral steroids, or long acting beta2-adrenoceptor agonists [26].
  • RESULTS: Respocort formulation produced the least post-dose mean maximum reduction in FEV1 (0.36 +/- 0.17 L; 14.3 +/- 7.2% of baseline FEV1), while the reduction caused by the control was similar (0.40 +/- 0.18 L; 16.2 +/- 9.9% of baseline FEV1) [27].

Analytical, diagnostic and therapeutic context of Beconase


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  2. Aqueous beclomethasone dipropionate in the treatment of ragweed pollen-induced rhinitis: further exploration of "as needed" use. Juniper, E.F., Guyatt, G.H., Archer, B., Ferrie, P.J. J. Allergy Clin. Immunol. (1993) [Pubmed]
  3. Oral beclometasone dipropionate in the treatment of active ulcerative colitis: a double-blind placebo-controlled study. Rizzello, F., Gionchetti, P., D'Arienzo, A., Manguso, F., Di Matteo, G., Annese, V., Valpiani, D., Casetti, T., Adamo, S., Prada, A., Castiglione, G.N., Varoli, G., Campieri, M. Aliment. Pharmacol. Ther. (2002) [Pubmed]
  4. Tracheo-bronchial mucin gene expression as detected by in situ hybridization. Verma, M., Blass, C., Davidson, E.A. Glycobiology (1996) [Pubmed]
  5. Contact dermatitis around a tracheostoma due to salbutamol sulfate and Aldecin. Tsuruta, D., Sowa, J., Kobayashi, H., Ishii, M. Contact Derm. (2006) [Pubmed]
  6. Beclometasone dipropionate/formoterol: in an HFA-propelled pressurised metered-dose inhaler. Dhillon, S., Keating, G.M. Drugs (2006) [Pubmed]
  7. Pharmacokinetic and pharmacodynamic properties of inhaled beclometasone dipropionate delivered via hydrofluoroalkane-containing devices. Derom, E., Pauwels, R.A. Clinical pharmacokinetics. (2005) [Pubmed]
  8. Oral beclometasone dipropionate in the treatment of extensive and left-sided active ulcerative colitis: a multicentre randomised study. Campieri, M., Adamo, S., Valpiani, D., D'Arienzo, A., D'Albasio, G., Pitzalis, M., Cesari, P., Casetti, T., Castiglione, G.N., Rizzello, F., Manguso, F., Varoli, G., Gionchetti, P. Aliment. Pharmacol. Ther. (2003) [Pubmed]
  9. A comparison of 2 extrafine hydrofluoroalkane-134a-beclomethasone formulations on methacholine hyperresponsiveness. Fardon, T.C., Burns, P., Barnes, M.L., Lipworth, B.J. Ann. Allergy Asthma Immunol. (2006) [Pubmed]
  10. Clinical management of bronchial asthma with inhaled high-dose beclomethasone dipropionate (Beclomet 250--Orion). Duţu, S., Stoicescu, P., Bistriceanu, G., Bîscă, N., Popescu, O. Pneumoftiziologia : revista Societătii Române de Pneumoftiziologie / [Societatea Română de Pneumoftiziologie]. (1991) [Pubmed]
  11. Flunisolide (Syntaris) and beclomethasone (Beconase) in the treatment of non-allergic eosinophilic rhinitis. Zawisza, E., Samoliński, B., Swierczyński, Z. Pneumonologia i alergologia polska : organ Polskiego Towarzystwa Ftyzjopneumonologicznego, Polskiego Towarzystwa Alergologicznego, i Instytutu Gruźlicy i Chorób Płuc. (1992) [Pubmed]
  12. The response of two different dosages of beclometasone dipropionate suspension for nebulization versus a standard dose of beclometasone dipropionate via a metered-dose inhaler on bronchoprovocation testing in adults with asthma. Bousquet, J., Meziane, H., Chanez, P., Mueser, M., Umile, A. Respiratory medicine. (2003) [Pubmed]
  13. Comparison of the bioavailability and systemic effects of beclometasone dipropionate suspension for nebulization and beclometasone dipropionate via a metered-dose inhaler after single-dose administration in healthy male volunteers. Poli, G., Acerbi, D. Respiratory medicine. (2003) [Pubmed]
  14. Deep-inspiration induced bronchoconstriction: a mechanism for beclomethasone aerosol intolerance. Charpin, D., Beaupre, A., Orehek, J. European journal of respiratory diseases. (1983) [Pubmed]
  15. Reservoir design and dose availability with long-term metered dose inhaler corticosteroid use. Rau, J.L., Zhu, Y. Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine. (1998) [Pubmed]
  16. Morphogenic mechanisms in the development of ethmoidal sinuses. Monteiro, V.J., Dias, M.P. Anat. Rec. (1997) [Pubmed]
  17. Surgical anatomy of the turbinal wall of the ethmoidal labyrinth. Bodino, C., Jankowski, R., Grignon, B., Jimenez-Chobillon, A., Braun, M. Rhinology. (2004) [Pubmed]
  18. An in-vitro assessment of a NanoCrystal beclomethasone dipropionate colloidal dispersion via ultrasonic nebulization. Ostrander, K.D., Bosch, H.W., Bondanza, D.M. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V. (1999) [Pubmed]
  19. Evaluating the delivery of nebulized and metered-dose inhalers in an in vitro infant ventilator lung model. Avent, M.L., Gal, P., Ransom, J.L., Brown, Y.L., Hansen, C.J., Ricketts, W.A., Soza, F. The Annals of pharmacotherapy. (1999) [Pubmed]
  20. Comparison of the efficacy and safety of high doses of beclometasone dipropionate suspension for nebulization and beclometasone dipropionate via a metered-dose inhaler in steroid-dependent adults with moderate to severe asthma. Grzelewska-Rzymowska, I., Kroczynska-Bednarek, J., Zarkovic, J. Respiratory medicine. (2003) [Pubmed]
  21. Clinical efficacy and safety of beclomethasone dipropionate inhalation capsules inhaled by Cyclohaler compared with Becotide Rotacaps inhaled by Rotahaler. Vink-van Wijngaarden, T., Blom-Ross, M.E., Lansdorp, D., Goedhart, D.M., Eelhart, J., Guelen, P.J., de Vos, D. International journal of clinical pharmacology and therapeutics. (1998) [Pubmed]
  22. Bronchial asthma showing reduction in FEV1 after inhalation of Qvar. Nobata, K., Fujimura, M., Myou, S., Ishiura, Y., Mizuguchi, M., Nishi, K., Nakao, S. The Journal of asthma : official journal of the Association for the Care of Asthma. (2006) [Pubmed]
  23. Direct measurement of BDP and 17-BMP in bronchial and peripheral lung tissue after inhalation of HFA- vs CFC-driven aerosols. Holz, O., Zühlke, I., Einhaus, M., Welker, L., Kanniess, F., Branscheid, D., Nakashima, M., Harrison, L.I., Jörres, R.A., Richter, K., Magnussen, H. Pulmonary pharmacology & therapeutics. (2004) [Pubmed]
  24. Deposition of corticosteroid aerosol in the human lung by Respimat Soft Mist inhaler compared to deposition by metered dose inhaler or by Turbuhaler dry powder inhaler. Pitcairn, G., Reader, S., Pavia, D., Newman, S. Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine. (2005) [Pubmed]
  25. The nasal application of beclomethasone diproprionate (Beconase) in allergic rhinitis. Rudolph, R., Kunkel, G., Staud, R.D., Koennecke, R. Clinical otolaryngology and allied sciences. (1976) [Pubmed]
  26. Management of paediatric asthma. Grigg, J. Postgraduate medical journal. (2004) [Pubmed]
  27. Post-inhalation bronchoconstriction by beclomethasone dipropionate: a comparison of two different CFC propellant formulations in asthmatics. Ruffin, R.E., Campbell, D.A., Chia, M.M. Respirology (2000) [Pubmed]
  28. A calorimetric study of dimyristoylphosphatidylcholine phase transitions and steroid-liposome interactions for liposomes prepared by thin film and proliposome methods. Elhissi, A.M., O'Neill, M.A., Roberts, S.A., Taylor, K.M. International journal of pharmaceutics. (2006) [Pubmed]
  29. Treatment of vasomotor rhinitis with intranasal beclomethasone dipropionate (Becotide). Results from a double-blind cross-over study. Löfkvist, T., Svensson, G. Acta allergologica. (1976) [Pubmed]
  30. Monitoring the initial pulmonary absorption of two different beclomethasone dipropionate aerosols employing a human lung reperfusion model. Freiwald, M., Valotis, A., Kirschbaum, A., McClellan, M., Mürdter, T., Fritz, P., Friedel, G., Thomas, M., Högger, P. Respir. Res. (2005) [Pubmed]
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