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Chemical Compound Review

arginine     2-amino-5- (diaminomethylideneamino) pentano...

Synonyms: arginin, Harg, DL-Arginine, Arginine, DL-, PubChem12342, ...
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Disease relevance of arginine


High impact information on arginine

  • Northern analysis using full-length MCP-1 cDNA demonstrated increased expression in Chol and LNA aortas; this expression was decreased in aortas from Arg animals [5].
  • The objective of this study was to investigate the mechanism of IDV-induced vasoconstriction and the effect that the vasodilator agents L-arginine (LA), nifedipine (NF), as well as magnesium supplementation (Mg), have on IDV-induced nephrotoxicity [6].
  • A close correlation was found between arginin in position 2218 in ISDR, the presence of IL-NS5A Ab, and the response to IFN therapy for genotype 1b, but this association did not predict a long-term response [7].
  • Occurrence of histone H4 arginine (Arg) 3 methylation by protein arginine methyltransferase 1 (PRMT1) represents an early promoter event in ER (estrogen receptor)-regulated gene activation [8].
  • The structural information led to a specific data base search from which a new class of OYE oxidoreductases was identified that exhibits a strict conservation of active site residues, which are critical for this subfamily, most notably Cys26, Tyr28, Lys109, and Arg336 [9].

Biological context of arginine


Anatomical context of arginine

  • Macrophages cultured in Gln-free medium containing Arg (0.6 mM) did not produce NO when stimulated with LPS [4].
  • BACKGROUND: The serine (Ser)-128-arginine (Arg) gene polymorphism of E-selectin has been implicated in the pathogenesis of coronary artery disease (CAD) [15].
  • Strains with requirements for either proline (Pro-) or arginine (Arg-) or for none of the compounds that are used for differentiation (zero phenotype) were more common in the oropharynx (91.3% of patients) than in anogenital sites (73.2% of patients) [16].

Associations of arginine with other chemical compounds

  • Morning peak expiratory flow in subjects with the Arg/Arg genotype showed 89.0 +/- 16.1 L/min improvement over baseline compared with 93.7 +/- 12.7 L/min for Gly/Gly subjects and 92.5 +/- 11.9 L/min for Arg/Gly subjects [17].
  • However, both HA and Arg exhibited significant induction on differentiation, as evidenced by increased lipoprotein lipase (LPL) and glycerol-3-phosphate dehydrogenase (GPDH) activities, as well as accelerated triacylglycerol (TG) accumulation [18].
  • In contrast, the catalytic efficiency of the CYP2A13 Ala(117) --> Val and His(372) --> Arg mutants was greatly increased (2.65 and 2.60 versus 0.31 for wild-type CYP2A13 protein) [19].
  • We studied lipid metabolism and the antioxidant defense system in plasma and liver of rats fed diets supplemented with L: (omega)-nitro-L: -arginine methyl ester (L: -NAME), isosorbide dinitrate (DIS), L: -arginine (Arg), or the associations of these drugs [20].
  • However, the concentrations of galanin, arginin, vasopressin, and somatostatin were significantly increased [21].

Gene context of arginine

  • A conserved arginine in FEN-1 (Arg339) and XPG (Arg992) was found to be crucial for PCNA binding activity [22].
  • Both these responses were, in turn, lower (p < 0.05) than that to ARG + GHRH (57.9 +/- 15.1 micrograms/l; 2483.6 +/- 696.6 micrograms/l/h) [23].
  • A heterozygous single base-pair transition (CTG to CGG, leucine to arginin) was detected in codon 527 of the TGFBI gene in both patients [24].
  • Arg regeneration by AS is rate-limiting to NO synthesis and apparently provides iNOS with a preferred cellular source of Arg [10].
  • Furthermore, a remarkable increase in the expression of the IFN regulating factor 1 (IRF-1), but not of IRF-2, mRNA was detected in AA-treated PM [1].

Analytical, diagnostic and therapeutic context of arginine


  1. Inhibitory activity of constitutive nitric oxide on the expression of alpha/beta interferon genes in murine peritoneal macrophages. Guillemard, E., Varano, B., Belardelli, F., Quero, A.M., Gessani, S. J. Virol. (1999) [Pubmed]
  2. The fibroblast growth factor receptor-4 Arg388 allele is associated with prostate cancer initiation and progression. Wang, J., Stockton, D.W., Ittmann, M. Clin. Cancer Res. (2004) [Pubmed]
  3. Oxidative stress in distant organs and the effects of allopurinol during experimental acute pancreatitis. Czakó, L., Takács, T., Varga, I.S., Tiszlavicz, L., Hai, D.Q., Hegyi, P., Matkovics, B., Lonovics, J. Int. J. Pancreatol. (2000) [Pubmed]
  4. Glutamine is essential for nitric oxide synthesis by murine macrophages. Bellows, C.F., Jaffe, B.M. J. Surg. Res. (1999) [Pubmed]
  5. Nitric oxide regulates monocyte chemotactic protein-1. Tsao, P.S., Wang, B., Buitrago, R., Shyy, J.Y., Cooke, J.P. Circulation (1997) [Pubmed]
  6. Vasodilator agents protect against indinavir nephrotoxicity. de Araujo, M., Seguro, A.C. Antivir. Ther. (Lond.) (2003) [Pubmed]
  7. Mutations in NS5A region of hepatitis C virus genome correlate with presence of NS5A antibodies and response to interferon therapy for most common European hepatitis C virus genotypes. Frangeul, L., Cresta, P., Perrin, M., Lunel, F., Opolon, P., Agut, H., Huraux, J.M. Hepatology (1998) [Pubmed]
  8. SET-mediated Promoter Hypoacetylation Is a Prerequisite for Coactivation of the Estrogen-responsive pS2 Gene by PRMT1. Wagner, S., Weber, S., Kleinschmidt, M.A., Nagata, K., Bauer, U.M. J. Biol. Chem. (2006) [Pubmed]
  9. The 1.3 A crystal structure of the flavoprotein YqjM reveals a novel class of Old Yellow Enzymes. Kitzing, K., Fitzpatrick, T.B., Wilken, C., Sawa, J., Bourenkov, G.P., Macheroux, P., Clausen, T. J. Biol. Chem. (2005) [Pubmed]
  10. Argininosuccinate synthetase overexpression in vascular smooth muscle cells potentiates immunostimulant-induced NO production. Xie, L., Gross, S.S. J. Biol. Chem. (1997) [Pubmed]
  11. Kinetics of CO ligation with nitric-oxide synthase by flash photolysis and stopped-flow spectrophotometry. Scheele, J.S., Kharitonov, V.G., Martásek, P., Roman, L.J., Sharma, V.S., Masters, B.S., Magde, D. J. Biol. Chem. (1997) [Pubmed]
  12. Capillary electrophoresis analysis of nitric oxide synthase related metabolites in single identified neurons. Floyd, P.D., Moroz, L.L., Gillette, R., Sweedler, J.V. Anal. Chem. (1998) [Pubmed]
  13. A central nervous system action of nitric oxide in blood pressure regulation. Togashi, H., Sakuma, I., Yoshioka, M., Kobayashi, T., Yasuda, H., Kitabatake, A., Saito, H., Gross, S.S., Levi, R. J. Pharmacol. Exp. Ther. (1992) [Pubmed]
  14. Arg16/Gly beta2-adrenergic receptor polymorphism alters the cardiac output response to isometric exercise. Eisenach, J.H., Barnes, S.A., Pike, T.L., Sokolnicki, L.A., Masuki, S., Dietz, N.M., Rehfeldt, K.H., Turner, S.T., Joyner, M.J. J. Appl. Physiol. (2005) [Pubmed]
  15. The E-selectin SER128ARG gene polymorphism and restenosis after successful coronary angioplasty. Rauchhaus, M., Gross, M., Schulz, S., Francis, D.P., Greiser, P., Norwig, A., Weidhase, L., Coats, A.J., Dietz, R., Anker, S.D., Gläser, C. International journal of cardiology. (2002) [Pubmed]
  16. Nutritional requirements and penicillin susceptibilities of gonococci from pharyngeal and anogenital sites. Catlin, B.W., Pace, P.J. The British journal of venereal diseases. (1977) [Pubmed]
  17. Salmeterol response is not affected by beta(2)-adrenergic receptor genotype in subjects with persistent asthma. Bleecker, E.R., Yancey, S.W., Baitinger, L.A., Edwards, L.D., Klotsman, M., Anderson, W.H., Dorinsky, P.M. J. Allergy Clin. Immunol. (2006) [Pubmed]
  18. Nitric oxide promotes differentiation of rat white preadipocytes in culture. Yan, H., Aziz, E., Shillabeer, G., Wong, A., Shanghavi, D., Kermouni, A., Abdel-Hafez, M., Lau, D.C. J. Lipid Res. (2002) [Pubmed]
  19. Identification of Val117 and Arg372 as critical amino acid residues for the activity difference between human CYP2A6 and CYP2A13 in coumarin 7-hydroxylation. He, X.Y., Shen, J., Hu, W.Y., Ding, X., Lu, A.Y., Hong, J.Y. Arch. Biochem. Biophys. (2004) [Pubmed]
  20. Lipid Metabolism in Rats is Modified by Nitric Oxide Availability Through a Ca(++)-Dependent Mechanism. Marra, C.A., Nella, J., Manti, D., de Alaniz, M.J. Lipids (2007) [Pubmed]
  21. Biochemical substrates in normal aging and Alzheimer's disease. Wallin, A., Gottfries, C.G. Pharmacopsychiatry (1990) [Pubmed]
  22. The DNA repair endonuclease XPG binds to proliferating cell nuclear antigen (PCNA) and shares sequence elements with the PCNA-binding regions of FEN-1 and cyclin-dependent kinase inhibitor p21. Gary, R., Ludwig, D.L., Cornelius, H.L., MacInnes, M.A., Park, M.S. J. Biol. Chem. (1997) [Pubmed]
  23. Hexarelin, a synthetic GH-releasing peptide, is a powerful stimulus of GH secretion in pubertal children and in adults but not in prepubertal children and in elderly subjects. Bellone, J., Bartolotta, E., Sgattoni, C., Aimaretti, G., Arvat, E., Bellone, S., Deghenghi, R., Ghigo, E. J. Endocrinol. Invest. (1998) [Pubmed]
  24. Late-onset form of lattice corneal dystrophy caused by leu527Arg mutation of the TGFBI gene. Hirano, K., Hotta, Y., Nakamura, M., Fujiki, K., Kanai, A., Yamamoto, N. Cornea (2001) [Pubmed]
  25. Reduction of serum citrulline levels in women at term toward the day of labor onset. Facchinetti, F., Valensise, H., Neri, I., Menghini, S., Romanini, C., Volpe, A. Acta obstetricia et gynecologica Scandinavica. (1998) [Pubmed]
  26. Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial. Israel, E., Chinchilli, V.M., Ford, J.G., Boushey, H.A., Cherniack, R., Craig, T.J., Deykin, A., Fagan, J.K., Fahy, J.V., Fish, J., Kraft, M., Kunselman, S.J., Lazarus, S.C., Lemanske, R.F., Liggett, S.B., Martin, R.J., Mitra, N., Peters, S.P., Silverman, E., Sorkness, C.A., Szefler, S.J., Wechsler, M.E., Weiss, S.T., Drazen, J.M. Lancet (2004) [Pubmed]
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