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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Matched-Pair Analysis

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Disease relevance of Matched-Pair Analysis


Psychiatry related information on Matched-Pair Analysis

  • Similar differences in favor of halazepam were observed at the same time points on paired comparison of percent improvement from baseline in scores for physician's global assessment of psychopathology and the Hamilton Anxiety Scale [6].

High impact information on Matched-Pair Analysis

  • In contrast, when Jv was increased, paired comparison of Ralb and RDX in the same AVR revealed a difference, 1.58 +/- 0.06 vs 1.72 +/- 0.08, respectively (P less than 0.01) [7].
  • In crude matched-pair analyses, baseline concentrations of tPA antigen were higher in cases than controls (p = 0.03) and strongly associated with risk of future MI [8].
  • Illness-recovery correlations using area under the curve for GH secretion during sleep were highly significant, whereas paired comparisons showed no significant differences [9].
  • A matched-pair analysis of NF-kappa B expression was performed in cases with vascular involvement and increased tumor vascularity versus matched controls lacking these factors [10].
  • First-line high-dose chemotherapy compared with standard-dose PEB/VIP chemotherapy in patients with advanced germ cell tumors: A multivariate and matched-pair analysis [11].

Chemical compound and disease context of Matched-Pair Analysis


Biological context of Matched-Pair Analysis


Anatomical context of Matched-Pair Analysis


Associations of Matched-Pair Analysis with chemical compounds

  • In paired comparisons of 100/cystatin C with iothalamate clearance at each examination, the two measures were numerically similar [25].
  • During chronic administration of 200 mg ketoconazole daily, decrements of plasma testosterone 2-4 h after drug administration were minimal and documented only by paired comparisons within subjects but not by unpaired tests between normal men and men receiving drug [26].
  • On paired comparisons, the hormone responses to MTC were lower (P less than 0.05) during the infusion of high dose DA (PRL, 2286 +/- 495% vs. 891 +/- 328%; TSH, 100 +/- 43% vs. 60 +/- 15%), but were not changed when MTC was given during the low and medium doses of DA [27].
  • Paired comparison of the results from each kit indicated that the NovoClone Target assay showed significantly lower diagnostic sensitivity (P less than 0.05) than did the Tandem Icon II or Abbott TestPack, both for urine and for serum samples [28].
  • Then a matched-pair analysis of patients treated without androgen deprivation was implemented [29].

Gene context of Matched-Pair Analysis

  • Paired comparison revealed a highly significant negative correlation between IFN-gamma and IgG (P=0.016), IgG1 (P<0.001) and IgG3 (P=0. 007) antibodies [30].
  • A matched pair analysis of normal and cancerous endometrial tissue confirmed the significance of the DPP III activity increase in the transformed tissue (n = 7, P = 0.022) [31].
  • Paired comparisons demonstrated a sexually dimorphic effect of rhGH therapy on the CYP3A activity [32].
  • The paired comparisons method of identifying developmental discrepancies with the ITPA [33].
  • Results of matched-pair analyses were calculated and revealed a significant with-in pair discordance, when comparing children with NF-1 and their siblings and when comparing children with NF-1 and their biological parents (in families with a sporadic, non-familial NF-1 child) [34].

Analytical, diagnostic and therapeutic context of Matched-Pair Analysis


  1. The fragile histidine triad/common chromosome fragile site 3B locus and repair-deficient cancers. Turner, B.C., Ottey, M., Zimonjic, D.B., Potoczek, M., Hauck, W.W., Pequignot, E., Keck-Waggoner, C.L., Sevignani, C., Aldaz, C.M., McCue, P.A., Palazzo, J., Huebner, K., Popescu, N.C. Cancer Res. (2002) [Pubmed]
  2. A paired comparison of cream and ointment-based dithranol in short contact treatment of psoriasis. Grattan, C.E., Christopher, A.P., Robinson, M. Br. J. Dermatol. (1987) [Pubmed]
  3. Risks of unoccluded topical steroids in clinical trials. Akers, W.A. Archives of dermatology. (1980) [Pubmed]
  4. Double-masked, paired-comparison clinical study of ketorolac tromethamine 0.5% ophthalmic solution compared with placebo eyedrops in the treatment of seasonal allergic conjunctivitis. Tinkelman, D.G., Rupp, G., Kaufman, H., Pugely, J., Schultz, N. Survey of ophthalmology. (1993) [Pubmed]
  5. Double-blind bilateral paired comparison of 0.05% halobetasol propionate cream and its vehicle in patients with chronic atopic dermatitis and other eczematous dermatoses. Kantor, I., Cook, P.R., Cullen, S.I., Willis, I., Gibson, J.R., Stanfield, J.W. J. Am. Acad. Dermatol. (1991) [Pubmed]
  6. Effectiveness of bedtime dosing of benzodiazepines: a placebo-controlled comparison of halazepam and clorazepate. Aden, G.C., O'Hair, D.E. Clinical therapeutics. (1980) [Pubmed]
  7. Molecular sieving of albumin by the ascending vasa recta wall. Pallone, T.L. J. Clin. Invest. (1992) [Pubmed]
  8. Endogenous tissue-type plasminogen activator and risk of myocardial infarction. Ridker, P.M., Vaughan, D.E., Stampfer, M.J., Manson, J.E., Hennekens, C.H. Lancet (1993) [Pubmed]
  9. Growth hormone secretion in prepubertal children with major depression. IV. Sleep-related plasma concentrations in a drug-free, fully recovered clinical state. Puig-Antich, J., Goetz, R., Davies, M., Tabrizi, M.A., Novacenko, H., Hanlon, C., Sachar, E.J., Weitzman, E.D. Arch. Gen. Psychiatry (1984) [Pubmed]
  10. NF-kappa B in the vascular progression of melanoma. Kashani-Sabet, M., Shaikh, L., Miller, J.R., Nosrati, M., Ferreira, C.M., Debs, R.J., Sagebiel, R.W. J. Clin. Oncol. (2004) [Pubmed]
  11. First-line high-dose chemotherapy compared with standard-dose PEB/VIP chemotherapy in patients with advanced germ cell tumors: A multivariate and matched-pair analysis. Bokemeyer, C., Kollmannsberger, C., Meisner, C., Harstrick, A., Beyer, J., Metzner, B., Hartmann, J.T., Schmoll, H.J., Einhorn, L., Kanz, L., Nichols, C. J. Clin. Oncol. (1999) [Pubmed]
  12. Clinical evaluation of ketorolac tromethamine 0.5% ophthalmic solution for the treatment of seasonal allergic conjunctivitis. Ballas, Z., Blumenthal, M., Tinkelman, D.G., Kriz, R., Rupp, G. Survey of ophthalmology. (1993) [Pubmed]
  13. Double-blind comparison of halcinonide and betamethasone valerate. Use with occlusive dressings in psoriasis treatment. Clark, R.F., Clement, E.R. Archives of dermatology. (1975) [Pubmed]
  14. Effect of mycophenolate mofetil on kidney graft function and body weight in patients with chronic allograft nephropathy. Grebe, S.O., Mueller, T.F., Troeltsch, M., Ebel, H., Lange, H. Transplant. Proc. (2004) [Pubmed]
  15. The value of colloid dressings in psoriasis. Agius, A., Borg, E., Pace, J.L. Adv. Exp. Med. Biol. (1999) [Pubmed]
  16. Impact of adverse events on prescribing warfarin in patients with atrial fibrillation: matched pair analysis. Choudhry, N.K., Anderson, G.M., Laupacis, A., Ross-Degnan, D., Normand, S.L., Soumerai, S.B. BMJ (2006) [Pubmed]
  17. A multicenter analysis of the first experience with FK506 for induction and rescue therapy after pancreas transplantation. Gruessner, R.W., Burke, G.W., Stratta, R., Sollinger, H., Benedetti, E., Marsh, C., Stock, P., Boudreaux, J.P., Martin, M., Drangstveit, M.B., Sutherland, D.E., Gruessner, A. Transplantation (1996) [Pubmed]
  18. Aerosolized albuterol improves airway reactivity in infants with acute respiratory failure from respiratory syncytial virus. Derish, M., Hodge, G., Dunn, C., Ariagno, R. Pediatr. Pulmonol. (1998) [Pubmed]
  19. Event-related potentials can reveal differences between two decision-making groups. Cutmore, T.R., Muckert, T.D. Biological psychology. (1998) [Pubmed]
  20. Quantitative assessment of postsurgical breakdown of the blood-aqueous barrier following administration of 0.5% ketorolac tromethamine solution. A double-masked, paired comparison with vehicle-placebo solution study. Flach, A.J., Graham, J., Kruger, L.P., Stegman, R.C., Tanenbaum, L. Arch. Ophthalmol. (1988) [Pubmed]
  21. Serum gastrin response to food stimulation in male azotemic patients. Gedde-Dahl, D. Scand. J. Gastroenterol. (1975) [Pubmed]
  22. Iohexol versus meglumine-Ca-metrizoate in cerebral angiography. A randomized double-blind cross-over study. Lovrencić, M., Jakovac, I., Klanfar, Z. Acta radiologica. Supplementum. (1986) [Pubmed]
  23. Impaired recognition memory in rats after damage to the hippocampus. Clark, R.E., Zola, S.M., Squire, L.R. J. Neurosci. (2000) [Pubmed]
  24. Short stature is related to high body fat composition despite body mass index in a Mexican population. López-Alvarenga, J.C., Montesinos-Cabrera, R.A., Velázquez-Alva, C., González-Barranco, J. Arch. Med. Res. (2003) [Pubmed]
  25. Detection of renal function decline in patients with diabetes and normal or elevated GFR by serial measurements of serum cystatin C concentration: results of a 4-year follow-up study. Perkins, B.A., Nelson, R.G., Ostrander, B.E., Blouch, K.L., Krolewski, A.S., Myers, B.D., Warram, J.H. J. Am. Soc. Nephrol. (2005) [Pubmed]
  26. Site of action of low dose ketoconazole on androgen biosynthesis in men. Santen, R.J., Van den Bossche, H., Symoens, J., Brugmans, J., DeCoster, R. J. Clin. Endocrinol. Metab. (1983) [Pubmed]
  27. Increased dopaminergic activity inhibits basal and metoclopramide-stimulated prolactin and thyrotropin secretion. Agner, T., Hagen, C., Andersen, A.N., Djursing, H. J. Clin. Endocrinol. Metab. (1986) [Pubmed]
  28. Three highly sensitive "bedside" serum and urine tests for pregnancy compared. Christensen, H., Thyssen, H.H., Schebye, O., Berget, A. Clin. Chem. (1990) [Pubmed]
  29. The Gleason score shift: score four and seven years ago. Chism, D.B., Hanlon, A.L., Troncoso, P., Al-Saleem, T., Horwitz, E.M., Pollack, A. Int. J. Radiat. Oncol. Biol. Phys. (2003) [Pubmed]
  30. Selective correlation of interferon-gamma, tumour necrosis factor-alpha and granulocyte-macrophage colony-stimulating factor with immunoglobulin G1 and immunoglobulin G3 subclass antibody in leprosy. Hussain, R., Kifayet, A., Dojki, M., Dockrell, H.M. Immunology (1999) [Pubmed]
  31. Dipeptidyl peptidase III in malignant and non-malignant gynaecological tissue. Simaga, S., Babić, D., Osmak, M., Ilić-Forko, J., Vitale, L., Milicić, D., Abramić, M. Eur. J. Cancer (1998) [Pubmed]
  32. Effects of growth hormone deficiency and rhGH replacement therapy on the 6beta-hydroxycortisol/free cortisol ratio, a marker of CYP3A activity, in growth hormone-deficient children. Sinués, B., Mayayo, E., Fanlo, A., Mayayo, E., Bernal, M.L., Bocos, P., Bello, E., Labarta, J.I., Ferrández-Longás, A. Eur. J. Clin. Pharmacol. (2004) [Pubmed]
  33. The paired comparisons method of identifying developmental discrepancies with the ITPA. Lavine, S.B. Journal of learning disabilities. (1978) [Pubmed]
  34. The association of neurofibromatosis type 1 and attention deficit hyperactivity disorder. Koth, C.W., Cutting, L.E., Denckla, M.B. Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence. (2000) [Pubmed]
  35. Effects of dietary propionate on carbohydrate and lipid metabolism in healthy volunteers. Venter, C.S., Vorster, H.H., Cummings, J.H. Am. J. Gastroenterol. (1990) [Pubmed]
  36. Topical prostaglandin E2 effects on normal human intraocular pressure. Flach, A.J., Eliason, J.A. Journal of ocular pharmacology. (1988) [Pubmed]
  37. Quality judgments of hearing aid-processed speech and music by normal and otopathologic listeners. Punch, J.L. Journal of the American Audiology Society. (1978) [Pubmed]
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