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Gene Review

Iapp  -  islet amyloid polypeptide

Rattus norvegicus

Synonyms: Amylin, DAP, Diabetes-associated peptide, Islet amyloid polypeptide
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Disease relevance of Iapp


Psychiatry related information on Iapp

  • In the present study, the amylin receptor antagonist acetyl-[Asn(30), Tyr(32)] sCT-(8-32) (AC187) was used to assess whether action of endogenous amylin is essential for normal satiation to occur [3].
  • Moreover, intra-Acb shell amylin reduced motor activity in nondeprived rats tested in the absence of food or water, indicating that the expression of amylin's effects is independent of drive or proximal incentives [4].
  • Amylin (5 micrograms/kg or 2.5 micrograms/rat) injected IP at dark onset after 24-h food deprivation elicited an anorectic effect of similar extent in STZ-diabetic and control rats [5].
  • Adult male rats were intraperitoneally (i.p.) injected with 1.0 microgram/kg amylin at the beginning of the dark phase in 24 h food deprived or undeprived rats, and a computerized system measured feeding behavior [6].
  • Actions of amylin on subfornical organ neurons and on drinking behavior in rats [7].

High impact information on Iapp

  • At the end of the 12-h study period, pancreatic RNA was extracted, proinsulin and amylin mRNAs were measured on total RNA, and glucokinase and glucose transporter (GLUT-2) mRNAs were measured on poly(A)+ RNA by dot blot analysis [8].
  • Amylin secretion from the rat pancreas and its selective loss after streptozotocin treatment [9].
  • Treatment with a borderline diabetogenic dose of streptozotocin reduced amylin response without significantly changing the insulin response [9].
  • Pharmacology of receptors for calcitonin gene-related peptide and amylin [10].
  • In this article, the current status of CGRP receptor classification is reviewed by David Poyner, taking particular account of species differences, and evidence is presented supporting the existence of multiple receptors for CGRP, as well as independent binding sites for amylin [10].

Chemical compound and disease context of Iapp


Biological context of Iapp


Anatomical context of Iapp


Associations of Iapp with chemical compounds


Physical interactions of Iapp

  • The Isl-1 gene in rat codes for a protein that binds to the insulin gene enhancer and is also involved in regulation of amylin and proglucagon genes [22].

Regulatory relationships of Iapp

  • These results indicate that amylin is positively regulated by cAMP and PKA through the transcription factors HNF-1 and NFY [18].
  • Our data suggest that alterations in UCP2 and PPARgamma2 play a role in the control of insulin and amylin release from the pancreas [23].
  • Pretreatment with Indo did not significantly increase the ulcer index induced by EtOH but counteracted the ability of amylin to prevent the ulcer formation [24].
  • Peripheral amylin activates circumventricular organs expressing calcitonin receptor a/b subtypes and receptor-activity modifying proteins in the rat [25].
  • After acute administration, amylin and its agonist salmon calcitonin (sCT) equally reduced food intake in Zucker and lean control rats while cholecystokinin's (CCK) anorectic effect was weaker in the Zucker rats [26].

Other interactions of Iapp


Analytical, diagnostic and therapeutic context of Iapp


  1. Antiobesity Effects of the {beta}-Cell Hormone Amylin in Diet-Induced Obese Rats: Effects on Food Intake, Body Weight, Composition, Energy Expenditure, and Gene Expression. Roth, J.D., Hughes, H., Kendall, E., Baron, A.D., Anderson, C.M. Endocrinology (2006) [Pubmed]
  2. Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red. Lorenzo, A., Yankner, B.A. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  3. Amylin receptor blockade stimulates food intake in rats. Reidelberger, R.D., Haver, A.C., Arnelo, U., Smith, D.D., Schaffert, C.S., Permert, J. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2004) [Pubmed]
  4. Amylin infusion into rat nucleus accumbens potently depresses motor activity and ingestive behavior. Baldo, B.A., Kelley, A.E. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2001) [Pubmed]
  5. Different influence of CGRP (8-37), an amylin and CGRP antagonist, on the anorectic effects of cholecystokinin and bombesin in diabetic and normal rats. Lutz, T.A., Pieber, T.R., Walzer, B., Del Prete, E., Scharrer, E. Peptides (1997) [Pubmed]
  6. Amylin decreases meal size in rats. Lutz, T.A., Geary, N., Szabady, M.M., Del Prete, E., Scharrer, E. Physiol. Behav. (1995) [Pubmed]
  7. Actions of amylin on subfornical organ neurons and on drinking behavior in rats. Riediger, T., Rauch, M., Schmid, H.A. Am. J. Physiol. (1999) [Pubmed]
  8. Feedback inhibition of insulin gene expression by insulin. Koranyi, L., James, D.E., Kraegen, E.W., Permutt, M.A. J. Clin. Invest. (1992) [Pubmed]
  9. Amylin secretion from the rat pancreas and its selective loss after streptozotocin treatment. Ogawa, A., Harris, V., McCorkle, S.K., Unger, R.H., Luskey, K.L. J. Clin. Invest. (1990) [Pubmed]
  10. Pharmacology of receptors for calcitonin gene-related peptide and amylin. Poyner, D. Trends Pharmacol. Sci. (1995) [Pubmed]
  11. Islet amyloid polypeptide (amylin) is expressed in sensory neurons. Mulder, H., Leckström, A., Uddman, R., Ekblad, E., Westermark, P., Sundler, F. J. Neurosci. (1995) [Pubmed]
  12. Islet amyloid polypeptide (amylin) and insulin are differentially expressed in chronic diabetes induced by streptozotocin in rats. Mulder, H., Ahrén, B., Sundler, F. Diabetologia (1996) [Pubmed]
  13. Amylin and bone metabolism in streptozotocin-induced diabetic rats. Horcajada-Molteni, M.N., Chanteranne, B., Lebecque, P., Davicco, M.J., Coxam, V., Young, A., Barlet, J.P. J. Bone Miner. Res. (2001) [Pubmed]
  14. Potential inhibitors of L-asparagine biosynthesis. 5. Electrophilic amide analogues of (S)-2,3-diaminopropionic acid. Mokotoff, M., Logue, L.W. J. Med. Chem. (1981) [Pubmed]
  15. Selective amylin inhibition of the glucagon response to arginine is extrinsic to the pancreas. Silvestre, R.A., Rodríguez-Gallardo, J., Jodka, C., Parkes, D.G., Pittner, R.A., Young, A.A., Marco, J. Am. J. Physiol. Endocrinol. Metab. (2001) [Pubmed]
  16. Rat amylin: cloning and tissue-specific expression in pancreatic islets. Leffert, J.D., Newgard, C.B., Okamoto, H., Milburn, J.L., Luskey, K.L. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  17. GSK3 involvement in amylin signaling in isolated rat soleus muscle. Abaffy, T., Cooper, G.J. Peptides (2004) [Pubmed]
  18. Amylin gene expression mediated by cAMP/PKA and transcription factors HNF-1 and NFY. Cluck, M.W., Murphy, L.O., Olson, J., Knezetic, J.A., Adrian, T.E. Mol. Cell. Endocrinol. (2003) [Pubmed]
  19. The anorectic hormone amylin contributes to feeding-related changes of neuronal activity in key structures of the gut-brain axis. Riediger, T., Zuend, D., Becskei, C., Lutz, T.A. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2004) [Pubmed]
  20. Relative hypersecretion of amylin to insulin from rat pancreas after neonatal STZ treatment. Inoue, K., Hisatomi, A., Umeda, F., Nawata, H. Diabetes (1992) [Pubmed]
  21. Islet amyloid polypeptide and insulin secretion from isolated perfused pancreas of fed, fasted, glucose-treated, and dexamethasone-treated rats. O'Brien, T.D., Westermark, P., Johnson, K.H. Diabetes (1991) [Pubmed]
  22. Expression, purification and characterization of the homeodomain of rat ISL-1 protein. Behravan, G., Lycksell, P.O., Larsson, G. Protein Eng. (1997) [Pubmed]
  23. Enterostatin decreases postprandial pancreatic UCP2 mRNA levels and increases plasma insulin and amylin. Arsenijevic, D., Gallmann, E., Moses, W., Lutz, T., Erlanson-Albertsson, C., Langhans, W. Am. J. Physiol. Endocrinol. Metab. (2005) [Pubmed]
  24. Protection by amylin of gastric erosions induced by indomethacin or ethanol in rats. Guidobono, F., Pagani, F., Ticozzi, C., Sibilia, V., Pecile, A., Netti, C. Br. J. Pharmacol. (1997) [Pubmed]
  25. Peripheral amylin activates circumventricular organs expressing calcitonin receptor a/b subtypes and receptor-activity modifying proteins in the rat. Barth, S.W., Riediger, T., Lutz, T.A., Rechkemmer, G. Brain Res. (2004) [Pubmed]
  26. Chronic infusion of the amylin antagonist AC 187 increases feeding in Zucker fa/fa rats but not in lean controls. Grabler, V., Lutz, T.A. Physiol. Behav. (2004) [Pubmed]
  27. Intermedin functions as a pituitary paracrine factor regulating prolactin release. Lin Chang, C., Roh, J., Park, J.I., Klein, C., Cushman, N., Haberberger, R.V., Hsu, S.Y. Mol. Endocrinol. (2005) [Pubmed]
  28. Calcitonin receptor isoforms expressed in the developing rat kidney. Tikellis, C., Xuereb, L., Casley, D., Brasier, G., Cooper, M.E., Wookey, P.J. Kidney Int. (2003) [Pubmed]
  29. Examination of somatostatin involvement in the inhibitory action of GIP, GLP-1, amylin and adrenomedullin on gastric acid release using a new SRIF antagonist analogue. Rossowski, W.J., Cheng, B.L., Jiang, N.Y., Coy, D.H. Br. J. Pharmacol. (1998) [Pubmed]
  30. Isolation and sequence determination of rat islet amyloid polypeptide. Asai, J., Nakazato, M., Kangawa, K., Matsukura, S., Matsuo, H. Biochem. Biophys. Res. Commun. (1989) [Pubmed]
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