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Gene Review

STC2  -  stanniocalcin 2

Homo sapiens

Synonyms: STC-2, STC-related protein, STCRP, Stanniocalcin-2, Stanniocalcin-related protein
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Disease relevance of STC2


High impact information on STC2


Chemical compound and disease context of STC2

  • Two putative paracrine/autocrine factors of potential importance in the regulation of the growth of breast cancer cells were identified to be highly up-regulated by E2: stanniocalcin 2, a calcium/phosphate homeostatic hormone; and inhibin-beta B, a TGF-beta-like factor [6].

Biological context of STC2

  • We speculate that STC2 may play a role in glucose homeostasis [7].
  • The STC2 gene was localized to human chromosome 5q35 [7].
  • We purified both the native hamster and recombinant human STC2 proteins and obtained a partial amino acid sequence of the hamster protein [7].
  • The function of STC-2 has not been examined; thus we generated two lines of transgenic mice overexpressing human (h)STC-2 to gain insight into its potential functions through identification of overt phenotypes [1].
  • Consequently, similar to STC-1, STC-2 can act as a potent growth inhibitor and reduce intramembranous and endochondral bone development and skeletal muscle growth, implying that these tissues are specific physiological targets of stanniocalcins [1].

Anatomical context of STC2


Associations of STC2 with chemical compounds

  • Thus, STC2 is a functional homodimeric glycoprotein, and thecal cell-derived STC2 could play a paracrine role during follicular development [8].
  • The STC2 suppression of progesterone production was associated with the inhibition of FSH-induced CYP11A and 3beta-hydroxysteroid dehydrogenase expression [8].
  • The second homologue (STC2) is 30-38% identical to the fish stanniocalcins, and is characterized by unique cysteine and histidine motifs that are not found in the other stanniocalcins [7].
  • The in vitro CK2 phosphorylation site was shown by matrix-assisted laser-desorption ionization-time-of-flight MS to be a single serine located between Ser-285 and Ser-298 in the C-terminal region of STC2 [3].
  • When Atlantic salmon glands were fractionated by concanavalin A (ConA)-Sepharose chromatography, two distinct forms of the hormone were identified, both of which were recognized by sockeye salmon STC antiserum, and designated as STC1 and STC2 [10].

Other interactions of STC2


Analytical, diagnostic and therapeutic context of STC2


  1. Human stanniocalcin-2 exhibits potent growth-suppressive properties in transgenic mice independently of growth hormone and IGFs. Gagliardi, A.D., Kuo, E.Y., Raulic, S., Wagner, G.F., DiMattia, G.E. Am. J. Physiol. Endocrinol. Metab. (2005) [Pubmed]
  2. Stanniocalcin 2 is an estrogen-responsive gene coexpressed with the estrogen receptor in human breast cancer. Bouras, T., Southey, M.C., Chang, A.C., Reddel, R.R., Willhite, D., Glynne, R., Henderson, M.A., Armes, J.E., Venter, D.J. Cancer Res. (2002) [Pubmed]
  3. Stanniocalcin 1 and 2 are secreted as phosphoproteins from human fibrosarcoma cells. Jellinek, D.A., Chang, A.C., Larsen, M.R., Wang, X., Robinson, P.J., Reddel, R.R. Biochem. J. (2000) [Pubmed]
  4. Molecular cloning of a second human stanniocalcin homologue (STC2). Ishibashi, K., Miyamoto, K., Taketani, Y., Morita, K., Takeda, E., Sasaki, S., Imai, M. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  5. Characterization of stanniocalcin 2, a novel target of the mammalian unfolded protein response with cytoprotective properties. Ito, D., Walker, J.R., Thompson, C.S., Moroz, I., Lin, W., Veselits, M.L., Hakim, A.M., Fienberg, A.A., Thinakaran, G. Mol. Cell. Biol. (2004) [Pubmed]
  6. Effects of estrogen on global gene expression: identification of novel targets of estrogen action. Charpentier, A.H., Bednarek, A.K., Daniel, R.L., Hawkins, K.A., Laflin, K.J., Gaddis, S., MacLeod, M.C., Aldaz, C.M. Cancer Res. (2000) [Pubmed]
  7. Stanniocalcin 2: characterization of the protein and its localization to human pancreatic alpha cells. Moore, E.E., Kuestner, R.E., Conklin, D.C., Whitmore, T.E., Downey, W., Buddle, M.M., Adams, R.L., Bell, L.A., Thompson, D.L., Wolf, A., Chen, L., Stamm, M.R., Grant, F.J., Lok, S., Ren, H., De Jongh, K.S. Horm. Metab. Res. (1999) [Pubmed]
  8. Identification of a stanniocalcin paralog, stanniocalcin-2, in fish and the paracrine actions of stanniocalcin-2 in the mammalian ovary. Luo, C.W., Pisarska, M.D., Hsueh, A.J. Endocrinology (2005) [Pubmed]
  9. Prospect of a stanniocalcin endocrine/paracrine system in mammals. Ishibashi, K., Imai, M. Am. J. Physiol. Renal Physiol. (2002) [Pubmed]
  10. Stanniocalcin in the seawater salmon: structure, function, and regulation. Wagner, G.F., Jaworski, E.M., Haddad, M. Am. J. Physiol. (1998) [Pubmed]
  11. Chromosomal localization of two human genes involved in phosphate homeostasis: the type IIb sodium-phosphate cotransporter and stanniocalcin-2. White, K.E., Biber, J., Murer, H., Econs, M.J. Somat. Cell Mol. Genet. (1998) [Pubmed]
  12. Avian stanniocalcin-2 is expressed in developing striated muscle and joints. Mittapalli, V.R., Pr??ls, F., Huang, R., Christ, B., Scaal, M. Anat. Embryol. (2006) [Pubmed]
  13. Expression and regulation of stanniocalcin 1 and 2 in rat uterus during embryo implantation and decidualization. Xiao, L.J., Yuan, J.X., Song, X.X., Li, Y.C., Hu, Z.Y., Liu, Y.X. Reproduction (2006) [Pubmed]
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