The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

AG-J-75572     3,3-dimethyl-7-oxo-6-(2...

Synonyms: SureCN9706988, CCG-113795, Oprea1_658892, Oprea1_777083, AC1L1ITW, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of penicillin v


High impact information on penicillin v


Chemical compound and disease context of penicillin v


Biological context of penicillin v


Anatomical context of penicillin v


Associations of penicillin v with other chemical compounds

  • An automated precolumn exchange system for on-line solid-phase extraction (OPS-2) coupled to liquid chromatography with photochemical degradation and electrochemical detection was used for the determination of residual amounts of penicillin G, penicillin V, oxacillin, cloxacillin and dicloxacillin [23].
  • The principal values of the chemical shift tensors of all 13C and 15N sites in two antibiotics, ampicillin and penicillin-V, were determined by 2-dimensional phase adjusted spinning sideband (2D-PASS) and conventional CP/MAS experiments [24].
  • For example cefpodoxime proxetil given twice daily for 10 days is comparable to penicillin V given three times daily for 10 days in achieving a clinical cure and appears to be significantly superior to penicillin in eradicating group A streptococci from the pharynx [25].
  • OBJECTIVE: To compare the efficacy/tolerability of cefdinir and penicillin V in the treatment of pediatric GABHS tonsillopharyngitis as demonstrated in two clinical trials of similar design [26].
  • Using NIPAB analogs with lower k(cat)/K(m) values, kinetic parameters for the hydrolysis of cephalexin and penicillin V were determined [27].

Gene context of penicillin v

  • There was no significant correlation between the use of penicillin V and the frequency of PNSP [28].
  • A 125 x 4 mm C18 column was used to separate penicillin-V from its main metabolites, 5R- and 5S-penicilloic acid and endogenous compounds [29].
  • Criteria for improvement was a change in tympanometric findings to type C1 or type A. RESULTS: The success rates were in favor of amoxicillin-clavulanate treatment for 28 days (P < .001) (rates for respective 14- and 28-day groups: penicillin V, 23% and 19%; amoxicillin-clavulanate, 31% and 44%) [20].
  • Group 1 (n=299) was treated with pehnoxymethyl penicillin V and group 2 (n=307) was treated with phenoxymethyl penicillin V plus antioxidant vitamins for eight weeks [30].
  • Two hundred and ninety-seven children, aged 6 months to 7 years, with AOM were treated with penicillin V [31].

Analytical, diagnostic and therapeutic context of penicillin v


  1. Platelet-activating factor-mediated NF-kappaB dependency of a late anaphylactic reaction. Choi, I.W., Kim, Y.S., Kim, D.K., Choi, J.H., Seo, K.H., Im, S.Y., Kwon, K.S., Lee, M.S., Ha, T.Y., Lee, H.K. J. Exp. Med. (2003) [Pubmed]
  2. A comparison of azithromycin and penicillin V for the treatment of streptococcal pharyngitis. Hooton, T.M. Am. J. Med. (1991) [Pubmed]
  3. Cefdinir: a review of its use in the management of mild-to-moderate bacterial infections. Perry, C.M., Scott, L.J. Drugs (2004) [Pubmed]
  4. Efficacy of orally administered penicillin V for prophylaxis of experimentally induced streptococcal endocarditis. Pujadas, R., Escriva, E., Jane, J., Galera, M.C., Fava, P., Garau, J., Mirelis, B. Antimicrob. Agents Chemother. (1987) [Pubmed]
  5. Use of biotinylated beta-lactams and chemiluminescence for study and purification of penicillin-binding proteins in bacteria. Dargis, M., Malouin, F. Antimicrob. Agents Chemother. (1994) [Pubmed]
  6. Site-directed mutagenesis of beta-lactamase I: role of Glu-166. Leung, Y.C., Robinson, C.V., Aplin, R.T., Waley, S.G. Biochem. J. (1994) [Pubmed]
  7. Tolerance and efficacy of parenterally administered penicillin-streptomycin and orally administered amoxicillin or penicillin V for prophylaxis of experimentally induced streptococcal endocarditis. Pujadas, R., Escriva, E., Jane, J., Argimon, J., Fernandez, F., Fava, P., Galera, M., Garau, J. Antimicrob. Agents Chemother. (1990) [Pubmed]
  8. Oral absorption of cephalosporin antibiotics. 1. Synthesis, biological properties, and oral bioavailability of 7-(arylacetamido)-3-chloro cephalosporins in animals. Kukolja, S., Wright, W.E., Quay, J.F., Pfeil-Doyle, J., Draheim, S.E., Eudaly, J.A., Johnson, R.J., Ott, J.L., Counter, F.T., Cooper, R.D. J. Med. Chem. (1988) [Pubmed]
  9. A comparison of cefadroxil and penicillin V in the treatment of streptococcal pharyngitis in children. Gerber, M.A. Drugs (1986) [Pubmed]
  10. Efficacy of cefuroxime axetil suspension compared with that of penicillin V suspension in children with group A streptococcal pharyngitis. Gooch, W.M., McLinn, S.E., Aronovitz, G.H., Pichichero, M.E., Kumar, A., Kaplan, E.L., Ossi, M.J. Antimicrob. Agents Chemother. (1993) [Pubmed]
  11. Five day clarithromycin modified release versus 10 day penicillin V for group A streptococcal pharyngitis: a multi-centre, open-label, randomized study. Portier, H., Filipecki, J., Weber, P., Goldfarb, G., Lethuaire, D., Chauvin, J.P. J. Antimicrob. Chemother. (2002) [Pubmed]
  12. Prophylactic administration of penicillins for endocarditis does not reduce the incidence of postextraction bacteremia. Hall, G., Hedström, S.A., Heimdahl, A., Nord, C.E. Clin. Infect. Dis. (1993) [Pubmed]
  13. Sequencing and heterologous expression of the gene encoding penicillin V amidase from Bacillus sphaericus. Olsson, A., Uhlén, M. Gene (1986) [Pubmed]
  14. Cloning and expression of a conjugated bile acid hydrolase gene from Lactobacillus plantarum by using a direct plate assay. Christiaens, H., Leer, R.J., Pouwels, P.H., Verstraete, W. Appl. Environ. Microbiol. (1992) [Pubmed]
  15. A new mercury-penicillin V derivative as a probe for ultrastructural localization of penicillin-binding proteins in Escherichia coli. Paul, T.R., Halligan, N.G., Blaszczak, L.C., Parr, T.R., Beveridge, T.J. J. Bacteriol. (1992) [Pubmed]
  16. Antibiotic prophylaxis of infective endocarditis in the United Kingdom and Europe. Shanson, D.C. J. Antimicrob. Chemother. (1987) [Pubmed]
  17. Cefuroxime axetil and penicillin V compared in the treatment of group A beta-hemolytic streptococcal pharyngitis. Gooch, W.M., Swenson, E., Higbee, M.D., Cocchetto, D.M., Evans, E.C. Clinical therapeutics. (1987) [Pubmed]
  18. Potential mechanisms for failure to eradicate group A streptococci from the pharynx. Gerber, M.A., Tanz, R.R., Kabat, W., Bell, G.L., Siddiqui, B., Lerer, T.J., Lepow, M.L., Kaplan, E.L., Shulman, S.T. Pediatrics (1999) [Pubmed]
  19. Comparative study of the penetration of penicillin V and cefadroxil into tonsils in man. Holm, S.E., Ekedahl, C. J. Antimicrob. Chemother. (1982) [Pubmed]
  20. Antibiotic treatment of children with secretory otitis media. Amoxicillin-clavulanate is superior to penicillin V in a double-blind randomized study. Thomsen, J., Sederberg-Olsen, J., Balle, V., Hartzen, S. Arch. Otolaryngol. Head Neck Surg. (1997) [Pubmed]
  21. Penicillin reduces secretory capacity in rat middle ear mucosa in acute otitis media. Cayé-Thomasen, P., Hermansson, A., Tos, M., Prellner, K. The American journal of otology. (1996) [Pubmed]
  22. Prophylaxis of streptococcal bacteraemia with oral penicillin V in children undergoing bone marrow transplantation. Castagnola, E., Lanino, E., Garaventa, A., Dini, G., Dallorso, S., Carrega, G., Viscoli, C. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer. (1995) [Pubmed]
  23. High-performance liquid chromatographic determination of penicillins by means of automated solid-phase extraction and photochemical degradation with electrochemical detection. Lihl, S., Rehorek, A., Petz, M. Journal of chromatography. A. (1996) [Pubmed]
  24. 13C and 15N-chemical shift anisotropy of ampicillin and penicillin-V studied by 2D-PASS and CP/MAS NMR. Antzutkin, O.N., Lee, Y.K., Levitt, M.H. J. Magn. Reson. (1998) [Pubmed]
  25. Pharyngitis/tonsillitis: European and United States experience with cefpodoxime proxetil. Dajani, A.S. Pediatr. Infect. Dis. J. (1995) [Pubmed]
  26. Comparison of cefdinir and penicillin V in the treatment of pediatric streptococcal tonsillopharyngitis. Pichichero, M.E., Gooch, W.M. Pediatr. Infect. Dis. J. (2000) [Pubmed]
  27. The use of chromogenic reference substrates for the kinetic analysis of penicillin acylases. Alkema, W.B., Floris, R., Janssen, D.B. Anal. Biochem. (1999) [Pubmed]
  28. Frequency of penicillin-resistant pneumococci in children is correlated to community utilization of antibiotics. Melander, E., Ekdahl, K., Jönsson, G., Mölstad, S. Pediatr. Infect. Dis. J. (2000) [Pubmed]
  29. Determination of penicillin-V in human plasma by high-performance liquid chromatography and solid-phase extraction. Krauwinkel, W.J., Volkers-Kamermans, N.J. J. Chromatogr. B, Biomed. Appl. (1996) [Pubmed]
  30. Antioxidant vitamins improves hemoglobin level in children with group a beta hemolytic streptococcal infection. Ahmed, J., Zaman, M.M., Ali, K. Mymensingh medical journal : MMJ. (2003) [Pubmed]
  31. Penicillin treatment of acute otitis media in children. A study of the duration of treatment. Ingvarsson, L., Lundgren, K. Acta Otolaryngol. (1982) [Pubmed]
  32. Penicillin allergy and desensitization in serious infections during pregnancy. Wendel, G.D., Stark, B.J., Jamison, R.B., Molina, R.D., Sullivan, T.J. N. Engl. J. Med. (1985) [Pubmed]
  33. Comparison of aqueous and nonaqueous carrier electrolytes for the separation of penicillin V and related substances by capillary electrophoresis with UV and mass spectrometric detection. Hilder, E.F., Klampfl, C.W., Buchberger, W., Haddad, P.R. Electrophoresis (2002) [Pubmed]
  34. Once daily therapy for streptococcal pharyngitis with cefadroxil. Gerber, M.A., Randolph, M.F., Chanatry, J., Wright, L.L., Anderson, L.R., Kaplan, E.L. J. Pediatr. (1986) [Pubmed]
  35. Biosensors in flow-injection systems for biomedical analysis, process and environmental monitoring. Tran-Minh, C. J. Mol. Recognit. (1996) [Pubmed]
WikiGenes - Universities