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Gene Review

Cdh5  -  cadherin 5

Mus musculus

Synonyms: 7B4, 7B4/cadherin-5, AA408225, CD144, Cadherin-5, ...
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Disease relevance of Cdh5


Psychiatry related information on Cdh5


High impact information on Cdh5

  • Overexpression of N1IC in immortalized endothelial cells in vitro induces EMT accompanied by oncogenic transformation, with corresponding induction of snail and repression of VE-cadherin expression [6].
  • Expression of VE-cadherin, CD45, and Ter119 was used to distinguish EC (VE-cadherin+CD45-Ter119-) from HPC (VE-cadherin-CD45+) [7].
  • Knockdown and overexpression studies revealed that HoxA9 acts as a master switch to regulate the expression of prototypical endothelial-committed genes such as endothelial nitric oxide synthase, VEGF-R2, and VE-cadherin, and mediates the shear stress-induced maturation of endothelial cells [8].
  • We show here that a subset of cells co-expressing the hematopoietic marker GATA-1 and the endothelial marker VE-cadherin localize on the yolk sac blood islands at embryonic day 7 [9].
  • N-cadherin acts upstream of VE-cadherin in controlling vascular morphogenesis [10].

Chemical compound and disease context of Cdh5

  • The delay of P100 peak latency of the VECP in patients with juvenile Parkinson's disease after cessation of L-dopa indicated the deficiency of dopamine in these patients, which in turn was considered as a clinical model of senescence [11].
  • Significant correlations were found between anti-VEC Abs and proteinuria greater than 1 g/day (P = 0.044), as well as IgA anti-VEC Abs and C3 or IgA deposition in renal arterioles (P = 0.048) [12].

Biological context of Cdh5


Anatomical context of Cdh5


Associations of Cdh5 with chemical compounds


Physical interactions of Cdh5


Regulatory relationships of Cdh5


Other interactions of Cdh5

  • These results support the existence of a novel layer of functional regulation of VEGFR-2 by VE-cadherin [17].
  • Exon-intron boundaries are similar to those of other cadherin genes, with some exceptions that may have a functional significance in VE-cadherin behavior [28].
  • Immunoblotting for LYVE-1 and Prox-1 showed strong expression on SV-LEC and VEC, but not AEC [29].
  • Occludin expression was seen in all cell types, junctional ZO-1 was detected at SV-LEC and VEC junctions, not AEC [29].
  • SV-LEC also expresses MAdCAM-1 in response to TNF- alpha, an effect seen in VEC, but not AEC [29].

Analytical, diagnostic and therapeutic context of Cdh5


  1. Cardiac ischemia activates vascular endothelial cadherin promoter in both preexisting vascular cells and bone marrow cells involved in neovascularization. Kogata, N., Arai, Y., Pearson, J.T., Hashimoto, K., Hidaka, K., Koyama, T., Somekawa, S., Nakaoka, Y., Ogawa, M., Adams, R.H., Okada, M., Mochizuki, N. Circ. Res. (2006) [Pubmed]
  2. Junctional adhesion molecule-C regulates vascular endothelial permeability by modulating VE-cadherin-mediated cell-cell contacts. Orlova, V.V., Economopoulou, M., Lupu, F., Santoso, S., Chavakis, T. J. Exp. Med. (2006) [Pubmed]
  3. Gene expression of VEGF and its receptors Flk-1/KDR and Flt-1 in cultured and transplanted rat islets. Vasir, B., Jonas, J.C., Steil, G.M., Hollister-Lock, J., Hasenkamp, W., Sharma, A., Bonner-Weir, S., Weir, G.C. Transplantation (2001) [Pubmed]
  4. Effects of cadmium on E-cadherin and VE-cadherin in mouse lung. Pearson, C.A., Lamar, P.C., Prozialeck, W.C. Life Sci. (2003) [Pubmed]
  5. Common quantitative trait loci for alcohol-related behaviors and CNS neurotensin measures: voluntary ethanol consumption. Gehle, V.M., Erwin, V.G. Alcohol. Clin. Exp. Res. (1998) [Pubmed]
  6. Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation. Timmerman, L.A., Grego-Bessa, J., Raya, A., Bertrán, E., Pérez-Pomares, J.M., Díez, J., Aranda, S., Palomo, S., McCormick, F., Izpisúa-Belmonte, J.C., de la Pompa, J.L. Genes Dev. (2004) [Pubmed]
  7. In vitro generation of lymphohematopoietic cells from endothelial cells purified from murine embryos. Nishikawa, S.I., Nishikawa, S., Kawamoto, H., Yoshida, H., Kizumoto, M., Kataoka, H., Katsura, Y. Immunity (1998) [Pubmed]
  8. Histone deacetylase activity is essential for the expression of HoxA9 and for endothelial commitment of progenitor cells. Rössig, L., Urbich, C., Brühl, T., Dernbach, E., Heeschen, C., Chavakis, E., Sasaki, K., Aicher, D., Diehl, F., Seeger, F., Potente, M., Aicher, A., Zanetta, L., Dejana, E., Zeiher, A.M., Dimmeler, S. J. Exp. Med. (2005) [Pubmed]
  9. Characterization of GATA-1(+) hemangioblastic cells in the mouse embryo. Yokomizo, T., Takahashi, S., Mochizuki, N., Kuroha, T., Ema, M., Wakamatsu, A., Shimizu, R., Ohneda, O., Osato, M., Okada, H., Komori, T., Ogawa, M., Nishikawa, S., Ito, Y., Yamamoto, M. EMBO J. (2007) [Pubmed]
  10. N-cadherin acts upstream of VE-cadherin in controlling vascular morphogenesis. Luo, Y., Radice, G.L. J. Cell Biol. (2005) [Pubmed]
  11. Senescence of visual function as studied by visually evoked cortical potentials. Adachi-Usami, E. Jpn. J. Ophthalmol. (1990) [Pubmed]
  12. Anti-vascular endothelial cell antibodies in patients with IgA nephropathy: frequency and clinical significance. Yap, H.K., Sakai, R.S., Bahn, L., Rappaport, V., Woo, K.T., Ananthurman, V., Lim, C.H., Chiang, G.S., Jordan, S.C. Clin. Immunol. Immunopathol. (1988) [Pubmed]
  13. VE-cadherin is not required for the formation of nascent blood vessels but acts to prevent their disassembly. Crosby, C.V., Fleming, P.A., Argraves, W.S., Corada, M., Zanetta, L., Dejana, E., Drake, C.J. Blood (2005) [Pubmed]
  14. Caveolin-1-deficient mice have increased tumor microvascular permeability, angiogenesis, and growth. Lin, M.I., Yu, J., Murata, T., Sessa, W.C. Cancer Res. (2007) [Pubmed]
  15. Distinct Pattern of Allelic Loss and Inactivation of Cadherin 1 and 5 Genes in Mammary Carcinomas Arising in p53(+/-) Mice. Umesako, S., Iiga, S., Takahashi, M., Imura, K., Mori, N., Hong, D.P., Song, C.W., Niwa, O., Okumoto, M. J. Radiat. Res. (2007) [Pubmed]
  16. Molecular cloning and expression of murine vascular endothelial-cadherin in early stage development of cardiovascular system. Breier, G., Breviario, F., Caveda, L., Berthier, R., Schnürch, H., Gotsch, U., Vestweber, D., Risau, W., Dejana, E. Blood (1996) [Pubmed]
  17. VE-cadherin increases the half-life of VEGF receptor 2. Calera, M.R., Venkatakrishnan, A., Kazlauskas, A. Exp. Cell Res. (2004) [Pubmed]
  18. Phenotype and hematopoietic potential of side population cells throughout embryonic development. Nadin, B.M., Goodell, M.A., Hirschi, K.K. Blood (2003) [Pubmed]
  19. Platelet-activating factor increases VE-cadherin tyrosine phosphorylation in mouse endothelial cells and its association with the PtdIns3'-kinase. Hudry-Clergeon, H., Stengel, D., Ninio, E., Vilgrain, I. FASEB J. (2005) [Pubmed]
  20. Vascular endothelial cell-specific phosphotyrosine phosphatase (VE-PTP) activity is required for blood vessel development. Bäumer, S., Keller, L., Holtmann, A., Funke, R., August, B., Gamp, A., Wolburg, H., Wolburg-Buchholz, K., Deutsch, U., Vestweber, D. Blood (2006) [Pubmed]
  21. Self-assembly of the vascular endothelial cadherin ectodomain in a Ca2+-dependent hexameric structure. Legrand, P., Bibert, S., Jaquinod, M., Ebel, C., Hewat, E., Vincent, F., Vanbelle, C., Concord, E., Vernet, T., Gulino, D. J. Biol. Chem. (2001) [Pubmed]
  22. Establishment of an immortalized human-liver endothelial cell line with SV40T and hTERT. Matsumura, T., Takesue, M., Westerman, K.A., Okitsu, T., Sakaguchi, M., Fukazawa, T., Totsugawa, T., Noguchi, H., Yamamoto, S., Stolz, D.B., Tanaka, N., Leboulch, P., Kobayashi, N. Transplantation (2004) [Pubmed]
  23. Phosphorylation of vascular endothelial cadherin controls lymphocyte emigration. Turowski, P., Martinelli, R., Crawford, R., Wateridge, D., Papageorgiou, A.P., Lampugnani, M.G., Gamp, A.C., Vestweber, D., Adamson, P., Dejana, E., Greenwood, J. J. Cell. Sci. (2008) [Pubmed]
  24. ETS1 lowers capillary endothelial cell density at confluence and induces the expression of VE-cadherin. Lelièvre, E., Mattot, V., Huber, P., Vandenbunder, B., Soncin, F. Oncogene (2000) [Pubmed]
  25. Role of adhesion and contraction in Rac 1-regulated endothelial barrier function in vivo and in vitro. Waschke, J., Drenckhahn, D., Adamson, R.H., Curry, F.E. Am. J. Physiol. Heart Circ. Physiol. (2004) [Pubmed]
  26. Modulation of VEGFR-2-mediated endothelial-cell activity by VEGF-C/VEGFR-3. Matsumura, K., Hirashima, M., Ogawa, M., Kubo, H., Hisatsune, H., Kondo, N., Nishikawa, S., Chiba, T., Nishikawa, S. Blood (2003) [Pubmed]
  27. Gas1 is induced by VE-cadherin and vascular endothelial growth factor and inhibits endothelial cell apoptosis. Spagnuolo, R., Corada, M., Orsenigo, F., Zanetta, L., Deuschle, U., Sandy, P., Schneider, C., Drake, C.J., Breviario, F., Dejana, E. Blood (2004) [Pubmed]
  28. Genomic structure and chromosomal mapping of the mouse VE-cadherin gene (Cdh5). Huber, P., Dalmon, J., Engiles, J., Breviario, F., Gory, S., Siracusa, L.D., Buchberg, A.M., Dejana, E. Genomics (1996) [Pubmed]
  29. Isolation and Characterization of A Novel Mouse Lymphatic Endothelial Cell Line: SV-LEC. Ando, T., Jordan, P., Joh, T., Wang, Y., Jennings, M.H., Houghton, J., Alexander, J.S. Lymphatic research and biology. (2005) [Pubmed]
  30. Targeted null-mutation in the vascular endothelial-cadherin gene impairs the organization of vascular-like structures in embryoid bodies. Vittet, D., Buchou, T., Schweitzer, A., Dejana, E., Huber, P. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  31. A general strategy for isolation of endothelial cells from murine tissues. Characterization of two endothelial cell lines from the murine lung and subcutaneous sponge implants. Dong, Q.G., Bernasconi, S., Lostaglio, S., De Calmanovici, R.W., Martin-Padura, I., Breviario, F., Garlanda, C., Ramponi, S., Mantovani, A., Vecchi, A. Arterioscler. Thromb. Vasc. Biol. (1997) [Pubmed]
  32. Cellular expression of integrin-beta 1 is of critical importance for inducing therapeutic angiogenesis by cell implantation. Li, T.S., Ito, H., Hayashi, M., Furutani, A., Matsuzaki, M., Hamano, K. Cardiovasc. Res. (2005) [Pubmed]
  33. Requirement of Rac activity for maintenance of capillary endothelial barrier properties. Waschke, J., Baumgartner, W., Adamson, R.H., Zeng, M., Aktories, K., Barth, H., Wilde, C., Curry, F.E., Drenckhahn, D. Am. J. Physiol. Heart Circ. Physiol. (2004) [Pubmed]
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