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Gene Review

Mag  -  myelin-associated glycoprotein

Rattus norvegicus

Synonyms: Brain neuron cytoplasmic protein 3, Myelin-associated glycoprotein, Sialic acid-binding Ig-like lectin 4a, Siglec-4a
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Disease relevance of Mag


High impact information on Mag

  • In mature myelin, periaxin colocalizes with the myelin-associated glycoprotein in the cytoplasm-filled periaxonal regions of the sheath but is excluded from compact myelin [5].
  • In contrast, MAG promotes neurite outgrowth from newborn DRG neurons [2].
  • These results suggest that MAG may be responsible, in part, for the lack of CNS nerve regeneration in vivo and may influence, both temporally and spatially, regeneration in the PNS [2].
  • Therefore, the effects of hypothyroidism on MAG mRNA and protein levels were most likely caused by decreased mRNA stability [1].
  • MAG mRNA started to accumulate in the cerebrum of normal animals by postnatal day 7, reaching maximal levels by day 20 [1].

Chemical compound and disease context of Mag


Biological context of Mag


Anatomical context of Mag


Associations of Mag with chemical compounds


Other interactions of Mag


Analytical, diagnostic and therapeutic context of Mag


  1. Neonatal hypothyroidism affects the timely expression of myelin-associated glycoprotein in the rat brain. Rodriguez-Peña, A., Ibarrola, N., Iñiguez, M.A., Muñoz, A., Bernal, J. J. Clin. Invest. (1993) [Pubmed]
  2. A novel role for myelin-associated glycoprotein as an inhibitor of axonal regeneration. Mukhopadhyay, G., Doherty, P., Walsh, F.S., Crocker, P.R., Filbin, M.T. Neuron (1994) [Pubmed]
  3. Expression of recombinant myelin-associated glycoprotein in primary Schwann cells promotes the initial investment of axons by myelinating Schwann cells. Owens, G.C., Boyd, C.J., Bunge, R.P., Salzer, J.L. J. Cell Biol. (1990) [Pubmed]
  4. Sulfated glucuronyl paragloboside in rat brain microvessels. Miyatani, N., Kohriyama, T., Maeda, Y., Yu, R.K. J. Neurochem. (1990) [Pubmed]
  5. Periaxin, a novel protein of myelinating Schwann cells with a possible role in axonal ensheathment. Gillespie, C.S., Sherman, D.L., Blair, G.E., Brophy, P.J. Neuron (1994) [Pubmed]
  6. Retinoic acid-regulated expression of proteolipid protein and myelin-associated glycoprotein genes in C6 glioma cells. Zhu, W., Kanoh, M., Ye, P., Laszkiewicz, I., Royland, J.E., Wiggins, R.C., Konat, G. J. Neurosci. Res. (1992) [Pubmed]
  7. Two forms of 1B236/myelin-associated glycoprotein, a cell adhesion molecule for postnatal neural development, are produced by alternative splicing. Lai, C., Brow, M.A., Nave, K.A., Noronha, A.B., Quarles, R.H., Bloom, F.E., Milner, R.J., Sutcliffe, J.G. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  8. Lipid rafts mediate the interaction between myelin-associated glycoprotein (MAG) on myelin and MAG-receptors on neurons. Vinson, M., Rausch, O., Maycox, P.R., Prinjha, R.K., Chapman, D., Morrow, R., Harper, A.J., Dingwall, C., Walsh, F.S., Burbidge, S.A., Riddell, D.R. Mol. Cell. Neurosci. (2003) [Pubmed]
  9. Myelin-associated glycoprotein inhibits microtubule assembly by a Rho-kinase-dependent mechanism. Mimura, F., Yamagishi, S., Arimura, N., Fujitani, M., Kubo, T., Kaibuchi, K., Yamashita, T. J. Biol. Chem. (2006) [Pubmed]
  10. Membrane-bound CSPG mediates growth cone outgrowth and substrate specificity by Schwann cell contact with the DRG neuron cell body and not via growth cone contact. Castro, C., Kuffler, D.P. Exp. Neurol. (2006) [Pubmed]
  11. Sex-dimorphic effects of progesterone and its reduced metabolites on gene expression of myelin proteins by rat Schwann cells. Magnaghi, V., Veiga, S., Ballabio, M., Gonzalez, L.C., Garcia-Segura, L.M., Melcangi, R.C. J. Peripher. Nerv. Syst. (2006) [Pubmed]
  12. Sialidase enhances spinal axon outgrowth in vivo. Yang, L.J., Lorenzini, I., Vajn, K., Mountney, A., Schramm, L.P., Schnaar, R.L. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  13. Myelin-associated glycoprotein and myelinating Schwann cell-axon interaction in chronic B,B'-iminodipropionitrile neuropathy. Trapp, B.D., Quarles, R.H., Griffin, J.W. J. Cell Biol. (1984) [Pubmed]
  14. Axonal regulation of Schwann cell integrin expression suggests a role for alpha 6 beta 4 in myelination. Einheber, S., Milner, T.A., Giancotti, F., Salzer, J.L. J. Cell Biol. (1993) [Pubmed]
  15. Gangliosides are functional nerve cell ligands for myelin-associated glycoprotein (MAG), an inhibitor of nerve regeneration. Vyas, A.A., Patel, H.V., Fromholt, S.E., Heffer-Lauc, M., Vyas, K.A., Dang, J., Schachner, M., Schnaar, R.L. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  16. Potent glycan inhibitors of myelin-associated glycoprotein enhance axon outgrowth in vitro. Vyas, A.A., Blixt, O., Paulson, J.C., Schnaar, R.L. J. Biol. Chem. (2005) [Pubmed]
  17. Blockade of Nogo-66, myelin-associated glycoprotein, and oligodendrocyte myelin glycoprotein by soluble Nogo-66 receptor promotes axonal sprouting and recovery after spinal injury. Li, S., Liu, B.P., Budel, S., Li, M., Ji, B., Walus, L., Li, W., Jirik, A., Rabacchi, S., Choi, E., Worley, D., Sah, D.W., Pepinsky, B., Lee, D., Relton, J., Strittmatter, S.M. J. Neurosci. (2004) [Pubmed]
  18. Down-regulation of myelin-associated glycoprotein on Schwann cells by interferon-gamma and tumor necrosis factor-alpha affects neurite outgrowth. Schneider-Schaulies, J., Kirchhoff, F., Archelos, J., Schachner, M. Neuron (1991) [Pubmed]
  19. Effects of neonatal hypothyroidism on rat brain gene expression. Muñoz, A., Rodriguez-Peña, A., Perez-Castillo, A., Ferreiro, B., Sutcliffe, J.G., Bernal, J. Mol. Endocrinol. (1991) [Pubmed]
  20. Molecular cloning and primary structure of myelin-associated glycoprotein. Arquint, M., Roder, J., Chia, L.S., Down, J., Wilkinson, D., Bayley, H., Braun, P., Dunn, R. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  21. Cellular localization of 1B236/myelin-associated glycoprotein mRNA during rat brain development. Higgins, G.A., Schmale, H., Bloom, F.E., Wilson, M.C., Milner, R.J. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  22. Myelin formation in rotation-mediated aggregating cell cultures: immunocytochemical, electron microscopic, and biochemical observations. Trapp, B.D., Webster, H.D., Johnson, D., Quarles, R.H., Cohen, S.R., Murray, M.R. J. Neurosci. (1982) [Pubmed]
  23. Changes in the concentrations of cerebral proteins following occlusion of the middle cerebral artery in rats. Inuzuka, T., Tamura, A., Sato, S., Kirino, T., Yanagisawa, K., Toyoshima, I., Miyatake, T. Stroke (1990) [Pubmed]
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