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Chemical Compound Review

AGN-PC-0030PN     2,7-diamino-4,6-dimethyl-3- oxo-N,N'-bis(7...

Synonyms: FLU 402, NSC-239759, LS-14852, NSC239759, NSC 239759, ...
 
 
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Disease relevance of FLU 402

 

High impact information on FLU 402

 

Biological context of FLU 402

 

Anatomical context of FLU 402

 

Associations of FLU 402 with other chemical compounds

 

Gene context of FLU 402

  • Quantification of apoptotic cells by 7-aminoactinomycin D staining and of senescent cells by X-gal staining showed that both processes were significantly increased in H460 cells treated with MDM2-specific ASODN and radiation [23].
  • Cross-linking of CD53 with the use of the mAb MEM-53 and a polyclonal sheep anti-mouse Ig promoted activation of resting B cells into the G1 phase of the cell cycle as judged by increased expression of the early activation Ag CD69, increases in cellular volume, RNA synthesis, and c-myc protein levels, and enhanced binding of 7-aminoactinomycin D [24].
  • We analyzed phytohemagglutinin (PHA)-stimulated peripheral blood T cells from COPD patients and controls for apoptosis using flow cytometry and staining with annexin V and 7-aminoactinomycin D [25].
  • Steady-state BM and LP CD34+ selected cells were triple-stained for CD34, for DNA using the intercalating dye 7-aminoactinomycin D, and for Ki-67, cyclins, or adhesion antigens [26].
  • All samples were stained using the pan-leukocyte marker (CD45) in combination with a granulocyte marker (CD15) and a cell viability marker (7-aminoactinomycin D) [27].
 

Analytical, diagnostic and therapeutic context of FLU 402

References

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  31. The drug resistance proteins, multidrug resistance-associated protein and P-glycoprotein, do not confer resistance to Fas-induced cell death. Cullen, K., Davey, R., Davey, M. Cytometry. (2001) [Pubmed]
 
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