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Chemical Compound Review

AGN-PC-0030PN     2,7-diamino-4,6-dimethyl-3- oxo-N,N'-bis(7...

Synonyms: FLU 402, NSC-239759, LS-14852, NSC239759, NSC 239759, ...
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Disease relevance of FLU 402


High impact information on FLU 402


Biological context of FLU 402


Anatomical context of FLU 402


Associations of FLU 402 with other chemical compounds


Gene context of FLU 402

  • Quantification of apoptotic cells by 7-aminoactinomycin D staining and of senescent cells by X-gal staining showed that both processes were significantly increased in H460 cells treated with MDM2-specific ASODN and radiation [23].
  • Cross-linking of CD53 with the use of the mAb MEM-53 and a polyclonal sheep anti-mouse Ig promoted activation of resting B cells into the G1 phase of the cell cycle as judged by increased expression of the early activation Ag CD69, increases in cellular volume, RNA synthesis, and c-myc protein levels, and enhanced binding of 7-aminoactinomycin D [24].
  • We analyzed phytohemagglutinin (PHA)-stimulated peripheral blood T cells from COPD patients and controls for apoptosis using flow cytometry and staining with annexin V and 7-aminoactinomycin D [25].
  • Steady-state BM and LP CD34+ selected cells were triple-stained for CD34, for DNA using the intercalating dye 7-aminoactinomycin D, and for Ki-67, cyclins, or adhesion antigens [26].
  • All samples were stained using the pan-leukocyte marker (CD45) in combination with a granulocyte marker (CD15) and a cell viability marker (7-aminoactinomycin D) [27].

Analytical, diagnostic and therapeutic context of FLU 402


  1. Characterization of YvcC (BmrA), a multidrug ABC transporter constitutively expressed in Bacillus subtilis. Steinfels, E., Orelle, C., Fantino, J.R., Dalmas, O., Rigaud, J.L., Denizot, F., Di Pietro, A., Jault, J.M. Biochemistry (2004) [Pubmed]
  2. 7-substituted actinomycin D analogs. Chemical and growth-inhibitory studies. Sengupta, S.K., Tinter, S.K., Lazarus, H., Brown, B.L., Modest, E.J. J. Med. Chem. (1975) [Pubmed]
  3. Automated quantitation of cell-mediated HIV type 1 infection of human syncytiotrophoblast cells by fluorescence in situ hybridization and laser scanning cytometry. Douglas, G.C., Thirkill, T.L., LaSalle, J. AIDS Res. Hum. Retroviruses (2001) [Pubmed]
  4. Detection of endogenous and antibody-conjugated alkaline phosphatase with ELF-97 phosphate in multicolor flow cytometry applications. Telford, W., Cox, W., Singer, V. Cytometry. (2001) [Pubmed]
  5. Effect of farnesyl transferase inhibitor R115777 on the growth of fresh and cloned myeloma cells in vitro. Ochiai, N., Uchida, R., Fuchida, S., Okano, A., Okamoto, M., Ashihara, E., Inaba, T., Fujita, N., Matsubara, H., Shimazaki, C. Blood (2003) [Pubmed]
  6. Development of human megakaryocytes: I. Hematopoietic progenitors (CD34+ bone marrow cells) are enriched with megakaryocytes expressing CD4. Dolzhanskiy, A., Basch, R.S., Karpatkin, S. Blood (1996) [Pubmed]
  7. A functional comparison of CD34 + CD38- cells in cord blood and bone marrow. Hao, Q.L., Shah, A.J., Thiemann, F.T., Smogorzewska, E.M., Crooks, G.M. Blood (1995) [Pubmed]
  8. Differential chromatin structure-dependent binding of 7-aminoactinomycin D in normal and malignant bone marrow hematopoietic cells. Stokke, T., Holte, H., Smeland, E.B., Lie, S.O., Steen, H.B. Cancer Res. (1992) [Pubmed]
  9. In vitro and in vivo activation of B-lymphocytes: a flow cytometric study of chromatin structure employing 7-aminoactinomycin D. Stokke, T., Holte, H., Steen, H.B. Cancer Res. (1988) [Pubmed]
  10. Moloney murine leukemia virus-induced preleukemic thymic atrophy and enhanced thymocyte apoptosis correlate with disease pathogenicity. Bonzon, C., Fan, H. J. Virol. (1999) [Pubmed]
  11. Actinomycin D binds to metastable hairpins in single-stranded DNA. Wadkins, R.M., Vladu, B., Tung, C.S. Biochemistry (1998) [Pubmed]
  12. Radiation enhancement by the combined use of topoisomerase I inhibitors, RFS-2000 or CPT-11, and topoisomerase II inhibitor etoposide in human lung cancer cells. Kim, J.S., Amorino, G.P., Pyo, H., Cao, Q., Choy, H. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. (2002) [Pubmed]
  13. Phagocytosis of apoptotic cells assessed by flow cytometry using 7-Aminoactinomycin D. Gaforio, J.J., Serrano, M.J., Algarra, I., Ortega, E., Alvarez de Cienfuegos, G. Cytometry. (2002) [Pubmed]
  14. Expansion and enhanced survival of natural killer cells expressing the killer immunoglobulin-like receptor KIR3DL2 in spondylarthritis. Chan, A.T., Kollnberger, S.D., Wedderburn, L.R., Bowness, P. Arthritis Rheum. (2005) [Pubmed]
  15. Functional Analysis of Neutralizing Antibodies against Clostridium perfringens Epsilon-Toxin. McClain, M.S., Cover, T.L. Infect. Immun. (2007) [Pubmed]
  16. Virus-induced polyclonal T cell activation is followed by apoptosis: partitioning of CD8+ T cells based on alpha 4 integrin expression. Christensen, J.P., Röpke, C., Thomsen, A.R. Int. Immunol. (1996) [Pubmed]
  17. Administration of low-dose cytarabine results in immediate S-phase arrest and subsequent activation of cell cycling in murine stem cells. van Pelt, K., de Haan, G., Vellenga, E., Daenen, S.M. Exp. Hematol. (2005) [Pubmed]
  18. Accessibility of 7-aminoactinomycin D to lymphocyte nuclei after paraformaldehyde fixation. Lindén, E., Skoglund, P., Rundquist, I. Cytometry. (1997) [Pubmed]
  19. A selective cyclooxygenase-2 inhibitor, NS-398, enhances the effect of radiation in vitro and in vivo preferentially on the cells that express cyclooxygenase-2. Pyo, H., Choy, H., Amorino, G.P., Kim, J.S., Cao, Q., Hercules, S.K., DuBois, R.N. Clin. Cancer Res. (2001) [Pubmed]
  20. Actinomycin D and 7-aminoactinomycin D binding to single-stranded DNA. Wadkins, R.M., Jovin, T.M. Biochemistry (1991) [Pubmed]
  21. Assessment of stromal function, and its potential contribution to deregulation of hematopoiesis in the myelodysplastic syndromes. Tauro, S., Hepburn, M.D., Bowen, D.T., Pippard, M.J. Haematologica (2001) [Pubmed]
  22. Texture analysis of fluorescence lifetime images of AT- and GC-rich regions in nuclei. Murata, S., Herman, P., Lakowicz, J.R. J. Histochem. Cytochem. (2001) [Pubmed]
  23. Murine double minute 2 as a therapeutic target for radiation sensitization of lung cancer. Cao, C., Shinohara, E.T., Niermann, K.J., Donnelly, E.F., Chen, X., Hallahan, D.E., Lu, B. Mol. Cancer Ther. (2005) [Pubmed]
  24. Cross-linking of CD53 promotes activation of resting human B lymphocytes. Rasmussen, A.M., Blomhoff, H.K., Stokke, T., Horejsi, V., Smeland, E.B. J. Immunol. (1994) [Pubmed]
  25. Increased production of TGF-beta and apoptosis of T lymphocytes isolated from peripheral blood in COPD. Hodge, S.J., Hodge, G.L., Reynolds, P.N., Scicchitano, R., Holmes, M. Am. J. Physiol. Lung Cell Mol. Physiol. (2003) [Pubmed]
  26. Delineation of cell cycle state and correlation to adhesion molecule expression of human CD34+ cells from steady-state bone marrow and peripheral blood mobilized following G-CSF-supported chemotherapy. Fruehauf, S., Veldwijk, M.R., Krämer, A., Haas, R., Zeller, W.J. Stem Cells (1998) [Pubmed]
  27. Determination of bronchoalveolar lavage leukocyte populations by flow cytometry in patients investigated for respiratory disease. Barry, S.M., Condez, A., Johnson, M.A., Janossy, G. Cytometry. (2002) [Pubmed]
  28. Immunophenotyping of peripheral blood leukocytes by laser scanning cytometry. Gerstner, A., Laffers, W., Bootz, F., Tárnok, A. J. Immunol. Methods (2000) [Pubmed]
  29. Analysis of fertilization and polyspermy in serotonin-spawned eggs of the zebra mussel, Dreissena polymorpha. Misamore, M., Silverman, H., Lynn, J.W. Mol. Reprod. Dev. (1996) [Pubmed]
  30. Apoptotic rate: a new indicator for the quantification of the incidence of apoptosis in cell cultures. Prieto, A., Díaz, D., Barcenilla, H., García-Suárez, J., Reyes, E., Monserrat, J., San Antonio, E., Melero, D., de la Hera, A., Orfao, A., Alvarez-Mon, M. Cytometry. (2002) [Pubmed]
  31. The drug resistance proteins, multidrug resistance-associated protein and P-glycoprotein, do not confer resistance to Fas-induced cell death. Cullen, K., Davey, R., Davey, M. Cytometry. (2001) [Pubmed]
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