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Chemical Compound Review

Hyprim     5-[(4-bromo-3,5-dimethoxy...

Synonyms: Brodimoprim, Brodimoprima, Brodimoprime, Bromdimoprim, Brodimoprimum, ...
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Disease relevance of Bromdimoprim


High impact information on Bromdimoprim


Chemical compound and disease context of Bromdimoprim

  • Eighty adult outpatients with acute sinusitis were randomly assigned to receive 200 mg of brodimoprim once daily or 750 mg of amoxicillin thrice daily for seven to 10 days [4].
  • Against a range of strains of the Enterobacteriaceae trimethoprim was slightly more active, although in an in vivo murine model brodimoprim had a significantly better cure rate [10].
  • The objective of the study was the comparison of the efficacy and tolerability of brodimoprim to those of erythromycin in children with acute tonsillitis or bronchitis [11].
  • OBJECTIVE: To compare efficacy and tolerability of brodimoprim tablets with doxycycline tablets in adults with acute sinusitis [12].
  • Eighty adult patients affected by acute bacterial otitis media were selected and randomized into two balanced groups of treatment: 1) brodimoprim 200 mg tablets at the dosage of 2 tablets in single dose on the first day and one tablet on the following days; 2) josamycin 500 mg tablets at the dosage of 3 tablets/day [13].

Biological context of Bromdimoprim


Anatomical context of Bromdimoprim


Associations of Bromdimoprim with other chemical compounds


Gene context of Bromdimoprim


Analytical, diagnostic and therapeutic context of Bromdimoprim


  1. 1H/15N HSQC NMR studies of ligand carboxylate group interactions with arginine residues in complexes of brodimoprim analogues and Lactobacillus casei dihydrofolate reductase. Morgan, W.D., Birdsall, B., Nieto, P.M., Gargaro, A.R., Feeney, J. Biochemistry (1999) [Pubmed]
  2. Brodimoprim synergy against Enterococcus faecalis evaluated in vitro. Richards, R.M., Xing, J.Z. J. Antimicrob. Chemother. (1996) [Pubmed]
  3. Brodimoprim in acute exacerbations of chronic bronchitis: a clinical and bacteriological pilot study. Maesen, F.P., Davies, B.I., van Noord, J.A., Salemans, T. J. Antimicrob. Chemother. (1984) [Pubmed]
  4. Brodimoprim versus amoxicillin in the treatment of acute sinusitis. Nyffenegger, R., Riebenfeld, D., Macciocchi, A. Clinical therapeutics. (1991) [Pubmed]
  5. Efficacy and tolerability of brodimoprim in respiratory tract infections. Moretti, M., Marchioni, C.F., Bisetti, A. Journal of chemotherapy (Florence, Italy) (1993) [Pubmed]
  6. Correlation of trimethoprim and brodimoprim physicochemical and lipid membrane interaction properties with their accumulation in human neutrophils. Fresta, M., Furneri, P.M., Mezzasalma, E., Nicolosi, V.M., Puglisi, G. Antimicrob. Agents Chemother. (1996) [Pubmed]
  7. Penetration of brodimoprim into human neutrophils and intracellular activity. Braga, P.C., Dal Sasso, M., Maci, S., Bondiolotti, G., Fonti, E., Reggio, S. Antimicrob. Agents Chemother. (1996) [Pubmed]
  8. Controlled study of brodimoprim and cephalexin in the treatment of patients with acute sinusitis in general practice. Bockmeyer, M., Riebenfeld, D., Clasen, B. Clinical therapeutics. (1994) [Pubmed]
  9. In vitro activity of epiroprim, a dihydrofolate reductase inhibitor, singly and in combination with brodimoprim and dapsone, against Mycobacterium leprae. Dhople, A.M. Int. J. Antimicrob. Agents (1999) [Pubmed]
  10. Comparative antibacterial spectrum of trimethoprim and brodimoprim. Amyes, S.G. Journal of chemotherapy (Florence, Italy) (1993) [Pubmed]
  11. A randomized, open, comparative study of brodimoprim versus erythromycin in patients with acute tonsillitis or bronchitis. Salzberg, R. Journal of chemotherapy (Florence, Italy) (1993) [Pubmed]
  12. Therapeutic efficacy and tolerability of brodimoprim in comparison with doxycycline in acute sinusitis in adults. Arndt, J., Riebenfeld, D., Maier, H., Weidauer, H. Journal of chemotherapy (Florence, Italy) (1994) [Pubmed]
  13. Efficacy and tolerability of brodimoprim in otitis. De Campora, E., Radici, M., Camaioni, A. Journal of chemotherapy (Florence, Italy) (1993) [Pubmed]
  14. Pharmacokinetics of brodimoprim. Weidekamm, E. Journal of chemotherapy (Florence, Italy) (1993) [Pubmed]
  15. Brodimoprim: effects of subminimal inhibitory concentrations on virulence traits of respiratory and urinary tract pathogens, and on plasmid transfer and stability. Marchese, A., Debbia, E.A., Massaro, S., Campora, U., Schito, G. Journal of chemotherapy (Florence, Italy) (1996) [Pubmed]
  16. Pharmacokinetic profile of brodimoprim: oral bioavailability and penetration into interstitial fluid. Bergan, T. Journal of chemotherapy (Florence, Italy) (1993) [Pubmed]
  17. In vitro effects of brodimoprim on human polymorphonuclear leukocyte functions. Preliminary results. Mini, E., Novelli, A., Coronnello, M., Fallani, S., Pesciullesi, A., Periti, P. Journal of chemotherapy (Florence, Italy) (1993) [Pubmed]
  18. Brodimoprim concentrations in bronchial mucosa, bronchial secretions and middle ear effusions. Scaglione, F., Cogo, R., Pintucci, J.P., Demartini, G., Dugnani, S., Maccarinelli, G., Fraschini, F. Journal of chemotherapy (Florence, Italy) (1993) [Pubmed]
  19. Preclinical toxicology and safety pharmacology of brodimoprim in comparison to trimethoprim and analogs. Stephan-Güldner, M. Journal of chemotherapy (Florence, Italy) (1993) [Pubmed]
  20. Efficacy and tolerability of brodimoprim od versus norfloxacin bid in the treatment of bacterial urinary tract infections. Scaglione, F., Demartini, G., Cocuzza, C., Raschi, S., Cogo, R. International journal of clinical pharmacology research. (1995) [Pubmed]
  21. History and future of antimicrobial diaminopyrimidines. Then, R.L. Journal of chemotherapy (Florence, Italy) (1993) [Pubmed]
  22. Properties of brodimoprim as an inhibitor of dihydrofolate reductases. Then, R.L., Hermann, F. Chemotherapy. (1984) [Pubmed]
  23. Determination of brodimoprim and its hydroxy metabolite in human plasma, blood and urine by high-performance liquid chromatography. Gaspari, F., Taiocchi, L., Pochobradsky, M.G. J. Chromatogr. (1992) [Pubmed]
  24. Efficacy and tolerability of brodimoprim and roxithromycin in acute sinusitis of bacterial origin in adults. Manzini, M., Caroggio, A. Journal of chemotherapy (Florence, Italy) (1993) [Pubmed]
  25. Efficacy and tolerability of brodimoprim in bacterial otitis media in children. Controlled study versus cefaclor. Galetti, G., Martini, A., Bergamini, G., Dallari, S., Ghidini, A., Mazzoli, M., Cantini, L., Monici Preti, P.A. Journal of chemotherapy (Florence, Italy) (1993) [Pubmed]
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