The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

Hyprim     5-[(4-bromo-3,5-dimethoxy...

Synonyms: Brodimoprim, Brodimoprima, Brodimoprime, Bromdimoprim, Brodimoprimum, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Bromdimoprim

 

High impact information on Bromdimoprim

 

Chemical compound and disease context of Bromdimoprim

  • Eighty adult outpatients with acute sinusitis were randomly assigned to receive 200 mg of brodimoprim once daily or 750 mg of amoxicillin thrice daily for seven to 10 days [4].
  • Against a range of strains of the Enterobacteriaceae trimethoprim was slightly more active, although in an in vivo murine model brodimoprim had a significantly better cure rate [10].
  • The objective of the study was the comparison of the efficacy and tolerability of brodimoprim to those of erythromycin in children with acute tonsillitis or bronchitis [11].
  • OBJECTIVE: To compare efficacy and tolerability of brodimoprim tablets with doxycycline tablets in adults with acute sinusitis [12].
  • Eighty adult patients affected by acute bacterial otitis media were selected and randomized into two balanced groups of treatment: 1) brodimoprim 200 mg tablets at the dosage of 2 tablets in single dose on the first day and one tablet on the following days; 2) josamycin 500 mg tablets at the dosage of 3 tablets/day [13].
 

Biological context of Bromdimoprim

 

Anatomical context of Bromdimoprim

 

Associations of Bromdimoprim with other chemical compounds

 

Gene context of Bromdimoprim

 

Analytical, diagnostic and therapeutic context of Bromdimoprim

References

  1. 1H/15N HSQC NMR studies of ligand carboxylate group interactions with arginine residues in complexes of brodimoprim analogues and Lactobacillus casei dihydrofolate reductase. Morgan, W.D., Birdsall, B., Nieto, P.M., Gargaro, A.R., Feeney, J. Biochemistry (1999) [Pubmed]
  2. Brodimoprim synergy against Enterococcus faecalis evaluated in vitro. Richards, R.M., Xing, J.Z. J. Antimicrob. Chemother. (1996) [Pubmed]
  3. Brodimoprim in acute exacerbations of chronic bronchitis: a clinical and bacteriological pilot study. Maesen, F.P., Davies, B.I., van Noord, J.A., Salemans, T. J. Antimicrob. Chemother. (1984) [Pubmed]
  4. Brodimoprim versus amoxicillin in the treatment of acute sinusitis. Nyffenegger, R., Riebenfeld, D., Macciocchi, A. Clinical therapeutics. (1991) [Pubmed]
  5. Efficacy and tolerability of brodimoprim in respiratory tract infections. Moretti, M., Marchioni, C.F., Bisetti, A. Journal of chemotherapy (Florence, Italy) (1993) [Pubmed]
  6. Correlation of trimethoprim and brodimoprim physicochemical and lipid membrane interaction properties with their accumulation in human neutrophils. Fresta, M., Furneri, P.M., Mezzasalma, E., Nicolosi, V.M., Puglisi, G. Antimicrob. Agents Chemother. (1996) [Pubmed]
  7. Penetration of brodimoprim into human neutrophils and intracellular activity. Braga, P.C., Dal Sasso, M., Maci, S., Bondiolotti, G., Fonti, E., Reggio, S. Antimicrob. Agents Chemother. (1996) [Pubmed]
  8. Controlled study of brodimoprim and cephalexin in the treatment of patients with acute sinusitis in general practice. Bockmeyer, M., Riebenfeld, D., Clasen, B. Clinical therapeutics. (1994) [Pubmed]
  9. In vitro activity of epiroprim, a dihydrofolate reductase inhibitor, singly and in combination with brodimoprim and dapsone, against Mycobacterium leprae. Dhople, A.M. Int. J. Antimicrob. Agents (1999) [Pubmed]
  10. Comparative antibacterial spectrum of trimethoprim and brodimoprim. Amyes, S.G. Journal of chemotherapy (Florence, Italy) (1993) [Pubmed]
  11. A randomized, open, comparative study of brodimoprim versus erythromycin in patients with acute tonsillitis or bronchitis. Salzberg, R. Journal of chemotherapy (Florence, Italy) (1993) [Pubmed]
  12. Therapeutic efficacy and tolerability of brodimoprim in comparison with doxycycline in acute sinusitis in adults. Arndt, J., Riebenfeld, D., Maier, H., Weidauer, H. Journal of chemotherapy (Florence, Italy) (1994) [Pubmed]
  13. Efficacy and tolerability of brodimoprim in otitis. De Campora, E., Radici, M., Camaioni, A. Journal of chemotherapy (Florence, Italy) (1993) [Pubmed]
  14. Pharmacokinetics of brodimoprim. Weidekamm, E. Journal of chemotherapy (Florence, Italy) (1993) [Pubmed]
  15. Brodimoprim: effects of subminimal inhibitory concentrations on virulence traits of respiratory and urinary tract pathogens, and on plasmid transfer and stability. Marchese, A., Debbia, E.A., Massaro, S., Campora, U., Schito, G. Journal of chemotherapy (Florence, Italy) (1996) [Pubmed]
  16. Pharmacokinetic profile of brodimoprim: oral bioavailability and penetration into interstitial fluid. Bergan, T. Journal of chemotherapy (Florence, Italy) (1993) [Pubmed]
  17. In vitro effects of brodimoprim on human polymorphonuclear leukocyte functions. Preliminary results. Mini, E., Novelli, A., Coronnello, M., Fallani, S., Pesciullesi, A., Periti, P. Journal of chemotherapy (Florence, Italy) (1993) [Pubmed]
  18. Brodimoprim concentrations in bronchial mucosa, bronchial secretions and middle ear effusions. Scaglione, F., Cogo, R., Pintucci, J.P., Demartini, G., Dugnani, S., Maccarinelli, G., Fraschini, F. Journal of chemotherapy (Florence, Italy) (1993) [Pubmed]
  19. Preclinical toxicology and safety pharmacology of brodimoprim in comparison to trimethoprim and analogs. Stephan-Güldner, M. Journal of chemotherapy (Florence, Italy) (1993) [Pubmed]
  20. Efficacy and tolerability of brodimoprim od versus norfloxacin bid in the treatment of bacterial urinary tract infections. Scaglione, F., Demartini, G., Cocuzza, C., Raschi, S., Cogo, R. International journal of clinical pharmacology research. (1995) [Pubmed]
  21. History and future of antimicrobial diaminopyrimidines. Then, R.L. Journal of chemotherapy (Florence, Italy) (1993) [Pubmed]
  22. Properties of brodimoprim as an inhibitor of dihydrofolate reductases. Then, R.L., Hermann, F. Chemotherapy. (1984) [Pubmed]
  23. Determination of brodimoprim and its hydroxy metabolite in human plasma, blood and urine by high-performance liquid chromatography. Gaspari, F., Taiocchi, L., Pochobradsky, M.G. J. Chromatogr. (1992) [Pubmed]
  24. Efficacy and tolerability of brodimoprim and roxithromycin in acute sinusitis of bacterial origin in adults. Manzini, M., Caroggio, A. Journal of chemotherapy (Florence, Italy) (1993) [Pubmed]
  25. Efficacy and tolerability of brodimoprim in bacterial otitis media in children. Controlled study versus cefaclor. Galetti, G., Martini, A., Bergamini, G., Dallari, S., Ghidini, A., Mazzoli, M., Cantini, L., Monici Preti, P.A. Journal of chemotherapy (Florence, Italy) (1993) [Pubmed]
 
WikiGenes - Universities