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Cbfb  -  core binding factor beta

Mus musculus

Synonyms: AI893578, CBF-beta, Core-binding factor subunit beta, PEA2, PEA2-beta, ...
 
 
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Disease relevance of Cbfb

 

High impact information on Cbfb

 

Chemical compound and disease context of Cbfb

 

Biological context of Cbfb

 

Anatomical context of Cbfb

 

Associations of Cbfb with chemical compounds

  • Exposing mice transplanted with CBFbeta-SMMHC-transduced cells to a mutagen, ethylnitrosourea, markedly accelerated leukemogenesis compared to expressing CBFbeta-SMMHC with loss of p16p19, indicating the need for multiple "hits" for transformation [4].
  • Cloning and expression pattern of a novel PEBP2 beta-binding protein (charged amino acid rich leucine zipper-1[Crl-1]) in the mouse [15].
  • We have developed Ba/F3 cell lines in which zinc regulates CBFbeta-SMMHC expression and 4-hydroxytamoxifen activates c-Myc-ER [16].
  • Here we report an alanine-scanning mutagenesis study of the Runt domain that targeted amino acids identified by structural studies to reside at the DNA or CBF beta interface, as well as amino acids mutated in human disease [17].
  • Site-directed mutagenesis of the amino acid residue 72, a highly conserved cysteine in the runt homology domain of AML1, to serine almost completely abolished DNA binding without altering the interaction with PEBP2beta/CBFbeta [18].
 

Physical interactions of Cbfb

 

Other interactions of Cbfb

 

Analytical, diagnostic and therapeutic context of Cbfb

  • Subcellular localizations of the wild-type CBFbeta and the CBFbeta-SMMHC fusion protein were determined by immunofluorescence of NIH 3T3 cells that overexpress wild-type or fusion protein [13].
  • On luciferase and electrophoretic mobility shift assays, Runx2-I was less active than Runx2-II in the absence of Cbfb, but the two Runx2 isoforms had similar activity levels in the presence of Cbfb [3].
  • Molecular cloning and characterization of PEBP2 beta, the heterodimeric partner of a novel Drosophila runt-related DNA binding protein PEBP2 alpha [9].
  • To examine the expression of the PEBP2beta/CBFbeta protein in vivo, we carried out immunohistochemistry using the tissues from adult mice as well as embryos [23].
  • Crystallization and preliminary X-ray analyses of quaternary, ternary and binary protein-DNA complexes with involvement of AML1/Runx-1/CBFalpha Runt domain, CBFbeta and the C/EBPbeta bZip region [24].

References

  1. Core-binding factor beta interacts with Runx2 and is required for skeletal development. Yoshida, C.A., Furuichi, T., Fujita, T., Fukuyama, R., Kanatani, N., Kobayashi, S., Satake, M., Takada, K., Komori, T. Nat. Genet. (2002) [Pubmed]
  2. Core-binding factor beta (CBFbeta), but not CBFbeta-smooth muscle myosin heavy chain, rescues definitive hematopoiesis in CBFbeta-deficient embryonic stem cells. Miller, J.D., Stacy, T., Liu, P.P., Speck, N.A. Blood (2001) [Pubmed]
  3. Cbf beta regulates Runx2 function isoform-dependently in postnatal bone development. Kanatani, N., Fujita, T., Fukuyama, R., Liu, W., Yoshida, C.A., Moriishi, T., Yamana, K., Miyazaki, T., Toyosawa, S., Komori, T. Dev. Biol. (2006) [Pubmed]
  4. Acceleration of G(1) cooperates with core binding factor beta-smooth muscle myosin heavy chain to induce acute leukemia in mice. Yang, Y., Wang, W., Cleaves, R., Zahurak, M., Cheng, L., Civin, C.I., Friedman, A.D. Cancer Res. (2002) [Pubmed]
  5. The PEBP2betaMYH11 fusion created by Inv(16)(p13;q22) in myeloid leukemia impairs neutrophil maturation and contributes to granulocytic dysplasia. Kogan, S.C., Lagasse, E., Atwater, S., Bae, S.C., Weissman, I., Ito, Y., Bishop, J.M. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  6. The core-binding factor beta subunit is required for bone formation and hematopoietic maturation. Miller, J., Horner, A., Stacy, T., Lowrey, C., Lian, J.B., Stein, G., Nuckolls, G.H., Speck, N.A. Nat. Genet. (2002) [Pubmed]
  7. Cbfbeta interacts with Runx2 and has a critical role in bone development. Kundu, M., Javed, A., Jeon, J.P., Horner, A., Shum, L., Eckhaus, M., Muenke, M., Lian, J.B., Yang, Y., Nuckolls, G.H., Stein, G.S., Liu, P.P. Nat. Genet. (2002) [Pubmed]
  8. Structural analyses of DNA recognition by the AML1/Runx-1 Runt domain and its allosteric control by CBFbeta. Tahirov, T.H., Inoue-Bungo, T., Morii, H., Fujikawa, A., Sasaki, M., Kimura, K., Shiina, M., Sato, K., Kumasaka, T., Yamamoto, M., Ishii, S., Ogata, K. Cell (2001) [Pubmed]
  9. Molecular cloning and characterization of PEBP2 beta, the heterodimeric partner of a novel Drosophila runt-related DNA binding protein PEBP2 alpha. Ogawa, E., Inuzuka, M., Maruyama, M., Satake, M., Naito-Fujimoto, M., Ito, Y., Shigesada, K. Virology (1993) [Pubmed]
  10. The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo. Wang, Q., Stacy, T., Miller, J.D., Lewis, A.F., Gu, T.L., Huang, X., Bushweller, J.H., Bories, J.C., Alt, F.W., Ryan, G., Liu, P.P., Wynshaw-Boris, A., Binder, M., Marín-Padilla, M., Sharpe, A.H., Speck, N.A. Cell (1996) [Pubmed]
  11. Role of Cbfb in hematopoiesis and perturbations resulting from expression of the leukemogenic fusion gene Cbfb-MYH11. Kundu, M., Chen, A., Anderson, S., Kirby, M., Xu, L., Castilla, L.H., Bodine, D., Liu, P.P. Blood (2002) [Pubmed]
  12. Overexpression of core-binding factor alpha (CBF alpha) reverses cellular transformation by the CBF beta-smooth muscle myosin heavy chain chimeric oncoprotein. Hajra, A., Liu, P.P., Speck, N.A., Collins, F.S. Mol. Cell. Biol. (1995) [Pubmed]
  13. Core binding factor beta-smooth muscle myosin heavy chain chimeric protein involved in acute myeloid leukemia forms unusual nuclear rod-like structures in transformed NIH 3T3 cells. Wijmenga, C., Gregory, P.E., Hajra, A., Schröck, E., Ried, T., Eils, R., Liu, P.P., Collins, F.S. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  14. A full-length Cbfa1 gene product perturbs T-cell development and promotes lymphomagenesis in synergy with myc. Vaillant, F., Blyth, K., Terry, A., Bell, M., Cameron, E.R., Neil, J., Stewart, M. Oncogene (1999) [Pubmed]
  15. Cloning and expression pattern of a novel PEBP2 beta-binding protein (charged amino acid rich leucine zipper-1[Crl-1]) in the mouse. Sakuma, T., Li, Q.L., Jin, Y., Choi, L.B., Kim, E.G., Ito, K., Ito, Y., Nomura, S., Bae, S.C. Mech. Dev. (2001) [Pubmed]
  16. c-Myc overcomes cell cycle inhibition by CBFbeta-SMMHC, a myeloid leukemia oncoprotein. Bernardin, F., Yang, Y., Civin, C.I., Friedman, A.D. Cancer Biol. Ther. (2002) [Pubmed]
  17. Energetic contribution of residues in the Runx1 Runt domain to DNA binding. Li, Z., Yan, J., Matheny, C.J., Corpora, T., Bravo, J., Warren, A.J., Bushweller, J.H., Speck, N.A. J. Biol. Chem. (2003) [Pubmed]
  18. A conserved cysteine residue in the runt homology domain of AML1 is required for the DNA binding ability and the transforming activity on fibroblasts. Kurokawa, M., Tanaka, T., Tanaka, K., Hirano, N., Ogawa, S., Mitani, K., Yazaki, Y., Hirai, H. J. Biol. Chem. (1996) [Pubmed]
  19. Runx1 deficiency predisposes mice to T-lymphoblastic lymphoma. Kundu, M., Compton, S., Garrett-Beal, L., Stacy, T., Starost, M.F., Eckhaus, M., Speck, N.A., Liu, P.P. Blood (2005) [Pubmed]
  20. The core-binding factor leukemias: lessons learned from murine models. Downing, J.R. Curr. Opin. Genet. Dev. (2003) [Pubmed]
  21. Isolation of PEBP2 alpha B cDNA representing the mouse homolog of human acute myeloid leukemia gene, AML1. Bae, S.C., Yamaguchi-Iwai, Y., Ogawa, E., Maruyama, M., Inuzuka, M., Kagoshima, H., Shigesada, K., Satake, M., Ito, Y. Oncogene (1993) [Pubmed]
  22. CBF beta-SMMHC, expressed in M4Eo AML, reduced CBF DNA-binding and inhibited the G1 to S cell cycle transition at the restriction point in myeloid and lymphoid cells. Cao, W., Britos-Bray, M., Claxton, D.F., Kelley, C.A., Speck, N.A., Liu, P.P., Friedman, A.D. Oncogene (1997) [Pubmed]
  23. Differentiation dependent expression and distinct subcellular localization of the protooncogene product, PEBP2beta/CBFbeta, in muscle development. Chiba, N., Watanabe, T., Nomura, S., Tanaka, Y., Minowa, M., Niki, M., Kanamaru, R., Satake, M. Oncogene (1997) [Pubmed]
  24. Crystallization and preliminary X-ray analyses of quaternary, ternary and binary protein-DNA complexes with involvement of AML1/Runx-1/CBFalpha Runt domain, CBFbeta and the C/EBPbeta bZip region. Tahirov, T.H., Inoue-Bungo, T., Sasaki, M., Shiina, M., Kimura, K., Sato, K., Kumasaka, T., Yamamoto, M., Kamiya, N., Ogata, K. Acta Crystallogr. D Biol. Crystallogr. (2001) [Pubmed]
 
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