Disease relevance of LGV1

• Transgenic expression of the alpha7beta1 integrin in the dystrophic mdx/utr(-/-) mouse decreases development of muscular dystrophy and enhances longevity [1].
• Family patterns of coronary heart disease mortality: the Framingham Longevity Study [2].
• CONCLUSION: Longevity of patients with unresectable synchronous liver metastases from colorectal cancer is affected adversely by the presence of nodal metastases and extent of liver metastases [3].
• Role of proinflammatory alleles in longevity and atherosclerosis: results of studies performed on -1562C/T MMP-9 in centenarians and myocardial infarction patients from sicily [4].
• Successful management of HF requires aggressive management of comorbid conditions and careful follow up to slow disease progression, optimize functional status, and improve longevity [5].

Psychiatry related information on LGV1

• Of the 75 patients in the February 1977 "class" at the Longevity Research Institute, Santa Barbara, California, 11 volunteers were pre- and posttested (21- to 23-day intervals) with the MMPI, 13 with the California Psychological Inventory, and 17 with four subtests of the WAIS (total: 21 males, 10 females) [6].

High impact information on LGV1

• Instead, they support mild uncoupling as a mechanism protecting mitochondrial function and contributing to the paradoxical longevity of the most active muscle fibers [7].
• The mitochondrial membrane potential was unchanged in KO versus wild-type neurons, suggesting that the effects of the ablation of Surf1 on Ca(2+) homeostasis, and possibly on longevity, may be independent, at least in part, from those on COX assembly and mitochondrial bioenergetics [8].
• Deletion of p66Shc Longevity Gene Protects Against Experimental Diabetic Glomerulopathy by Preventing Diabetes-Induced Oxidative Stress [9].
• OX40-OX40 Ligand Interaction through T Cell-T Cell Contact Contributes to CD4 T Cell Longevity [10].
• {alpha}-Linolenic Acid-Enriched Diet Prevents Myocardial Damage and Expands Longevity in Cardiomyopathic Hamsters [11].

Biological context of LGV1

• The number, phenotype, effector function, and in vitro longevity of generated CTL were determined [12].
• Chronic stress can also have an effect on telomere lengths, determining cell senescence and longevity [13].
• The possible association between two polymorphisms in the first intron of this gene, alone or in combination, and bone mineral density at various sites was examined in participants in the National Institute for Longevity Sciences Longitudinal Study of Aging, a population-based prospective cohort study of aging and age-related diseases [14].
• Thus, sustained repression of NPY signaling in the hypothalamus by leptin transgene expression can improve the quality of life and extend longevity [15].
• Hence, genotypes of natural immunity should play an opposite role in atherosclerosis and longevity [4].

Anatomical context of LGV1

• Cryopreservation of boar sperm compromises fertility after thawing by reducing sperm longevity and inducing acrosome reaction-like changes [16].
• REASONS FOR PERFORMING STUDY: This study was part of a programme to optimise the longevity and maximise the health and welfare of the Thoroughbred racehorses in Hong Kong. Injuries to the superficial digital flexor (SDF) tendon are the most common veterinary reason for premature retirement in this population [17].
• There was a strong correlation between species longevity and resistance to the metabolic effects of low-glucose medium among the rodent cell lines, but this test did not distinguish mice and rats from the much longer-lived little brown bat [18].
• Adhesion to dentin with bonding to the tooth structure in the canal may provide greater resistance to tooth fracture and greater clinical longevity of an endodontically treated tooth [19].

Associations of LGV1 with chemical compounds

• SETTING: The study was part of the Longevity Genes Project at Albert Einstein College of Medicine. PARTICIPANTS: Ashkenazi Jewish centenarians (n = 27, 98.4 +/- 10.4 years) and their offspring (n = 33, 67.4 +/- 1.4 years) [20].
• Such effects could be important determinants of the extent of ethanol migration and longevity as well as groundwater impacts [21].
• OBJECTIVES: Longevity of particulate filler resin (PFR) is controversial for large restorations with high occlusal-stresses [22].
• Fractal analysis of heart rate variability and mortality in elderly community-dwelling people -- Longitudinal Investigation for the Longevity and Aging in Hokkaido County (LILAC) study [23].
• Here, we took a comparative approach, using short-lived invertebrate species, to directly test the effects of two tocopherols (Vitamin E) on longevity. gamma-Tocopherol represents the most abundant tocopherol in the Western diet, while alpha-tocopherol is selectively enriched in human plasma [24].

Physical interactions of LGV1

• The brain detects and overcomes oxidative stress by a complex network of "longevity assurance processes" integrated to the expression of genes termed vitagenes [25].

Regulatory relationships of LGV1

• The brain response to detect and control metabolic or oxidative stress is accomplished by a complex network of "longevity assurance processes" integrated to the expression of genes termed vitagenes [26].

Other interactions of LGV1

• METHODS: Subjects were recruited from participants in the National Institute for Longevity Sciences, Longitudinal Study of Aging. Genotyping of methylenetetrahydrofolate reductase (MTHFR) C677T gene mutation and brain MRI examination were performed in 1721 subjects free of any history of stroke [27].
• However, present results do not exclude that differential expression of MMP-9 playing an opposite role in AMI and longevity because other kinds of regulation might be more relevant than those linked to the SNP under study [4].

Analytical, diagnostic and therapeutic context of LGV1

• RESEARCH METHODS AND PROCEDURES: Subjects were 895 participants of the Baltimore Longitudinal Study of Aging in the US (BLSA) and 1705 participants of the Longitudinal Study of Aging by the National Institutes for Longevity Science in Japan (NILS-LSA) [28].
• SETTING: The study was part of the Longevity Genes Project at Albert Einstein College of Medicine. PARTICIPANTS: Centenarians (n=145), offspring of centenarians (n=180), and spouses of the offspring of centenarians (n=75) as a control group [29].
• BACKGROUND: Alternative bearings have been explored in an attempt to improve the longevity of total hip prostheses [30].
• Improvements in the performance and longevity of biological valve prostheses have steadily increased their rates of implantation in recent years [31].
• The healthy diets recommended for the general population to promote longevity (such as the Mediterranean diet), are defined based on epidemiological and intervention studies and are usually characterized by a relatively higher amount of protein than the usual Western diet [32].

References